ライフサイエンスコーパス: fimbria

1 iotic piglets expressing receptors for F4(+) fimbria.

2 e that regulated the phase variation of MR/P fimbria.

3 dominant species expressed in the developing fimbria.

4 iously identified as the P. gingivalis minor fimbria.

5 the antigenically variable epitopes of that fimbria.

6 ls of serum IgG and mucosal IgA against 987P fimbria.

7 eviously described tip protein of the type 2 fimbria.

8 egions required for expression of the AAF/II fimbria.

9 ncers, ovarian cancer cell lines, and normal fimbria.

10 and eventually away into the alveus, and the fimbria.

11 at are specific to either the K88ac or K88ad fimbria.

12 ed the binding activity of each K88 chimeric fimbria.

13 d linked to a serous cancer precursor in the fimbria.

14 tively affected the binding capacity of each fimbria.

15 ning to detect microscopic carcinomas in the fimbria.

16 ch encodes another important UPEC adhesin, P fimbria.

17 on of TosR synthesis reduces production of P fimbria.

18 We have recently demonstrated that type 1 fimbria, a phase-variable virulence factor involved in a

19 associated with the Actinomyces oris type 2 fimbria, a surface structure assembled by sortase (SrtC2

20 ded by one of the two pap operons encoding P fimbria adherence factor, represses flagella-mediated mo

21 ymphocytes during C trachomatis infection of fimbria and ampulla autografts in subcutaneous pockets i

22 y present in the angular bundle, alveus, and fimbria and relatively scant immunoreactivity in the nas

23 o evaluate the role of CA3 efferents via the fimbria and the CA1 efferents via the dorsal fornix for

24 igodendrocyte myelination in the hippocampal fimbria and the corpus callosum during development, and

25 )) produced systemic antibodies against both fimbria and the TGEV C epitope but not against the TGEV

26 n inflammatory stimulus into the area of the fimbria and transplanting enhanced green fluorescent pro

27 omposed of MrpH, the tip adhesin of the MR/P fimbria, and cholera toxin to prevent urinary tract infe

28 own-regulation of motility, acid resistance, fimbria, and curlin genes.

29 fiber tracts, including the corpus callosum, fimbria, and internal capsule in the brain, and pyramida

30 e also found in the body of the fornix, left fimbria, and superior longitudinal fasciculus (SLF).

31 and sRNA350--were shown to regulate urease, fimbria, and the LEE, respectively.

32 campal commissure, septohippocampal nucleus, fimbria, anteroventral thalamic nucleus, frontal and par

33 ells inhibited invasion, but the anti-type-C-fimbria antibody inhibited invasion to a greater extent

34 aqueductal gray matter ( approximately 13%), fimbria ( approximately 18%), and anterior commissure (

35 discuss the emergence of the fallopian tube fimbria as a field of origin for high-grade serous carci

36 the chaperone-subunit complex led to delayed fimbria assembly, whereas destabilizing the complex resu

37 ing an energetic landscape unique to class 5 fimbria assembly.

38 tite (SHA), or in its ability to express the fimbria-associated adhesin Fap1.

39 hrlichiosis agent 130-kDa protein and of the fimbria-associated adhesin protein Fap1 of Streptococcus

40 Mature Fap1, a 200-kDa fimbria-associated adhesin, is required for fimbrial bio

41 tudies in our laboratory have identified two fimbria-associated adhesins, FimA and Fap1, of Streptoco

42 Fap1, a fimbria-associated glycoprotein, is essential for biofil

43 The fimbria-associated MrkD1P protein mediates adherence of

44 fimbrial genes resulted in severe defects in fimbria-associated phenotypes, revealing roles in cell-c

45 FimH consists of a fimbria-associated pilin domain and a mannose-binding le

46 Fimbria-associated protein 1 (Fap1) is a high-molecular-

47 A fimbria-associated protein, Fap1, is identified as an ad

48 d to each other and to genes that may encode fimbria-associated proteins.

