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1 ng the Tudor domain, mediates the binding of fibrillarin.
2 nvolved in rRNA processing and interact with fibrillarin.
3 mice that targets the nucleolar autoantigen fibrillarin.
4 ages resulted in the proteolytic cleavage of fibrillarin.
5 hypermethylation and fail to associate with fibrillarin.
6 in boxes C, C', D, and D' and associate with fibrillarin.
7 of MPP10 arrived at the nucleolus later than fibrillarin.
8 NA) species, the vast majority of which bind fibrillarin.
9 f the NTD itself prevented dimerization with fibrillarin.
10 minal domain of Nop56/58 that interacts with fibrillarin.
11 olar markers such as B23 (nucleophosmin) and fibrillarin.
12 along with three proteins: L7Ae, Nop5p, and fibrillarin.
13 otein encoded by open reading frame 3), with fibrillarin.
14 differences at the cofactor-binding site in fibrillarin.
15 ith Nop58, and the D and D' boxes contacting fibrillarin.
16 NLS-containing proteins Arabidopsis thaliana fibrillarin 1 (AtFib1) and the Nuk6, Nuk7 and Nuk12 cand
17 ies of nucleostemin differed strikingly from fibrillarin (a protein directly involved in rRNA process
18 n prostate cancer, we examined FBL (encoding fibrillarin), a MYC target gene, and report that fibrill
19 nucleolar autoantibody response that targets fibrillarin, a 34-kDa protein component of many small nu
20 ve demonstrated that SMN also interacts with fibrillarin, a highly conserved nucleolar protein that i
22 hout mitosis, it co-localizes with NOP56 and fibrillarin, a putative methyl transferase, only during
23 miR-16-1, mir-28, miR-31 and let-7g) bind to fibrillarin, a specific protein component of functional
24 t H-2s does not program mice to produce anti-fibrillarin Abs in response to nonspecific immune stimul
25 In contrast, mercuric chloride induces anti-fibrillarin Abs only in SJL and other H-2s mice, and not
26 brillarin, the 19-kDa fragment produced anti-fibrillarin Abs with some of the properties of the HgCl2
27 Calorimetry studies of cofactor binding to fibrillarin alone and to fibrillarin-Nop5p binary comple
29 strate such as the glutathione S-transferase-fibrillarin amino-terminal fusion protein (GST-GAR), it
30 histone H2A and a glutathione S-transferase-fibrillarin (amino acids 1-148) fusion protein (glutathi
31 o catalyze the in vitro methylation of a GST-fibrillarin (amino acids 1-148) fusion protein (GST-GAR)
32 a cation-pi bridge formed between Tyr-89 of fibrillarin and Arg-169 of Nop5p, although dispensable f
33 cently determined crystal structures of free fibrillarin and fibrillarin-Nop5p-AdoMet tertiary comple
34 e arginine- and glycine-rich domains of both fibrillarin and GAR1 and is defective in SMN mutants fou
37 f SMN to the nucleolar periphery and loss of fibrillarin and GAR1 colocalization with SMN in gems.
38 two major families of small nucleolar RNPs, fibrillarin and GAR1, suggesting that SMN may also funct
40 homologs of the box C/D snoRNP core proteins fibrillarin and Nop56/58 have also been identified but a
43 harbors nascent pol I transcripts as well as fibrillarin and nucleolin, which function in early phase
45 uorescence, MPP10 colocalized with nucleolar fibrillarin and other known nucleolar proteins in interp
47 autoantibodies (ANoA) and for antibodies to fibrillarin and the U3 snoRNP-specific proteins Mpp10 an
50 inding factor [UBF]), processing (nucleolin, fibrillarin, and RNase MRP subunits, Rpp29), and ribosom
51 creased frequencies of anti-topoisomerase I, fibrillarin, and RNP autoantibodies compared with whites
52 eport that the nucleolar RNA proteins Rpp29, fibrillarin, and RPL23a are also components of this H3.3
53 BIG1, nucleolin, U3, the U3-binding protein fibrillarin, and the RNA-binding protein La may exist to
54 s infectious virus than extracts depleted of fibrillarin, another resident of the nucleolus, indicati
55 ations from T. brucei extracts with the anti-fibrillarin antibodies indicated that this trypanosomati
57 duced cell death was associated with loss of fibrillarin antigenicity and modification of the molecul
58 modification of the molecular properties of fibrillarin as revealed by aberrant migration under nonr
59 larin autoantibodies, pointing to unmodified fibrillarin as the B cell Ag and implicating mercury-mod
61 ient, impair the interaction between SMN and fibrillarin (as well as the common snRNP protein SmB).
