ライフサイエンスコーパス: feedback regulation

1 n specifying network outputs and fine-tuning feedback regulation.

2 omplex, providing for both reinforcement and feedback regulation.

3 nded the model to explore mechanisms of Atf3 feedback regulation.

4 /E)L sequence that is essential for negative feedback regulation.

5 immunizations to bypass TE-mediated negative feedback regulation.

6 sis and is therefore subjected to allosteric feedback regulation.

7 ing opens calcium-activated ion channels for feedback regulation.

8 ription, consistent with previously reported feedback regulation.

9 orption and vitamin A production by negative feedback regulation.

10 uence specificity reflecting its efficacy in feedback regulation.

11 were similarly regulated by TCRbeta-mediated feedback regulation.

12 GluR1, thereby constituting a useful form of feedback regulation.

13 ally after genetic removal of a key negative-feedback regulation.

14 rom inhibitory BCR-specific and trans-active feedback regulation.

15 lex (TSC) gene products are a model for this feedback regulation.

16 ules at the same site for the most efficient feedback regulation.

17 ial gene expression patterns and ABA pathway feedback regulation.

18 volve by optimizing the strength of negative-feedback regulation.

19 ly caused by the lack of proteasome-mediated feedback regulation.

20 receptor-mediated signaling and its negative feedback regulation.

21 r loss of mRNA, suggesting the potential for feedback regulation.

22 n is controlled by a BCO1-dependent negative feedback regulation.

23 cytokines, which induced SOCS3 for negative-feedback regulation.

24 of wild type levels as a result of disturbed feedback regulation.

25 tream target of FoxOs in NVP-BEZ235-mediated feedback regulation.

26 verned in part by differential mechanisms of feedback regulation after activation.

27 Negative feedback regulation also constrains the range of QS outp

28 e also provide evidence of auto-, para-, and feedback regulation among these factors at the transcrip

29 etwork interactions that correspond to known feedback regulations among multiple network species and

30 IGCR1 is also required for feedback regulation and allelic exclusion of proximal V(

31 ssue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signali

32 citrate synthase (HCS), is the target of the feedback regulation and is strongly inhibited by l-lysin

33 el mechanism of PI3K-AKT inhibition-mediated feedback regulation and may identify FoxO as a novel bio

34 The feedback regulation and mechanical-biochemical integrati

35 ween signaling pathways, involving extensive feedback regulation and multiple levels of cross-talk, u

36 subtilis during evolution for the purpose of feedback regulation and not for the creation of a bona f

37 en concentrations via hypothalamic-pituitary feedback regulation and prolonged ligand half-life.

38 s the protein at a constant rate without any feedback regulation, and any form of feedback (positive,

39 -translational modifications, its metabolite feedback regulation, and its enzyme organization is high

40 -translational modifications, its metabolite feedback regulation, and its enzyme organization.

41 erating multiple states is an alternative to feedback regulation, and its general principle should be

42 ture on expression variability and implicate feedback regulation as an effective mechanism to ensure

43 mics and plant development and reveals tight feedback regulation at both the transcriptional and prot

44 t the hypothesis that ABA signaling is under feedback regulation at the level of isoprenylcysteine me

45 We found that positive feedback regulation at the sre1(+) promoter increases th

46 metabolism in cardiomyocytes, and a negative feedback regulation between CBS and CSE in the heart.

47 and TNF-alpha in RA monocytes, suggesting a feedback regulation between IL-7/IL-7R and TNF-alpha cas

48 ression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFAT

49 Together, our findings suggest that positive feedback regulation between Lhx8, TrkA, and NGF is an im

50 ic analysis reveals no evidence for negative feedback regulation, but provides evidence that the choi

51 , cyclic ADPR, H(2)O(2), NAADP, and negative feedback regulation by AMP and permeating protons (pH).

52 ltage-gated Ca2+ channels undergo a negative feedback regulation by Ca2+ ions, Ca2+-dependent inactiv

53 hing is subject to a dual and interdependent feedback regulation by chemoreceptors.

54 iosynthesis in B. fragilis and is subject to feedback regulation by CMP-Kdo.

55 hTR-/hTERT-E1A mRNA differential, evidencing feedback regulation by E1A.

