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4 lysis revealed that M10(Full)LZ meandered on filopodial actin bundles to both x- and y- directions.
5 G-actin diffusion by the porous structure of filopodial actin filament bundle, we used a particle-bas
6 owever, is limited by the connection between filopodial actin filaments and the membrane at the tip.
7 in family, which facilitates the assembly of filopodial actin filaments that are bundled by Fascin.
11 nism by which a cell can use rotation of the filopodial actin shaft to induce coiling and hence axial
12 omplex to maintain RhoA activity and promote filopodial actin-spike formation and invasive migration.
13 to promote lamellipodia formation and oppose filopodial actin-spike formation, and led to activation
14 in-containing 3 (FHOD3) pathway and generate filopodial actin-spike protrusions which drive invasion.
15 ssue asymmetry, but neglect the preferential filopodial activity along the convergent axis observed i
16 (W650A) or UAS-IR-EcR (core) showed moderate filopodial activity and normal, albeit reduced, adult-li
17 hr APF, when growth is characterized by high filopodial activity at both terminal and interstitial po
20 ted, live analysis reveals that it can alter filopodial activity within specific subsets of neurons s
21 egulates growth cone navigation by promoting filopodial activity, we adopted a live analysis strategy
24 gration and PI3K/AKT signalling, but impairs filopodial alignment along AC processes, suggesting that
25 ogether with frictional coupling between the filopodial and cortical actin networks as the main retra
28 on microscopy revealed that CXCL8-stimulated filopodial and microvilli-like protrusions that interact
29 endritic neurons have small somata with many filopodial appendages, no observable dendrites, and high
31 10 localizes in filopodia, and BMP-dependent filopodial assembly decreases when Myo10 expression is r
32 pose an extension of the existing models for filopodial assembly in which any cluster of actin filame
35 ells only, mDia1 and VASP also contribute to filopodial assembly, and filopodia are disproportionatel
36 dicating that in addition to its function in filopodial assembly, Myo10 also participates in a requis
37 in, which enter the filopodial tube from the filopodial base and diffuse toward the filament barbed e
40 ed that Diaphanous and Enabled each regulate filopodial behavior in vivo and defined a quantitative "
43 infected cells, either as membrane sheets or filopodial bridges, are present and may be involved in H
44 ganization from the lamellipodial network to filopodial bundle during bridge formation occurs in a pr
48 actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows
51 n assembles into parallel bundles, and known filopodial components localize to the tip and shaft.
52 hila, correlate growth factor signaling with filopodial contact between signaling and responding cell
55 reduced Myo3A tip localization was decreased filopodial density along the cell periphery, identifying
56 e, Src2 or cortactin up-regulation increased filopodial density, length, and protrusion time, whereas
59 nown filopodial markers (MyoX/Cdc42) and the filopodial disrupter, low-dose cytochalasin-B, we demons
63 te our technique in living cells, we measure filopodial dynamics and quantify spatiotemporal localiza
65 rvations suggest that neurotrophins regulate filopodial dynamics by depressing the activation of RhoA
68 the intermittent signaling induced by these filopodial dynamics generates a type of structured noise
71 g spinning disk confocal microscopy to image filopodial dynamics in mouse resident Lifeact-EGFP macro
72 We propose that Ena/VASP proteins control filopodial dynamics in neurons by remodeling the actin n
73 In vivo imaging reveals that the dendritic filopodial dynamics of motoneurons map onto their recrui
74 n to in vivo axon development is to regulate filopodial dynamics that influence growth cone guidance.
