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1 formed from two cell lineages, myogenic and fibroblastic.
2 ne serum, to cause the keratocytes to become fibroblastic.
3 re aggressive, less differentiated, and more fibroblastic.
4 mas included one secretory meningioma and 11 fibroblastic, 11 transitional, 14 meningothelial, and tw
5 minant isoform, was ectopically expressed in fibroblastic 3T3-L1 pre-adipocytes that normally lack th
7 tified in our study, may explain some of the fibroblastic abnormalities previously observed in patien
8 tain all the bone-marrow colony-forming-unit fibroblastic activity and can be propagated as non-adher
9 been postulated that certain drugs increase fibroblastic activity through alterations in levels of v
10 a product, tenv could induce cytotoxicity to fibroblastic and B-lymphoid cells but not to T-lymphoid
12 Similar behavior was observed not only with fibroblastic and epithelial cell lines but also explants
14 siently transfected into human cell lines of fibroblastic and epithelial origins that differed in the
17 in vitro, keratocytes proliferate, becoming fibroblastic, and lose biosynthesis of unique corneal ma
18 s cultured in 10% FBS proliferated, appeared fibroblastic, and synthesized only 9% of the total glyco
21 te that primary cultures of keratocytes made fibroblastic by exposure to serum can return to their ke
24 orneal stroma with the appropriate number of fibroblastic cell layers and Descemet's membrane of appr
28 ism in the embryo itself, we derived primary fibroblastic cell lines from foetuses affected by NTDs a
29 of myosin VI at the Golgi complex, immortal fibroblastic cell lines of Snell's waltzer mice lacking
30 vated receptor (PPAR) gamma in non-precursor fibroblastic cell lines resulted in conversion to adipoc
32 arget, equine macrophages, permissive equine fibroblastic cell lines, and an engineered mouse cell li
33 d by Gi- but not Gs-linked receptors in many fibroblastic cell lines, we observed the opposite in PC1
34 n of TIMP-3 was associated with a scattered, fibroblastic cell morphology, as well as enhanced prolif
37 now show that for some melanoma, sarcoma, or fibroblastic cell types that survive without integrin-me
39 litate relevant studies of cancer-associated fibroblastic cell/cholangiocarcinoma cell interactions t
40 ine-rich peptide synthesized and secreted by fibroblastic cells after activation with transforming gr
41 ells from OC-activated livers yield Thy-1(+) fibroblastic cells and a population of E-cadherin(+) mes
43 genic capacity to stimulate the migration of fibroblastic cells and promote their ability to secrete
44 n microtubule organization at centrosomes in fibroblastic cells and provide new insights into dynacti
45 totic effects of lipopolysaccharide (LPS) on fibroblastic cells and to investigate the role that the
47 Expression of wild-type INO80 in patients' fibroblastic cells corrected their hypersensitivity to h
48 e mechanisms through which cancer-associated fibroblastic cells crosstalk with cholangiocarcinoma cel
49 eractive pathways by which cancer-associated fibroblastic cells crosstalk with cholangiocarcinoma cel
50 phosphatidic acid (LPA)-induced migration of fibroblastic cells derived from beta1-null mouse embryon
52 ollagenase (MMP-13; collagenase-3) gene from fibroblastic cells directly adjacent to macrophages with
54 , control DCs and IL-4-transduced T cells or fibroblastic cells failed to alter the course of the dis
56 ogenic progenitors form muscle cells whereas fibroblastic cells give rise to the supportive connectiv
57 duction of sustained transgene expression in fibroblastic cells in mice using a chimeric gene encodin
58 ooth muscle actin-positive cancer-associated fibroblastic cells in promoting intrahepatic cholangioca
59 ooth muscle actin-positive cancer-associated fibroblastic cells in the stroma of intrahepatic cholang
60 en found to transform both hematopoietic and fibroblastic cells in vitro, while inducing predominantl
61 y demonstrated that LPS induces apoptosis of fibroblastic cells in vivo, largely through TNF-alpha.
