ライフサイエンスコーパス: final step

1 uction of sugar units (here, glucose) in the final step.

2 e 1, converting it to an RNA ligase, for the final step.

3 ent for the formation of the oxindole in the final step.

4 C and a global deprotection strategy as the final step.

5 form, and is the rate-limiting event of the final step.

6 without the use of protecting groups as the final step.

7 nd the metabolites, with age then added as a final step.

8 epoxide-alkyne reductive cyclizations as the final step.

9 ned by oxidative cyclodehydrogenation in the final step.

10 rdinated to the nanoparticle surface, in the final step.

11 The final step, a DNA strand transfer reaction that joins th

12 In the final step, a quick and almost barrierless sulfoxidation

13 However, the final step, acyl migration (am), that takes place throug

14 ime constant that is thought to describe the final step, as supported by ultra-high resolution mass s

15 ely on evaporative cooling, a time-consuming final step associated with substantial atom loss.

16 the distal convoluted tubule represents the final step before Mg(2+) is excreted into the urine, thu

17 agarose gel matrix to avoid damage until the final steps before microinjection.

18 fication process, and that is removed in the final step by a protease.

19 The final step, called maturation, involves a concerted effo

20 psid protein subunits to a nucleus, with the final step completing the icosahedron.

21 A final step consists of partial replacement of aragonite

22 nd negative selection must still undergo one final step, generally termed T cell maturation, before t

23 in 1 (XRCC1), which completes the fourth and final step in (short-patch) BER.

24 espectively, in a process that serves as the final step in a nutrient-driven "hexosamine-signaling pa

25 eochemistry of the aldol reaction and as the final step in a short synthesis of members of the phaseo

26 >3)-galactosyltransferase (GTB) catalyze the final step in ABO(H) blood group A and B antigen synthes

27 2'-O-methylation of siRNAs may be the final step in assembly of the RNAi-enzyme complex, RISC,

28 The final step in bile acid synthesis involves conjugation w

29 The inhibition of the final step in blood coagulation, the factor XIIIa (FXIII

30 ylation of 7-methylxanthine to xanthine, the final step in caffeine N-demethylation.

31 The final step in cardiolipin biosynthesis is catalyzed by c

32 Cytokinesis, the final step in cell division, is dependent on formation a

33 The mechanism underlying cytokinesis, the final step in cell division, remains one of the major un

34 nery from biological membranes is a critical final step in cellular processes that require the ESCRT

35 e and phytyl pyrophosphate, required for the final step in chlorophyll a synthesis.

36 downstream from the Plo1 kinase to control a final step in contractile ring assembly.

37 For this report, we examined a final step in disassembly of the mammalian reovirus oute

38 ent methionine synthase (MetE) catalyzes the final step in Escherichia coli methionine biosynthesis b

39 Caulobacter crescentus, which catalyzes the final step in GDP-perosamine synthesis, the conversion o

40 Pyruvate kinase catalyzes the final step in glycolysis and is allosterically regulated

41 The final step in heme biosynthesis, insertion of ferrous ir

42 The final step in heme utilization and iron acquisition in m

43 erol acyltransferase 2 (DGAT2) catalyzes the final step in hepatocyte triglyceride biosynthesis.

44 t phosphorylation for the execution of a pre-final step in human NK-cell cytotoxicity.

45 dependent GTPase that is responsible for the final step in initiation, which involves the displacemen

46 A final step in integrin activation is the binding of tali

47 KDO8PP and KDN9PP catalyze the final step in KDO and KDN synthesis, respectively, prior

48 (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethano

49 ction-like behavior in animals, an essential final step in linking animal and human studies of addict

50 hyl-coenzyme M reductase (MCR) catalyzes the final step in methane biosynthesis by methanogenic archa

51 yl alcohol dehydrogenase (CAD) catalyzes the final step in monolignol biosynthesis, reducing sinapald

52 The final step in Na(+) channel biosynthesis in central neur

53 uminal site of an inflammatory stimulus, the final step in neutrophil recruitment.

54 Follicle rupture, the final step in ovulation, utilizes conserved molecular me

55 ibit D,D-transpeptidases, which catalyze the final step in peptidoglycan biosynthesis.

