ライフサイエンスコーパス: filopodium

1 p and the retrograde flow at the base of the filopodium.

2 dling and completed formation of the nascent filopodium.

3 with retrograde movement of actin inside the filopodium.

4 Filopodium, a spike-like actin protrusion at the leading

5 At the core of each filopodium an actin bundle forms and grows into the lame

6 and flow rate can vary with time in a single filopodium and between filopodia in a single growth cone

7 ibution of individual filaments in a growing filopodium and studied how it depends on various physica

8 eins, and heightened membrane tension as the filopodium attempts to retract but is held in place by a

9 he putative microtubule-based barrier at the filopodium base.

10 We model the growth of a filopodium based on a stochastic description which incor

11 ated phosphoprotein (VASP) is active in many filopodium-based and cytoskeleton reorganization process

12 e polarized actin filament bundle within the filopodium becoming confined to a single point at the ti

13 Recent work has shown that a filopodium begins deciding to become a stable branch wit

14 capping protein, the number of fibers in the filopodium bundle decreases down the length of the enclo

15 effect on P domain retrograde actin flow or filopodium bundle number.

16 Without external influences, the filopodium can extend indefinitely up to the buckling le

17 Each filopodium contains a rigid and organized bundle of para

18 The tip of each filopodium crawls along ECM fibers, tugs the surrounding

19 A subset of PC12 cells displayed high filopodium density on PCD.

20 Mechanistically, Slit evokes changes in filopodium dynamics by increasing direct binding of its

21 Perturbing filopodium dynamics pharmacologically or genetically dis

22 This filopodium-ECM interaction is modeled as a stochastic pr

23 of a neuroblastoma cell line, we found that filopodium extension and retraction are governed by a ba

24 bolished neurabin I dimerization and induced filopodium extension.

25 ur study revealed a novel mechanism, whereby filopodium formation and cell migration are regulated th

26 actin regulator filamin-A (FLNa) to modulate filopodium formation and cell migration.

27 LNa and Arl4C is essential for Arl4C-induced filopodium formation and increases the association of FL

28 h-1 can activate PAK-1 and JNK-1, and induce filopodium formation and stress fiber dissolution.

29 P-binding protein Cdc42 is thought to induce filopodium formation by regulating actin polymerization

30 Measurement of filopodium formation by time-lapse imaging of live cells

31 inity for TEM4 and producing Rac activation, filopodium formation, and cell motility.

32 ied and some of them have been implicated in filopodium formation, the precise role of Cdc42 in modul

33 lpha appeared to mediate Cdc42 signaling for filopodium formation, whereas Nckbeta mediated Rho signa

34 e formation of dendritic spines but inhibits filopodium formation.

35 and morphology and was linked to effects on filopodium formation.

36 bilizes actin filaments and is important for filopodium formation.

37 ogressive fiber end-capping occurring as the filopodium grows.

38 Realistic future dynamical theories for filopodium growth are likely to rely on an accurate trea

39 lly resolved protein concentration along the filopodium independent of bending, lateral shift, or til

40 ion of calcium concentration within a single filopodium induced new branch filopodia.

41 A filopodium is a cytoplasmic projection, exquisitely buil

42 umber of fibers down the length of a growing filopodium is found to have profound implications for th

43 e concentration profile of G actin along the filopodium is rather nontrivial, containing a narrow min

44 This surfing-like behavior along the filopodium is recorded by feedback-controlled interferom

45 riched in localized patches on the PM and in filopodium-like extensions.

46 PCs continuously extend and retract numerous filopodium-like processes as they migrate and settle int

47 n order to extend integrin beta1-containing, filopodium-like protrusions (FLPs), which enable them to

48 ed levels of filamentous actin and inhibited filopodium mobility in the growth cones.

49 e lens pit stage--there is approximately one filopodium per epithelial cell.

50 is known to decrease down the length of the filopodium, presumably due to progressive fiber end-capp

51 thod we observed an increase in the spine-to-filopodium ratio from P9-P16, indicating a period of rap

52 ngly, actin bundles that are associated with filopodium roots elongated by approximately 83% after in

53 Any realistic future theories for filopodium stability are likely to rely on an accurate t

54 t a minimum number of fibers is required for filopodium stability.

55 m an actin patch elongating into a dendritic filopodium, which tip subsequently expands via Arp2/3 co

56 This process endows filopodium with a finite lifetime.