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1 tion of proteins and signal transduction via fibroblast growth-factor receptor.
2 rmal growth factor receptor, Ins-Ralpha, and fibroblast growth factor receptors.
3 changes associated with focal adhesions and fibroblast growth factor receptors.
4 RBB2 and ERBB3; and trace phosphorylation of fibroblast growth factor receptors.
5 ition of EGFRs but not by the stimulation of fibroblast growth factor receptors.
6 rrelations of diseases caused by variants in Fibroblast Growth Factor Receptor 1 ( FGFR1) and report
8 revious studies have individually implicated fibroblast growth factor receptor 1 (FGFR1) and canonica
11 post-implantation lethality associated with fibroblast growth factor receptor 1 (FGFR1) deficiency,
12 L in cell motility control via regulation of fibroblast growth factor receptor 1 (FGFR1) endocytosis.
14 on and differentiation via expression of the fibroblast growth factor receptor 1 (FGFR1) gene is posi
15 atively spliced alpha-exon of the endogenous fibroblast growth factor receptor 1 (FGFR1) gene, which
25 lpha-exon by alternative RNA splicing of the fibroblast growth factor receptor 1 (FGFR1) primary tran
27 d growth factor receptor alpha (PDGFRA), and fibroblast growth factor receptor 1 (FGFR1) to cell prol
28 tivated with other tyrosine kinases, such as fibroblast growth factor receptor 1 (FGFR1), concomitant
29 nescence resonance energy transfer analysis, fibroblast growth factor receptor 1 (FGFR1)-5-hydroxytry
31 mal growth factor receptor (HEGFR) and human fibroblast growth factor receptor 1 (HFGFR1) mRNAs in th
32 hypothalamic amenorrhea: two variants in the fibroblast growth factor receptor 1 gene FGFR1 (G260E an
34 et-derived growth factor receptor beta and a fibroblast growth factor receptor 1 kinase inhibitor) an
35 cible transcript-3.0 (wit3.0), also known as fibroblast growth factor receptor 1 oncogene partner 2 (
37 as inhibited the mitogenic activity of both fibroblast growth factor receptor 1-expressing BaF3 cell
40 thelial growth factor receptors 1, 2, and 3, fibroblast growth factor receptors 1 through 4, platelet
41 the second half of Ig-like domain 3 (D3) of fibroblast growth factor receptors 1-3 (FGFR1 to -3) gen
43 s of hypertrophy, including type X collagen, fibroblast growth factor receptors 1-3, parathyroid horm
45 owever, DNA synthesis and phosphorylation of fibroblast growth factor receptor-1 (FGFR-1) induced by
46 contrast, hypoxic mice carrying a disrupted fibroblast growth factor receptor-1 (Fgfr1) gene in GFAP
49 on-cleavage screen, including Hsp70, Notch1, fibroblast growth factor receptor-1 (FGFR1), poly-A-bind
50 ell-surface proteins cytokeratin-7 (CK7) and fibroblast growth factor receptor-1 (FGFR1), which are t
52 , we discovered that activation of inducible fibroblast growth factor receptor-1 (iFGFR1) in the mamm
53 vitro, this differentiation was inhibited by fibroblast growth factor receptor-1 Ab, demonstrating a
54 r-1 Ab, demonstrating a role of the CD56 and fibroblast growth factor receptor-1 interaction in this
55 lar endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 that are two key gro
56 ss in self-renewal occurs via alterations in fibroblast growth factor receptor-1, p38alpha and p38bet
63 single nucleotide polymorphisms (SNP) within fibroblast growth factor receptor 2 (FGFR2) as one of th
66 report that mice lacking the IIIb isoform of fibroblast growth factor receptor 2 (Fgfr2) exhibit seve
69 ntify substitutions at nucleotide 755 of the fibroblast growth factor receptor 2 (FGFR2) gene in sper
71 have recently shown activating mutations in fibroblast growth factor receptor 2 (FGFR2) in 16% of en
72 etic evidence that En1 functions upstream of fibroblast growth factor receptor 2 (Fgfr2) in regulatin
75 on of epithelial and mesenchymal isoforms of Fibroblast Growth Factor Receptor 2 (FGFR2) is achieved
77 The regulatory mechanism of one such RTK, fibroblast growth factor receptor 2 (FGFR2) kinase, is s
80 ome (ABS), which has also been attributed to fibroblast growth factor receptor 2 (FGFR2) mutations.
