ライフサイエンスコーパス: ferret

1 nimal models, including mouse, pig, rat, and ferret.

2 viral disease were observed in EBOV-infected ferrets.

3 three additional transmission experiments in ferrets.

4 cquired efficient in-contact transmission in ferrets.

5 viruses to respiratory tissues of humans and ferrets.

6 se in mice and ferrets and to transmit among ferrets.

7 properties of 20 H10 viruses in vitro and in ferrets.

8 ted respiratory droplet transmission between ferrets.

9 IV-H3N2 was selected for characterization in ferrets.

10 cluding the contribution of the C protein in ferrets.

11 the dynamic responses of cortical neurons in ferrets.

12 a petechial rash was observed with moribund ferrets.

13 ssues following influenza virus infection in ferrets.

14 pable of respiratory droplet transmission in ferrets.

15 onfers heterosubtypic protection in mice and ferrets.

16 epithelium and subsequently transmit between ferrets.

17 5N1 strains, and improved viral clearance in ferrets.

18 smitted efficiently by the airborne route in ferrets.

19 ith or without the oil-in-water adjuvants in ferrets.

20 tigate dynamics of infection/transmission in ferrets.

21 ess was evaluated in cell culture, mice, and ferrets.

22 ing a heterologous lethal virus challenge in ferrets.

23 The H7N9 ca vaccine virus was immunogenic in ferrets.

24 elds in the auditory cortex of freely moving ferrets.

25 lesions were induced in 24 canine teeth of 6 ferrets.

26 nogenic and exhibited protective efficacy in ferrets.

27 y and are transmissible by direct contact in ferrets.

28 transmission of avian viruses in humans and ferrets.

29 by the airborne route and was pathogenic in ferrets.

30 genic ebolaviruses in mice, guinea pigs, and ferrets.

31 accine candidates were assessed in preimmune ferrets.

32 was inefficiently transmitted among cohoused ferrets.

33 rose in the lungs of H1N1pdm virus-infected ferrets 6 h postinfection and became concentrated at are

34 ue for visualizing neuronal migration in the ferret, a gyrencephalic carnivore, and found that migrat

35 We present Ferret, a prototype retrieval system, designed to retrie

36 We developed Ferret, a user-friendly Java tool, to easily extract gen

37 In ferrets, a single 1-mg/kg prophylactic dose provided 100

38 , MEDI8852 blocked influenza transmission in ferrets, a unique finding among influenza-specific mAbs.

39 A ferret-adapted revertant (HA1-H17Y/HA2-R106K) regained a

40 n by recording local field potentials in two ferrets after administration of isoflurane in concentrat

41 antibodies are readily detected in mice and ferrets after infection with a series of distinct influe

42 ribe protective immune responses in mice and ferrets after vaccination with a novel HA-based influenz

43 inding site cross-reactivity and can protect ferrets against a pathogenic novel H1N1 virus.

44 hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus

45 ccine was immunogenic and protected mice and ferrets against homologous and heterologous EIV.

46 as highly immunogenic and protected mice and ferrets against homologous and heterologous H3N8 avian v

47 etely protected mice and partially protected ferrets against lethal heterosubtypic H5N1 influenza vir

48 f antisera against influenza A(H3N2) from 24 ferrets against the same panel of viruses.

49 Compared to naive ferrets, all vaccinated ferrets showed improved cellular

50 In ferrets, all viruses replicated to high titers in the up

51 the receptor binding site caused escape from ferret and human antibodies elicited after primary A(H1N

52 Although the overall structure of the ferret and human antigenic maps is similar, local differ

53 Head-to-head comparison between ferret and human antisera derived antigenic maps reveale

54 f similarity between serological patterns in ferret and human data.

