ライフサイエンスコーパス: fide

1 city is revealed by a small fraction of bona-fide 14-mers (<4%) that may enable subunit exchange.

2 sorbent assay confirmed the presence of bona fide Abeta oligomers, whereas immunoprecipitation-Wester

3 the FDA approved drug hydralazine is a bona fide activator of the NRF2/SKN-1 signaling pathway.

4 rted in Arabidopsis are indicative of a bona fide activity that can be associated with the regulation

5 Finally, as predicted for a bona fide AD, mutation of this newly identified AD reduced th

6 odel by inserting an Sgamma2b region, a bona fide AID target, into the first intron of c-myc.

7 y injury (AKI), we interrogated another bone fide AKI marker, Kim1 and noted ectopic expression in P7

8 Thus, sphincter muscle cells are bona fide, albeit unconventional, photoreceptors.

9 Thus, CRAF is a bona fide alternative oncogene for BRAF/NRAS/GNAQ/GNA11 wild

10 Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics

11 damage patterns of a test dataset with bona fide ancient and modern DNA.

12 Our study establishes HMGB1 as a bona fide and targetable DAMP that selectively triggers a neu

13 ctly demonstrate that SIVrcm Nef is the bona fide antagonist of red-capped mangabey tetherin.

14 (++)CD16- monocyte differentiation into bona fide anti-inflammatory Mvarphis in a self-autonomous man

15 revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion.

16 with sclerosis is completely devoid of bona fide astrocytes and gap junction coupling, whereas coupl

17 ric complex, it might not function as a bona fide ATP synthase.

18 and IL-23-responsive cells in both the bona fide autoimmune rheumatic diseases rheumatoid arthritis

19 s Chaetomium thermophilum captured in a bona fide autoinhibited state, which represents a novel confo

20 ere report that leucettine L41 triggers bona fide autophagy in osteosarcoma U-2 OS cells and immortal

21 UIS3 acts as a bona fide autophagy inhibitor by competing with host LC3-inte

22 of Bathyarchaeota is similar to that of bona fide bacterial homoacetogens, by having pathways for ace

23 lack many functional characteristics of bona fide beta cells.

24 B associate with STAT5 at sites lacking bona fide binding motifs.

25 3'-5' polymerase activity of TLPs as a bona fide biological activity for the first time since its un

26 s support the hypothesis that CelR is a bona fide c-di-GMP synthase and that the nucleotide signal pr

27 alignancies, but whether they represent bona fide cancer drivers and therapeutically actionable targe

28 eIF4E1b/eIF4E1c-type proteins, although bona fide cap-binding proteins, have divergent properties and

29 rol tumors but a network of arterioles, bona fide capillaries, and venules in FGF9-expressing tumors.

30 Here, we identify a bona fide cardiac-specific Prkaa2 enhancer that is synergisti

31 conclude that large COPII vesicles are bona fide carriers of PC1.

32 This allowed for dissecting bona fide caveolar functions from those supported by mere cav

33 , presents the structural features of a bona fide CCD, and is able to cleave zeaxanthin, the presumed

34 In this article, we identified bona fide cDCs in chicken spleen.

35 irm previously identified MARCKS as a a bona fide Cdk5 substrate.

36 e, this is the first demonstration of a bona fide cell adhesion molecule, NECL4, regulating choline h

37 embrane-associated peroxidase GPx8 as a bona fide cellular substrate of the HCV NS3-4A protease.

38 ve Sirt2 inhibitors with thalidomide, a bona fide cereblon ligand.

39 Our study correlates bona fide changes in PSP and CBD brains with cellular models,

40 trates in the ER, and as expected for a bona fide chaperone, it does not interact with folded secreto

41 Among them, some members exhibited bona fide CHI activity, which catalyze stereospecific cycliza

42 However, so far the bona fide CHIs are found only in vascular plants, and their o

43 Expressing those primitive bona fide CHIs in the Arabidopsis chi mutant restores the see

44 s PKA, AMPK, and LKB1 were validated as bona fide ciliary proteins and PKA was found to regulate Hedg

45 helial circRNAs fulfill all criteria of bona fide circRNAs.

46 the PDZ domain of nNOS can behave as a bona fide class III PDZ domain and bind to C-terminal sequenc

47 olobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved

48 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor supp

49 Our results identify INO80 as a bona fide component of the proteolytic pathway for RNAPII deg

50 ctivity-dependent processes are central bona fide components of neuronal TF-differentiation programs

51 ghtly than domains in proteins that are bona fide components.

