ライフサイエンスコーパス: female-specific

1 d in both samples, and the associations were female specific.

2 s not to determine sex or to be functionally female specific.

3 wild type, Sxl would seem to be functionally female specific.

4 dorsolaterally in the female AL appear to be female-specific.

5 ntial gonad and subsequently become male- or female-specific.

6 Most drug effects appeared to be female-specific.

7 hich recombinant TRA/TRA2 could activate the female-specific 5'-splice site of fru.

8 pheromone 11-cis-vaccenyl acetate (cVA) and female-specific 7,11-dienes influence courtship behavior

9 By using monoclonal antibodies against female-specific A. gambiae salivary gland proteins, two

10 f which two were male specific and four were female specific; all were ancestry specific.

11 This is because m(6)A is required for female-specific alternative splicing of Sxl, which deter

12 ibility to arthritis) and disease onset were female specific and were identified on chromosomes 3, 7,

13 ether the facts that (1) the ix phenotype is female-specific and (2) functions at the end of the sex

14 e ability of hTRA-2 alpha to regulate dsx is female-specific and depends on the presence of the dsx s

15 t vitamin D(3)-mediated protection in EAE is female-specific and E(2)-dependent suggests that declini

16 The three female-specific and five male-specific transcripts are t

17 We validated seven female-specific and two sex-associated markers in a larg

18 This makes the W (female-specific) and the Z chromosomes an excellent mode

19 kcrosses to distinguish among male-specific, female-specific, and zygote-specific sources of transmis

20 tative A. gambiae odorant receptors exhibits female-specific antennal expression and is down-regulate

21 less-expressing neurons and examined whether female-specific apoptosis in these lineages accounts for

22 Seven dimorphic lineages also had female-specific arbors.

23 A new female-specific arthritis-severity recessive locus was i

24 We also identify a Latino female-specific association in RAP1GAP2.

25 Insects carrying a female-specific autocidal genetic system offer an attrac

26 alternative splicing in insects to engineer female-specific autocidal genetic systems in the Mediter

27 The adult UBR3-/- mice had female-specific behavioral anosmia.

28 hat Trpc2-/- female mice show a reduction in female-specific behaviour, including maternal aggression

29 mones in organizing and activating male- and female-specific brain circuits and have uncovered new me

30 onstrate that gld-1(null) germ lines express female-specific, but not male-specific, molecular marker

31 ) for fatal cancer; and 0.37 (0.12-0.87) for female-specific cancers.

32 overall) were most commonly associated with female-specific cancers: endometrial cancer in 83 (30%)

33 correspond to either the non-specific or the female-specific carcass and the testis-specific transcri

34 3.0-kb testis-specific transcript, a 4.5-kb female-specific carcass transcript, a 3.5-kb ovary-speci

35 male Swiss Webster mice detected a potential female-specific cDNA, designated Y2.

36 neurons in the ventral nerve cord undergoes female-specific cell death that is DSX(F)-dependent.

37 There were female-specific changes in metabotropic glutamate recept

38 and how these inputs are processed to direct female-specific changes that occur in response to mating

39 Female-specific characteristics increasing stroke risk i

40 result of the lack of recombination in this female-specific chromosome.

41 controls the expression of key factors in a female-specific circuit.

42 Further, this "female-specific crossover maturation inefficiency" is in

43 ore frequently with other males that secrete female-specific cuticular hydrocarbon pheromones, but no

44 es of male courtship behavior in response to female-specific cuticular hydrocarbons.

45 : male-biased BCL6, which was repressed, and female-specific CUX2, which was induced.

46 deficiency resulted in the repression of the female-specific Cyp2a4 and expression of the male-specif

47 le liver and can strongly trans-activate the female-specific CYP2C12 promoter.

48 s in females), whereas OT knockdown produces female-specific deficits in gregariousness, pair bonding

49 dependent on both DSXF and HER controls the female-specific differentiation of the foreleg bristles

50 ions between cells in mosaic females lead to female-specific disease manifestations.

51 sion molecule, how its mutations bring about female-specific disorders remains elusive.

52 a and tra-2 of both a 5' splice site and the female-specific doublesex (dsx) 3' splice site, suggesti

53 ndantly to direct female differentiation and female-specific doublesex pre-mRNA splicing.

54 athway, which is positively regulated by the female-specific doublesex protein (DSXF).

