ライフサイエンスコーパス: fibrillar collagen

1 0/G1 arrest of human melanoma cells grown on fibrillar collagen.

2 isrupt cell proliferation in the presence of fibrillar collagen.

3 n attenuates platelet adhesion to soluble or fibrillar collagen.

4 tor was responsible for cell cycle arrest on fibrillar collagen.

5 ary evidence for the expression of a B-clade fibrillar collagen.

6 ith extracellular matrix proteins, including fibrillar collagen.

7 collagens, as well as impaired migration on fibrillar collagen.

8 anism for tension-dependent stabilization of fibrillar collagen.

9 been shown to be activated mainly by soluble fibrillar collagen.

10 h type IV collagen and gelatin prepared from fibrillar collagen.

11 cellular layers and a diminished content of fibrillar collagen.

12 mesenchymal tissues, the ligand of which is fibrillar collagen.

13 which appears restricted in the presence of fibrillar collagen.

14 independent platelet adhesion to immobilized fibrillar collagen.

15 t zones, enriched either in proteoglycans or fibrillar collagen.

16 lation may regulate cross-link maturation in fibrillar collagen.

17 r thermal stability is comparable to that of fibrillar collagen.

18 fibrosis and changes in the organization of fibrillar collagen.

19 d emerging microscopy techniques to quantify fibrillar collagen.

20 expression of EMT/myofibroblast markers and fibrillar collagens.

21 ed to the protostome/deuterostome A clade of fibrillar collagens.

22 the -Gly-X-Y- repeating pattern found in non-fibrillar collagens.

23 t are uniquely able to cleave triple helical fibrillar collagens.

24 tients harboring mutations in genes encoding fibrillar collagens.

25 ase collagen receptors that are activated by fibrillar collagens.

26 der resulting from altered metabolism of the fibrillar collagens.

27 he cross-striated banding pattern typical of fibrillar collagens.

28 may be common aggregation motifs for the non-fibrillar collagens.

29 uration of extracellular matrices containing fibrillar collagens.

30 s different than that caused by mutations in fibrillar collagens.

31 ential for the processing of procollagens to fibrillar collagens.

32 lization of TIMP-2 with type IV collagen and fibrillar collagens.

33 d fibroblasts and pathological deposition of fibrillar collagens.

34 capable of initiating degradation of native fibrillar collagens.

35 ed to the formation and further expansion of fibrillar collagens.

36 An increase in fibrillar collagens 1 and 5 was detected.

37 collagen, indicative of a limbal annulus of fibrillar collagen 2.2 mm in diameter, was identified in

38 diac fibrosis, and morphological evidence of fibrillar collagen accumulation at the infarcted and non

39 M2 macrophages, IL-4, IL-13, fibrillar collagen accumulation, and proteolysis of coll

40 m Aggregatibacter actinomycetemcomitans is a fibrillar collagen adhesin belonging to the family of tr

41 oviding a physical barrier against invasion, fibrillar collagen also restricts cell proliferation.

42 Fibrillar collagen, an essential structural component of

43 een cloned including a basement membrane and fibrillar collagen and an A and B chain of laminin.

44 accompanied by proteolytic modifications of fibrillar collagen and an influx of host proteins, the r

45 combinant human CTRP-1 specifically bound to fibrillar collagen and blocked collagen-induced platelet

46 es depend on changes in extracellular matrix fibrillar collagen and cardiomyocyte titin.

47 In culture, tumor cells are invasive in a fibrillar collagen and COX-2-dependent manner.

48 -induced alterations in extracellular matrix fibrillar collagen and diastolic function.

49 efficient induction of invadopodia on dense fibrillar collagen and for local degradation of collagen

50 primary mouse megakaryocytes in response to fibrillar collagen and in response to cross-linking of t

51 th PyMT(mgko) tumors is stiffer and has more fibrillar collagen and increased expression of the colla

52 cantly different, and the average content of fibrillar collagen and macrophages in the lesions was si

53 tilage and bone cells to cleave high-density fibrillar collagen and modulate their resident matrix to

54 nization, including density and alignment of fibrillar collagen and myofibroblasts.