77 of ADF/cofilin mimics the effects of BDNF on filopodial dynamics, whereas ADF/cofilin inactivity bloc
84 in cytoskeletal regulation directs dendritic filopodial emergence or their subsequent maturation into
86 lso identify a transient period of MF bouton filopodial exploration, followed by refinement of sites
87 how in epithelial cells that the dynamics of filopodial extension and retraction are determined by th
90 leading front of actin polymerization at the filopodial extension and thus could potentially enhance
93 nsistent with the observed proliferation and filopodial extension of Pneumocystis organisms adherent
94 Thus, Slit locally stimulates directional filopodial extension, a process that is required for sub
95 9 small-interfering RNA resulted in enhanced filopodial extension, decreased cell adhesion, increased
96 CTGF by specific antibody affected vascular filopodial extension, growth of the superficial vascular
97 ngiogenic effects by stimulating directional filopodial extension, whereas matrix metalloproteinase i
98 of filopodia-associated proteins during the filopodial extension-retraction cycle in a variety of ce
101 posure leads to a reduction in the number of filopodial extensions at the medial epithelial edge of t
103 microscopy demonstrated IQGAP2 expression in filopodial extensions of activated platelets and colocal
104 gnaling through Arp2/3 and Diaph2, decreased filopodial extensions on dendritic cells, and inhibited
105 formation of neurites and lamellipodial and filopodial extensions similar to those induced by activa
108 estrogen can also stimulate the formation of filopodial extensions, an early step in the formation of
109 ing cell shape changes, cell rearrangements, filopodial extensions, and convergent extension movement
110 s displayed giant mossy fiber terminals with filopodial extensions, demonstrating that not all mossy
116 ments, we demonstrate that lamellipodial and filopodial filament breaking contribute equally to the r
117 evealed that fascin rapidly dissociates from filopodial filaments with a kinetic off-rate of 0.12 s(-
119 lar cell type expresses the lamellipodial or filopodial form of the actin machinery is essential to u
120 ordingly, Ena/VASP function was required for filopodial formation from the growth cone in response to
122 lated genes 3 and 5 (PRG3 and PRG5) increase filopodial formation in various cell lines, independentl
126 Dyn1 actin binding domain mutant inhibits filopodial formation, suggesting a role in actin elongat
127 , we demonstrate that it specifically blocks filopodial formation, tumour cell migration and invasion
135 toward BMP6 gradients via the regulation of filopodial function and amplification of BMP signals.
138 ent with experiments, in terms of predicting filopodial growth retraction cycles and the average filo
139 ty by suppressing Abl signaling to stimulate filopodial growth while presumably reducing substratum a
140 erential regulation of the lamellipodial and filopodial growth-cone actin-cytoskeleton domains underl
142 urons with amphetamine increased mobility of filopodial HA-DAT and accelerated HA-DAT endocytosis in
150 Our results indicate that BDNF regulates filopodial length and number through a Rho kinase-depend
152 n binding and unbinding leads to macroscopic filopodial length fluctuations, compared with minuscule
153 and relative protein concentration along the filopodial length for a broad range of signal distributi
155 eals that one of the key limiting factors of filopodial length is diffusional transport of G-actin mo
156 vercome the membrane resistance and that the filopodial length is limited by buckling for 10-30 filam
159 osin-10 (Myo10) and its expression increases filopodial length, filopodial number, and Myo10-dependen
160 though inhibition of myosin II also enhances filopodial length, our results indicate that BDNF signal
161 del generates testable predictions about how filopodial length, rate of growth, and interfilopodial d
162 hoA blocks neurotrophin-induced increases in filopodial length, whereas inhibition of RhoA enhances f
163 led to approximately threefold increases in filopodial length, with the transport being mainly limit
167 sitive to neurotrophins but display enhanced filopodial lengths comparable with neurotrophin-treated
168 e counterparts, consistent with the enhanced filopodial lengths observed on mutant growth cones.
169 length, whereas inhibition of RhoA enhances filopodial lengths, similar to neurotrophin treatment.
172 ampal neurons with a concomitant increase in filopodial-like outgrowths, suggesting an effect on syna
173 on of mature dendritic spines to an immature filopodial-like phenotype in primary hippocampal culture
174 tinotectal synapses are formed on developing filopodial-like processes to a circuit in which RGC axon
183 of the growth cone generates an asymmetry in filopodial motility and PY signaling that promotes repul
184 ough the signaling cues underlying dendritic filopodial motility are mostly unknown, brain-derived ne
186 We propose that neuronal activity controls filopodial motility in a developmentally regulated manne
187 e imaging of radial glial cells and measured filopodial motility in the intact albino Xenopus laevis
190 dritic protrusions and accelerates dendritic filopodial motility through an Abl kinase-dependent path
191 ndritic growth cones and filopodia, mediates filopodial motility, and does so via the phosphoinositid
192 ventional myosin with important functions in filopodial motility, cell migration, and cell adhesion.