55 her activate Takeout expression, whereas the female-specific Doublesex protein represses takeout inde

56 first empirical demonstration of the strong female-specific drive predicted by new models of selfish

57 so evident by the up- and down-regulation of female-specific Ds-Yolk protein 1 (Ds-Yp1) gene expressi

58 midline crossing is repressed in females by female-specific Dsx (Dsx(F)).

59 h the male-specific DSX(M) represses and the female-specific DSX(F) activates transcription of yolk p

60 gaster encodes both male-specific (DSXM) and female-specific (DSXF) polypeptides, which are required

61 thought to be mediated by numerous male- and female-specific effector genes whose expression is contr

62 Pcgf3/5 gene knockout results in female-specific embryo lethality and abrogates Xist-medi

63 We examined whether estrogen modulates the female-specific EOD and, if so, whether it regulates EOD

64 of the Tcdsx pre-mRNA were identified in the female-specific exon and the adjoining intronic sequence

65 lation of nonsynonymous substitutions in the female-specific exon occurred at less than linear rate r

66 id rate than either the common domain or the female-specific exon.

67 ated on the domain common to both sexes, the female-specific exons, and the and male-specific exon.

68 a steroid hydroxylase cytochrome P450 whose female-specific expression in adult rat liver is transcr

69 signal element genes (XSEs) that induce the female-specific expression of Sxl are transcribed extrem

70 Female-specific expression of the fourth gene, fit (fema

71 Unlike the chicken Z chromosome, which has female-specific expression of the noncoding RNA MHM (mal

72 Furthermore, this female-specific expression pattern is dependent on the p

73 utations, which inappropriately activate Sxl female-specific expression.

74 ail and present evidence suggesting that the female-specific fl(2)d(1) allele is antimorphic with res

75 egypti, was engineered to have a repressible female-specific flightless phenotype.

76 It is expressed in male- and female-specific forms and these proteins function as sex

77 that, in the case of the Georgian Jews, the female-specific founder event appears to have resulted i

78 enhancer located immediately upstream of the female-specific fru 5' splice site and are recognized by

79 e-specific pattern through activation of the female-specific fru 5' splice site.

80 Activation of female-specific fru splicing requires cis-acting tra and

81 The TIF pathway may represent an ancestral female-specific function acquired by Sxl in an early evo

82 Genes involved in female-specific functions moved onto the X chromosome wh

83 ally female specific not because it lost non-female-specific functions, but because those functions a

84 allowed Sxl to lose essential ancestral non-female-specific functions, we determined the CG3056 null

85 efine when Sxl might have lost ancestral non-female-specific functions, we isolated and characterized

86 cestor of melanogaster Sxl ever shed its non-female-specific functions.

87 this is the first observation of exclusively female-specific gene activity during preadult developmen

88 ublesex, typically involved in fat body- and female-specific gene activity in Diptera.

89 response to a male stimulus, is a model for female-specific gene regulation.

90 he XY(DSD) gonad, and high activation of the female specific genes, including FOXL2, RSPO1, CYP19A1,

91 rentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulate

92 We characterized four novel, male- or female-specific genes and found that all are expressed m

93 genes within 4 days; however, several highly female-specific genes showed weak or no feminization, ev

94 Both genes are physically linked to female-specific genes that encode proteins expressed in

95 rect CUX2 binding was seen at several highly female-specific genes that were positively regulated by

96 ata imply a major role for XCI in generating female-specific, genetically directed, stochastic divers

97 We performed male- and female-specific genome-wide association studies in 2653

98 5b gene disruption also led to the loss of a female-specific, GH-regulated hepatic CYP2B enzyme.

99 in local tissues act together to specify the female-specific growth of the larval body.

100 A female-specific high density linkage map was built for S

101 n the two sites previously described for the female-specific histamine-binding protein (FS-HBP), the

102 ether this male/female difference was due to female-specific hormones such as estrogen, the hearts of

103 /Ca2+ exchanger can be overcome partially by female-specific hormones such as estrogen.

104 For example, downregulation of the female-specific hub gene Dusp6 in mouse prefrontal corte

105 (protoperithecia) and chemotropic growth of female-specific hyphae (trichogynes) towards a cell of t

106 nd EGCs and identify DUSP9 as a regulator of female-specific hypomethylation.