49 Fap1, a fimbria-associated serine-rich glycoprotein, is required

50 n and biofilm formation are independent of a fimbria-associated serine-rich repeat adhesin, Fap1, dem

51 is critical for the biogenesis of a type IV fimbria because of the essential role of a disulphide bo

52 presubiculum (beta=-0.29, p=0.030), and left fimbria (beta=-0.30, p=0.023).

53 unocytochemistry studies of BMEC with anti-S fimbria-binding protein antibodies revealed that the 65-

54 f Ecgp, showed 70% sequence homology to an S-fimbria-binding sialoglycoprotein reported earlier.

55 lated, and the glycosylation is required for fimbria biogenesis and bacterial adhesion.

56 ss glycosylated surface adhesin required for fimbria biogenesis and biofilm formation in Streptococcu

57 In the adult fimbria, brevican expression was restricted to astrocyte

58 in fractional anisotropy in the ipsilateral fimbria but not in the contralateral fimbria from p8 to

59 es, dendrites (stratum radiatum), and axons (fimbria), but not astrocytes.

60 e by polymerase chain reaction for adherence fimbria, but 11 strains were positive for EAggEc heat-st

61 ndrocytes and white matter astrocytes in the fimbria, but the expression of brevican in these two gli

62 We have now purified the native minor fimbria by ion-exchange chromatography and sequenced the

63 on-exchange chromatography and sequenced the fimbria by tandem mass spectrometry (MS/MS), confirming

64 n, the major structural subunit of a type-IV fimbria called the bundle-forming pilus (BFP), a prepili

65 us and a secondary germinal matrix, near the fimbria, called the hippocampal subventricular zone (HSV

66 pectrometry (GC-MS) confirmed that the minor fimbria contains the DC-SIGN-targeting carbohydrates fuc

67 P(+) oligodendrocytes that migrated into the fimbria, corpus callosum, and cerebral cortex.

68 es using ETEC-expressing colonization factor fimbria CS17 and CS19.

69 ses to both the Shigella vector and the ETEC fimbria CS4.

70 vated cell sorter, but not with noninvasive, fimbria-deficient mutant or purified P. gingivalis antig

71 EC) cultured with wild-type P. gingivalis, a fimbria-deficient mutant, and purified antigens.

72 riated P. gingivalis 381, in contrast to its fimbria-deficient mutant, P. gingivalis DPG3, efficientl

73 DPG3, a P. gingivalis fimbria-deficient mutant, was impaired in its invasion c

74 ve P. gingivalis (strain 381) (10(7) CFU); a fimbria-deficient P. gingivalis; or metronidazole before

75 can form biofilm on HEp-2 cells in a type 1 fimbria-dependent manner.

76 Monocytes used as controls demonstrated fimbria-dependent uptake of 381 as well but produced low

77 onditioning stimulation of the contralateral fimbria depressed the CA3 synaptic response and left the

78 A mutagenesis, we have characterized a novel fimbria (designated AAF/II) which mediates HEp-2 adheren

79 ection by Escherichia coli expressing the Dr fimbria (Dr(+)).

80 To define the connection between P fimbria expression and motility in UPEC, the role of pap

81 ompetence but are apparently not involved in fimbria expression of A. actinomycetemcomitans.

82 ilA or pilBC deletion did not seem to affect fimbria expression or cell surface structure in either r

83 of the invertible element controlling type 1 fimbria expression to phase vary contributes significant

84 MR/P fimbria expression, which correlates with the swimmer ph

85 electron microscopy revealed that the minor fimbria forms fibers approximately 200 nm in length that

86 h factor, can also prevent the loss of these fimbria fornix axotomised cholinergic neurons, where GM1

87 11 and continuing until p28, the ipsilateral fimbria fornix degenerates.

88 Transection of the fimbria fornix leads to retrograde degeneration of axoto

89 migrated into corpus callosum, striatum, and fimbria fornix to differentiate into the NG2-positive no

90 is (cynomolgous) monkeys received unilateral fimbria fornix transections followed by chronic intracra

91 We have lesioned the fimbria fornix, a major pathway of septal cholinergic fi

92 ptum following unilateral transection of the fimbria fornix.

