ライフサイエンスコーパス: fetal sheep

1 ovascular adaptations in chronically anaemic fetal sheep.

2 cardiovascular development or growth in the fetal sheep.

3 an hematopoiesis after transfer to preimmune fetal sheep.

4 ephalic vasculature of the intact, near term fetal sheep.

5 vasculature served by the carotid artery of fetal sheep.

6 factors reduces myofibre hypertrophy in IUGR fetal sheep.

7 we transplanted clonally derived BMSCs into fetal sheep.

8 hydrate metabolism and insulin signalling in fetal sheep.

9 or intrahepatic (n = 6) route into preimmune fetal sheep.

10 ion model in the instrumented 0.65 gestation fetal sheep.

11 -pseudotyped retroviruses for injection into fetal sheep.

12 nsplanted by intraperitoneal injections into fetal sheep.

13 anges of CBF in the chronically instrumented fetal sheep.

14 product of the gene c-fos in late-gestation fetal sheep.

15 resistance artery function of mid-gestation fetal sheep.

16 cortical vascular resistance by ~15 % in the fetal sheep.

17 lanted in the cerebral cortices of near-term fetal sheep.

18 od flow and oxygen consumption rates in IUGR fetal sheep.

19 rticotropic hormone (ACTH) in late-gestation fetal sheep.

20 mmunodeficiency (NOD-SCID) mice or preimmune fetal sheep.

21 s engrafted primary, secondary, and tertiary fetal sheep.

22 acid uptake was significantly lower in IUGR fetal sheep.

23 by improved fetal lung function after 4 d in fetal sheep.

24 ta reported in this study of unanaesthetised fetal sheep (1) show that minute-by-minute analyses of h

25 During a 3-year period in 88 fetal sheep, 1) left-sided diaphragmatic hernias were cr

26 Fourteen fetal sheep (105-109 days gestational age) were instrume

27 In unanaesthetized chronically instumented fetal sheep (118-121 days gestation) we investigated the

28 In fetal sheep (123-129 days gestation) we investigated the

29 duced for 30 min in chronically catheterized fetal sheep (125 +/- 3 days), with or without ketamine (

30 tact and nine carotid sinus denervated (CSD) fetal sheep (125-128 days gestation) we measured heart r

31 ebral blood flow in chronically instrumented fetal sheep (127-135 days gestation, term approximately

32 was measured in cardiomyocytes isolated from fetal sheep (135 day gestational age) in response to 100

33 eration, and dendritic maturation in preterm fetal sheep 4 weeks after HI.

34 We studied a total of nine fetal sheep (95 to 103 days of gestation; term = 145 to

35 VIP immunostaining was extremely robust in fetal sheep adrenal cortical neurofibers and cells while

36 eta-cell responsiveness in hypoglycaemic (H) fetal sheep and ascertain whether a 5 day euglycaemic re

37 sent throughout the adrenal cortices of both fetal sheep and baboons, were heavily innervated by VIP-

38 olypeptide (VIP) and tyrosine hydroxylase in fetal sheep and fetal baboon adrenal cortices and medull

39 mboxane mimetic stimulates ACTH secretion in fetal sheep, and that the endogenous production of throm

40 Under anesthesia, 5 fetal sheep at 0.8 gestation were instrumented with vasc

41 Under anaesthesia, 12 fetal sheep at 118 +/- 1 days of gestation (term ca 145

42 IL-6 mAbs and systemically infused mAbs into fetal sheep at 126 days of gestation after exposure to b

43 aortopulmonary anastomosis was created in 10 fetal sheep at 140 +/- 1.2 days of gestation.