56 metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related

57 We further demonstrate feedback regulation by finding that ZBP1 physically asso

58 (2+)-dependent inactivation, a fast negative feedback regulation by incoming Ca(2+) ions, which depen

59 response to 2-APB, and strikingly different feedback regulation by intracellular Ca(2+).

60 al regulatory domain, which confers negative feedback regulation by isoleucine in planta.

61 GTPCH-1 undergoes negative feedback regulation by its end-product BH(4) via interac

62 ax2 seedlings, which could indicate negative feedback regulation by KAR/SL signaling.

63 The lacustrine Si:C atomic ratio is negative feedback regulation by phytoplankton, which may result i

64 hese results also explain the known negative feedback regulation by PTEN on its own synthesis through

65 s of several protein cofactors is subject to feedback regulation by riboswitches.

66 trate that PI3K/AKT signals enforce positive-feedback regulation by suppressing PTEN function.

67 crassa, by removing the endogenous negative feedback regulation by the circadian oscillator.

68 tive distal nephron (ASDN) is under negative-feedback regulation by the renin-angiotensin-aldosterone

69 Negative feedback regulation correlated with increased systemic T

70 , we classify these observations as negative-feedback regulation due to the deficient BMP antagonism

71 l3 complexes also provide essential negative feedback regulation during both thymocyte development an

72 GE expression is under negative feedback regulation; endogenous GE expression is upregul

73 s and also demonstrate the important role of feedback regulation for the polarization toward distinct

74 o investigate the mechanism of this negative feedback regulation from mTOR to Akt.

75 -like mutant EK genes, in which the site for feedback regulation has been mutated, were used, CMP-Neu

76 This feedback regulation has broad relevance to understanding

77 Moreover, our data suggest a feedback regulation in amiR-cpgi plants that fine-tunes

78 RT6, revealing the existence of LD and FOXO3 feedback regulation in colonic cells.

79 pha and indicate the existence of a positive feedback regulation in excitotoxicity involving calpain

80 Our research underscores the importance of feedback regulation in generating robust and adaptable b

81 tial firing and shape calcium influx through feedback regulation in mature neurons.

82 Chellamuthu et al. now identify a feedback regulation in plant nitrogen metabolism through

83 suggesting a functioning short-loop negative feedback regulation in PRL KO mice.

84 ing for NMD and demonstrate that reversal of feedback regulation in response to NMD perturbation is c

85 hich ubiquitin ligases cooperate and provide feedback regulation in the clearance of misfolded protei

86 Our findings support a model of feedback regulation in which RNase L and TTP target SRF

87 Thus, our studies identify a compensatory feedback regulation in which the activation of Akt is in

88 terminals, show two types of Ca2+-dependent feedback regulation-inactivation (CDI) and facilitation

89 n but then undergo various forms of negative feedback regulation including voltage- and calcium-depen

90 We further demonstrate how this negative feedback regulation insulates alternative sigma factor a

91 his constitutes a complete endocrine system; feedback regulation involving amino acids regulates alph

92 ty in cell cycle activity to double-negative feedback regulation involving CDK2, p21, and E3 ubiquiti

93 observed sarcomere length-dependent positive feedback regulation is a key determinant in the length-d

94 We suggest that sRNA-mediated feedback regulation is a network design feature that per

95 -STAT activation due to loss of LNK negative feedback regulation is a novel mechanism of MPN pathogen

96 ork replete with interpathway cross-talk and feedback regulation is broadly appreciated, kinetic data

97 Feedback regulation is conferred by different branches o

98 that the resulting tissue selective negative feedback regulation is essential to establish sex-specif

99 Evidence is provided that positive feedback regulation is independent from commensal germs

100 ndent Cav-1 phosphorylation in eNOS negative feedback regulation is investigated.

