ライフサイエンスコーパス: filament protein

1 hat encodes the major astrocyte intermediate filament protein.

2 3 different proteins with a single flagellar filament protein.

3 e filament protein vimentin, an intermediate filament protein.

4 on of nestin, an embryonic cell intermediate filament protein.

5 lens proteins and the ancestral intermediate filament protein.

6 times, containing predominantly intermediate filament proteins.

7 d diverse interactions with neighboring thin filament proteins.

8 l modifications (PTMs) in bovine lens beaded filament proteins.

9 lowed by multiple structural changes of thin filament proteins.

10 ared by K6, other keratins, and intermediate filament proteins.

11 nization, such as lamin nuclear intermediate filament proteins.

12 ssion of genes encoding thick, but not thin, filament proteins.

13 of structural changes in cTnC and other thin filament proteins.

14 ovel nonmechanical function for intermediate filament proteins.

15 mechanisms involving phosphorylation of thin filament proteins.

16 Cia export requires at least one of the two filament proteins.

17 (K18), two epithelial-specific intermediate filament proteins.

18 I (K9-K20) and type II (K1-K8) intermediate filament proteins.

19 epeat domains characteristic of intermediate filament proteins.

20 , all common features of type 6 intermediate filament proteins.

21 K8) and 18 (K18) as their major intermediate filament proteins.

22 eton belonging to the family of intermediate filament proteins.

23 y the most abundant of neuronal intermediate filament proteins.

24 -linked to TnI, TnC, Tm, and all of the thin filament proteins.

25 K8) and 18 (K18) as their major intermediate filament proteins.

26 auxiliary beta subunit through intermediate filament proteins.

27 simple epithelial cell-specific intermediate filament proteins.

28 s prevented the loss of both desmin and thin filament proteins.

29 the FlaA major flagellin and other flagellar filament proteins.

30 to promote differentiation by citrullinating filament proteins.

31 Beaded filament protein accumulation lags significantly behind

32 is review describes the isoforms of the thin filament proteins actin and tropomyosin and the three tr

33 rotein as the neuronal specific intermediate filament protein, alpha-internexin.

34 function of internexin neuronal intermediate filament protein-alpha a (inaa), the encoding gene of wh

35 Gelsolin-dependent removal of thin filament proteins also reduced myofilament-bound PKA-typ

36 e roles of vimentin, a type III intermediate filament protein and a marker of epithelial-mesenchymal

37 tion is modified by specific changes in thin filament proteins and by agents that promote the actin-m

38 ing insights into the basic biology of thick filament proteins and reinforce the idea that myosin bin

39 unsuspected association between intermediate filament proteins and the adaptor complex AP-3.

40 found both in the invertebrate intermediate filament proteins and the vertebrate lamins, the CP49 ge

41 with pan-specific antibodies to intermediate filament proteins and to cytokeratins suggest that contr

42 to LNDS in vimentin, a Type III intermediate filament protein, and have examined the impact of this c

43 posed of two major proteins: PP1, the phloem filament protein, and PP2, the phloem lactin.

44 myosin messenger RNAs, reexpression of thick-filament proteins, and increased specific tension were o

45 NH2-terminal region does not bind other thin filament proteins, and its sequence is hypervariable bet

46 epeat domains characteristic of intermediate filament proteins, and several of the mutations in Bic-D

47 within the SC is similar to other transverse-filament proteins, and that the N terminus of C(2)M is l

48 ctions with 14-3-3 and vimentin intermediate filament proteins, and vimentin depletion increased auto

49 n the alpha-helical sections of intermediate-filament proteins are hydrophobic, and the remaining loc

50 Mutations in genes encoding thin filament proteins are less prevalent in HCM than previou

51 ells, suggesting that these two intermediate filament proteins are necessary for fulvestrant-induced

52 VI nestin and type III vimentin intermediate filament proteins are replaced by a series of type IV pr

53 Lamins, the type V nuclear intermediate filament proteins, are reported to function in both inte

54 characteristic of the ancestral intermediate filament protein as it is found in many invertebrate int