44 med in cerebral cortical cell membranes from fetal sheep at 88, 120, and 136 d gestation (term = 150

45 the endogenous production of new glucose by fetal sheep at a time when the amount of glucose transfe

46 raperitoneal or intrahepatic route (IH) into fetal sheep at concentrations ranging from 1.1-2.6 x 10(

47 er with a fluorescent O2 probe, in near-term fetal sheep at low altitude (n = 8) and those acclimatiz

48 of measuring cerebral metabolic rate in the fetal sheep based on heat production in a local region o

49 In pancreatic islets isolated from intact fetal sheep, beta cell proliferation in vitro was reduce

50 Eight chronically catheterised fetal sheep between 122 and 134 days gestation were subj

51 del, and human cells harvested from chimeric fetal sheep bone marrow have been shown to successfully

52 androgen, estrogen, and progesterone in the fetal sheep brain during the critical period for sexual

53 ervated by VIP-immunoreactive neurofibers in fetal sheep, but not in fetal baboons.

54 We isolated fetal sheep cardiomyocytes and cultured them for 96 h, a

55 nsin II (Ang II) stimulates proliferation in fetal sheep cardiomyocytes when growth is dependent on t

56 exposure on later reactivity to adenosine in fetal sheep cerebral arterioles.

57 examethasone (n = 6) was infused for 48 h in fetal sheep commencing at 125 days of gestation.

58 drenal cortex and medulla is much greater in fetal sheep compared to fetal baboons.

59 normal sera from neonatal and adult, but not fetal, sheep contained IgM and IgG XNA reactive with rat

60 medulla were smaller in diameter compared to fetal sheep cortex (1.22+/-0.13 vs. 2.93+/-0.34 microm,

61 This study in fetal sheep demonstrates that fetoscopic and open transu

62 distribution of ligand binding sites in the fetal sheep diencephalon indicated that the highest leve

63 distribution of adenosine A(2A) receptors in fetal sheep diencephalon, we have used a receptor autora

64 ysiological responses to acute hypoxaemia in fetal sheep during and following maternal treatment with

65 ic GHR mRNA has therefore been determined in fetal sheep during late gestation and after experimental

66 The results show that glucogenesis occurs in fetal sheep during late gestation in conditions in which

67 In fetal sheep during late gestation the aims of the presen

68 human mesenchymal stem cell population into fetal sheep early in gestation, before and after the exp

69 In a model of human chorioamnionitis, fetal sheep exposed to a single injection, but not repea

70 ing primary and to a lesser degree secondary fetal sheep, failed to engraft tertiary recipients.

71 , transfer of CD34+/CD38+ cells to preimmune fetal sheep generated only short-term human hematopoiesi

72 We tested the hypothesis that high-altitude fetal sheep have evolved cardiovascular compensatory mec

73 de that cardiac nerves in the late-gestation fetal sheep have minor influences on plasma renin activi

74 identification and pathway analysis of novel fetal sheep heart transcriptome splice variants is a fir

75 We have examined the expressed fetal sheep heart transcriptome using high-throughput se

76 A recent finding of persisting fetal sheep hypoxia beyond the duration of CO2 pneumoper

77 ateral ventricle of chronically instrumented fetal sheep in utero at 128 +/- 1 days gestation (term i

78 ultilineage human hematopoiesis in the human-fetal sheep in vivo model.

79 nd dexamethasone treatment of late-gestation fetal sheep, in doses similar to those employed clinical

80 Hypothyroidism in fetal sheep induced by removal of the thyroid gland caus

81 , and that growth retardation in hypothyroid fetal sheep is associated with reductions in pancreatic

82 One marker of this state in fetal sheep is neck nuchal muscle atonia (NA).

83 ronary conductance with adenosine in anaemic fetal sheep is twice that of non-anaemic fetuses.

84 In isolated fetal sheep islets studied in vitro, thyroid hormones in

85 While cortisol is known to reduce growth in fetal sheep, its effects on the uteroplacental handling

86 in cerebral vascular response to hypoxia in fetal sheep may not be attributed to changes in vascular

87 VIP fibers in fetal sheep medulla were smaller in diameter compared to

88 PS), we validated this hypothesis in primary fetal sheep microglia cultures re-exposed to LPS in pres

89 We employed a preterm fetal sheep model of global cerebral ischemia in which a

90 Here we used a fetal sheep model of in utero transplantation to investi

91 during basal and insulin clamp periods in a fetal sheep model of placental insufficiency and IUGR.