101 This feedback regulation is responsible for the transient act

102 or and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL

103 matory cytokine signaling through a negative feedback regulation loop involving down-regulation of TL

104 the existence of an ATAF2-BAS1/SOB7-BR-ATAF2 feedback regulation loop, as well as a light-ATAF2-BAS1/

105 construction of kinase-substrate network and feedback regulation loops downstream of SDF-1/CXCR4 sign

106 sis is maintained in part by transcriptional feedback regulation loops that control the expression of

107 ion, loss of silencing sequence and positive feedback regulation may lead to drastic upregulation of

108 Feedback regulation may occur when the concentration of

109 In addition to classic feedback regulation mediated by a rise in extracellular

110 of purine precursors is under tight negative feedback regulation mediated by adenosine and guanine nu

111 We specifically tested the role of feedback regulations mediated by G1- and SG2M-phase cycl

112 elease probability, and we suggest that this feedback regulation might be required to maintain synaps

113 data demonstrate that short-term biochemical feedback regulation of 1-deoxy-d-xylulose-5-phosphate sy

114 ism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with i

115 Thus feedback regulation of a shared component can restrict t

116 regulated by Sir-based silencing, providing feedback regulation of a silencing protein by silencing.

117 Feedback regulation of adaptive immunity is a fundamenta

118 ss was blocked by HSL inhibition, suggesting feedback regulation of adipocyte lipolysis via CD36 traf

119 Negative feedback regulation of ALAS-1 by the end product heme is

120 lts yield new insights into the mechanism of feedback regulation of an enzyme central to lysine biosy

121 orylation, implicating a role for Srx in the feedback regulation of AP-1 activity.

122 that PLN may be a critical CaMKII target for feedback regulation of APD in ventricular myocytes.

123 erve to override the autoinhibitory negative feedback regulation of ARF2 on its own transcription and

124 f Egr1 was lost, demonstrating that negative feedback regulation of Atf3 by Atf3 itself is implausibl

125 de-reactive CD4(+) Treg involved in negative feedback regulation of autoimmunity use a highly limited

126 These results reveal a novel negative feedback regulation of BCR signaling by HPK1-mediated ph

127 Negative feedback regulation of bile acid synthesis mediated by t

128 (FGF19) plays a crucial role in the negative feedback regulation of bile salt synthesis.

129 Overall, GABA(B) receptors do contribute to feedback regulation of bipolar cell transmitter release.

130 ition to that of VEGF, allowing for negative feedback regulation of BMP by MGP.

131 We also demonstrate that feedback regulation of both the activity and the abundan

132 ncy seemed to reflect disruption of negative feedback regulation of c-MPL signaling by the E3 ligase

133 Phosphorylation-mediated negative feedback regulation of cAMP levels by phosphodiesterase

134 Ca(2+)/CaM mediates a negative feedback regulation of Cav1.2 by incoming Ca(2+) ions (C

135 Feedback regulation of cell lineage dynamics alone howev

136 Feedback regulation of cell lineage progression plays an

137 ablishes that the ORMDL proteins mediate the feedback regulation of ceramide biosynthesis in mammalia

138 ns, when crossed into a line lacking calcium feedback regulation of cGMP synthesis, produced much lar

139 lifetime in normal rods are also dampened by feedback regulation of cGMP synthesis.

140 Ser1198 in the II-III loop and the positive feedback regulation of channel gating both in intact cel

141 n multiple cytokines by both feedforward and feedback regulation of common signaling intermediates an

142 d that all three pigmentation genes exercise feedback regulation of conidiation.

143 We have investigated the feedback regulation of cytokine-induced iNOS expression

144 TRPC3 channels also provide negative feedback regulation of cytosolic Ca(2+), mediated by a C

145 it through degradation, suggesting negative feedback regulation of damage-induced cell-cycle checkpo

146 initiation of PKD signaling through positive feedback regulation of diacylglycerol production, unveil

147 S by IFN-I meditates the subsequent positive feedback regulation of DNA-triggered IFN-I production.

148 with elevated AVP release compromises normal feedback regulation of ENaC in Adx mice in response to c

149 Thus, loss of paracrine ATP feedback regulation of ENaC in Cx30(-/-) mice disrupts n

150 The negative feedback regulation of epidermal growth factor receptor

151 Studying negative feedback regulation of Erk in genetic experiments at thr

152 c signaling by strong activation of negative feedback regulation of Erk signaling.

153 Feedback regulation of Ero1p through reduction and oxida

154 demonstrate a key role for integrins in the feedback regulation of excitatory synaptic strength.

155 nds appeared to act by reducing the negative feedback regulation of FAAH activity by free ethanolamin

156 er-expression of PDAT1, indicating a lack of feedback regulation of FAS in tgd1-1.