93 cellularis, or unilateral transection of the fimbria fornix.

94 the septum 3 weeks before transection of the fimbria fornix.

95 er-matched controls along the left and right fimbria-fornix (FF), parahippocampal WM bundle (PWMB), a

96 thalamic nuclei (ATN) or transection of the fimbria-fornix (FF).

97 ll animals received a complete lesion of the fimbria-fornix (FF).

98 region (PARA) or electrolytic lesions of the fimbria-fornix (FNX) and were tested for their (a) discr

99 Lesions of the fimbria-fornix disrupt auditory gating by preventing cho

100 Results demonstrate the importance of the fimbria-fornix fiber system in spatial short-term memory

101 pal white matter bundle, and the ipsilateral fimbria-fornix in regions located within the medial temp

102 ast, patterned electrical stimulation of the fimbria-fornix increased TGC in amnestic animals and par

103 control animals 2 weeks following unilateral fimbria-fornix lesion.

104 of trkA (RTA) into the lateral ventricle of fimbria-fornix lesioned animals.

105 pal injections of 192 IgG-saporin (SAP-HPC), fimbria-fornix lesions (FF), or sham control surgeries w

106 ions on hippocampal physiology compared with fimbria-fornix lesions and septal inactivation, we obser

107 Fimbria-fornix transection resulted in a marked loss of

108 Similar to the effects of fimbria-fornix transection, Pb exposure resulted in a lo

109 Fimbria-fornix transections (FFTs), conducted 1 day afte

110 gnocellularis, radiofrequency lesions of the fimbria-fornix, and aspiration lesions of the frontal co

111 From preoperative imaging, the fimbria-fornix, parahippocampal white matter bundle and

112 s have demonstrated that DBS targeted to the fimbria-fornix, the region that appears to regulate hipp

113 toration of auditory gating by DMXB-A in the fimbria-fornix-lesioned rats was blocked by intracerebro

114 DMXB-A restored auditory gating in the fimbria-fornix-lesioned rats, indicating that activation

115 of colchicine-pretreated, control, untreated fimbria-fornix-transected (5 days), as well as perforant

116 ubcortical inputs to the hippocampus via the fimbria-fornix.

117 ore auditory gating following lesions of the fimbria-fornix.

118 (approximately 100 msec duration) evoked by fimbria/fornix (FF) stimulation in a majority of neurons

119 sly, we demonstrated that transection of the fimbria/fornix blocked the excitatory effect of corticot

120 atter regions including the corpus callosum, fimbria/fornix, and cerebellar deep white matter.

121 entorhinal cortices, the corpus callosum and fimbria/fornix, and cerebellar white matter.

122 ased dramatically in the corpus callosum and fimbria/fornix.

123 ections from the ventral hippocampus via the fimbria/fornix.

124 lateral fimbria but not in the contralateral fimbria from p8 to p42.

125 t MrpG, a putative minor subunit of the MR/P fimbria, functions as an adhesin responsible for hemaggl

126 ene cluster kps, and the P (pap) and S (sfa) fimbria gene clusters.

127 nscriptome profiling revealed YjgK represses fimbria genes at 8 h (corroborated by qRT-PCR and a yeas

128 Wild type fimbria genes were replaced both in Salmonella enteritid

129 e, corpus callosum, anterior commissure, and fimbria hippocampi, were investigated for structural and

130 aining for myelin basic protein (MBP) at the fimbria hippocampus and the internal capsule areas in th

131 ial adhesin designated aggregative adherence fimbria I (AAF/I), the genes for which have been cloned

132 a caused 20-fold increases in GFAP-IR in the fimbria/IC and 2-fold increases in the hippocampal neuro

133 P-IR in the hippocampal neuropil than in the fimbria/IC and the GFAP-IR remained greatly increased at

134 fold higher in old than in young mice in the fimbria/IC but not appreciably changed in hippocampus.