55 t is found in many invertebrate intermediate filament proteins but has been lost from all vertebrate

56 oes not contain binding sites for other thin filament proteins, but alteration of its structure affec

57 eukaryotic actin, tubulin, and intermediate filament proteins, but they also have cytoskeletal eleme

58 s with sequences from the smooth muscle thin filament protein caldesmon (CaD) by using small-angle X-

59 The thin filament protein cardiac troponin T (cTnT) is an importa

60 ha-tropomyosin (alpha-TM), an essential thin filament protein, cause both dilated cardiomyopathy (DCM

61 Lengsin and lens intermediate filament proteins co-localize at the plasma membrane in

62 arked reduction in detectable FlaB flagellar filament protein compared to that of wild type; however,

63 nary complex and in the presence of all thin filament protein components.

64 Myosin-binding protein C (MyBP-C) is a thick filament protein consisting of 1274 amino acid residues

65 AP-3 and intermediate filament proteins cosedimented and coimmunoprecipitated

66 Importantly, dL5 fusions to an intermediate filament protein CreS are significantly less perturbativ

67 manner similar to deleting the intermediate filament protein crescentin, but it does not disrupt cre

68 el association of AIRE with the intermediate filament protein cytokeratin 17 (K17) in the THP-1 monoc

69 The cytoplasmic filament protein-deficient mutant exhibited pleiotropic

70 1 induced the expression of the intermediate filament protein desmin and interstitial matrix componen

71 we describe the muscle-specific intermediate filament protein desmin as a novel caspase substrate.

72 Mice lacking the intermediate filament protein desmin demonstrate abnormal mitochondri

73 The intermediate filament protein desmin is encoded by the gene DES and c

74 how that S-nitrosylation of the intermediate filament protein desmin is significantly increased (5.7-

75 in the DES gene coding for the intermediate filament protein desmin may cause skeletal and cardiac m

76 loss of immunostaining for the intermediate filament protein, desmin.

77 To evaluate the effects of two thick filament protein domains on passive sarcomeric stiffness

78 erone for the reorganization of intermediate filament proteins during terminal differentiation in the

79 lternative, antigenic forms of its flagellin filament protein, either type B or C.

80 The A-type lamins, nuclear intermediate filament proteins encoded by the LMNA gene, are basic co

81 s been lost from all vertebrate intermediate filament proteins except the nuclear lamins.

82 aracterized as an intracellular intermediate filament protein expressed broadly in mesenchymal cells.

83 also positive for vimentin, an intermediate filament protein expressed by mesenchymal cells.

84 express a limited subset of the muscle thick filament proteins expressed in BHK cells.

85 The basis for the lack of filament protein expression is unknown.

86 This interdependence of thin-filament protein expression led us to postulate that som

87 s in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss

88 Vimentin, a member of the intermediate filament protein family, is regulated both developmental

89 The lens fiber cell-specific intermediate filament protein filensin is essential for beaded filame

90 t induced increased expression of the beaded filament protein filensin when compared with control cel

91 The lens beaded filament proteins filensin and CP49 are phosphorylated p

92 eins revealed the lens-specific intermediate filament proteins filensin and CP49.

93 d markedly decreased levels of the flagellar filament proteins FlaA and FlaB.

94 c flagella consist of a polymer of the major filament protein FlaB and a minor protein, FlaA.

95 ene encoding the major periplasmic flagellar filament protein FlaB.

96 E), the hook-capping protein (FlgD), and the filament protein flagellin (FliC).

97 t repression of translation of the flagellar filament protein, flagellin.

98 ired to activate expression of the flagellar filament protein, flagellin.

99 The flagellar filament protein FliC is a natural antigen recognized by

100 m mutants unable to synthesize the flagellar filament protein FliC.

