ライフサイエンスコーパス: fenoterol

1 ceptor agonists (salbutamol, procaterol, and fenoterol).

2 GP-12177A as did the addition of the agonist fenoterol.

3 bation of bovine tracheal smooth muscle with fenoterol (10(-7) M) for 2 h increased H(1) receptor mRN

4 relative to epinephrine (100%) were 42% for fenoterol, 4.9% for albuterol, 2.5% for dobutamine, and

5 uterol (5.83 +/- 0.06 and 4.71 +/- 0.16) and fenoterol (6.33 +/- 0.07 and 5.67 +/- 0.05) were less se

6 1 (ISO-beta(1)-AR stimulation) or 0.1 microM fenoterol, a beta(2)-AR agonist (FEN-beta(2)-AR stimulat

7 onists activate both G(s) and G(i) proteins, fenoterol, a full agonist of beta(2)-adrenoceptor, selec

8 8551, but not by CGP 20712A, indicating that fenoterol acts via beta(2)-adrenoceptors.

9 the receptor, and K(i) values determined for fenoterol analogs model much better the cAMP activity of

10 ter understand the molecular interactions of fenoterol analogs with the beta(2)-adrenergic receptor,

11 It is noteworthy that although (R,R)-fenoterol and (R,R)-methoxyfenoterol preferentially acti

12 0 times more potent than L-isoproterenol and fenoterol and 100 times more potent than albuterol.

13 Some ligands (e.g., fenoterol and cimaterol) were more readily inhibited by

14 ave synthesized a series of stereoisomers of fenoterol and its derivatives and characterized their re

15 We found that the R,R isomers of fenoterol and methoxyfenoterol exhibited more potent eff

16 dobutamine, 0.148 with albuterol, 0.194 with fenoterol, and 0.212 with epinephrine.

17 ency, with ephedrine, dobutamine, albuterol, fenoterol, and epinephrine giving 0, 7, 17, 48, and 55%

18 cluding the single enantiomers of verapamil, fenoterol, and isoproterenol.

19 haled short-acting beta2-agonists albuterol, fenoterol, and terbutaline provide rapid as-needed sympt

20 In contrast, fenoterol, another beta2-AR agonist, induced a full posi

21 ther beta2-agonists (salbutamol, formoterol, fenoterol, clenbuterol, or adrenaline).

22 ificantly to the left after 18-h exposure to fenoterol, consistent with the increase in receptor numb

23 Fenoterol contains two chiral centers and may exist as f

24 trast to zinterol, stimulation of I(Ca,L) by fenoterol (fen-beta(2)-AR), a beta(2)-AR agonist that ac

25 as coupling efficiency, i.e. epinephrine >/= fenoterol > albuterol > dobutamine > ephedrine.

26 lase, namely epinephrine > or = formoterol = fenoterol > terbutaline = zinterol = albuterol > salmete

27 Fenoterol increased both the stability and the transcrip

28 Thus, fenoterol increases the expression of airway smooth musc

29 L-Isoproterenol and fenoterol induced > 90% relaxation (percentage of maxima

30 Alprenolol inhibited fenoterol-induced beta3-adrenoceptor responses while act

31 The fenoterol-induced increase in H(1) receptor mRNA was con

32 tion of H(1) receptor mRNA and augmented the fenoterol-induced increase in H(1) receptor mRNA.

33 treatment with dexamethasone did not prevent fenoterol-induced up-regulation of H(1) receptor mRNA.

34 mation, being purely entropy-driven for each fenoterol isomer, rather than a mixture of entropy and e

35 n a mixture of entropy and enthalpy when the fenoterol isomers binding was determined using [(3)H]CGP

36 effects of the beta(2)-adrenoceptor agonist, fenoterol, on the expression of H(1) receptors at the mR

37 week) administration of the beta2AR agonists fenoterol or zinterol, starting at 2 weeks after MI, red

38 The extent of internalization caused by fenoterol over a 1000-fold range of occupancy was propor

39 hrine and the beta(2) adrenoreceptor agonist fenoterol potently inhibited LPS-induced TNF-alpha and I

40 The two strongest agonists, epinephrine and fenoterol, provoked 11-13-fold increases in the level of

41 ive activation of beta2-AR/G(s) signaling by fenoterol restores the blunted beta2-AR contractile resp

42 o probe the binding affinity for a series of fenoterol stereoisomers and derivatives.

43 differential G protein selectivities of the fenoterol stereoisomers were further confirmed by photoa

44 occupancy and with various concentrations of fenoterol that gave occupancies from 0.93 to 0.001.

45 ed with the low concentrations (0.2 and 2 nM fenoterol), these concentrations did cause significant d