107 These data strongly suggest that the female-specific increasing risk of MS is mediated throug

108 specific expression of the fourth gene, fit (female-specific independent of transformer), is not cont

109 he short integument (sin1) mutation causes a female-specific infertility, and a defect in the control

110 partially permissive in mice and results in female-specific infertility.

111 Consistent with the female-specific inheritance pattern of FDH, Porcn hemizy

112 Two male-specific and one female-specific isoforms of T. castaneum transformer (Tc

113 Male- and female-specific isoforms of the Doublesex (DSX) transcri

114 ikely to be the molecular transducer for the female-specific KOR component of spinal morphine antinoc

115 One adult female-specific lectin was identified as mannan-specific

116 ects homozygous for a dominant, repressible, female-specific lethal gene system are used.

117 that loss-of-function mutations in the flex (female-specific lethal on X) gene caused female-specific

118 ex (female-specific lethal on X) gene caused female-specific lethality because flex(+) acts as a posi

119 es are deficiencies that cause lethality and female-specific lethality in a piwi2 mutant background,

120 llow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipu

121 oth MSL1 and MSL2 in females results in 100% female-specific lethality.

122 Repression of female-specific lincRNAs in male liver, but not that of

123 Here we investigated whether CUX2, a highly female-specific liver transcription factor, contributes

124 This study identified 2 novel female-specific loci, and 1 male-specific locus.

125 former in chromosomal females eliminates the female-specific Lon isoform expression, Lon proteolytic

126 imals, suggesting a possible explanation for female-specific lymphoproliferative disorder.

127 ce, although viable, display fully penetrant female-specific lymphoproliferative disorder.

128 The proarrhythmic effects of BPS were female specific; male rat hearts were not affected by BP

129 o and ovarian tumor (otu) are expressed in a female-specific manner in embryonic germ cells, consiste

130 fic markers and activating the expression of female-specific markers.

131 regions predicted to be most susceptible to female-specific meiotic drive, but we found a significan

132 single decision is used, a male-specific or female-specific meiotic entry would lead necessarily tow

133 that the Anopheles gambiae protein AgOr1, a female-specific member of a family of putative odorant r

134 Female-specific molecular changes potentially account fo

135 The expression of a female-specific mouse lacrimal gland mRNA that encoded p

136 odel can account for both high mean rates of female-specific nondisjunction in Drosophila and humans

137 that Drosophila Sxl may appear functionally female specific not because it lost non-female-specific

138 upted in male splice variants but not in the female-specific one.

139 sformation of synaptic inputs into male- and female-specific outputs that generate sexually distinct

140 ha2 urinary globulin (alpha2u) genes and the female-specific P450 2C12 gene was down-regulated by som

141 epresent a unique pharmacological target for female-specific pain control.

142 However, a female-specific pathway that is dependent on both DSXF a

143 One is a female-specific pathway, which is positively regulated b

144 der CSD, while another putative QTL showed a female-specific pattern consistent with either a sex-dif

145 The female-specific pattern of CYP2C12 expression is thus pr

146 al males into pseudo-females and confers the female-specific pattern of Lon isoform expression, Lon p

147 licing from the male-specific pattern to the female-specific pattern through activation of the female

148 We unambiguously defined male- and female-specific patterns of gene expression during Arabi

149 ly, we show that the production of male- and female-specific piRNAs is conserved in all four species,

150 such as Sxl, snf, ovo and otu which control female-specific processes in the ovary.

151 -function activity in males: it promotes the female-specific processing of tra pre-mRNAs.

152 which our results suggest is related to the female-specific production of the sex pheromones ascr#1

153 ta), alternatively spliced male-specific and female-specific products of the doublesex (dsx) gene pla

154 the bipotential somatic gonad to promote the female-specific program.

155 ific expression systems (e.g., early-acting, female-specific promoters) in insects other than Drosoph

156 mous feminizing signals was known to involve female-specific protein encoded by the master sex-determ

157 ads to the inference that ix may require the female-specific protein product of the doublesex (dsx) g

158 f positional candidate genes showed that the female-specific QTL failed to complement a P-element ins

159 This female-specific QTL, which we name Fsia1, is located on

160 With this data set, we identified 26 female-specific RAD loci, putatively located on the W ch

161 3a13 shares 92% nucleotide identity with the female-specific rat CYP3A9, its expression does not exhi

162 CYP2C12 encodes a female-specific rat liver P450 steroid hydroxylase whose

163 ttribute these observations to high rates of female-specific recombination near the chromosomal ends

164 These results identify female-specific regulation of LXA4-producing tissue PMN

165 We also show that female-specific regulation of Sxl in the germline involv

166 l anatomy and also resulted in abrogation of female-specific regulation of these genes.