101 ecific CD4+ T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacit

102 sed in number with aging, and the two beaded filament proteins form covalent complexes with crystalli

103 purified flagellin (FliC or FljB), the major filament protein from Salmonella enterica serovar Enteri

104 the gene that encodes a lens-specific beaded filament protein gene, BFSP2.

105 Mutations in intermediate filament protein genes are responsible for a number of i

106 in astrocytes that contain the intermediate filament protein GFAP in association with small heat-sho

107 e was loss of expression of the intermediate filament proteins GFAP and vimentin, the expression of b

108 from missense mutations of the intermediate filament protein, GFAP.

109 tions in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP).

110 rmined by the expression of the intermediate filament proteins glial fibrillary acidic protein, vimen

111 The accumulation of the intermediate filament protein, glial fibrillary acidic protein (GFAP)

112 into the role of the astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP)

113 ich encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP)

114 myopathy and indicate that this intermediate filament protein has an important role in cardiac conduc

115 Several hair-specific keratin intermediate filament proteins have been characterized, and all have

116 Mutations in thin-filament proteins have been linked to hypertrophic cardi

117 n gene (ACTA1) is one of five genes for thin filament proteins identified so far as responsible for d

118 rofilaments, but its effects on intermediate filament proteins (IFs) are unknown.

119 In addition, an increase in intermediate filament protein immunoreactivity (vimentin and glial fi

120 Alpha-internexin, a neuronal intermediate filament protein implicated in neurodegenerative disease

121 Peripherin, a neuronal intermediate filament protein implicated in neurodegenerative disease

122 le-type epithelial keratins are intermediate filament proteins important for mechanical stability and

123 The gene encoding the phloem filament protein in pumpkin (Cucurbita maxima Duch.) has

124 ontribute to its function as an intermediate filament protein in radial glia.

125 Desmin is an intermediate filament protein in skeletal muscle that forms a meshlik

126 g the role of Akt signaling and intermediate filament proteins in autophagy and cancer.

127 s of neurofilament and vimentin intermediate filament proteins in cultured cells using cell fusion, p

128 e than 20 keratin type I and II intermediate filament proteins in epithelial cells.

129 ions in lamins A and C, nuclear intermediate-filament proteins in nearly all somatic cells, cause a v

130 ges in the expression levels of intermediate filament proteins in response to these treatments were a

131 inal ends of the rod domains of intermediate filament proteins in reverse transcriptase-PCR experimen

132 The evidence for proteolysis of thin filament proteins in situ during ischemia and stunning i

133 rotein is found associated with intermediate filament proteins in the cytoplasm and the nuclear lamin

134 keratin-18 (K18) are the major intermediate filament proteins in the intestinal epithelia.

135 ression of vimentin, a type III intermediate filament protein, in alveolar epithelial cells (AECs) ar

136 f phosphorylated 14-3-3 binding intermediate filament proteins, including keratins, coupled with redu

137 ed myosin heavy chain isoforms and many thin filament proteins, including troponin T and tropomyosin

138 experiments using 0.5 M KCl-extracted thick filament proteins indicate that native MRP is a homodime

139 Co-sedimentation of thin filament proteins indicated that no significant changes

140 Thus, both thin and thick filament proteins influence the ability of cardiac tropo

141 h border, and redistribution of intermediate filament proteins into the brush border.

142 on, expression levels of alpha-actin, a thin filament protein involved in contraction, remained relat

143 Myosin binding protein C (MyBP-C) is a thick filament protein involved in the regulation of muscle co

144 Loss of sarcomere thin filament proteins is a frequent cause of NM; therefore,

145 Although no binding site for the other thin filament proteins is found at the COOH terminus of TnI,

146 Although the decreased content of thick-filament proteins is important for prolonged muscle weak

147 yperphosphorylation of neuronal intermediate filament proteins is involved in AD.

148 The expression of intermediate filament proteins is remarkably tissue specific, which s

149 Vimentin, an intermediate filament protein, is an M phase substrate for both Auror

150 uman, Krt16 in mouse), a type I intermediate filament protein, is constitutively expressed in epithel

151 Nestin, an intermediate filament protein, is widely used as stem cell marker.

152 fter birth; however, during adult life, thin filament protein isoform composition seems to be stable

153 of the sarcomere and changes in contractile filament protein isoforms.