82 or receptor-bound protein 2 (Grb2), controls fibroblast growth factor receptor 2 (FGFR2) signaling by
83 In epithelial cells, alternative splicing of fibroblast growth factor receptor 2 (FGFR2) transcripts
86 Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kin
87 In a panel of gastric cancer cell lines, fibroblast growth factor receptor 2 (FGFR2) was overexpr
88 g from activating or neomorphic mutations in fibroblast growth factor receptor 2 (FGFR2), underscore
97 s to study renal development in mice lacking fibroblast growth factor receptor 2 in the ureteric bud
98 n breast cancer prevention, and suggest that fibroblast growth factor receptor 2 signalling has an im
99 XA1, GATA3 and PTTG1 as master regulators of fibroblast growth factor receptor 2 signalling, and show
103 es expression of bone morphogenic protein 7, fibroblast growth factor receptor 2, insulin-like growth
107 FR-2, showed very modest selectivity against fibroblast growth factor receptor-2 (IC(50) = 0.21 micro
108 suggested that FGF10, acting mainly through fibroblast growth factor receptor 2b (FGFR2b), is crucia
109 lacks a Src-binding site, using shedding of fibroblast growth factor receptor 2iiib variant as an as
110 an autosomal-dominant activating mutation in fibroblast growth factor receptor 3 (FGFR3(P250R) ).
111 ice with the K644E kinase domain mutation in fibroblast growth factor receptor 3 (Fgfr3) (EIIa;Fgfr3(
112 have the same point mutation in the gene for fibroblast growth factor receptor 3 (FGFR3) and more tha
113 n that it involves 2 potential target genes: fibroblast growth factor receptor 3 (FGFR3) and multiple
115 athymic nude mice, due to down regulation of fibroblast growth factor receptor 3 (FGFR3) and PI3K/Akt
120 have previously shown that dysregulation of fibroblast growth factor receptor 3 (FGFR3) by the t(4;1
122 380R mutation in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) causes achon
124 ently reported that receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) directly tyr
126 380R mutation in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) in >97% of t
133 ly, we found that the enhanced activation of fibroblast growth factor receptor 3 (FGFR3) is linked to
137 Gly380 --> Arg mutation in the TM domain of fibroblast growth factor receptor 3 (FGFR3) of the RTK f
139 ysregulation of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) plays a path
143 is associated with ectopic overexpression of fibroblast growth factor receptor 3 (FGFR3) that sometim
144 y of dimer formation of the G380R mutants of fibroblast growth factor receptor 3 (FGFR3) transmembran
145 for heterodimer formation between wild-type fibroblast growth factor receptor 3 (FGFR3) transmembran
146 hogenic mutations (V664E in Neu and A391E in fibroblast growth factor receptor 3 (FGFR3)) on receptor
149 ons that exaggerate the signal output of the fibroblast growth factor receptor 3 (FGFR3), a receptor
150 estigated whether the TM domains of one RTK, fibroblast growth factor receptor 3 (FGFR3), dimerize in
151 nic mutation is the Ala391-->Glu mutation in fibroblast growth factor receptor 3 (FGFR3), linked to C
152 erozygous Pro250Arg substitution mutation in fibroblast growth factor receptor 3 (FGFR3), which incre
157 rmation induced by the constitutively active fibroblast growth factor receptor 3 (K/E-FR3) (Oncogene,
158 g 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (fibroblast growth factor receptor 3 [FGFR3] and multiple
159 E TM domain mutation on the stability of the fibroblast growth factor receptor 3 dimer in the presenc
161 ge and the frequencies of sperm with DFI and fibroblast growth factor receptor 3 gene (FGFR3) mutatio
162 ude HER2, epidermal growth factor receptors, fibroblast growth factor receptor 3, mTOR and others.