56 tial positioning of MurG which catalyses the final step in peptidoglycan precursor synthesis.

57 ol carrier protein SCPx, which catalyzes the final step in peroxisomal fatty acid beta-oxidation.

58 dehydratase (ADT1-6) gene family encodes the final step in Phe biosynthesis in Arabidopsis thaliana r

59 atic activity of EPT1, thereby hindering the final step in phosphatidylethanolamine synthesis.

60 The final step in polyketide synthase-mediated biosynthesis

61 The final step in Q biosynthesis is the reduction of the epo

62 The final step in releasing iron is the oxidative cleavage o

63 e miRNA* strand from pre-RISC and may be the final step in RISC assembly, ultimately enhancing target

64 drobenzophenanthridine oxidase (DBOX) is the final step in sanguinarine biosynthesis.

65 rmation of SatPC via LPCAT1 reacylation is a final step in SatPC synthesis prior to transport.

66 ctivation coincides with spermiogenesis, the final step in spermatogenesis, when the spherical sperma

67 oreductase (L-lysine forming)] catalyzes the final step in the alpha-aminoadipate pathway for lysine

68 The enzyme catalyzes the final step in the arginine dihydrolase pathway convertin

69 DNA/dNTP complex is thought to represent the final step in the assembly of the catalytic complex and

70 The final step in the assembly of the ubiquinol-cytochrome c

71 MCR) from methanogenic archaea catalyzes the final step in the biological synthesis of methane.

72 on IscU provides a general mechanism for the final step in the biosynthesis of [4Fe-4S]2+ clusters.

73 zyme aromatase, which is responsible for the final step in the biosynthesis of estrogens.

74 The final step in the biosynthesis of fosfomycin in Streptom

75 Escherichia coli and have identified the key final step in the biosynthesis of Q.

76 of ( S)-3-chloro-beta-tyrosyl-S-SgcC2 as the final step in the biosynthesis of the ( S)-3-chloro-5-hy

77 The final step in the biosynthesis of the antibiotic chloram

78 em-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful

79 Lipoyl synthase (LipA) catalyzes the final step in the biosynthesis of the lipoyl cofactor, t

80 The final step in the biosynthesis of the sesquiterpenoid an

81 hoxy-3beta-tropine) with benzoic acid is the final step in the biosynthetic pathway leading to the pr

82 Sepiapterin reductase catalyzes the final step in the biosynthetic pathway of tetrahydrobiop

83 ves pGpG, which is necessary to complete the final step in the c-di-GMP degradation pathway.

84 The final step in the cascade involves reduction of the Cys(

85 oxidation of toxic sulfite to sulfate as the final step in the catabolism of the sulfur-containing am

86 indings illuminate an important role for the final step in the CD74-MHC II pathway and a new target f

87 b(I)alamin adenosyltransferase catalyzes the final step in the conversion of vitamin B 12 into the ac

88 te (PLP)-dependent enzyme that catalyzes the final step in the cysteine biosynthetic pathway in enter

89 hosphate-dependent enzyme that catalyzes the final step in the cysteine biosynthetic pathway in enter

90 residues 200-593)/IMPCH (ATIC) catalyzes the final step in the de novo purine biosynthesis pathway th

91 The final step in the degradation of heparin sulfate involve

92 pimelate decarboxylase (DAPDC) catalyzes the final step in the diaminopimelate biosynthesis pathway o

93 The final step in the egress of herpes simplex virus (HSV) v

94 Enoyl-ACP reductases catalyze the final step in the elongation cycle of the bacterial fatt

95 A final step in the influenza virus replication cycle is t

96 findings suggest that uropod elongation is a final step in the leukocyte extravasation cascade, which

97 The final step in the maturation of paramyxoviruses, orthomy

98 on pathways evolve in reverse order from the final step in the pathway to the first step.

99 noyl-CoA, thus forming the substrate for the final step in the pathway.

100 ls upstream of Aurora B to regulate when the final step in the physical separation of daughter cells

101 oxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusi

102 eine carboxylmethyltransferase (Icmt) is the final step in the prenylation pathway.