154 Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulate

155 The intermediate filament protein keratin 17 (Krt17) shows highly dynamic

156 3 protein family bind the human intermediate filament protein keratin 18 (K18) in vivo, in a cell-cyc

157 The intermediate filament protein keratin 8 (K8) and its cross-linking by

158 The intermediate filament protein keratin 8 (K8) is critical for the deve

159 nd the breast-cancer marker and intermediate filament protein keratin-19.

160 Mutation of the cytoskeletal intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is a

161 nucleus comes from meshworks of intermediate filament proteins known as lamins forming the inner laye

162 rane zone components, including an anchoring filament protein, ladinin.

163 r membrane is enriched with the intermediate filament protein lamin A.

164 d, there is evidence that the nuclear lamina filament protein Lamin A/C protects RB from proteasomal

165 We report that the intermediate filament protein lamin B, a component of the interphase

166 The intermediate filament protein lamin B2 (LB2), normally associated wit

167 gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural

168 ar lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear

169 implicated in NM, as well as a putative thin filament protein, leiomodin 3 (LMOD3).

170 Its filament protein-like structure makes it a likely candid

171 Tomato MFP1 has a predicted filament-protein-like structure and is associated with t

172 llary acidic protein (GFAP), an intermediate filament protein located within their cytoplasm.

173 of Tax and a neuronal specific intermediate filament protein may provide a clue to the pathogenesis

174 atins, members of the family of intermediate filament proteins, may represent a new class of receptor

175 nase-dependent reaction of this intermediate filament protein might influence the shape and plasticit

176 onally engineered TnC constructs, three thin filament protein modifications representing different pr

177 mong these is expression of the intermediate filament protein nestin and the brain fatty acid binding

178 e also have determined that the intermediate filament protein nestin correlates with tumorigenic and

179 The intermediate filament protein Nestin identifies stem/progenitor cells

180 The intermediate filament protein Nestin labels populations of stem/proge

181 We found that the intermediate filament protein nestin physically interacts with Cdk5 a

182 The intermediate filament protein Nestin serves as a biomarker for stem c

183 ese cells expressed the type VI intermediate filament protein nestin whose expression was upregulated

184 s known to bind the cytoplasmic intermediate filament protein nestin with high affinity.

185 d astrocytes, and expressed the intermediate filament protein nestin, a marker for progenitor cells.

186 The intermediate filament protein, nestin, marks progenitor cells of the

187 Vimentin is an intermediate filament protein normally expressed in cells of mesenchy

188 dic protein (GFAP) is the major intermediate filament protein of astrocytes in the vertebrate central

189 hat is specific for a cytosolic intermediate filament protein of astrocytes.

190 e the role of desmin, the major intermediate filament protein of muscle in organizing costameres.

191 ociation with nebulin, a major actin-binding filament protein of striated muscle.

192 Myosin binding protein C is a thick filament protein of vertebrate striated muscle.

193 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispose to several

194 teracts with the characteristic intermediate filament proteins of postsynaptic densities, and that th

195 8 and 18 (K8/18) are the major intermediate filament proteins of simple-type epithelia.

196 w alterations in A-type lamins, intermediate filament proteins of the nuclear envelope expressed in m

197 atins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive epithelia an

198 Understanding the effects of thin and thick filament proteins on the kinetics of Ca(2+) exchange wit

199 mutations in desmin, a type III intermediate filament protein, or alphaB-crystallin, a chaperone for

200 show that NF-M can partner with intermediate filament proteins other than the NF-H and NF-L subunits

201 induction of expression of the intermediate filament protein peripherin, which is associated with CN

202 rtin and of the neuron-specific intermediate filament protein, peripherin, and by RA-stimulated exten

203 -crystallins, the lens-specific intermediate filament proteins phakinin (CP49) and filensin (CP115),

204 stallins (possibly fragments) and two beaded filament proteins (phakinin and filensin).