163 caused by gain-of-function mutations in the fibroblast growth factor receptor 3-encoding (FGFR3-enco
164 ctivity, including: CHIR-258, which inhibits fibroblast growth factor receptor 3; NVP-ADW742, which i
166 rm of human achondrodysplasia, linked to the fibroblast-growth-factor receptor 3 locus, not linked to
169 thelial cells, secretoneurin also stimulated fibroblast growth factor receptor-3 and insulin-like gro
170 receptor, bone morphogenetic protein-7, and fibroblast growth factor receptor-3 expression increased
174 l approach involving antisense inhibition of fibroblast growth factor receptor 4 (FGFR4) in periphera
176 KLB rs17618244 with 3 nonsynonymous SNPs of fibroblast growth factor receptor 4 (FGFR4) revealed tha
177 ocal acetylcholine release, synergizing with fibroblast growth factor receptor activation to increase
178 Y240 phosphorylation can be mediated by both fibroblast growth factor receptors and SRC family kinase
179 ing platelet-derived growth factor receptor, fibroblast growth factor receptor, and Met, leading to i
181 t to a LOX-PP target at or near the level of fibroblast growth factor receptor binding or activation.
182 epithelial growth factor receptor (EGFR) and fibroblast growth factor receptor/breathless (FGFR, Btl)
183 transition promoted by the oncogenic Met and fibroblast growth factor receptors, but not by progester
184 the Notch ligands Jagged1 and Delta1 induced fibroblast growth factor receptor-dependent cell transfo
185 growth factor-A (PDGF-A), dominant-negative fibroblast growth factor receptor (DN-FGFR), or DN-Sprou
186 Signaling by the Caenorhabditis elegans fibroblast growth factor receptor EGL-15 is activated by
187 f both populations, whereas argonaute2 and a fibroblast growth factor receptor-encoding gene are requ
188 Interestingly, FAK knockdown did not modify fibroblast growth factor receptor expression induced by
189 p11;q12) results in expression of the ZNF198-fibroblast growth factor receptor (FGFR) 1 fusion tyrosi
191 iency results in cell-autonomous loss of the fibroblast growth factor receptor (Fgfr) 2b, which is re
192 ithelial cells resulted in a higher level of fibroblast growth factor receptor (FGFR) activation and
193 to mediate cell repulsion is antagonized by fibroblast growth factor receptor (FGFR) activation that
195 athway analysis of these 69 genes implicated fibroblast growth factor receptor (FGFR) as a key regula
196 F3 cell line expresses only a single type of fibroblast growth factor receptor (FGFR) but produces ne
199 n of Frs2alpha (Six2creFrs2alphaKO), a major fibroblast growth factor receptor (Fgfr) docking protein
200 esses paralleled the dorsoventral changes in fibroblast growth factor receptor (FGFR) expressions.
202 ivation specific for the PTKs in the Src and fibroblast growth factor receptor (FGFR) families, key e
203 FGFRL1 is a newly identified member of the fibroblast growth factor receptor (FGFR) family expresse
205 c pathways mediated by the VEGFR family, the fibroblast growth factor receptor (FGFR) family, the pla
206 red receptor tyrosine kinase families is the fibroblast growth factor receptor (FGFR) family, with am
209 -frame the tyrosine kinase coding domains of fibroblast growth factor receptor (FGFR) genes (FGFR1 or
212 s, an effect abolished by treatment with the fibroblast growth factor receptor (FGFR) inhibitor SU540
213 e rates have been low for biomarker-directed fibroblast growth factor receptor (FGFR) inhibitor thera
214 ng mutation, and the combination of EGFR and fibroblast growth factor receptor (FGFR) inhibitors was
215 Epidermal Growth Factor Receptor (EGFR) and Fibroblast Growth Factor Receptor (FGFR) is required for
216 e the dimer stabilities of three full-length fibroblast growth factor receptor (FGFR) mutants harbori
217 identified cross-talk between the Hippo and fibroblast growth factor receptor (FGFR) oncogenic signa
218 d enhanced Ihh and Pthrp expression, whereas fibroblast growth factor receptor (FGFR) or mitogen-acti
219 nto the eye field, whereas activation of the fibroblast growth factor receptor (FGFR) represses these
221 tivating activity, controls ERK1/2-dependent fibroblast growth factor receptor (FGFR) signaling in ch
224 ce that this alternative pathway may involve fibroblast growth factor receptor (FGFR) signaling.