55 t1 expression also leads to dysregulation of fibrillar collagen and periostin expression, as well as

56 atrix proteins have been reported to bind to fibrillar collagen and regulate the diameter of collagen

57 al in vivo degradation of the self-assembled fibrillar collagen and the majority of implants experien

58 iple sites on the triple helical portions of fibrillar collagens and also capable of competing for su

59 wn to catalyze the covalent cross-linking of fibrillar collagens and elastin at peptidyl lysine resid

60 he catalysis of lysyl-derived cross-links in fibrillar collagens and elastin in the extracellular mat

61 s unique structural features of invertebrate fibrillar collagens and is expressed predominantly in bo

62 secreted by lung fibroblasts was retained on fibrillar collagen, and ACLP-deficient lung fibroblasts

63 iological stimulus for MT1-MMP expression is fibrillar collagen, and it has been shown that it up-reg

64 e growth regulatory signals originating from fibrillar collagen, and the proteolytic degradation of f

65 occurrence of related motifs in other human fibrillar collagens, and located a conserved array of no

66 include MMP-1, which preferentially degrades fibrillar collagens, and MMP-3, which can initiate a loc

67 found in the triple-helix domains of all non-fibrillar collagens, and perturbations to the triple-hel

68 We conclude that autoantibodies to fibrillar collagen antigens are present frequently in lu

69 ephrotic syndrome and glomerular deposits of fibrillar collagen are associated with multiple exostose

70 The thermal transitions of fibrillar collagen are investigated with second-harmonic

71 Thrombin and fibrillar collagen are potent activators of platelets at

72 Fibrillar collagens are present in a wide variety of ani

73 Non-fibrillar collagens are structurally more variable and r

74 Type I and III fibrillar collagens are the major structural proteins of

75 crosirius red-positive streaks," enriched in fibrillar collagens, are a hallmark of adipose tissue su

76 ages in cell culture, suggesting proteolyzed fibrillar collagen as a candidate ECM mediator of macrop

77 hough sulfate and divalent phosphate bind to fibrillar collagen at physiological concentrations, our

78 MMPs, which have a unique ability to degrade fibrillar collagens at neutral pH.

79 Fibrillar collagen, being highly noncentrosymmetric, pos

80 ECM and was inhibited by laminin and type-1 fibrillar collagen but increased by fibronectin.

81 s is critically dependent on the cleavage of fibrillar collagen by a previously unidentified intersti

82 nic fluid, characteristic of the cleavage of fibrillar collagen by interstitial collagenase.

83 proteinase-14 is required for degradation of fibrillar collagen by mesenchymal cells.

84 xtracellular matrix components, particularly fibrillar collagens, by PRDM5 is a key molecular mechani

85 Additionally, we demonstrate that fibrillar collagen can also arrest cells at the G2 phase

86 Thus, fibrillar collagen can be a formidable barrier to viral

87 one position in the triple-helical domain of fibrillar collagen chains, and its biological significan

88 ions (PTMs) than do similar domains of other fibrillar collagen chains, PTMs consisting of hydroxylat

89 These results indicate that fibrillar collagen cleavage at collagenase-specific site

90 damts14, and of the genes encoding the major fibrillar collagens, Col1a1, Col2a1 and Col3a1, during m

91 to vertebrates, possess an ancestral clade A fibrillar collagen (ColA) gene that is expressed in the

92 hesis by SoxE and SoxD regulation of clade A fibrillar collagen (ColA) genes--suggesting that the cho

93 ing Mg++-independent adhesion to immobilized fibrillar collagen, collagen-induced platelet aggregatio

94 Cre tumors was enriched with stromal-derived fibrillar collagen, compared with wild-type or Hras-driv

95 Type V collagen is a quantitatively minor fibrillar collagen comprised of different chain composit

96 activity accompanied by an increase in total fibrillar collagen content and an increase in myocardial

97 changes in total MMP activity and myocardial fibrillar collagen content were related to a time- depen

98 addition, in SPARC-null mice, TAC increased fibrillar collagen content, albeit significantly less th

99 oad causes myocardial hypertrophy, increased fibrillar collagen content, and abnormal diastolic funct

100 expression, myocardial diastolic stiffness, fibrillar collagen content, and soluble and insoluble co

101 that was accompanied by an increase in total fibrillar collagen content.

102 rresponded to a decrease in total myocardial fibrillar collagen content.

103 esponded with a decrease in total myocardial fibrillar collagen content.