103 act in concert to catalyze folding, with the final step in the process involving closure of the ends

104 lex that spans the periplasm carries out the final step in the process of host lysis.

105 membrane receptors by gamma-secretase is the final step in the process of regulated intramembrane pro

106 minal fragment (APP-betaCTF) constitutes the final step in the production of Abeta peptides.

107 on of signaling precursors and catalyzes the final step in the production of the amyloid beta-peptide

108 The final step in the proposed bioactivation is the formatio

109 chain nuFeHis dropped sharply at 20 mus, the final step in the R-T transition.

110 The final step in the referencing makes use of spacing diffe

111 remain significant after age was added as a final step in the regression.

112 Distal sodium transport is a final step in the regulation of blood pressure.

113 The final step in the retinoid visual cycle is catalyzed by

114 g as transcriptional activators, mediate the final step in the signaling cascade.

115 nimmobilized GlmU and provides a more facile final step in the synthesis of an unnatural UDP-donor.

116 Gibberellin 3-oxidase (GA3ox) catalyzes the final step in the synthesis of bioactive gibberellins (G

117 kotriene A(4) hydrolase, which catalyzes the final step in the synthesis of leukotriene B(4) (LTB(4))

118 beta, and PIP5KIgamma) can each catalyze the final step in the synthesis of phosphatidylinositol-4,5-

119 l transferase MsbB (LpxM) that catalyzes the final step in the synthesis of the lipid A moiety of lip

120 PAM, an essential enzyme, catalyzes the final step in the synthesis of the majority of neuropept

121 The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in

122 nt thymidylate synthase (FDTS) catalyzes the final step in this de novo production of thymidylate in

123 The final step in this pathway is methylation of the carboxy

124 yltransferase, the enzyme that catalyzes the final step in triglyceride synthesis, results in improve

125 of two known DGAT enzymes that catalyze the final step in triglyceride synthesis.

126 wo isoforms (Dgat1 and Dgat2), catalyzes the final step in triglyceride synthesis.

127 LEF/TCFs direct the final step in Wnt/beta-catenin signalling by recruiting

128 ucts from glycolysis and catalyze one of the final steps in carbon fixation, respectively.

129 mprised of the two enzymes that catalyze the final steps in cysteine biosynthesis: serine O-acetyltra

130 In opium poppy, the antepenultimate and final steps in morphine biosynthesis are catalyzed by th

131 nment plays a critical role in promoting the final steps in neuronal development during the early pos

132 ne group that leads to a different series of final steps in one Rh-based catalytic cycle, thereby ena

133 eductase (XOR), an enzyme that catalyzes the final steps in purine degradation.

134 is a bifunctional protein that catalyzes the final steps in the biosynthesis of the purine IMP.

135 s during turnover under H2 suggests that the final steps in the catalytic cycle of H2 oxidation by Hy

136 the free substrate premalbrancheamide as the final steps in the malbrancheamide biosynthetic pathway.

137 One of the final steps in the morphogenetic pathway of phage lambda

138 mals through the mevalonate pathway, and the final steps in the synthesis are catalyzed by the relate

139 cid (DHAA) provided strong evidence that the final steps in the synthesis of artemisinin are nonenzym

140 The final steps in this pathway involve the secondary acylat

141 n (pp150; encoded by UL32) that supports the final steps in virion maturation at cytoplasmic assembly

142 The final step involved a highly unusual Heck cyclization wh

143 The final step involved an SN1-type ring closure catalyzed b

144 The observed KIE (3.3) indicates that the final step involves cleavage of at least one C-H bond.

145 The final step involves the conversion of 4-hydroxy-2-oxo-he

146 ociation of the U1A-SL2 RNA complex, and the final step is assigned to a reorganization of the U1A pr

147 rstanding of Rab11-regulated mechanisms, the final steps mediating docking and fusion of Rab11-positi

148 imary 3' --> 5' exonucleases involved in the final step of 3'-end maturation, compete with poly(A) po

149 ne synthase (CYP11B2) is responsible for the final step of aldosterone synthesis.