167 (vi) CUX2, a female-specific repressor of male-biased genes, also act

168 echanisms of male-specific vulnerability and female-specific resilience impacting intracellular signa

169 ion of LXRalpha in transgenic mice confers a female-specific resistance to lithocholic acid (LCA)-ind

170 Sxl encodes a female-specific RNA binding protein and in somatic cells

171 ost-transcriptionally by Sex lethal (SXL), a female-specific RNA-binding protein that regulates alter

172 sexually dimorphic and therefore may play a female-specific role, such as processing of information

173 an sexual development have either a male- or female-specific role.

174 lly deep framework for the evolution of OT's female-specific roles in pair bonding and maternal funct

175 Our results indicate that female-specific selection has a significant effect on W

176 SC), a tug-of-war between opposing male- and female-specific selection pressures.

177 romosome after >100 generations of different female-specific selection regimens in different breeds o

178 omosome is predicted to be subject to strong female-specific selection stemming from its female-limit

179 n of up-regulation associated with increased female-specific selection.

180 We have created a conditional female-specific self-limiting strain of B. oleae (OX3097

181 target gene hunchback but also the normally female specific Sex-lethal promoter, Sxl-Pe, in the pole

182 on caused a delay in production of the major female-specific sex pheromones (the 7,11-C27 and -C29 di

183 The initial expression of the female-specific sex-determining gene Sex-lethal in the b

184 In Drosophila, the female-specific SEX-LETHAL (SXL) protein is required for

185 licing event, yet the mechanism by which the female-specific SEX-LETHAL RNA-binding protein prevents

186 ovide further evidence of the existence of a female-specific SIA mechanism and highlight the importan

187 male-specific sites and induced a subset of female-specific sites in male livers.

188 Here, we report that a group of female-specific small proteins, early nodulin-like prote

189 cell number and type contribute to male- and female-specific songs in frogs and birds.

190 red and sufficient to activate the regulated female-specific splice site.

191 osphorylation of one or more proteins in the female-specific splicing enhancer complex.

192 The Drosophila doublesex female-specific splicing enhancer consists of two classe

193 Female-specific splicing is activated through the activi

194 Male- and female-specific splicing isoforms of DSX share a novel D

195 Male- and female-specific splicing isoforms share a novel DNA-bind

196 le differentiation pathways by directing the female-specific splicing of Sxl and tra pre-mRNAs.

197 suggested a role for snf in establishing the female-specific splicing pattern of the sex determinatio

198 In addition, mRNA levels for ST2A2, a female-specific ST gene, were suppressed 50% in females

199 mpatibilities that produce male-specific vs. female-specific sterility.

200 uirement of m(6)A and its reader YT521-B for female-specific Sxl alternative splicing reveals that th

201 al Sxl as a major intronic m(6)A target, and female-specific Sxl splicing is compromised in multiple

202 ation, and YT521-B overexpression can induce female-specific Sxl splicing.

203 This female-specific system is now known to be estrogen-depen

204 The absence of female-specific Tap gene defects also indicates this can

205 All the three female-specific TcDsx proteins share common OD1 and OD2

206 's zygotic function suggests that one set of female-specific terminal differentiation genes, the yolk

207 and in fat body cells of the spermatheca (a female-specific tissue), through a canonical DSX-binding

208 osomal and X-linked genes with expression in female-specific tissues evolve at similar rates.

209 We found female-specific tra mRNA in eggs as predicted by this tr

210 pattern of variation was found for a cryptic female-specific transcript (H5) but a very different pat

211 These factors regulate male- and female-specific transcription of many genes.

212 For example, female-specific transcription of the yolk protein 1 gene

213 Subsequent to the discovery of a female-specific urinary discriminator by LC-MS, further

214 Our analysis also shows that female-specific viruses generally give better results th

215 male-specific vitelline coat lysin (VCL) and female-specific vitelline envelope receptor for lysin (V

216 Maternal inheritance via the female-specific W chromosome was long ago proposed as a

217 on the Z chromosome and the nonrecombining, female-specific W chromosome.

218 at this transcript comes from a locus on the female-specific W chromosome.

219 regulates the LXA4 circuit to induce delayed female-specific wound healing in the cornea.