104 Exposure of platelets to fibrillar collagen converts the surface-bound proMMP-1 z

105 metalloproteinase-1 (MMP-1), which initiates fibrillar collagen degradation.

106 idinoline (HP), a specific marker for mature fibrillar collagen degradation.

107 s important in cell cycle arrest mediated by fibrillar collagen, demonstrate the complexity of cell c

108 The tensile strength of fibrillar collagens depends on stable intermolecular cro

109 50 Pa and increased to 1-6 kPa in areas near fibrillar collagen deposition in fibrotic livers.

110 On the other hand, fibrillar collagen deposition was significantly increase

111 ding high matrix metalloproteinase activity, fibrillar collagen deposition, and release of bioactive

112 inal cord parenchyma do not normally contain fibrillar collagens, except in disease states.

113 Fibrillar collagen expression and content were increased

114 tigated the role of CRT in the regulation of fibrillar collagen expression, secretion, processing, an

115 A-3D mouse immortal keratinocytes growing on fibrillar collagen failed to activate FiRE and subsequen

116 , third clade (type C) within the vertebrate fibrillar collagen family.

117 cross-linking collagen I and III to form the fibrillar collagen fibers.

118 Collagen XV (COLXV) is a secreted non-fibrillar collagen found within basement membrane (BM) z

119 each antibody inhibited platelet adhesion to fibrillar collagen from 70 to 85%, especially during the

120 Although other fibrillar collagen-gene mutations that lead to allele in

121 port the characterization of a further three fibrillar collagen genes (Hcol2, Hcol3, and Hcol5) and t

122 mice revealed a significant upregulation of fibrillar collagen genes at mRNA level, as well as incre

123 Phylogenetic analyses reveal that the hydra fibrillar collagen genes form a distinct clade that appe

124 Mutations in the major fibrillar collagen genes lead to osteogenesis imperfecta

125 p27(KIP1) in cells plated in the presence of fibrillar collagen has led to the assumption that this k

126 Fibrillar collagens have an absolute requirement for Gly

127 We report that a novel high-density fibrillar collagen (HDFC) matrix is a potent inducer of

128 ge tumors that are characterized by abundant fibrillar collagen, high cyclooxygenase-2 (COX-2) expres

129 -/-) MEFs) have reduced transcript levels of fibrillar collagen I and III and less soluble collagen a

130 wn of collagen IV in the basal lamina and of fibrillar collagen I in the adjacent interstitium in the

131 We found that fibrillar collagen I induced linear F-actin structures,

132 This study demonstrates that fibrillar collagen I is the physiological inducer of a n

133 r invadosomes upon contact of the cells with fibrillar collagen I.

134 proteinase activity that processes the major fibrillar collagens I-III.

135 ure in the pathogenesis of liver fibrosis is fibrillar Collagen-I deposition; yet, mediators that cou

136 Mapping integrin-binding sites within the fibrillar collagens identified GFOGER as a high affinity

137 proteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal memb

138 es new blood vessel growth into well-defined fibrillar collagen implants.

139 s emerged as a powerful modality for imaging fibrillar collagen in a diverse range of tissues.

140 Fibrillar collagen in its native form inhibits cell prol

141 in the human melanoma Mu89 is limited by the fibrillar collagen in the extracellular matrix.

142 Biosynthesis of fibrillar collagen in the skin is precisely regulated to

143 show that it is possible to optically image fibrillar collagen in tumors growing in mice using secon

144 d-order nonlinear polarization properties of fibrillar collagen in various rat tissues (vertebrae, ti

145 d that OSCAR binds to specific motifs within fibrillar collagens in the ECM that become revealed on n

146 ation of extracellular matrix (ECM), namely, fibrillar collagens in the hepatic stellate cells (HSCs)

147 llagen fiber architecture in tissues rich in fibrillar collagen, including bone, tendon, and skin.

148 ere shown by immunohistochemistry to contain fibrillar collagens, including type I collagen.

149 ts and enhanced expression and deposition of fibrillar collagens) increased progressively.

150 n the presence of Mg2+, platelet adhesion to fibrillar collagen induced activation of the GP IIb-IIIa

151 In unchallenged endothelial cells, fibrillar collagen induced robust capillary morphogenesi

152 e I collagen and a delayed onset to low dose fibrillar collagen-induced aggregation, results consiste

153 ablish a general approach to investigate MMP-fibrillar collagen interactions.