62 include the nucleolar proteins nucleolin and fibrillarin, as well as the eukaryotic initiation factor
63 Our results indicate that T. brucei has many fibrillarin-associated box C/D snoRNAs with roles in 2'-
64 We report the identification of 17 box C/D fibrillarin-associated small nucleolar RNAs (snoRNAs) fr
67 e show that, in addition to U22, seven novel fibrillarin-associated snoRNAs, named U25-U31, are encod
69 mercury reduced immunoprecipitation by anti-fibrillarin autoantibodies, pointing to unmodified fibri
71 e modification of the molecular structure of fibrillarin by mercury reduced immunoprecipitation by an
72 We previously proposed that replacement of fibrillarin by Nop52 (RRP1/NNP-1) for the binding to p32
74 Evidence that BIG1 and nucleolin, but not fibrillarin, can be present with p62 at the nuclear enve
75 nucleolar dense fibrillar component protein fibrillarin closely matched the level of nucleolar assem
76 report the crystal structure of the Nop56/58-fibrillarin complex bound with methylation cofactor, S-a
77 x revealed a symmetric dimer of two Nop56/58-fibrillarin complexes linked by the coiled-coil domains
83 g CBs to enter the nucleolus and, along with fibrillarin, exit the nucleus to form viral 'transport-c
84 eroderma, coupled with the observations that fibrillarin expression is positively linked to collagen
85 e-peptide mutants exhibit small nucleoli and fibrillarin expression, as do long-lived dietary restric
86 d cell cycle factors, the nucleolar proteins fibrillarin (Fb) and Nopp140 (Nopp), the survival motor
88 ein via Cajal bodies, relocalization of some fibrillarin from the nucleolus to cytoplasm, and assembl
91 very after photobleaching (FRAP) showed that fibrillarin-GFP reassociates with the NDF and PNBs at ra
92 cepting substrates glutathione S-transferase fibrillarin glycine arginine domain fusion protein or he
93 g a GST fusion with the N-terminal domain of fibrillarin (GST-GAR), myelin basic protein, and recombi
95 hii (Mj) Nop56/58 with the methyltransferase fibrillarin has been investigated using site-directed mu
96 g recombinant core proteins L7, Nop56/58 and fibrillarin has yielded an RNA:protein enzyme that guide
99 many yeast nucleolar proteins, including the fibrillarin homolog Nop1p, to relocate to the cytoplasm.
101 Here we report the crystal structure of the fibrillarin homologue from Methanococcus jannaschii, a h
104 vealed that the P20 protein colocalized with fibrillarin in the nucleoli and formed punctate structur
106 mall nucleolar RNP (snoRNP) proteins, Nop1p (fibrillarin in vertebrates) and Nop58p (also known as No
109 e 19-kDa fragment, suggesting that a mercury-fibrillarin interaction was not necessary for the unique
112 ts revealed that the major nucleolar protein fibrillarin is coprecipitated in the P20 protein complex
114 how that the glycine/arginine-rich domain of fibrillarin is necessary and sufficient for SMN binding
115 Sm snRNP proteins, interaction with GAR1 and fibrillarin is not enhanced by arginine dimethylation.
117 collagen expression in fibroblasts and that fibrillarin is overexpressed in scleroderma fibroblasts,
119 illarin), a MYC target gene, and report that fibrillarin is required for proliferation, clonogenic su
120 d, suggesting that binding of Nop5p alone to fibrillarin is sufficient to stabilize the AdoMet-bindin
121 hyltransferase in yeast and demonstrate that fibrillarin is the orthologue enzyme in human cells.