157 l of this research was to identify potential feedback regulation of fatty acid biosynthesis in Brassi

158 homeostasis in many organisms is achieved by feedback regulation of fatty acid desaturase gene transc

159 e propose that Atrophin2 plays a role in the feedback regulation of Fgf8 signaling.

160 activity through inhibition of CYP1 disturbs feedback regulation of FICZ levels, with potential detri

161 factor 1 (IGF1) resistance, and a defect in feedback regulation of GH.

162 in cocaine-evoked neuronal activity-mediated feedback regulation of glutamatergic synapses.

163 ntaining neurons, suggesting that any direct feedback regulation of GnRH by itself must act through t

164 tions, nongenomic effects may play a role in feedback regulation of GnRH secretion.

165 biquitin ligase component and a mechanism of feedback regulation of GPCR signaling.

166 ted degradation significantly contributes to feedback regulation of HMGCR in vivo Results of these st

167 paired glucocorticoid receptor (GR)-mediated feedback regulation of HPA function, since cocaine self-

168 ultiple mechanisms contribute to the overall feedback regulation of HVA-mediated I(Ca) by estradiol.

169 These data indicate that feedback regulation of immediate-early and early genes o

170 are metabolic hormones that provide natural feedback regulation of immune function.

171 hat this "FOXO-to-FOXO" signaling occurs via feedback regulation of ins-7 insulin gene expression.

172 gnaling pathway that is involved in negative feedback regulation of insulin action.

173 Our findings show that feedback regulation of insulin gene expression coordinat

174 Negative feedback regulation of insulin signaling involves ubiqui

175 rotein interaction as an element of negative-feedback regulation of intracellular antiviral signaling

176 excitation-transcription coupling or normal feedback regulation of ion channels blocked by PAHs.

177 Inhibition of PKC relieves negative feedback regulation of IP3 accumulation and, thereby, sh

178 Thus, feedback regulation of IR trafficking and function by cl

179 These spinal reflexes could contribute to feedback regulation of locomotor body undulations and to

180 gest novel molecular mechanisms for negative-feedback regulation of MAVS by vIRF-1 during virus repli

181 +-activated K+ (BK) channels encode negative feedback regulation of membrane voltage and Ca2+ signali

182 hieved through metabolite sensing coupled to feedback regulation of metabolic enzyme activity or expr

183 ition, it was demonstrated that the negative feedback regulation of miR-146 on NF-kappaB activation m

184 We found coordinated positive feedback regulation of mRNA for ZEB1 and beta-tubulin is

185 ning the complex with UNAM for the efficient feedback regulation of murein biosynthesis and by primin

186 S-Nitrosylation mediates the feedback regulation of N-type channels by NO.

187 This defective feedback regulation of NF-kappaB by IkappaBalpha not onl

188 e demonstrate that the IkappaBalpha-mediated feedback regulation of NF-kappaB has an essential role i

189 ogical significance of IkappaBalpha-mediated feedback regulation of NF-kappaB, we generated mice harb

190 el mechanism by which HS suppresses negative-feedback regulation of Nlrp3 inflammasome to enhance IL-

191 EGFR activation without the feedback regulation of normal degradation leads to uncon

192 ular quality control pathways to bring about feedback regulation of normal proteins is a unifying the

193 Short-term feedback regulation of Ntcp by primary bile salts has no

194 ovided a novel approach to understanding the feedback regulation of olfactory signal transduction pat

195 Atf3 is required for negative feedback regulation of other genes, but is itself subjec

196 adeoff is most likely mediated by allosteric feedback regulation of phosphofructokinase and ADP-gluco

197 ating the proposed ephaptic mechanism for HC feedback regulation of photoreceptor Ca(2+) channels, ou

198 signal via yet unknown target proteins in a feedback regulation of photosynthesis.

199 ious work has shown that there is reciprocal feedback regulation of PI3K and AR signaling in PCa, sug

200 d a key role for tachykinins in the positive feedback regulation of platelet aggregation and thrombus

201 s its transcriptional activity, suggesting a feedback regulation of PPARgamma transcriptional activit

202 the NEDA neurons, may facilitate homeostatic feedback regulation of prolactin release.