150 ma-lactone oxidase, which is involved in the final step of ascorbate biosynthesis, in many vertebrate

151 en, Miranda may play a redundant role in the final step of bicoid mRNA localization.

152 The final step of biogenesis is a concerted reaction involvi

153 Together, our findings indicate that the final step of C-type inactivation of hERG1 channels invo

154 oxyl methyltransferase (ICMT), catalyzes the final step of CAAX processing after prenylation of the c

155 x with affinity-based rapid filtration and a final step of capillary-based enrichment.

156 ughout T cell differentiation, including the final step of CD8 SP selection.

157 d function, mediating OM constriction at the final step of cell division as well as the positioning o

158 onserved role in cytokinetic abscission, the final step of cell division where daughter cells are phy

159 Cytokinesis, the final step of cell division, usually ends with the absci

160 gs of the CYP4G1/2 enzymes that catalyze the final step of CHC biosynthesis in Drosophila and Musca d

161 on of a latent aldehyde tag, unmasked in the final step of chemical synthesis, providing a generic en

162 duce sterol double bonds at carbon 24 in the final step of cholesterol or ergosterol biosynthesis.

163 eukaryotic genomes is now possible, but the final step of circularizing sequences remains unsolved.

164 ase (CYP11B1), an enzyme responsible for the final step of cortisol biosynthesis, and the two electro

165 Abscission is the final step of cytokinesis and results in the physical se

166 The final step of cytokinesis in animal cells is abscission,

167 Before the final step of cytokinesis, termed abscission, dividing c

168 tor, is required during mitosis exit for the final step of cytokinesis.

169 ent methionine synthase (MetE) catalyzes the final step of de novo methionine synthesis using the tri

170 xamide ribonucleotide (FAICAR) to IMP in the final step of de novo purine biosynthesis.

171 cid oxidase (ACO), the enzyme catalysing the final step of ethylene formation.

172 We propose that the final step of GFP folding is a "locking" mechanism leadi

173 greater decrease in lung function during the final step of glucocorticoid withdrawal.

174 6-phosphatase, an enzyme which catalyses the final step of gluconeogenesis and glycogenolysis.

175 f glucose-6-phosphatase, which catalyzes the final step of glucose production, were significantly hig

176 Pyruvate, which is produced in the final step of glycolysis, participates in anabolic metab

177 , ferrochelatase, the enzyme involved in the final step of heme synthesis, is deficient in these pati

178 of conformational change is provided by the final step of hinge-region expulsion and subsequent clos

179 Another mutant blocked in the final step of His biosynthesis (hisn8) and a double muta

180 At the final step of homologous recombination, Holliday junctio

181 acts with the ESCRT-III complex to drive the final step of ILV formation.

182 on of the gene for the enzyme catalysing the final step of InsP6 biosynthesis (InsP5 2-kinase) also d

183 A final step of integrin activation is talin binding to 2

184 The final step of iron-sulfur protein assembly involves tran

185 mmed cell death process that constitutes the final step of leaf development, and it can be regulated

186 The final step of locking has been proposed to involve confo

187 (waaL) at PG1051, which is required for the final step of LPS biosynthesis, abolished the linkage of

188 Alveologenesis, the final step of lung development, is characterized by the

189 The final step of lysis in phage lambda infections of Escher

190 ces to an inward-facing conformation and the final step of maltose translocation into the cell.

191 MCR) from methanogenic archaea catalyzes the final step of methane formation, in which methyl-coenzym

192 In methanogenic Archaea, the final step of methanogenesis generates methane and a het

193 on of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis

194 ntrinsic membrane fission properties, at the final step of mitochondrial division.

195 Cytokinesis is the final step of mitosis when a mother cell is separated in

196 matic depletion of enzymes that catalyze the final step of NAD(+) biosynthesis revealed cell-specific

197 yltransferase (DGAT1-2), which catalyzes the final step of oil synthesis.