52 stent time-independent detection of its bona fide components.

53 entified, but nonetheless can represent bona fide compounds, also considerably complicates biological

54 able region mutants that have different bona fide conformations on the membrane.

55 det-Biedl syndrome proteins (BBSome) as bona fide constituents of IFT in olfactory sensory neurons, a

56 is is a valuable method for identifying bona fide contributors to follicular lymphoma transformation

57 ome CD11c(hi) cells that may not have a bona fide counterpart in vivo.

58 Mesp1-EYFP+ cells are bona fide CPCs and they integrated well in infarcted hearts a

59 clearly demonstrate that Amb a 11 is a bona fide cysteine protease exhibiting a strong allergenicity

60 m a C18 aldehyde substrate and thus has bona fide decarbonylase activity similar to that of dmCYP4G1/

61 moted the protein stability of USP28, a bona fide deubiquitinase of LSD1.

62 escue studies revealed that Card10 is a bona fide direct miR-181b target.

63 ther demonstrate that Msx2 and Pbx1 are bona fide direct regulators of early Six3.2 distribution in d

64 niversally conserved GTPase (HflX) as a bona fide dissociation factor of the S. aureus 100S ribosome.

65 erved plasmid-encoded DsbP protein is a bona fide disulfide isomerase and suggest that a dedicated ox

66 structure provides a prime exemplar of bona fide domain-swapping.

67 Here we report that crenactin forms bona fide double helical filaments that show exceptional simi

68 Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signali

69 okines, and p53 gene family members) as bona fide downstream transcriptional targets of TAZ.

70 y the lack of a gold standard, that is, bona fide driver gene mutations.

71 icking proteins have been identified as bona fide drivers of tumorigenesis.

72 harmaceutical ingredient (API)-into the bona fide drug supply poses a significant threat to consumers

73 Our work thus identifies TRPA1 as a bona fide drug target for the amelioration of alpha-DC stress

74 trategy towards eventual acquisition of bona fide drug-resistance mechanisms.

75 nscription factors, FOXK1 and FOXK2, as bona fide DVL-interacting proteins.

76 This vector functions as a bona fide E1A-deleted RD vector in infected tumor cells.

77 We demonstrate TaU4 to be a bona fide E2 enzyme through an E2 charging assay.

78 d binding domains of PPARgamma and is a bona fide E3 ligase for PPARgamma.

79 sive high grade mammary carcinomas with bona fide EMT, histologically similar to human metaplastic br

80 However, validating such candidates as bona fide enhancers requires functional characterization, typ

81 Hence, Mfn2 stands as a bona fide ER-mitochondria tether whose ablation decreases int

82 ese results indicate that TTP acts as a bona fide ERalpha corepressor and suggest that this protein m

83 dentifies these late-activated genes as bona fide ERalpha targets but describes a novel mechanism for

84 The bona fide F-box AnkB effector protein of L. pneumophila strai

85 ar pathogen Legionella pneumophila is a bona fide F-box protein, which is localized to the cytosolic

86 Cumulatively, we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susc

87 ormal hematopoiesis and that Brca1 is a bona fide FA-like gene.

88 the rigid ligand-binding site of these bona fide folate receptors.

89 wever, it is crucial to demonstrate the bona fide formation of G4 structures within an endogenous chr

90 ssays, we showed that the mutation is a bona fide gain-of-function oncogenic mutation.

91 are able to promote the development of bona fide gammadeltaT17 cells from peripheral CD122(-)IL-23R(

92 ons being prerequisites to constitute a bona fide GDI displacement factor.

93 e definitive evidence that TRAPPII is a bona fide GEF for the yeast Rab11 homologues Ypt31/32.

94 all, similar effects were described for bona fide genes, including RGS2, CD200, and CRISPLD2.

95 crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.

96 and SDC-2, but not SDC-3 or SDC-4, are bona fide HCV attachment receptors.

97 ent T cells were indistinguishable from bona fide highly proinflammatory Th17 cells because they indu

98 ated ultrastructural features represent bona fide HIV protein complexes.

99 :01, we used this knowledge to identify bona fide HIV-derived peptide epitopes with similar propertie

100 d AddAB even in the complete absence of bona fide hotspot sequences.