64 stitutive activation of TGFbeta signaling in fibroblastic cells of mice after birth caused a marked f
65 poptosis of resident non-bone marrow-derived fibroblastic cells of the corneal stroma is strongly cor
66 al neural crest (CNC) cells give rise to the fibroblastic cells of the tongue skeletal muscle in mice
67 lturing normal rat kidney epithelial and 3T3 fibroblastic cells on a collagen-coated polyacrylamide s
69 xperiments in other neuron-like cells and in fibroblastic cells revealed that N-glycosylation of neur
70 n in the dermal layer of cell aggregates and fibroblastic cells surrounded by a pericellular matrix e
71 and associated stromal components, including fibroblastic cells that contribute to tumor growth and p
72 arge number of genes that favor apoptosis of fibroblastic cells that is dependent upon activation of
75 astic prostate revealed that FGF7-expressing fibroblastic cells were present in higher numbers near t
76 we report that stimulation of epithelial or fibroblastic cells with G protein-coupled receptor agoni
78 ate that PDL cells are a mixed population of fibroblastic cells, capable of forming a mineralized mat
81 en bacteria were cocultured with Detroit 532 fibroblastic cells, ExoS-producing 388 bacteria caused a
83 fully functional brown fat program in naive fibroblastic cells, including skin fibroblasts from mous
84 esent in inflamed tissues and joints rich in fibroblastic cells, no significant data on fibrin(ogen)-
93 that zonal organization of osteoblastic and fibroblastic cellular phenotypes can be engineered by a
95 fraction of Nestin(+) cells, containing most fibroblastic CFUs, mesenspheres, and self-renewal capaci
97 (low) sub-population, which possesses higher fibroblastic colony-forming units (CFUs) and mesensphere
100 ation: human embryonic stem cells (hESCs), a fibroblastic differentiated derivative of the hESCs, and
108 P = 0.012; fibroblasts, P < 0.001), but only fibroblastic expression was related to the presence of i
111 ance of four individual histologic features (fibroblastic foci [FF], interstitial mononuclear cell in
113 STAT3 was not present in alpha-SMA-positive fibroblastic foci but was observed in the nuclei of cell
115 lung specimens of IPF, myofibroblasts within fibroblastic foci demonstrated diminished PTEN expressio
116 decrease in the number of myofibroblasts at fibroblastic foci in animals treated with SD-208 but not
118 eomycin-induced lung fibrosis in mice and in fibroblastic foci of human subjects with IPF, using phos
125 ty is regionally decreased in IPF within the fibroblastic foci, and that within these areas PEDF was
138 rly within the fibrotic interstitium and the fibroblastic focus, and prominently within the epitheliu
140 2 patients), telangiectatic (four patients), fibroblastic (four patients), small cell (one patient),
142 diocytes with interleukin-1 (IL-1) and basic fibroblastic growth factor (bFGF), with some induction a
149 S) are part of a wide spectrum of disordered fibroblastic growth that display striking clinical and p
150 lates were morphologically heterogeneous and fibroblastic, had a normal-appearing actin cytoskeleton
151 urface mesenchymal epitopes, expressed broad fibroblastic hallmarks, and increasingly synthesized col
152 um-free medium appeared dendritic and became fibroblastic in appearance when exposed to medium contai
153 ted beta-catenin mutants are dispersed, more fibroblastic in morphology, and less efficient in formin
154 ally infect (invade) mouse cytokine-treated, fibroblastic L929 cells and macrophagelike RAW264.7 cell
157 ell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein mar
158 -1 and vimentin, indicating that they are of fibroblastic lineage and express a well-characterized ad
159 differentiation of mesenchymal cells into a fibroblastic lineage while repressing their transformati
163 (a) alveolar collapse, (b) incorporation of fibroblastic material into alveolar walls, and (c) cigar
164 s in histogram measures of CP and CS between fibroblastic meningiomas and other subtypes were observe
167 altered the shape of CECs from polygonal to fibroblastic morphologies in a time- and dose-dependent
169 tumor progression, with the development of a fibroblastic morphology characteristic of metastatic cel
170 R inhibition resulted in a transition from a fibroblastic morphology to a more epithelial phenotype i
171 acteristics; i.e., change from epithelial to fibroblastic morphology, enhanced cell motility, decreas
172 1 in Madin-Darby canine kidney cells induced fibroblastic morphology, increased intercellular junctio
173 way, which induces EMT-like reprogramming to fibroblastic morphology, loss of cell polarity, contact
174 ed with changing cell shape into a flattened/fibroblastic morphology, suppression of E-cadherin expre
177 in transfectants revealed a reversion from a fibroblastic, motile phenotype to a more stationary epit
178 A-null mice, suggesting that a uPA-dependent fibroblastic nAChRalpha1 pathway promotes renal fibrosis
179 the absence of RhoA and p160ROCK activity in fibroblastic NIH 3T3 cells and its presence in epithelia
183 and most have used immortalized epithelial, fibroblastic, or hematopoietic cell lines that may not n
185 ells of B-cell, endothelial, epithelial, and fibroblastic origin; however, in all cases, infection pr
187 rsed the loss of differentiation markers and fibroblastic phenotype in Bcl-2-deficient chondrocytes.