154 mong other requirements, cross-links between fibrillar collagens, introduced by tissue transglutamina

155 Glomerular deposition of fibrillar collagen is a characteristic finding of geneti

156 Highly resistant to proteolysis, fibrillar collagen is degraded by specific matrix metall

157 A hierarchical organizational model of fibrillar collagen is developed to interpret the second-

158 y Tnap ectopic expression in cells producing fibrillar collagen is sufficient to induce pathological

159 Type I fibrillar collagen is the most abundant protein in the h

160 sumed that the growth regulatory activity of fibrillar collagen is the result of an indirect restrict

161 The mechanical strength of fibrillar collagens is highly dependent on the formation

162 Degradation of fibrillar collagens is important in many physiological a

163 density on top of or within 100-microm-thick fibrillar collagen lattices.

164 Fibrillar collagen levels and proteolysis increased dram

165 al cultures from cKO mice expressed elevated fibrillar collagen levels, providing further evidence th

166 pattern recognition collectins that contain fibrillar collagen-like regions and globular carbohydrat

167 amily of innate immune proteins that contain fibrillar collagen-like regions and globular carbohydrat

168 le blood over a 250-mum long patch of type I fibrillar collagen/lipidated tissue factor (TF; approxim

169 s in mouse (termed SMKO) resulted in altered fibrillar collagen localization with larger, poorly orga

170 On polymerized fibrillar collagen, M24met cells are growth arrested at

171 human corneal fibroblasts were plated inside fibrillar collagen matrices.

172 asement membrane components and disorganized fibrillar collagen matrix, independently of classical in

173 oinformatic analysis provides insight on how fibrillar collagens might have arisen from the duplicati

174 Three fibrillar collagen mRNAs, alpha1(I), alpha2(I), and alph

175 gth of the heart is provided by a continuous fibrillar collagen network embracing individual myocytes

176 A GVMGFO motif in fibrillar collagens (O denotes 4-hydroxyproline) binds 3

177 r, and collagen type I constitutes the major fibrillar collagen of bone.

178 Type V collagen is a fibrillar collagen of low abundance that is incorporated

179 man atherosclerotic lesions by digesting the fibrillar collagens of the neointimal ECM.

180 e evidence for a direct inhibitory effect of fibrillar collagen on proliferation of human melanoma an

181 rombin, but not saturating concentrations of fibrillar collagen or adenosine 5'-diphosphate, uniquely

182 -Danlos syndrome gene that does not encode a fibrillar collagen or collagen-modifying enzyme, we sugg

183 ts failed to aggregate in response to type I fibrillar collagen or convulxin, a snake venom protein a

184 hese sites, together with an accumulation of fibrillar collagen, or fibrosis, as evidenced by a signi

185 We measured the local fibrillar collagen order using X-ray diffraction methods

186 After release from the fibrillar collagen, PDE1C expression is induced and asso

187 l components of extracellular matrices (ECM) fibrillar collagens play a critical role, and single ami

188 Defective fibrillar collagen polymerization in primary tumors has

189 differences are shown in ability to process fibrillar collagen precursors and to cleave Chordin, the

190 An annulus of fibrillar collagen probably exists near the limbus of th

191 er SLP-76(+/-) or SLP-76(-/-) platelets, but fibrillar collagen produced a 1.9-fold increase in proco

192 ceptor tyrosine kinase in that its ligand is fibrillar collagen rather than a growth factor-like pept

193 Type XI collagen is a quantitatively minor fibrillar collagen related to type V collagen and associ

194 -1(-/-) LDLR(-/-) plaques were enriched with fibrillar collagens relative to LDLR(-/-), which also co

195 eterotypic fibrils composed of two different fibrillar collagens represents a general mechanism regul

196 direct mechanism by which cell contact with fibrillar collagen restricts proliferation.