55 gle-cell transcriptional profiling in human, ferret and mouse revealed more cells coexpressing proneu

56 encephalic cortex, retroviral studies in the ferret and primate suggest that, unlike the rodent, pyra

57 h perceptual difficulty in the freely-moving ferret and the resulting signal may provide top-down beh

58 nd group II (H7N9) pandemic IAVs in mice and ferrets and could be used to block transmission of influ

59 was associated with mild illness in mice and ferrets and did not spread well between ferrets, it none

60 ruses lacked the ability to transmit between ferrets and exhibited low to moderate virulence in mamma

61 demonstrated that SAM(HA) was immunogenic in ferrets and facilitated containment of viral replication

62 tian H5N1 viruses (isolated in 2014-2015) in ferrets and found that three of them transmitted via res

63 cordings from the primary auditory cortex of ferrets and found that: (1) the decoding filters of audi

64 rotective efficacy against H7N9 infection in ferrets and hold potential as a vaccination regimen.

65 We show that antibodies elicited in ferrets and humans exposed to the egg-adapted 2016-2017

66 g 240 estimates of influenza transmission in ferrets and humans.

67 he mapping between influenza transmission in ferrets and in humans is unsubstantiated.

68 thogenicity and airborne transmissibility in ferrets and is associated with pandemic potential in hum

69 Y/108), caused mild and transient illness in ferrets and mice but did not transmit to naive cohoused

70 When tested in ferrets and pigs, a single DNA delivery with low doses o

71 MVA-H7-Sh2 viral vector was used to immunize ferrets and proved to be immunogenic, even after a singl

72 Two reassortant viruses were assessed in ferrets and showed transmission to aerosol contacts.

73 bed previously in experimental infections in ferrets and swine with a swine FLUDV, which supported vi

74 ted from humans to cause disease in mice and ferrets and to transmit among ferrets.

75 are present in carnivores (such as cats and ferrets) and primates but are absent in rodents.

76 ) in tracheal mucosa from human, sheep, pig, ferret, and rabbit and in two types of cultured cells.

77 In rat, ferret, and sheep hearts t-tubule density and AmpII prot

78 the ability to transmit efficiently between ferrets, and possibly humans.

79 te disease was observed in infected mice and ferrets, and the virus was inefficiently transmitted amo

80 H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathoge

81 e constructed and probed for reactivity with ferret antisera against MN/10 and BJ/92 in hemagglutinat

82 clonal antibodies may be a useful adjunct to ferret antisera for detecting antigenic drift in influen

83 n/26221/2014 (H5N6) virus was developed, and ferret antisera generated against this virus were demons

84 Human and ferret antisera were tested in HI assays against 1 repre

85 tested against strain-specific postinfection ferret antisera.

86 ment at K163 was not highlighted by standard ferret antisera.

87 fluenza A(H3N2) (sH3N2), using postinfection ferret antisera.

88 970s-1990s were observed using postinfection ferret antisera.

89 Ferrets are an ideal animal model to study transmission,

90 Domestic ferrets are commonly used to study other RNA viruses, in

91 Although ferrets are considered by many to be ideal for modeling

92 To address this, we demonstrated that ferrets are susceptible models to BDBV infection as well

93 pathogenesis (mouse, hamster, guinea-pig and ferret) are naturally resistant to MERS-CoV.

94 We found that ferret astrocytes share, on average, half of their terri

95 e present a model of neural responses in the ferret auditory cortex (the IC Adaptation model), which

96 njecting tracers into one or more regions of ferret auditory cortex.

97 Collectively, these findings suggest that ferret B cells expressing an Igkappa or Iglambda BCR pos

98 the visual cortex of freely-moving juvenile ferrets before and after eye-opening.

99 showed less severe pathogenicity in mice and ferrets but acquired efficient in-contact transmission i

100 nd highly transmissible by direct contact in ferrets but showed less-severe pathogenicity than the pa

101 Both H7N8 viruses replicated similarly in ferrets, but only the H7N8 HPAI virus caused moderate we

102 pH1N1-1 transmitted to aerosol contact ferrets, but pH1N1low-1 did not.