205 se in myofibrillar Ca2+ sensitivity and thin filament protein phosphorylation is noted.

206 No changes in thin filament protein phosphorylation were evident.

207 en troponin C (TnC) and other thin and thick filament proteins play a key role in the regulation of c

208 nt experiments show that the conformation of filament proteins play a role in the motility and morpho

209 Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle con

210 Keratin 8 (K8) is a major intermediate filament protein present in enterocytes and serves an an

211 Vimentin, an abundant intermediate filament protein, presumably has an important role in st

212 Keratins are cytoplasmic intermediate filament proteins providing crucial structural support i

213 ere we show that keratin 17, an intermediate filament protein rapidly induced in wounded stratified e

214 ed proteins; c) very low thick-filament/thin-filament protein ratios; d) absence of myosin messenger

215 associated with a specific decrease in thick-filament proteins related to an altered transcription ra

216 tion might extend to nonkeratin intermediate filament protein-related diseases.

217 The functions of these filament proteins remain unknown.

218 deleted the genes encoding two intermediate filament proteins required for astrocyte activation-glia

219 ly is desmin, a muscle-specific intermediate-filament protein responsible for the structural integrit

220 Neither beaded filament protein showed focal basal accumulations.

221 ular distribution of vimentin and the beaded filament proteins showed marked differences within the c

222 The gene for the sarcomeric thin-filament protein, slow skeletal muscle troponin T (TNNT1

223 49 (BFSP2; phakinin), a related intermediate filament protein specific to the lens.

224 astoma, including expression of intermediate filament proteins specific for neurons and glia.

225 del in which a mutation in a sarcomeric thin filament protein, specifically TM, leads to DCM.

226 ing a mechanism for the regulation of beaded filament protein stoichiometry.

227 These results show that alterations in thin filament protein structure and function can lead to sign

228 To understand how mutations in thick filament proteins such as cardiac myosin binding protein

229 In addition, several intermediate filament proteins such as vimentin and annexin, as well

230 similar sites in multiple other intermediate filament proteins, suggests that the processing of IFs d

231 in, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent osteocalcin

232 The intermediate filament protein synemin is present in astrocyte progeni

233 gether, Nes-S is a new neuronal intermediate filament protein that exerts a cytoprotective function i

234 Flightin is a thick filament protein that in Drosophila melanogaster is uniq

235 n-A (LaA), a well-characterized intermediate filament protein that is a constituent of the nuclear la

236 Keratin 17 (K17) is a type I intermediate filament protein that is constitutively expressed in ect

237 olypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and sim

238 GFAP is an intermediate filament protein that is expressed predominately within

239 muscle tropomyosin (TM) is an essential thin filament protein that is sterically and allosterically i

240 yosin-binding protein-C (cMyBP-C) is a thick filament protein that modulates cross-bridge cycling rat

241 Cardiac MYBPC is a thick filament protein that regulates sarcomere organization a

242 sed mainly of lamins, which are intermediate filament proteins that assemble into a filamentous meshw

243 Lamins are intermediate filament proteins that assemble into a meshwork undernea

244 e of the interactions between the transverse filament proteins that create this structure has emerged

245 Lamins are intermediate filament proteins that form a scaffold, termed nuclear l

246 A-type lamins are intermediate filament proteins that provide a scaffold for protein co

247 ith that of peripherin, another intermediate filament protein, the RNA for which does not bind hnRNP

248 d function depend on the type V intermediate filament proteins, the lamins, which are major structura

249 it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not

250 hagfishes contains thousands of intermediate filament protein threads that are manufactured within sp

251 he gene for CP49 (phakinin), an intermediate filament protein thus far demonstrated only in the lens

252 nary interactions between TnT and other thin filament proteins, TnI, TnC and Tm.