101 pluripotency via multiple mechanisms in bona fide hPSCs and reprogrammed cells.

102 s in vitro that exhibit key features of bona fide human beta cells, remain functional after short-ter

103 an pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outline som

104 not well characterized, specifically in bona fide human disease tissue.

105 work demonstrates that BCAN-NTRK1 is a bona fide human glioma driver and describes a general strateg

106 he data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo.

107 often cited as the primary example of a bona fide hydride that can be isolated and characterized on t

108 We establish ZFP91 as a bona fide IMiD-dependent CRL4(CRBN) substrate and further sho

109 Therefore, novel strategies to generate bona fide in vitro-induced Treg (iTreg) are critical.

110 The bona fide, in vivo VFT ligands that remain to be identified a

111 ctivated later during the transition to bona fide induced pluripotent stem cells (iPSCs).

112 from homeostasis to stress response to bona fide inflammatory response.

113 resents the first characterization of a bona fide ino80 mutation in any metazoan, raising the possibi

114 We also demonstrate a bona fide interaction between six human TCRs and CD1c-mycoket

115 ays to determine which of these exhibit bona fide interactions.

116 170 independent experiments, to filter bona fide interactors.

117 Bona fide intracellular bacterial pathogens, such as Salmonel

118 e transcription factor, PPARgamma, is a bona fide intracellular target for S1P and thus suggest that

119 n recognition to accurately distinguish bona fide iPSCs from improperly reprogrammed cells.

120 nd epithelial junctional remodeling, as bona fide IRF6 partner proteins.

121 article, we demonstrate that BAFF is a bona fide ISG and that IFN regulatory factors (IRFs) control

122 These data confirm that Neto2 is a bona fide KAR auxiliary subunit that is an important constitu

123 We establish mammalian NDR1/2 as bona fide kinases that target YAP1 on S127 in vitro and in vi

124 emonstrated that those cells behaved as bona fide LCs when inserted in a three-dimensional rebuilt ep

125 scarinic receptor blockade results in a bona fide learning impairment that may arise because cortical

126 blish that another MHC-Ib, H2-Q10, is a bona fide ligand for the inhibitory Ly49C receptor.

127 o the same extent as that of any of the bona fide ligand+target pairs.

128 e hypothesis that tetrapods inherited a bona fide limb regeneration programme concomitant with the fi

129 lcium imaging to determine how a set of bona fide lineage-related interneurons contribute to sensorim

130 isplay to isolate peptides that possess bona fide LIR (LC3-interacting region) properties and are sel

131 vivo upon transplantation-hallmarks of bona fide LMC MNs.

132 n summary, ALT joins PAN/nut1/T1.1 as a bona fide lncRNA of KSHV with potentially important roles in

133 Our findings uncover a key class of bona-fide LRRK2 substrates and a novel regulatory mechanism o

134 lineage progenitors expressed CX3CR1, a bona fide marker for DC progenitors.

135 protein-coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial ti

136 physiological temperature in individual bona-fide mature central synapses.

137 stablish protein domain distortion as a bona fide mechanism for mechanotransduction in vivo.

138 r studies present deep insight into the bona fide mechanisms underlying castration resistance and pro

139 teractions authenticate CAPERalpha as a bona fide member of the UHM family of proteins.

140 of African trypanosomiasis, possesses a bona fide member of this family (called TbSNM1) with expressi

141 1 expression superimposes with Lmx1a, a bona-fide mesDA lineage marker, during the active phase of me

142 or the trimeric G protein Galphai and a bona fide metastasis-related gene that serves as a platform f

143 ing mechanism that allows GIV/Girdin, a bona fide metastasis-related protein and a guanine-nucleotide

144 a multimodular signal transducer and a bona fide metastasis-related protein.

145 In vitro MGE-like cells resembled bona fide MGE cells but expressed lower levels of Foxg1 and E

146 ble via optical microscopy, making them bona fide microbes.

147 t to other cell types of the human CNS, bona fide microglia have not yet been derived from cultured h

148 s (sRNAs) but the biological role(s) of bona fide microRNAs (miRNAs) remains unclear.

149 ion defect, suggesting that BAFF-R is a bona fide miR-142 target through which it controls B-cell hom

150 hase subunit genes ATP5G1 and ATPIF1 as bone fide miR29b-1/a targets.