198 The final step of peptidoglycan (PG) biosynthesis in bacteri

199 that Pex11p also plays a crucial role in the final step of peroxisomal fission: dynamin-like protein

200 t intermediates and that Tdrkh promotes this final step of piRNA biogenesis but not the ping-pong cyc

201 The protein encoded by pqqC catalyzes the final step of PQQ formation, which involves a ring closu

202 ssembles and is loaded onto chromatin in the final step of prereplicative complex (pre-RC) formation.

203 tate a novel sialidase reaction in which the final step of product formation is direct abstraction of

204 on mechanism with other sialidases up to the final step of product formation.

205 mate semialdehyde to glutamate, which is the final step of proline catabolism.

206 esses diacylglycerol to triglycerides in the final step of resynthesis for the absorption of fat acro

207 teinyl-tRNA synthase (SepSecS) catalyzes the final step of selenocysteine formation by a poorly under

208 cleaves sphingosine 1-phosphate (S1P) in the final step of sphingolipid catabolism.

209 erase (PfCEPT), a key enzyme involved in the final step of synthesis of phosphatidylcholine (PC).

210 ay, but which more generally may exclude the final step of synthesizing acetyl-CoA.

211 ybenzoate (4-HB) and coenzyme A (CoA) in the final step of the 4-chlorobenzoate dehalogenation pathwa

212 glycosyltransferases are responsible for the final step of the biosynthesis of ABO(H) human blood gro

213 of TCA was most effective when added in the final step of the clean-up procedure instead of during e

214 The final step of the four-step dTDP-L-rhamnose biosynthesis

215 holine phosphotransferases that catalyze the final step of the highly conserved Kennedy pathway for p

216 by a water-catalyzed proton transfer in the final step of the hydroarylation.

217 ds and processes uridylated pre-let-7 in the final step of the Lin28-let-7 pathway.

218 The final step of the marineosin pathway is thus a MarA cata

219 ferrous enzyme (and formation of NFK) in the final step of the mechanism, which formally requires red

220 The final step of the methylerythritol phosphate isoprenoid

221 iphosphate decarboxylase (MDD) catalyzes the final step of the mevalonate pathway, the Mg(2+)-ATP dep

222 3 phosphorylation may play a key role in the final step of the PAK1 activation process.

223 hat acts to reduce enoyl-ACP substrates in a final step of the pathway.

224 rms the six-membered carbocyclic ring in the final step of the pathway.

225 is a novel metalloenzyme that catalyzes the final step of the post-translational synthesis of hypusi

226 The final step of the protocol involves colabeling by immuno

227 late intermediates formed in the initial and final step of the reaction supported the first mechanism

228 njugate, while the second is involved in the final step of the reaction, a thiol-disulfide exchange r

229 O-O bond-forming reaction that occurs in the final step of the S state cycle can only be fulfilled by

230 eogenic center in each product is set at the final step of the synthesis by enantioselective (er = 61

231 ion to give tetracyanobuta-1,3-dienes in the final step of the synthesis, undergoes four reversible 3

232 aryotic thiazole synthase and identifies the final step of the thiamin-thiazole biosynthesis.

233 It has long been hypothesized that the final step of thiazolyl peptide biosynthesis involves a

234 the midhypocotyl, whose expansion drives the final step of this developmental transition under optima

235 hiol oxidoreductase ERp57 participate in the final step of this process as part of the peptide-loadin

236 The final step of this process involves severing the SP1 pep

237 The final step of this route demonstrates the chemical feasi

238 The final step of this route exemplifies a novel synthesis o

239 l six compounds inhibit strand transfer, the final step of Tn5 transposition.

240 LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked p

241 f the tags is predicted to change during the final step of transposition, this recognition strategy s

242 major 3' --> 5' exonucleases involved in the final step of tRNA 3'-end maturation, confirming their r

243 E3 ubiquitin ligases catalyze the final step of ubiquitin conjugation and regulate numerou

244 el mechanism of APC/C inhibition wherein the final step of ubiquitin transfer is targeted and raise t

245 At the final step of VEPART, robustness is assessed by identify

246 A final step of wastewater treatment with lime was perform

247 al RNA metabolism, most likely acting in the final steps of 23S rRNA maturation.