253 he first vertebrate cytoplasmic intermediate filament protein to be described with an extended helix

254 e nucleoporin Nup153 and the pore-associated filament protein Tpr, previously shown to reside at dist

255 Nestin is an intermediate filament protein, transiently and abundantly expressed e

256 e expression of two radial glia intermediate filament proteins, transitin and vimentin, in the develo

257 nd structural changes in cTnC and other thin filament proteins triggered by Ca(2+) movement.

258 tal proteins, including several intermediate filament proteins, triggers the dramatic disassembly of

259 Thin filament proteins tropomyosin (Tm), troponin T (TnT), an

260 eraction is sterically regulated by the thin filament proteins tropomyosin and troponin (Tn), with th

261 Selective proteolysis of the thin filament protein troponin I has been correlated with stu

262 resulting from the hdp2 mutation in the thin filament protein troponin I.

263 Missense mutations in the cardiac thin filament protein troponin T (TnT) are a cause of familia

264 The thin filament protein troponin T (TnT) is a regulator of sarc

265 htly regulated by Ca(2+) binding to the thin filament protein troponin.

266 ration conditions due to actions of the thin filament protein troponin.

267 muscles are regulated by Ca(2+) via the thin filament proteins troponin (Tn) and tropomyosin (Tm).

268 that differences among other thick and thin filament proteins underlie these XBr alterations.

269 , we find that the rapid destruction of thin filament proteins upon fasting was accompanied by increa

270 tified by mass spectrometry the intermediate filament protein vimentin and the microtubule protein al

271 1 as bait, we have isolated the intermediate filament protein vimentin as a Raf-1-associated protein.

272 ed by the redistribution of the intermediate filament protein vimentin as well as by the recruitment

273 superresolution imaging of the intermediate filament protein vimentin by stimulated emission depleti

274 The intermediate filament protein vimentin is involved in the regulation

275 ated C kinase 1 (RACK1) and the intermediate filament protein vimentin that correlated with increased

276 panied by redistribution of the intermediate filament protein vimentin to form a cage surrounding a p

277 All cells expressed the intermediate filament protein vimentin, an intermediate filament prot

278 pathway, is associated with the intermediate filament protein vimentin, in NIH 3T3 fibroblasts and co

279 The intermediate filament protein vimentin, which has been previously sho

280 Focusing on the intermediate filament protein vimentin, which is frequently citrullin

281 domain and rod domain 1A of the intermediate filament protein vimentin.

282 in and the structurally related intermediate filament protein vimentin.

283 -kDa protein, identified as the intermediate filament protein vimentin.

284 ior of in vitro networks of the intermediate filament protein vimentin.

285 e proteins H2A, H3, and H4; the intermediate filament protein vimentin; the major HSV-1 capsid protei

286 antly differed from that of the intermediate filament proteins vimentin and desmin as well as that of

287 AEEEKKVEGAGEEQAAAK) and another intermediate filament protein, vimentin (FADLSEAANR).

288 The intermediate filament protein, vimentin, was upregulated approximatel

289 between SspC and an eukaryotic intermediate filament protein was identified.

290 were identified that encoded an intermediate filament protein we subsequently named desmuslin (DMN).

291 ubulin associates strongly with intermediate filament proteins, we examined the contribution of cytok

292 (MYH7, MYBPC3) and thin (TNNT2, TNNI3, TPM1) filament proteins were compared with sarcomere mutation-

293 The sequences of lens beaded filament proteins were systematically mapped, and putati

294 Vimentin is an intermediate filament protein whose expression correlates with increa

295 Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the sup

296 Myosin binding protein-C (MyBP-C) is a thick-filament protein whose precise function within the sarco

297 yosin binding protein-C (cMyBP-C) is a thick-filament protein whose presence and phosphorylation by p

298 atin polypeptide 20 (K20) is an intermediate filament protein with preferential expression in epithel

299 intervening at the level of regulatory thin filament proteins would have potential therapeutic benef

300 se set of proteins, including the transverse filament protein, Zip1.