151 P hydrolysis relative to complexes with bona fide MMR substrates and that MutSbeta increases the stab

152 -compromised mice, and validate it as a bona fide model of hFL-HCCs by multiple methods.

153 that Drosophila nonmuscle myosin-2 is a bona fide molecular motor and establish an important link bet

154 While some progenitors are bona fide multipotent and contribute progeny to all major pan

155 n is well established, the existence of bona fide N(omega)-methylarginine demethylases (RDMs) is cont

156 lase AbyU, an enzyme shown here to be a bona fide natural Diels-Alderase.

157 at colorectal juvenile polyps in CS are bona fide neoplastic precursor lesions.

158 tin and mimicking that functioning on a bona fide NER substrate.

159 his code enabled in silico discovery of bona fide notochord enhancers, including those containing low

160 also provides evidence for thousands of bona fide novel elements of RNA processing-alternative splice

161 FXR activity in vivo, thus providing a bona fide novel therapeutic agent to treat enterohepatic diso

162 esented here demonstrate that CPS1 is a bona fide nuclear protein involved in homocitrullination (hci

163 also identified translocations between bona fide nuclease targets on homologous chromosomes, an unde

164 with each other, but recent findings on bona fide nucleation factors also regulating microtubule dyna

165 3- and 4-finger ZFNs, and validated 13 bona fide off-target sites for these nucleases by DNA sequenc

166 set, which increased the percentage of bona fide off-target sites found within the top PROGNOS ranki

167 and timely differentiation into mature bona fide oligodendrocytes.

168 le in the helicase domain of Rep68 as a bona fide oligomerization domain (OD).

169 isoform PRKCE (PKCvarepsilon) acts as a bona fide oncogene in in vitro and in vivo models of tumorige

170 ole in cell transformation, making it a bona fide oncometabolite.

171 s) are a family of enzymes endowed with bona fide oxygen- and/or nitric-oxide reductase activity, alt

172 tion by Pol II, which we validated as a bona fide P-TEFb substrate in vivo and in vitro.

173 As bona fide p53 transcriptional targets, miR-34 microRNAs (miRN

174 es, we propose a high confidence set of bona fide palmitoylated proteins in brain and provide a resou

175 ancreatic acinar cell injury induced by bona fide pancreatitis-inducing agents, such as POA.

176 Our approach reliably discerns bona fide PAS from false PAS that arise due to internal poly(

177 ing that the corresponding genes encode bona fide PAT.

178 affected individuals carried additional bona fide pathogenic alleles in another BBS gene.

179 dentifies c.620C>T;p.S207L as the first bona fide pathogenic RAD51D missense cancer susceptibility al

180 conformational changes are sensitive to bona-fide phosphorylation on S13 and S16 within the N17 domai

181 ination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal tr

182 e, this is the first demonstration of a bona fide physiological role for a Tad pilus in this bacteria

183 e demonstrated that, despite exhibiting bona fide podosomes, these cells presented dysfunctional SZs.

184 Thus, Rpb4 is a bona fide Pol II core subunit that functions mainly in mRNA s

185 ld not corroborate their findings using bona fide Pol III from two laboratory sources.

186 Identifying a bona fide population of cardiac stem cells (CSCs) is a critic

187 ls for managing Wnt-driven tumors, is a bona fide PORCN inhibitor whose IC50 for inhibition of Wnt fa

188 orces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-frequenc

189 ein (OSP)/claudin-11 (hOSP), one of the bona fide potential primary target antigens in MS.

190 The bona fide PPARgamma activators we identified induced adipogen

191 ese transmembrane interactions define a bona fide pre-integrated intermediate along a facilitated rou

192 from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.

193 In other disorders, the bona fide prion characteristics are still under investigation

194 we show that CARD and PYRIN function as bona fide prions in yeast and that their prion forms are indu

195 ted in the absence of any cofactors are bona fide prions provides a strong support for the protein-on

196 (O2()) and hydrogen peroxide (H2O2) as bona fide products in reactions involving 1- or 2-electron re

197 ramework improves the identification of bona fide prognostic biomarkers from DNA methylation studies,

198 Here we show that TaPIN1 is a bona fide prolyl isomerase and that it interacts with the hos

199 and chloroplasts, the identification of bona fide protease substrates has been very challenging.

200 ction that cannot be distinguished from bona fide protein isoforms.

201 M glycosylation, identifying CEACAMs as bona fide protein receptors for Hp.

202 ize was below the cutoff for annotating bona fide proteins.