189 ighly proliferative component demonstrated a fibroblastic phenotype that readily underwent myofibrobl
190 ls which expressed the transgene exhibited a fibroblastic phenotype, co-localized with sites of activ
197 al reorganization and cell shape change from fibroblastic preadipocytes to spherical adipocytes occur
202 adenocarcinoma, associated with a pronounced fibroblastic reactive stroma activation surrounding pros
203 ocytic) and, to a lesser degree, peripheral (fibroblastic) regions of normal, degenerative uncalcifie
204 osthetic mesh induces a chronic foreign-body fibroblastic response creating scar tissue that imparts
206 trated that Prx-2 affected a number of fetal fibroblastic responses believed to be important in media
208 eukin (IL)-7 that is 'posted' on the stromal fibroblastic reticular cell (FRC) network on which T cel
209 The underlying structural elements of LTs, fibroblastic reticular cell (FRC) network, not only form
210 ll access to the survival factor IL-7 on the fibroblastic reticular cell (FRC) network, resulting in
211 sly showed that lymphotoxin signaling in the fibroblastic reticular cell (FRC) stromal subset was req
212 nd intravital microscopy, we showed that the fibroblastic reticular cell network regulated naive T ce
213 tial association of dendritic cells with the fibroblastic reticular cell network within lymph nodes a
214 ce the distance between intersections in the fibroblastic reticular cell network, suggesting that at
215 h T cells largely move along conduits of the fibroblastic reticular cell network, they appear to exec
216 ll responses and pathological alterations of fibroblastic reticular cell networks in the draining lym
217 CAM-1 expression, and disrupted perivascular fibroblastic reticular cell organization, the re-establi
219 eatment altered stromal subset, particularly fibroblastic reticular cell, production of cytokines and
220 node paracortex is composed of a network of fibroblastic reticular cells (FRC) and reticular fibers
221 infection, we demonstrate viral targeting of fibroblastic reticular cells (FRC) in the lymphoid organ
223 on conditioning caused a loss of T-cell zone fibroblastic reticular cells (FRCs) and CCL21 expression
224 t by podoplanin (PDPN) signalling in stromal fibroblastic reticular cells (FRCs) and its modulation b
229 that, as recently described for lymph nodes, fibroblastic reticular cells (FRCs) form a network in th
233 zones are organized in a rigid 3D network of fibroblastic reticular cells (FRCs) that are a rich cyto
235 Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical st
239 okine Ccl19-expressing host cells, including fibroblastic reticular cells and follicular dendritic ce
240 driven by the synergistic cross-talk between fibroblastic reticular cells and interstitial flow.
241 some transgenic IL-7-Cre mice, we found that fibroblastic reticular cells and LECs strongly up-regula
243 PN is expressed by lymphatic endothelial and fibroblastic reticular cells and promotes blood-lymph se
245 sion of adhesion molecules and chemokines by fibroblastic reticular cells most likely facilitates the
246 These stromal cells expressed markers of fibroblastic reticular cells of lymphoid organs and were
248 s regulation occurs in the lymph node, where fibroblastic reticular cells support the maintenance of
249 a meshwork of collagen fibers ensheathed by fibroblastic reticular cells that connects the subcapsul
251 dence suggests that the extensive network of fibroblastic reticular cells within the T cell areas hel
252 ht the varied immunoregulatory properties of fibroblastic reticular cells, we reviewed the most recen
253 analyses demonstrated that PDPN expressed on fibroblastic reticular cells, which surround HEVs, funct
258 of lymph node vasculature, expansion of the fibroblastic reticular network and maintenance of lympho
259 The induced defect in the remodeling of the fibroblastic reticular system results in the loss of nor
261 steoblastic ROS17/2.8 cells) or inactive (in fibroblastic ROS24/1 cells) using chromatin immunoprecip
262 ated that murine keratocytes also acquired a fibroblastic shape and lost keratocan expression after f
264 acquisition correlated with transition to a fibroblastic spindle shape, assembly of actin stress fib
265 l proliferation at low doses and induced the fibroblastic spindle-shape and express alpha-sm actin at
266 included cell proliferation, adoption of a "fibroblastic" spindle-shaped morphology associated with
269 een studied extensively, the contribution of fibroblastic stromal cells as portals of entry into the
270 requirement for RANKL gene transcription in fibroblastic stromal cells but may enhance responsivenes
272 we have uncovered a pathogenic function for fibroblastic stromal cells in alloimmune reactivity that
275 inactivation of Dll1 and Dll4 in subsets of fibroblastic stromal cells that were derived from chemok
276 ne (C-X-C motif) ligand 13 in epithelial and fibroblastic stromal cells that, in turn, is pivotal for
278 ipheral T cells or Notch ligands on putative fibroblastic stromal cells, we show that Notch signaling
279 ptor activator of NFkappaB ligand (RANKL) by fibroblastic stromal cells, which some evidence suggests
281 GF-overexpressing tumors exhibited extensive fibroblastic stromal content, a clinical feature called
283 ulation of tumour-stromal cross-talk through fibroblastic TGF-beta pathway may depend on fibroblast p
285 ment of a novel, inducible, conditional, and fibroblastic TGF-beta type II receptor knockout (Tgfbr2(
288 n in four (100%) telangiectatic, three (75%) fibroblastic, three (25%) chondroblastic, three (6%) con
289 complete occlusion of the airway lumen with fibroblastic tissue and collagen scar by day 28 after tr
292 in the transition of epithelial cells from a fibroblastic to a polarized structure and function by di
293 RNA gene knockdown in MCF-7 cells triggered fibroblastic transformation and cell invasion, resulting
294 lial cells, which may promote mesothelial to fibroblastic transition (MFT) in an NLRP3-dependent mann
295 e process of asbestos-induced mesothelial to fibroblastic transition and its amelioration in caspase-
296 suggest that asbestos induces mesothelial to fibroblastic transition in an inflammasome-dependent man
297 xperiments, we found that asbestos induces a fibroblastic transition of mesothelial cells with a gain
298 immunophenotyping, we studied a group of 59 fibroblastic tumors with variable protein expression pat
299 that dendritic cells can stimulate increased fibroblastic VEGF, suggesting the scenario that lymph no
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