203 these dopamine/GABA neurons had no effect on feedback regulation of prolactin secretion.

204 but these neurons are not necessary for the feedback regulation of prolactin secretion.

205 volvement of cis-carotenoid metabolites in a feedback regulation of PSY1 gene expression.

206 extent of the anaerobic response by negative feedback regulation of RAP2.12.

207 lso function in mammals and mediate an early feedback regulation of receptor signaling.

208 gonist-stimulated EC monolayers via negative-feedback regulation of Rho signaling, stimulation of act

209 ents included the discovery of translational feedback regulation of ribosomal protein synthesis and t

210 sults demonstrate the importance of negative feedback regulation of RTK signaling during kidney induc

211 PS25) in MDM2-mediated p53 degradation and a feedback regulation of S25 by p53.

212 sclosed a role for sphingolipids in negative feedback regulation of serine metabolism, we investigate

213 s upstream of 5-HT neurons provides negative feedback regulation of serotonergic firing to modulate a

214 tudies have identified an important negative feedback regulation of SLP-76 by HPK1 (hematopoietic pro

215 (cells are "on" or "off") is predicated upon feedback regulation of SOS.

216 Orm protein phosphorylation mediating feedback regulation of SPT activity occurs in response t

217 ent in a signaling pathway that mediates the feedback regulation of starch breakdown by sucrose, pote

218 n or eye results from abrogation of negative feedback regulation of STAT6 activation and CCR7 express

219 uctase (HMGR) both possess SSDs required for feedback regulation of sterol-related genes and sterol s

220 ial step of telomerase activation as well as feedback regulation of telomerase by telomere length, wh

221 lmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2+)-stimulatin

222 PhuS-dependent flux of heme through HemO to feedback regulation of the cell surface signaling system

223 sylation may provide a mechanism in vivo for feedback regulation of the chitinase activity of human A

224 Y repressor complex is critical for negative feedback regulation of the circadian clock of mammals.

225 ly nuclear import of PER/CRY in the negative feedback regulation of the circadian clock.

226 igs, contributes to the complex, multivalent feedback regulation of the enzyme.

227 nes in a stepwise manner by initial positive feedback regulation of the Etv1 gene itself followed by

228 Ralpha signaling pathways to convey estrogen feedback regulation of the female hypothalamic-pituitary

229 In agreement with homeostatic feedback regulation of the GA biosynthetic pathway, we f

230 oint to activated Cdc42 providing a positive feedback regulation of the GEF activity of p220.

231 We also found evidence for TRA-1 feedback regulation of the global sex-determination path

232 BR-dependent feedback regulation of the GUS reporter constructs indic

233 exogenous cortisol further established that feedback regulation of the hypothalamic-pituitary-adrena

234 resistance, provides novel insights into the feedback regulation of the Lia system, and demonstrates

235 a striking photosynthetic phenotype in which feedback regulation of the light reactions was strongly

236 including small RNAs that mediated negative feedback regulation of the miRNA pathway and miR390-depe

237 The mechanism involves cooperative feedback regulation of the near-terminal pathway enzyme

238 y identify cell type-specific differences in feedback regulation of the PI3K pathway.

239 the mouse BCR is subject to general negative feedback regulation of the receptor proteins, as well as

240 predicts a role for calcium in the negative feedback regulation of the ROP1 activity.

241 and is thought to be important for negative feedback regulation of the Th1 response.

242 emonstrate cell type specific differences in feedback regulation of the ubiquitous PI3K pathway.

243 defect in thymic HPC homing, suggesting the feedback regulation of thymic progenitor homing by thymi

244 have characterized the ontogeny of negative feedback regulation of thyrotrope function and examined

245 To investigate whether GABA is involved in feedback regulation of TIDA neurons, we examined the phy

246 pose tissue to liver and a possible negative feedback regulation of tissue inflammation that may inst

247 lation of Ron by LPS could provide classical feedback regulation of TLR signaling.

248 on of corticotropin-releasing factor and its feedback regulation of TLR4 expression, likely contribut

249 Feedback regulation of transcription factor NF-kappaB by

250 tory loops of the circadian clock consist of feedback regulation of transcription/translation circuit

251 Disruption of this uORF stops the ascorbate feedback regulation of translation and results in increa

252 ne that is required for T4-mediated negative feedback regulation of TSH expression.