103 Immunization of ferrets by a universal influenza virus vaccine strategy

104 s in its HA, additionally was able to infect ferrets by airborne transmission as effectively as the p

105 MEDI8852 was administered to mice and ferrets by intraperitoneal injection at varying doses, 2

106 ow here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a t

107 stimuli that are presented to visually naive ferrets can influence the parameters of speed tuning and

108 minance (OD) in the primary visual cortex of ferrets, cats and monkeys can be individually changed by

109 H10 virus infection of ferrets caused variable weight loss, and all 20 viruses

110 ctive treatment for lethal H5N1 infection in ferrets compared to oseltamivir and R347, and MEDI8852 p

111 block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control mAb R347 and

112 sites) by incubating them with human and/or ferret convalescent sera to human H1N1 and H3N2 viruses.

113 d emergence of viruses with R292K in treated ferrets correlates well with the multiple reports on thi

114 al glia is conserved in developing mouse and ferret cortex and in human stem cell-derived cerebral or

115 at early postnatal ages in the gyrencephalic ferret cortex.

116 hereas antisera from dk/Hok/69 ca-vaccinated ferrets cross-reacted with clade 2.3.4.4 and 2.2.1 virus

117 HI data was similar to the map created using ferret data.

118 When tested in ferrets, delayed 81.39a treatment reduced viral titers,

119 leading to 60% mortality, and the surviving ferrets demonstrated sequelae similar to those for human

120 ith 1.25% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsulated in a hydroge

121 nd that viruses which replicated well in the ferret did not replicate to the same extent in the human

122 These ferrets did not shed the virus or seroconvert.

123 eural activity from auditory cortex of awake ferrets during presentation of natural sound stimuli.

124 selection for K627 over E627 was observed in ferrets during the chicken-to-ferret or ferret-to-ferret

125 eral frontal cortex (dl-FC) of freely-moving ferrets encode task variables in a two-alternative force

126 broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses.

127 sion via the airborne route was observed for ferrets exposed to the SCk1772- or HK3263-infected chick

128 specific antibodies are commonly elicited in ferrets following sequential infection with antigenicall

129 mice but did not transmit to naive cohoused ferrets following traditional or aerosol-based inoculati

130 COBRA HA proteins were screened in mice and ferrets for the elicitation of antibodies with HA inhibi

131 MEDI8852 was able to protect naive ferrets from airborne transmission of H1N1pdm09.

132 multiple formulations protects both mice and ferrets from lethal H5N1 homologous virus challenge.

133 Using ferret-generated antiserum, we determined that CIV-H3N2

134 nonpermissive small-animal species, namely, ferret, guinea pig, and hamster.

135 Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus r

136 These COBRA preimmune ferrets had superior breadth of HAI activity after vacci

137 on, several DPP4 orthologs, including mouse, ferret, hamster, and guinea pig DPP4, do not.

138 so acts as a determinant of permissivity for ferret, hamster, and guinea pig DPP4.

139 In ferrets, HK3263 transmitted more efficiently than SCk177

140 in the upper and lower respiratory tracts of ferrets; however, the clinical symptoms were generally m

141 (Igkappa) and lambda (Iglambda) L chains of ferret Ig.

142 virus positions indicate that the human and ferret immune system might see antigenic properties of v

143 Ferrets immunized twice with a mix of recombinant rabies

144 ruses lacked the ability to transmit between ferrets in a direct contact setting.

145 experienced milder disease compared to other ferrets in the group.

146 d the activity of CG neurons in anesthetized ferrets in vivo using a combined viral-infection and opt

147 s in fruit flies, zebrafish larvae, mice and ferrets in vivo.

148 vaccines were attenuated and immunogenic in ferrets, inducing antibodies that neutralized homologous

149 Three donor ferrets infected with 2009 pandemic influenza A(H1N1) un

150 Bioluminescent imaging of ferrets infected with A/California/04/2009 H1N1 virus (C

151 ceived MEDI8852 or R347 prior to exposure to ferrets infected with an H1N1pdm09 virus.