135 d the fimbrial antigen aggregative adherence fimbria II (AAF/II), all of which are encoded on the 65-

136 and 130 (minor)-kDa sialoglycoproteins by S fimbria immunoblotting and were purified from bovine BME

137 The phase variation of type 1 fimbria in E. coli provides a unique system in which to

138 ls should employ thorough examination of the fimbria, including multiple sections from each tissue bl

139 sed of a mannose-binding lectin domain and a fimbria-incorporating pilin domain.

140 ohesin-1, was shown to mediate P. gingivalis fimbria-induced activation of beta(2) integrin for ICAM-

141 Indeed, treatments that interfered with fimbria-induced activation of CD11b/CD18 (i.e., blockade

142 raft organization, was found to inhibit the fimbria-induced assembly of CD14/TLR2 signaling complexe

143 relatively low within areas of white matter (fimbria, internal capsule) and select neuronal fields (h

144 Type 1 fimbria is a proven virulence factor of uropathogenic Es

145 y the gene locus fimQ-fimP-srtC1, the type 1 fimbria is comprised of the fimbrial shaft FimP and the

146 that the receptor-binding domain of a K88ac fimbria is contained, at least in part, within the antig

147 We further show that the minor fimbria is glycosylated by ProQ staining and that glycos

148 ion of mannose-resistant/Proteus-like (MR/P) fimbria is phase variable because of the inversion of a

149 Expression of the fimbria is regulated at the transcriptional level by a p

150 d to determine how much of the assembled K99 fimbria is required to maintain protective immunity.

151 P5-fimbria is the critical appendage of NTHI that participa

152 The fimbria is the source of nearly one half of PPSCs, sugge

153 hogenic Escherichia coli expresses a type IV fimbria known as the bundle-forming pilus (BFP) that is

154 ile diarrhoea worldwide, expresses a type IV fimbria known as the bundle-forming pilus that promotes

155 ion or by anterograde degeneration following fimbria lesion.

156 s with a high degree of identity to the Flp (fimbria-like protein) encoded by the first open reading

157 electron microscopy revealed the absence of fimbria-like surface structures on an OxyR-deficient str

158 sed with its fimH deletion mutant and type 1 fimbria locked-off mutant, while they were significantly

159 were significantly increased with its type 1 fimbria locked-on mutant.

160 tutes the tip of a unique form of the type 2 fimbria long known for its role in coaggregation.

161 protein level) to the Salmonella long polar fimbria (LPF) operon.

162 , the transcription of genes responsible for fimbria, LPS, and EPS production, as well as the transla

163 ferent target areas that communicate via the fimbria may be critically involved in CRH-enhanced start

164 rent target areas, which communicate via the fimbria, may be critically involved in CRH-enhanced star

165 Type 1 fimbria-mediated adherence to HEp-2 cells by two strains

166 In clinical settings, blocking of the P5-fimbria-mediated attachment of NTHIF+ by passive or acti

167 lycoprotein showed effective inhibition of S fimbria-mediated binding of E. coli to BMEC.

168 fraction showed significant inhibition of P fimbria-mediated haemagglutination assay of uropathogeni

169 ability to switch off the expression of MR/P fimbria might be important for kidney colonization.

170 Our results, using conditional fimbria mutants of P. gingivalis, show that P. gingivali

171 In the adult fimbria, no brevican expression was observed in oligoden

172 m an occult intraepithelial carcinoma in the fimbria of the fallopian tube and involves the ovary sec

173 anti-minor fimbria serum bound to the minor fimbria on the cell surface of the wild-type strain.

174 to be closely related to the long polar (LP) fimbria operon (lpf) of Salmonella enterica serovar Typh

175 This fiber pathway did not enter the fimbria or alveus along the entire distance of the trace

176 ociated with HBMEC were predominantly type 1 fimbria phase-on (i.e., fimbriated) bacteria.

177 ing to and invasion of HBMEC and that type 1 fimbria phase-on E. coli is the major population interac

178 st report on the identification of the minor fimbria produced by P. gingivalis.