253 er fertilization and that TH-driven negative feedback regulation of tshb transcription appears in the

254 Here, we sought to identify possible feedback regulation of VEGFR2 by calpain via its substra

255 These data implicate calpain/PTP1B negative feedback regulation of VEGFR2, in addition to the primar

256 ene perception is to antagonize the negative feedback regulation on EIN3 by promoting EBF1 and EBF2 m

257 2-ERK signaling pathway and demonstrated the feedback regulation on MEK, ERK1/2, delta-catenin, and P

258 ddition, c-Myc was shown to exert a positive feedback regulation on ROCK by increasing RhoA mRNA expr

259 they help establish GA homeostasis by direct feedback regulation on the expression of GA biosynthetic

260 her genes, but is itself subject to negative feedback regulation possibly by autorepression.

261 An entirely new level of feedback regulation -- post-transcriptional regulatory m

262 onduit of neuronal Ca2+ entry, so their Ca2+ feedback regulation promises widespread neurobiological

263 However, the underlying mechanisms of such feedback regulation remain incompletely understood.

264 hibitors is associated with loss of negative feedback regulation, resulting in phosphorylation and ac

265 integrated into the receivers under positive-feedback regulation, resulting in population density-dep

266 tate of insulin resistance due to a negative feedback regulation, resulting in reduced Akt phosphoryl

267 high sterol levels, recapitulating the same feedback regulation seen at the endogenous LDLR locus.

268 Presumably, this considerable degree of feedback regulation serves to promote a robust and stabl

269 f the transcription factor required for this feedback regulation, sterol regulatory element-binding t

270 e by SA and is thus a key part of a negative feedback regulation system of SA levels during senescenc

271 nd conversion to retinoids is under negative feedback regulation that adapts this process to the actu

272 ent characteristic features for each form of feedback regulation that can aid in their identification

273 These data identify positive feedback regulation that couples age-dependent MMP-1-cat

274 the identification of an additional level of feedback regulation that depends on the negative transcr

275 the molecular underpinnings of this positive feedback regulation that enhances neuronal sensitivity t

276 mponents could establish a means of positive feedback regulation that maintains an active growth site

277 -466l expression within human macrophages, a feedback regulation that most likely prepares for homeos

278 ion and degradation is an important negative feedback regulation that specifically terminates Akt act

279 ne protein Crumbs and bypassing the negative feedback regulation that targets the same expanded enhan

280 rform a systematic analysis of mechanisms of feedback regulation that underlie short-term adaptation

281 ific isoform expression and by BET-dependent feedback regulation through distal regulatory elements.

282 trate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the

283 appaB activation is controlled by a negative feedback regulation through the ubiquitin editing enzyme

284 CNS-derived serotonin synthesis and central feedback regulation to control HSC numbers.

285 g cell fate decisions, often employ positive feedback regulation to establish and stabilize new cellu

286 Thus, the embryo rewires its feedback regulation to meet two different developmental

287 transport and Cl-dependent tubuloglomerular feedback regulation to occur over a wider Cl concentrati

288 We conclude that positive feedback regulation to up-regulate Sre1 precursor synthe

289 of the PTR is transcriptional-translational feedback regulation (TTR), common to all circadian syste

290 The forward feedback regulation we describe here between GIV and STA

291 To identify components critical for this feedback regulation, we performed a genetic screen for A

292 of stochastic gene expression with nonlinear feedback regulation, we reveal the relationship between

293 an unexpected component of opioid-dependent feedback regulation, where low levels of opioid receptor

294 the PITX2 and Wnt pathway exerts a positive feedback regulation, whereas frizzled receptors generate

295 ssion of EP(4) receptor, suggesting positive feedback regulation which may lead to accelerated catabo

296 ed by cell density and subjected to positive feedback regulation, which requires the transcription fa

297 Interestingly, TNF-alpha has a feedback regulation with TLR5 expression in RA monocytes

298 Lack of transcriptional and translational feedback regulation within the CLPPR gene family indicat

299 ity, potential novel functions for PTEN, and feedback regulation within the pathway.

300 at targeted mutants with defects in negative feedback regulation yielded a fully viable arrhythmic st