152 and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic

153 Specifically, ferrets infected with the 1986 virus and vaccinated with

154 ing to gain access to these relationships in ferrets infected with the 2009 H1N1 pandemic influenza A

155 Importantly, antibodies elicited in ferrets infected with the current circulating H3N2 viral

156 ion of viral titers was detected on day 5 in ferrets infected with the I222K virus.

157 nt resistance, experiments were conducted in ferrets infected with virus carrying wild-type or varian

158 Treatment of ferrets infected with wild-type virus resulted in a mode

159 In both mice and ferrets, intranasal administration of a single dose of t

160 Ferret is designed to assist bio scientists at different

161 Airborne transmission in ferrets is accompanied by the mutations in PB1, NP and N

162 Influenza transmission efficiency in ferrets is vital for risk-assessment studies.

163 and ferrets and did not spread well between ferrets, it nonetheless possessed several markers of vir

164 t only in the NI assay, but also in infected ferrets, judged particularly by viral loads in nasal was

165 ion (pH 6.0) was less pathogenic in mice and ferrets, less transmissible by contact, and no longer ai

166 diversity is tightly restricted in infected ferrets, limiting further adaptation to a fully transmis

167 utrophils invaded the H1N1pdm virus-infected ferret lung globally and focally at sites of infection.

168 Sites in the H1N1pdm virus-infected ferret lung with high FDG uptake had high levels of prol

169 g risk assessment models for H9N2 viruses in ferrets may not always have a strong correlation with th

170 considerable interest in efforts to move the ferret model forward for influenza vaccine and challenge

171 The ferret model has emerged as the preferred small-animal m

172 sis and transmission of influenza virus, the ferret model is typically used.

173 hus, these clinical outcomes measured in the ferret model may correlate with clinically relevant osel

174 Employing the ferret model of H1N1pdm virus infection, we used live im

175 We used the ferret model of human influenza to systematically invest

176 contributions of the C and W proteins in the ferret model of NiV pathogenesis.

177 Here, we used the ferret model to address this for an avian influenza H5N1

178 report provides more evidence for using the ferret model to assess the susceptibility of influenza A

179 The ferret model was used to assess the potential of hemaggl

180 of which were airborne-transmissible in the ferret model without prior adaptation.

181 filoviral disease were recapitulated in the ferret model, including substantial decreases in lymphoc

182 Using a ferret model, this study demonstrated the roles of the N

183 Within our ferret model, vaccination is more effective than prophyl

184 Using the ferret model, we trace the evolutionary pathway by which

185 CNS invasion via the olfactory nerve in our ferret model.

186 iV V and W proteins to NiV pathogenesis in a ferret model.

187 ong with virus antigenic characterization by ferret model.

188 uenza virus infection and vaccination in the ferret model.

189 r universal influenza vaccine in a preimmune ferret model.IMPORTANCE Currently, many groups are testi

190 influenza A/Italy/3/2013 virus in mouse and ferret models and examined the replication kinetics of t

191 uely combine the advantages of the mouse and ferret models for influenza virus infection.

192 human airway cells and in vivo in mouse and ferret models.

193 third waves, through 2015, in the mouse and ferret models.

194 ich may explain the enhanced transmission in ferret models.

195 cy of retinal waves pharmacologically in the ferret (Mustela putorius furo) during a period of retino

196 The domestic ferret (Mustela putorius furo) is a commonly used animal

197 The ferret (Mustela putorius furo), a gyrencephalic mammal,

198 udies of auditory cortical processing in the ferret (Mustela putorius), very little is known about th

199 in the various germinal zones of developing ferret neocortex.

200 Ferret neocortical progenitors were found to exhibit lon

201 radial glia, suggesting a mechanism by which ferret neurons disperse laterally.

202 Interestingly, ferret neurons displayed more tortuous migration routes

203 We found that ferret neurons use several different radial glial fibers

204 This new ferret NiV C and W knockout model may allow, for the fir

205 hogenicity, and transmissibility in mice and ferrets of four H5N6 isolates derived from waterfowl in

206 e-existing tools (e.g. PLINK and HaploView), Ferret offers a straightforward way, even for non-bioinf

207 as observed in ferrets during the chicken-to-ferret or ferret-to-ferret transmission.