92 We used a preterm fetal sheep model that reproduces key features of brain

93 We used a preterm fetal sheep model using both sexes that reproduces the s

94 In fetal sheep (n = 8) with laser Doppler flowmeter, fluore

95 We conclude that, in fetal sheep, neither adrenaline nor cGMP stimulate lung

96 ration induced by intraamniotic endotoxin in fetal sheep occurred without an increase in fetal plasma

97 In 5 fetal sheep of 109 to 111 days of gestation (term, 147 d

98 Sixteen fetal sheep of known gestational ages (124-128 days' ges

99 We hypothesize that in fetal sheep of this age, medullary neurofibers derive pr

100 Fetal sheep of ~131 days gestation (n = 8) were chronica

101 tic hernias were created surgically in seven fetal sheep on gestational day 100 (term = 145 days).

102 Experiments in the fetal sheep or neonatal rat, mouse, or pig reveal dramat

103 In the fetal sheep, parturition is triggered by an increase in

104 Fetal sheep physiology has been extensively studied sinc

105 have since used the chronically instrumented fetal sheep preparation to investigate the fetal compens

106 harvested from the brains of third trimester fetal sheep previously exposed in the second trimester t

107 s were injected into a total of 14 preimmune fetal sheep recipients using the amniotic bubble techniq

108 Prenatal glucocorticoid plus T4 treatment of fetal sheep results in improvements in oxygenation, gas

109 days in media containing 10% control or IUGR fetal sheep serum (FSS).

110 The present study utilized late gestation fetal sheep, stereotaxic methodology and retrograde axon

111 rs occurred in greater (P<0.05) frequency in fetal sheep than in fetal baboons (14.82+/-3.10 vs. 0.84

112 3 mmHg) steady-state conditions in near-term fetal sheep that had undergone either surgical sham or b

113 al cortex (FCTX) and olfactory bulbs (OB) of fetal sheep that were delivered on day 64 of gestation.

114 In fetal sheep, the rates of growth and umbilical glucose u

115 Therefore, in fetal sheep, thyroid hormones are important for the prep

116 eriments were carried out in unanaesthetized fetal sheep to evaluate the significance of non-N-methyl

117 Exposure of the fetal sheep to moderate to severe hypoxic stress results

118 133-selected cells engraft successfully in a fetal sheep transplantation model, and human cells harve

119 conclusion, rodent grafts transplanted into fetal sheep undergo HAR, likely through direct activatio

120 Instrumented fetal sheep underwent UPE for either 10 or 20 days.

121 Experimental manipulation of the fetal sheep urinary tract has proved informative in unde

122 high-titer retroviral vectors into preimmune fetal sheep was previously demonstrated.

123 The purpose of this study in fetal sheep was to assess the feasibility of fetoscopic

124 Using in utero transplantation into fetal sheep, we examined the capability of human bone ma

125 tion control (CON) (n = 8) and IUGR (n = 13) fetal sheep were catheterized with aortic and femoral ca

126 Late gestation fetal sheep were chronically catheterised in utero to al

127 Sixteen fetal sheep were chronically instrumented at 118+/-2 day

128 Fifteen fetal sheep were chronically instrumented between 117 an

129 Fetal sheep were given intra-amniotic (IA) injections of

130 Fetal sheep were given intra-amniotic injections of sali

131 latory responses to acute hypoxia, near-term fetal sheep were instrumented with laser Doppler probes

132 Under anaesthesia, 18 fetal sheep were instrumented with vascular and amniotic

133 Chronically instrumented, late-gestation fetal sheep were prepared to: (1) characterize cardiovas

134 rticoids correct the pulmonary immaturity of fetal sheep with CDH by physiologic, biochemical, and hi

135 In summary, fetal sheep with IUGR have increased hepatic glucose pro

136 of systems approaches uniquely available in fetal sheep with the power of genomic studies.

137 otoxin would induce early lung maturation in fetal sheep without increasing fetal cortisol.