203 ed spectra that are more reminiscent of bona fide PrP(Sc).

204 ions in the free form and when bound to bona fide Py-tract RNA ligands.

205 nly RGTA1.RGTB1 and RGTA1.RGTB2 exhibit bona fide Rab-GGT activity, and they are biochemically redund

206 ed by SLC10A1), the recently identified bona fide receptor for HBV and HDV.

207 ied through a biochemical approach is a bona fide receptor for HBV and HDV.

208 new regulator of body weight and as the bona fide receptor mediating the metabolic effects of GDF15,

209 -target" DNA breaks at matched pairs of bona fide recombination signal sequences (RSSs).

210 olved redox events, and (ii) screen for bona fide redox-sensor targets.

211 ursor for intracellular signaling and a bona fide regulator of actin cytoskeleton reorganization.

212 resented here demonstrate that tRFs are bona-fide regulatory microRNA-like small RNAs involved in the

213 reptomyces coelicolor IHF duplex DNA, a bona fide relative of mIHF, revealed the presence of Arg-170,

214 rtable cells that is highly enriched in bona fide reprogramming progenitors.

215 Vgamma6T cells are bona fide resident, but precursors of dermal Vgamma4T cells m

216 Despite APOBEC3H being a bona fide restriction factor, there has been no comparative b

217 ity, can functionally substitute to the bona fide Rho GAP, GRAF1 (GTPase Regulator Associated with Fo

218 CYLD) demonstrated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antiviral res

219 7-mer and 16-mer synthetic bRNAs reveal bona fide RNA branchpoints in the Dbr1 active site.

220 The presence of bona fide RNA G4s in cells has long been a matter of debate.

221 We demonstrate that YonO is a bona fide RNAP of the SPbeta bacteriophage that specifically

222 of a different evolutionary origin than bona fide RRs.

223 SRSF11 and Acinus S', but not with the bona fide RS-domain of SRSF1.

224 in a reporter system as efficiently as bona fide RSSs that flank gene segments of the T-cell recepto

225 nzimidazoles-related 1 (BUBR1) siRNA, a bona fide SAC component, EDD siRNA abrogated G2/M accumulatio

226 terion to identify and characterize the bona fide SARS-CoV FP.

227 ive, thus demonstrating that LRRK2 is a bona fide self-contained GTPase.

228 We recently identified PfSR1 as a bona fide Ser/Arg-rich (SR) protein that shuttles between the

229 ike protein phosphatase 2 (AtSLP2) is a bona fide Ser/Thr protein phosphatase that is targeted to the

230 target proteins, with orally available, bona fide small molecules remains a significant but immensely

231 We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and sta

232 This work establishes SORB-1 as a bona fide sorbin family protein-one of the late additions to

233 ive function of PTBP1 and its role as a bona fide splicing activator.

234 e physiology, identify c-MYC as a novel bona fide SPOP substrate, and help explain the frequent inact

235 We verified that this approach captures bona fide sRNA-mRNA interactions.

236 s fulfill all the criteria required for bona fide SSCs.

237 Here we show that CD25, a bona fide STAT5 regulated gene, is a mechanistically relevant

238 rsist for months and continue to act as bona fide stem cells by participating in tissue maintenance a

239 nsient progenitor cells from permanent, bona fide stem cells in the retina.

240 nteracting protein during mitosis and a bona fide substrate of MELK.

241 Here, we showed that Pah1p is a bona fide substrate of protein kinase C; the phosphorylation

242 suggesting that this mutated form is a bona fide substrate of this degradation pathway.

243 nds protein family, Spenito, as a novel bona fide subunit of the methyltransferase complex.

244 The presence of bona fide SUMOylated proteins in the mut5 mutant at 25 degree

245 nly syncytin-Opo1 being the present-day bona fide syncytin active in the opossum and related species.

246 all of the characteristic features of a bona fide syncytin gene: It is fusogenic in an ex vivo cell-c

247 cally shown that psoriasis represents a bona fide T cell-mediated disease primarily driven by pathoge

248 In addition to being bona fide T. pallidum rare outer membrane proteins, TprC/D an

249 patients, and we provide evidence that bona-fide T3 phosphorylation alters Huntingtin exon 1 protein

250 To identify the bona fide target genes of Hog1, we inducibly expressed the sp

251 induction of Bcl-xL and IkappaBalpha, 2 bona fide target genes of the canonical NF-kappaB pathway.