208 ere permissive of MERS-CoV, whereas hamster, ferret, or mouse cell lines were not, despite the presen

209 alpha2,6-linked sialic acids is conserved in ferret, pig and human soft palate.

210 virus displayed limited transmissibility in ferrets placed in direct contact with an inoculated anim

211 enza virus (A/California/07/2009), and these ferrets poorly transmitted the virus to naive contacts.

212 We found, however, that ferrets possess multiple forms of plasticity that are ex

213 Moreover, ferrets possessing HA stalk-specific antibody were prote

214 ity (ON or OFF) in the superficial layers of ferret primary visual cortex.

215 Activating the neurogenin pathway in ferret progenitors promoted delamination and outward mig

216 Moreover, cortical recordings in ferrets reared with asymmetric hearing loss suggest that

217 ransmission study, naive respiratory contact ferrets received MEDI8852 or R347 prior to exposure to f

218 A(H1N1)pdm09-infected ferrets receiving a single dose (25 mg/kg) had reduced v

219 E627 and K627 were observed in chickens and ferrets, respectively.

220 From a locus, gene(s) or SNP(s) of interest, Ferret retrieves genotype data for 1KG SNPs and indels,

221 We demonstrate that estimates of ferret secondary attack rate (SAR) explain 66% of the va

222 e vaccine was changed because human, but not ferret, sera distinguish A(H1N1)pdm09 viruses isolated a

223 The human and ferret serology data suggest that a single dose of the v

224 Compared to naive ferrets, all vaccinated ferrets showed improved cellular immunity in the lungs a

225 with this one virus, we demonstrate that the ferret soft palate, a tissue not normally sampled in ani

226 In this study, we used cross-reactive and ferret-specific antibodies to study the leukocyte compos

227 These ferrets still suffered severe neurological disease: 60%

228 g, glycan-array receptor-binding assays, and ferret studies reveal the H7N9 virus to have increased b

229 The latter observation was confirmed in a ferret study.

230 Ferret successfully retrieved relevant gene-centric sent

231 y of the tl/TX/079/07 ca vaccine in mice and ferrets support further evaluation of this vaccine in hu

232 imates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exc

233 Here we show in ferrets that at eye opening, the cortical response to vi

234 On challenge, ferrets that received adjuvanted vaccines showed lower v

235 rk, we studied Purkinje cells in decerebrate ferrets that were conditioned using electrical stimulati

236 In ferrets, the human isolate HK3263 replicated to higher t

237 This staining pattern was also consistent in ferrets, the primary animal model for human influenza pa

238 le by in-pen contact, but not from cattle to ferrets through fomite exposure.

239 er cattle through direct contact, but not to ferrets through fomite routes.

240 in vivo properties and antibody response in ferrets to 20 diverse H10 viruses.

241 cortex is required for the normal ability of ferrets to detect a mistuned harmonic within a complex s

242 We tested the ability of adult female ferrets to detect the presence of a mistuned harmonic in

243 We used live imaging of ferrets to monitor host responses within the lung over t

244 d in ferrets during the chicken-to-ferret or ferret-to-ferret transmission.

245 lasticity in the inferior colliculus (IC) of ferrets trained to detect a pure tone target in a sequen

246 Further analysis shows that ferret transmission experiments have potential to identi

247 nfluenza viruses has highlighted the role of ferret transmission experiments in studying the transmis

248 Thus, ferret transmission experiments provide valid prediction

249 Chicken-to-ferret transmission via the airborne route was observed,

250 ts during the chicken-to-ferret or ferret-to-ferret transmission.