193 ) transients in growth cone filopodia reduce filopodial motility, slow neurite outgrowth, and promote
202 its expression increases filopodial length, filopodial number, and Myo10-dependent cell motility in
203 Silencing of Daam1 led to severe defects in filopodial number, integrity, and architecture, similar
204 model for selection of lamellipodial versus filopodial organization in which CP is a negative regula
205 ve (post-UVR) conditions, which we call the "filopodial-phagocytosis model." This model also provides
207 by increasing the formation of cytoskeletal filopodial precursors (patches) through localized microd
210 ogenous ephrinAs (EphAs) induce outgrowth of filopodial processes from astrocytes within minutes in r
211 cells continuously change shape and project filopodial processes in their direction of motion, sugge
212 Notably, MsEphrin could be detected on the filopodial processes of the EP cells that extended up to
214 eporting in Nature, Sanders et al. implicate filopodial projections in Sonic hedgehog (Shh) patternin
215 o induced the formation of long, thread-like filopodial projections, similar to previously described
216 length and then contract over time; and that filopodial protrusion and expansion were affected by PAR
217 CC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40-UNC-5 he
218 owth cones and for inhibition of growth cone filopodial protrusion caused by activated MYR::UNC-40 an
220 s were required for the normal limitation of filopodial protrusion in developing growth cones and for
222 amily GTPase, Rif, as a potent stimulator of filopodial protrusion through a mechanism that does not
226 DOCK4 signalling is necessary for lateral filopodial protrusions and tubule remodelling prior to l
228 g that the Xena/XVASP family of proteins and filopodial protrusions are non-essential for pathfinding
230 ascade for the formation of endothelial cell filopodial protrusions necessary for tubule remodelling,
231 eveloping optic tectum extend highly dynamic filopodial protrusions within the tectal neuropil, the m
232 fascin are required for the organization of filopodial protrusions, Rac-dependent migration, and tum
233 growing actin filaments in lamellipodial and filopodial protrusions, thus corresponding to the tips o
236 ave disorganized F-actin and display reduced filopodial protrusive activity at their leading edge.
237 ve turning, suggesting that local changes in filopodial PY levels may underlie growth cone pathfindin
240 halasin D to disrupt F-actin assembly led to filopodial retraction and growth cone collapse and resul
245 a coli) particles by (i) capturing along the filopodial shaft and surfing toward the cell body, the m
246 binding kinetics between integrins along the filopodial shaft and the ligands on the surrounding ECM
247 s known about how the actin filaments in the filopodial shaft are spatially organized to form a bundl
248 bundling protein and localizes all along the filopodial shaft, which differs from other formins that
250 d centripetal flow, drove a lamellipodial-to-filopodial shape change in suspended cells, and induced
251 everal methods exist that analyze changes in filopodial shape, a software solution to reliably correl
254 fibronectin-rich 3D ECM, driven by RhoA and filopodial spike-based protrusions, not lamellipodia.
255 ment, both beta-actin immunofluorescence and filopodial spines were increased (from 70.57 +/- 1.09% t
256 s the barbed-end polymerase VASP to modulate filopodial stability during netrin-dependent axon guidan
260 yrosine phosphorylation, which mediates both filopodial stabilization and reduced lamellipodial protr
262 ectionally along filopodia and fuse with the filopodial surface in response to focal stimulation, all
264 in to interact with and facilitate dendritic filopodial targeting of FGF22, triggering presynaptic ma
267 se a cell-based CE model based on asymmetric filopodial tension forces between cells and investigate
269 uits the Ena/WASP family protein Mena to the filopodial tip and protects elongating actin filaments f
270 Arp2/3 complex activators, self-assembly of filopodial tip complexes on the membrane, and outgrowth
272 the kinetic properties and the effect on the filopodial tip localization of the recombinant mouse myo
273 mediated ubiquitination of VASP reduces VASP filopodial tip localization, VASP dynamics at tips, and
277 el by which myosin 10 rapidly targets to the filopodial tip via a sequential reduction in dimensional
278 were found to retract beads attached to the filopodial tip, and retraction was found to correlate wi
279 ticles of GFP-Myo5a can also move toward the filopodial tip, but at a slower characteristic velocity
282 The resulting molecular traffic jams at filopodial tips amplify fluorescence intensities and all
284 cking the motor region failed to localize to filopodial tips but still bound transiently at the plasm
287 merization module became translocated to the filopodial tips in the presence of cargo complex, i.e.,
290 yosin that transports the specific cargos to filopodial tips, and is associated with the mechanism un
296 hich leads to smaller G-actin flux along the filopodial tube compared with the prediction using the d
297 equire transport of G-actin, which enter the filopodial tube from the filopodial base and diffuse tow
300 tors, which may have differential effects on filopodial versus lammelipodial actin-based protrusions.
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