252 romosome 10 (PTEN), was identified as a bona fide target of both miR-92a and miR-19a in cholangiocarc

253 esearch reveals that mitochondria are a bona fide target of Coxiella effectors and MceA is a complex-

254 These findings establish DNMT1 as a bona fide target of miR-185 in HCC cells.

255 We demonstrate here that Rab10 is a bona fide target of the GTPase-activating protein AS160, whic

256 Here we sought to identify a bona fide target of ZIP and, in so doing, unveiled a novel me

257 scle, in addition to NPR3 and SERPINA3, bona fide targets of MR in other tissues.

258 by a process analogous to that used by bona fide TBDT ligands.

259 cytokine production than either Th1 or bona fide Th17 cells, and produced increased amounts of proin

260 The tetramers defined bona fide Th2 cells.

261 nges to translate AXL inhibitors into a bona fide therapeutic option.

262 ults support the notion that SPHK1 is a bona fide therapeutic target for the treatment of AML.

263 fraction is a useful predictor to find bona-fide therapeutic-targetable fusion transcripts.

264 ung rather than residing in the lung as bona fide tissue-resident CD69(+) NK cells.

265 aldehyde), confirming that it encodes a bona fide TMAO demethylase (Tdm).

266 Our results establish UvrD as a bona fide transcription elongation factor that contributes to

267 We recently reported that ZBTB7A is a bona fide transcription repressor of key glycolytic genes and

268 Our results prove that HDAC7 is a bona fide transcriptional repressor essential for B cell deve

269 chanistically, we identified FOXO1 as a bona fide transcriptional repressor of HAS2.

270 affected H3K27 acetylation contained a bona fide TRbeta1-binding site.

271 hat is selectively demethylated only in bona fide Tregs (Treg-specific demethylated region, TSDR) rep

272 ent, for the first time, that, in AILD, bona-fide Tregs produce less interleukin (IL)-10 and are impa

273 Th1/Tregs arise in atherosclerosis from bona fide Tregs, rather than from T-effector cells.

274 ility of these tRNA-like small RNAs and bona fide tRNAs is monitored by the CCA-adding enzyme.

275 Bona fide trophoblast stem cell lines and extra-embryonic end

276 Also, the ability of hESCs to form bona fide trophoblasts has been intensely debated.

277 of the complex have been shown to have bona fide tumor suppressor activity.

278 Here we show that KMT2D functions as a bona fide tumor suppressor and that its genetic ablation in B

279 ologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stabilit

280 provide genetic evidence that Bap1 is a bona fide tumor suppressor gene and offer key insights into t

281 incing genetic evidence that MCPH1 is a bona fide tumor suppressor gene.

282 H3K27me3 demethylase UTX functions as a bona fide tumor suppressor in T-ALL.

283 TET2 functions as a bona fide tumor suppressor particularly in the pathogenesis o

284 Although RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 as a t

285 Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regula

286 Long understood as a bona fide tumor suppressor that safeguards the integrity of t

287 In parallel, we validate CUX1 as a bona fide tumor suppressor using mouse transposon-mediated in

288 as liver-specific microRNA (miR)-122, a bona fide tumor suppressor, is down-regulated in hepatocellul

289 e types, supporting its role as a broad bona fide tumor suppressor.

290 we provide evidence that both HATs are bona fide tumor suppressors that control MHCII expression and

291 tic CHIs, suggest that emergence of the bona fide type II CHIs is an ancient evolution event that occ

292 eum subterraneum' operate together as a bona fide ubiquitin modification system, mediating a sequenti

293 ncer antigen 3 has emerged as the first bona-fide urinary biomarker for prostate cancer.

294 rmore, GSC also transdifferentiate into bona fide vascular endothelial cells (GEC), which inherit mut

295 our knowledge, the first characterized, bona fide virulence factor secreted by Acinetobacter species.

296 om primordial selfish genetic elements, bona fide viruses evolved on multiple, independent occasions

297 These findings identifying STRA6 as a bona fide vitamin A transporter have important implications f

298 is feasible to generate high numbers of bona fide XCR1(+) human DC in vitro as a model to decipher th

299 rt that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MOMP that can trigge

300 tR from S. agalactiae (PDB 3KKC) is the bona fide zinc efflux regulator SczA, and binds two zinc ions