248 These data suggest that M2 mediates the final steps of budding for influenza viruses, bypassing

249 The final steps of cell division are tightly coordinated in

250 a peptide from another peptidoglycan in the final steps of cell wall assembly.

251 The biosynthetic enzymes for the final steps of chloroplast lipid assembly are associated

252 ich were previously believed to occur as the final steps of chromomycin A(3) biosynthesis, indeed tak

253 hase is a bifunctional enzyme catalyzing the final steps of CoA biosynthesis by coupling phosphopante

254 nsendothelial migration, indicating that the final steps of extravasation, where actin polymerization

255 erts pyruvate into the mitochondrion for the final steps of glucose oxidation.

256 Thus, ESCRT machinery is involved in the final steps of HCMV replication.

257 The final steps of lacticin 481 biosynthesis are proteolytic

258 earliest moments of tumor development to the final steps of metastasis.

259 s, are opening the gates to study one of the final steps of mitosis--silencing the spindle checkpoint

260 recting the cytokinesis machinery during the final steps of mitosis.

261 he hybrid state of binding that precedes the final steps of mRNA and tRNA translocation.

262 h then, in turn, provides cues to permit the final steps of neuronal differentiation.

263 NafY participates in the final steps of nitrogenase maturation, having a dual rol

264 rocess associated with DSB formation and the final steps of oocyte selection.

265 omologue Chp2 (Rv1184c) is essential for the final steps of PAT biosynthesis.

266 re bacterial DD-peptidases that catalyze the final steps of peptidoglycan biosynthesis.

267 , is an essential enzyme responsible for the final steps of peptidoglycan synthesis and is covalently

268 This sequence models the final steps of proposed Fe-mediated nitrogen fixation pa

269 s a Rab11-binding partner that regulates the final steps of Rab11-positive vesicle docking at the pla

270 of initiation complex formation licenses the final steps of ribosome maturation by signaling RNases t

271 However, the final steps of secretion have remained unclear.

272 A gamma-glutamyl ligase catalyzes the final steps of the F420biosynthesis pathway by successiv

273 C, 14), a triketone that failed to reach the final steps of the herbicidal design and development pro

274 educed degradative capacity that impairs the final steps of the intimately connected autophagic and p

275 and opposite dependencies of the initial and final steps of the mechanism on the heme reduction poten

276 n and Cu2+-mediated Eglinton coupling in the final steps of their syntheses.

277 Deletion of the final steps of this pathway revealed that quinone molecu

278 and Vamp7 with Stx3, which cooperate in the final steps of this selective apical traffic pathway.

279 l changes occurring during maturation, whose final step often requires the specific binding of 'decor

280 As a final step, phosphorylated ATP7B was transferred from th

281 eport thermodynamically distinct initial and final steps, respectively, in the Hv1 activation pathway

282 gatorily occur on cell surfaces, whereas the final step(s) is endosomal.

283 This modification is usually performed as a final step, since sulfonated molecules are poorly solubl

284 functionalization, and a surprisingly simple final step that intersects a presumed biosynthetic inter

285 In the final step, the 3-ketone intermediate undergoes a beta-e

286 ntenyl phosphate kinase (IPK) catalyzing the final step, the formation of IPP.

287 The final step, the formation of the thioether linkage with

288 In its final step, the procedure reconstitutes the original dat

289 [2 + 2 + 2] alkyne cyclotrimerization as the final step, the short and efficient synthesis of cyclopr

290 ol is significantly more efficient than the "final-step-threading" method employed previously and ena

291 precursor that can be fully aromatized in a final step through a DDQ-mediated dehydrogenation reacti

292 aniline derivative, and an annulation in the final step to close the quinoline ring, leading to a dih

293 C-2 arylation as a final step was also possible by Liebeskind-Srogl cross-c

294 The final step was thwarted by a pinacol-like rearrangement

295 At the final step, we introduce a method to automatically seed

296 In the final step, we show that the experimentally observed app

297 As a final step, we then demonstrate that the feedback system

298 of the epidithiodiketopiperazine core in the final step, were developed to address this highly sensit

299 In particular, we have focused on the final step wherein the neural folds approach one another

300 resulting in an overall yield of 74% with a final step yield of 91%.