123 denosine deaminase acting on RNA 1 and 2 and fibrillarin negatively influence each other's expression
124 mperature-sensitive mutations found in yeast fibrillarin Nop1 to the Methanococcus homologue structur
128 box C/D RNP containing three core proteins (fibrillarin, Nop56/58, and L7Ae) and a half-mer box C/D
131 cofactor binding to fibrillarin alone and to fibrillarin-Nop5p binary complex provided further suppor
132 ymmetries in both the box C/D RNA and in the fibrillarin-Nop5p complex are required for efficient cat
133 g one of the two box C/D motifs and a mutant fibrillarin-Nop5p complex deficient in self-association.
135 d crystal structures of free fibrillarin and fibrillarin-Nop5p-AdoMet tertiary complex revealed large
136 lude alpha tubulin, beta actin, desmoplakin, fibrillarin, nuclear lamin B1, nonmuscle myosin heavy ch
137 sing, including U3 small nucleolar (sno)RNA, fibrillarin, nucleolin, and proteins B23 and p52, accumu
138 g fusions of the processing-related proteins fibrillarin, nucleolin, or B23 with green fluorescent pr
139 Later analyses revealed the presence of fibrillarin, nucleoporin p62, and La in BIG1 and nucleol
140 , the survival of motor neurons protein, and fibrillarin occur together in a nuclear body that is clo
143 cted in the coiled bodies stained for either fibrillarin or p80 coilin, a protein found only in the c
144 ions that did not affect Nop56/58 binding to fibrillarin or sRNP assembly nevertheless disrupted sRNP
145 se a model of the structural organization of fibrillarin-ORF3 protein complexes and discuss potential
147 own by decreased nascent pre-rRNA synthesis, fibrillarin perinucleolar cap formation and upregulation
148 whose exceptionally stable interaction with fibrillarin plays a role in both RNP assembly and methyl
151 iously identified nucleolar proteins B23 and fibrillarin, proteins with electrophoretic mobilities ch
152 f enzyme mutants identified three additional fibrillarin residues (Thr-70, Glu-88, and Asp-133) to be
155 ide insight into movement of satBaMV via the fibrillarin-satBaMV-P20 RNP complex in phloem-mediated s
159 optosis suggests that the immune response to fibrillarin that characterizes a subset of patients with
160 h was the generation of a 19-kDa fragment of fibrillarin that was not found following apoptotic or no
161 In contrast to immunization with full-length fibrillarin, the 19-kDa fragment produced anti-fibrillar
162 metric, with the C' box contacting Nop56 and fibrillarin, the C box interacting with Nop58, and the D
163 distinct foci of other CB markers, including fibrillarin, the survival motor neuron (SMN) protein, U2
164 itivity of the HgCl2-induced modification of fibrillarin to 2-ME, iodoacetamide, and hydrogen peroxid
165 nvolved not only in competitive binding with fibrillarin to C1QBP on 90S but also in site 2 cleavage
168 function is to target the methyltransferase fibrillarin to rRNA (for example, SNORD27 performs 2'-O-
169 5p caused the nucleolar protein Nop1p (yeast fibrillarin) to be localized to the nucleus and cytosol.
170 extract made under native conditions, where fibrillarin was not detected, indicating that a fraction
172 g of the eukaryotic rRNA processing protein, fibrillarin, was also upregulated sixfold in the presenc
173 cDNA for the box C/D snoRNA common protein, fibrillarin, was cloned and polyclonal antibodies to the
174 sequence derived from the in vivo substrate fibrillarin we observed that PRMT1 methylated substrates
176 leoprotein (RNP) complex composed of P20 and fibrillarin, whereas BaMV movement proteins, capsid prot
177 ght regions contain DmNopp140 and endogenous fibrillarin, whereas the phase-dark regions contain endo
178 methionine to the target RNA is performed by fibrillarin, which by itself has no affinity for the sRN
179 ze and number, we examined the expression of fibrillarin, which did not correlate with rRNA levels.
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