179 on of mrkJ resulted in an increase in type 3 fimbria production and biofilm formation as a result of

180 n-containing proteins, in controlling type 3 fimbria production and biofilm formation in K. pneumonia

181 sent findings show that the locus for type 1 fimbria production in this strain includes three genes,

182 kDa protein that structurally may be a minor fimbria-protein complex and functionally effectuates coa

183 From controls, the alveus, fimbria, pyramidal cell layer, hippocampal sulcus, and g

184 ion-positive women should be assigned to the fimbria rather than the ovary, and future clinical and r

185 nes encode a novel usher/chaperone assembled fimbria regulated by an ON/OFF invertible promoter switc

186 No fimbria-related genes are evident either 5' or 3' to the

187 urrounding ORFs revealed homology with other fimbria-related proteins.

188 The mannose-resistant, Proteus-like (MR/P) fimbria, responsible for mannose-resistant hemagglutinat

189 p50 subunit) was significantly inhibited in fimbria-restimulated cells.

190 The anti-minor fimbria serum also reacts with the same-molecular-size f

191 ectron microscopy showed that the anti-minor fimbria serum bound to the minor fimbria on the cell sur

192 In immunoblotting analysis, anti-minor fimbria serum reacted with both the 100 degrees C- and t

193 thus supports the assumption that the type 1 fimbria shaft and the FimH adhesin-receptor interaction

194 onditioning stimulation of the contralateral fimbria significantly depressed the CA3 population respo

195 0 kDa were identified by immunoblotting with fimbria-specific antibodies.

196 tive hemagglutination and agglutination with fimbria-specific antiserum.

197 is analysis revealed elevated numbers of K99 fimbria-specific IgA-producing cells in the LP, PP, and

198 the LP, PP, and spleen, whereas elevated K99 fimbria-specific IgG-producing cells were detected only

199 r structural subunit, and srtC1 for a type 1 fimbria-specific sortase involved in the assembly of the

200 Fimbrial polymerization requires the fimbria-specific sortase SrtC1, which catalyzes covalent

201 Thus, SrtC2 is a fimbria-specific sortase that is essential for assembly

202 l GTPases, that Rac1 mediates the ability of fimbria-stimulated monocytes to bind ICAM-1.

203 second from accumbens neurons responsive to fimbria stimulation.

204 The cerebral cortex, septum, diagonal band, fimbria, striatum, hippocampus, hypothalamus, substantia

205 roscopy demonstrated that a mutant of type 1 fimbria structural genes (DeltafimAICDHF) and a ycfR mut

206 real-time PCR (qRT-PCR) revealed that type 1 fimbria structural genes and a gene encoding a putative

207 , mutations in an oxyR homolog and predicted fimbria structural genes were identified.

208 m women with cystitis were tested for type 1 fimbria switch orientation.

209 Results showed that each fimbria switched binding specificity to that of the reci

210 trains harbor genes encoding adhesive type 1 fimbria (T1F).

211 gingivalis, through its 67-kDa Mfa1 (minor) fimbria, targets the C-type lectin receptor DC-SIGN for

212 o epithelial cells is dependent on a type IV fimbria, termed the bundle-forming pilus (BFP).

213 es the bundle-forming pilus (BFP), a type IV fimbria that has been implicated in virulence, autoaggre

214 Expression of an EAF plasmid-encoded type IV fimbria, the bundle-forming pilus (BFP), is associated w

215 ion of brevican in the postnatal hippocampal fimbria to explore the role of the proteoglycan in centr

216 Fimbria transection blocked CRH-enhanced startle almost

217 the adhesin-receptor interaction of a type 1 fimbria varies as a bacterium is affected by a time-depe

218 a and around the Pia mater, corpus callosum, fimbria, ventricles, and blood vessels in sections from

219 ents demonstrated conclusively that the MR/P fimbria was a critical bladder colonization factor of ur

220 Each fimbria was characterized by its capacity to bind partic

221 bodies the force required to unwind a single fimbria was increased several-fold and the extension len

222 Volume reductions in the CA1 and fimbria were 44% and 60% smaller than in the CA2-CA3.

223 Two putative adhesins, flagella and F9 fimbria, were upregulated in the cadA mutant, suggestive

224 immunoreactivity was observed throughout the fimbria, with particularly strong immunoreactivity in th