225 n fibroblasts, RCC broadly induced low-level fibroblast growth factor receptor (FGFR) signaling.
226 HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling.
227 n substrate for two proteins involved in the fibroblast growth factor receptor (FGFR) signalling path
228 th factor receptor (KGFR) is a member of the fibroblast growth factor receptor (FGFR) superfamily.
229 for the work described here, we selected the fibroblast growth factor receptor (FGFR) tyrosine kinase
230 JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor (FGFR) tyrosine kinase
235 ed significant inhibitory activities against fibroblast growth factor receptor (FGFR), platelet-deriv
236 of diverse transmembrane receptors including fibroblast growth factor receptor (FGFR), platelet-deriv
238 en induced cell growth, MM134 cells required fibroblast growth factor receptor (FGFR)-1 signaling to
245 study the hetero-interactions between three fibroblast growth factor receptors-FGFR1, FGFR2, and FGF
247 ct gain-of-function mutations in five genes (fibroblast growth factor receptors FGFR2 and FGFR3, tyro
248 th factor receptor alpha (PDGFRA) and type 3 fibroblast growth factor receptor (FGFR3), receptor tyro
250 rs351855) in the transmembrane domain of the fibroblast growth factor receptor (FGFR4) is associated
255 ingly, Prox1 also controls the expression of fibroblast growth factor receptors (FGFRs) and can bind
269 olid tumors harboring genetic alterations in fibroblast growth factor receptors (FGFRs) to determine
271 rogen receptor gene (ESR1), PIK3CA gene, and fibroblast growth factor receptor gene (FGFR2), among ot
273 ell-based models of fibroblast growth factor/fibroblast growth factor receptor, glial cell line-deriv
274 mediated by the Forkhead TFs regulating the fibroblast growth factor receptor Heartless (Htl) and th
276 domain, FGF23-21c was still able to activate fibroblast growth factor receptors in the presence of al
279 alpha), a key docking protein that transmits fibroblast growth factor receptor intracellular signalin
280 bited the highest kinase selectivity against fibroblast growth factor receptor kinase, platelet-deriv
282 og; OSX, osterix transcription factor; FGFR, fibroblast growth factor receptor; PMN, polymorphonuclea
283 In vitro binding assays with recombinant fibroblast growth factor receptor protein revealed that
284 in unanswered, such as the identification of fibroblast growth factor receptor responsible for glucos
285 s differential responses to EGF receptor vs. fibroblast growth factor receptor signaling as well as t
287 tes the epidermal growth factor receptor and fibroblast growth factor receptor signaling pathways inv
292 ing pathways through their interactions with fibroblast growth factor receptor substrate 2 (FRS2).
294 ion of a pan-FGF receptor adaptor Frs2alpha (fibroblast growth factor receptor substrate 2 alpha) in
295 ching defects; however, ureteric deletion of fibroblast growth factor receptor substrate 2alpha (Frs2
296 t either the neurotrophic signaling effector fibroblast growth factor receptor substrate 2alpha or th
297 cular endothelial growth factor receptor and fibroblast growth factor receptor, to cetuximab has show
298 f a plasmid expressing the nucleus-targeting fibroblast growth factor receptor type 1 resulted in sig
299 as platelet-derived growth factor receptor, fibroblast growth factor receptor, VEGF-R1, and VEGF-R3,
300 tinib, a potent tyrosine-kinase inhibitor of fibroblast growth factor receptors, VEGF receptors, PDGF
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