251 hird-wave viruses caused moderate disease in ferrets, transmitted efficiently to cohoused, naive cont

252 zed ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmissi

253 By housing ferrets under different conditions, it is possible to mi

254 on in mice and nearly complete protection in ferrets upon heterologous challenge with the H3N8 (eq/Ne

255 ng spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticog

256 Zaire species of Ebolavirus in the domestic ferret, using wild-type nonadapted viruses.

257 h COBRA HA VLP vaccines than COBRA preimmune ferrets vaccinated with VLP vaccines expressing wild-typ

258 All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-

259 on to demonstrate that inhibitory neurons in ferret visual cortex respond robustly and selectively to

260 of astrocyte somata and territory overlap in ferret visual cortex using a combination of in vivo two-

261 individual pyramidal neurons in layer 2/3 of ferret visual cortex.

262 Ferret was successful in finding valuable information in

263 A subset of ferrets was infected with influenza viruses expressing t

264 gated and transmission via direct contact in ferrets was significantly impaired compared to pH1N1-1,

265 inant H9 viruses previously evaluated in the ferret, we found that viruses which replicated well in t

266 ing electrophysiological recordings in young ferrets, we show that auditory cortex neurons respond to

267 Ferrets were also infected with Ebola virus (EBOV) to co

268 ts were susceptible to filovirus infections, ferrets were challenged with a clinical isolate of BDBV.

269 When vaccinated ferrets were challenged with homologous and heterologous

270 Subsequently, ferrets were challenged with influenza virus A/Anhui/1/2

271 Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under c

272 To mimic zoonotic transmission, two ferrets were exposed to a plastic toy fomite soaked with

273 Ferrets were first infected then challenged 1-14 days la

274 s, sequential sH1N1 influenza virus-infected ferrets were protected from challenge with a novel H1N1

275 order Mononegavirales To investigate whether ferrets were susceptible to filovirus infections, ferret

276 Ferrets were then challenged with the wild-type virus an

277 Ferrets were then challenged with wild-type H7N9 virus t

278 Ferrets were vaccinated intramuscularly or received osel

279 Ferrets were vaccinated with 2 doses of unadjuvanted, MF

280 in HA (acquired during virus replication in ferrets) were essential to restore HA stability.

281 was equally effective for H7N9 infection in ferrets while the combination yielded similar protection

282 (pH1N1low-1) cannot transmit via aerosol in ferrets, while another highly homologous virus with HA a

283 A vaccinated ferret with no detectable HAI-antibodies but high flu-sp

284 while either V627 or K627 was transmitted to ferrets with a narrow transmission bottleneck.

285 MEDI8852 is effective in mice and ferrets with a therapeutic window superior to that of os

286 trast, secondary infection of H1N1 preimmune ferrets with an antigenically distinct H1N1 virus elicit

287 binding assays, that sequential infection of ferrets with antigenically distinct seasonal H1N1 (sH1N1

288 Here, we show that sequential infection of ferrets with antigenically distinct seasonal H1N1 influe

289 Immunization of ferrets with beta-propiolactone-inactivated recombinant

290 Overall, priming naive ferrets with COBRA HA based viruses or using COBRA HA ba

291 sequentially infected mice, guinea pigs and ferrets with divergent H1N1 or H3N2 subtypes of influenz

292 Vaccination of mice and ferrets with H1-SS-np elicited broadly cross-reactive an

293 Moreover, sequential infection of ferrets with H1N1 influenza viruses elicited an Igkappa-

294 l-in-water adjuvants, we generated groups of ferrets with undetectable (geometric mean titer [GMT] <

295 fluenza A infection of immunologically naive ferrets with various H1N1 or H3N2 strains, the acute Ab

296 Furthermore, sequential infection of ferrets with viral vectors expressing chimeric HA, aimed

297 Vaccinating ferrets with virus-like particle (VLP) vaccines expressi

298 ble virus emerged in experimentally infected ferrets within 24 hours after infection and was remarkab

299 rgence of R292K virus was detected in 3 of 6 ferrets within 5 to 7 days postinfection.

300 suggesting heterogeneity at the MHC locus in ferrets within commercial populations, a finding of cons