197 le helices (FACITs) must differ from that of fibrillar collagens, since they lack the characteristic

198 opy of the pellet cultures revealed abundant fibrillar collagen, some of which was aligned in paralle

199 Thus, fibrillar collagen specifically regulates early integrin

200 Fibrillar collagens store, transmit and dissipate elasti

201 cks, powder, and HA/TCP powder-type I bovine fibrillar collagen strips, and bone was maintained for a

202 /TCP powder, the HA/TCP powder-type I bovine fibrillar collagen strips, and HA/TCP powder held togeth

203 The mechanism by which fibrillar collagen structures form from liquid crystalli

204 te limiting in remodeling of tissues rich in fibrillar collagen such as the skin and lungs.

205 normally in the triple helix domains of non-fibrillar collagens, such as type IV collagen in basemen

206 es P3H1 specifically to tissues that express fibrillar collagens, suggesting that other P3H family me

207 negative microvessels embedded in bundles of fibrillar collagen surrounded by F4/80-positive MC/Mph.

208 that the 5' stem-loop specifically regulates fibrillar collagen synthesis and represents a novel targ

209 selective transcriptional downregulation of fibrillar collagen synthesis.

210 exhibited higher stiffness and expression of fibrillar collagens than control fibroblasts, concomitan

211 ino acid sequence of type VI collagen, a non-fibrillar collagen that forms antiparallel dimers.

212 le in amnion fibroblasts, which lay down the fibrillar collagen that gives tensile strength to the am

213 I collagen gene codes for a novel vertebrate fibrillar collagen that is highly conserved in man, mous

214 triple helices (FACITs) differs from that of fibrillar collagens that have special C-propeptides.

215 Fibrillar collagens, the most abundant proteins in the v

216 h a small collagenous region, interacts with fibrillar collagens through its C-terminal region.

217 that is missing in many structural models of fibrillar collagen to date.

218 is an association between IOP regulation and fibrillar collagen turnover.

219 -) fibroblasts lost their ability to process fibrillar collagen type I and to activate proMMP-2.

220 t endothelial cell adhesion and migration on fibrillar collagen type I.

221 ed human SMCs made quiescent by attaching to fibrillar collagen type I.

222 and an X chromosome that disrupts the minor fibrillar collagen type V gene COL5A1 in a patient with

223 The low abundance fibrillar collagen type V is incorporated into and regul

224 The low abundance fibrillar collagen type V is widely distributed in tissu

225 Mutations in the genes encoding the major fibrillar collagen types I and III have been demonstrate

226 VWF) mediates adhesion of blood platelets to fibrillar collagen types I, II, and III, which is essent

227 The fibrillar collagen types I, II, and V/XI have recently b

228 1) and alpha(2) (alpha(1)I and alpha(2)I) to fibrillar collagen types I-III and showed that each I do

229 apy, mean serum levels of antibodies binding fibrillar collagen types I-III and V were significantly

230 llagen C-proteinase that processes the major fibrillar collagen types I-III, and it may process proly

231 However, compared with other vertebrate fibrillar collagens (types I, II, III, V, and XI), type

232 esion to immobilized monomeric and polymeric fibrillar collagen under static conditions in the presen

233 Degradation of fibrillar collagen underlies processes including tissue

234 the alpha2-I domain (alpha2-I), which binds fibrillar collagen via Mg(2+)-bridged interactions.

235 l area was increased with selective MMPi but fibrillar collagen volume fraction remained unchanged re

236 usceptibility to CatK-mediated hydrolysis of fibrillar collagen was observed following mineralization

237 The fibrillar collagen weave in MHCmTNF mice with concentric

238 and increased collagen content, whereas the fibrillar collagen weave in the MHCsTNF2 mice with LV di

239 independent conditions, platelets adhered to fibrillar collagen were able to secrete contents of both

240 Cells plated in the presence of fibrillar collagen were growth arrested in the G0/G1 pha

241 oid potential immunogenicity associated with fibrillar collagens, were fabricated with and without ch

242 Types I, II, III, V, and XI constitute the fibrillar collagens, whereas types IV, VI to X, and XII

243 on of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of sta

244 least partly, via biosynthetic processing of fibrillar collagens, while TLD affects dorsal-ventral pa

245 h encodes the alpha chain of an atypical non-fibrillar collagen with a single transmembrane domain.

246 Mineralization of fibrillar collagen with biomimetic process-directing age

247 of A2058 human melanoma cells cocultured in fibrillar collagen with HS-68 primary human fibroblasts.

248 s to enter the cell cycle in the presence of fibrillar collagen without a requirement for spreading a