1 3.77, suggestive evidence for linkage after
fine mapping).
2 s chromosome and creating a new tool for QTL
fine mapping.
3 ion, considerably limiting the resolution of
fine mapping.
4 a combination of candidate gene analysis and
fine mapping.
5 12p11-q13 (D12S1048), which we confirmed by
fine mapping.
6 of incorporating additional ancestry in MHC
fine-mapping.
7 After
fine mapping,
a gene encoding a calcium(2+)/hydrogen(+)
8 RASQUAL substantially improves
fine-mapping accuracy and sensitivity relative to existi
9 ll as functional annotation data, to improve
fine-mapping accuracy at pleiotropic risk loci.
10 functional elements to increase trans-ethnic
fine-mapping accuracy.
11 analyses for narcolepsy with replication and
fine mapping across three ethnic groups (3,406 individua
12 We performed common variant
fine-mapping across a 23-Mb interval in a multiethnic sa
13 Fine-mapping across African American cohorts was conduct
14 Imputation-based
fine-mapping across the class II MHC region suggests tha
15 Imputation-based
fine-mapping across the extended MHC region showed that
16 Here we developed a
fine-mapping algorithm to identify candidate causal vari
17 Association and
fine-mapping analyses identified a protein-coding varian
18 The initial analyses were followed by
fine-mapping analyses in genomic regions with initial he
19 Imputation and
fine-mapping analyses were performed in these two region
20 Fine mapping analysis by integration with genome-wide ex
21 r renal cell carcinoma (RCC), we conducted a
fine mapping analysis of a 120 kb region that includes E
22 across this region and PrCa, we performed a
fine-mapping analysis by genotyping 134 SNPs using a cus
23 Fine-mapping analysis of bm4 narrowed the candidate regi
24 Fine-mapping analysis of MHC region demonstrates an impo
25 Here, we conducted a large-scale MHC
fine-mapping analysis of rheumatoid arthritis (RA) in a
26 Here, we report a
fine-mapping analysis of the 9q31.2 susceptibility locus
27 We performed genetic
fine-mapping analysis of the CCNE1 region using data fro
28 cancer risk, we performed a high resolution
fine-mapping analysis that involved genotyping 517 SNPs
29 osomes 7, 8, 14, and 19 and 11 SNPs from the
fine-mapping analysis that were associated with high-den
30 Applying
fine-mapping analysis to 233 known and new loci associat
31 We apply
fine-mapping analysis to dissect associations in the hum
32 In this study, a
fine-mapping analysis using HapMap SNPs was conducted ac
33 In the
fine-mapping analysis, 52 939 single-nucleotide polymorp
34 h, and de novo marker utility for downstream
fine-mapping analysis.
35 may guide the development of new methods for
fine mapping and association mapping of complex traits.
36 We report the
fine mapping and cloning of a tomato (Solanum lycopersic
37 For each COPD eQTL,
fine mapping and colocalization analysis to identify cau
38 in these QTL regions can be used for future
fine mapping and developing SNP chips for marker-assiste
39 most cases seems bound to require extensive
fine mapping and functional analysis before it is reveal
40 naringenin chalcone accumulation followed by
fine mapping and genetic transformation, we identified a
41 By
fine mapping and genomic re-sequencing in ethnically div
42 The recent novel discoveries in
fine mapping and genotype-phenotype studies will be high
43 e performed genome-wide linkage analysis and
fine mapping and identified linkage to 3p21-p22 with a s
44 markers of this QTL can be used for further
fine mapping and marker assisted selection in peanut bre
45 Genetic
fine mapping and Mendelian randomization uncover wide-sp
46 analytical framework that integrates genetic
fine mapping and Mendelian randomization with epigenome-
47 Here, we have identified through
fine mapping and meta-analysis EVI5 as the most plausibl
48 sed to identify a disease locus, followed by
fine mapping and positional candidate gene sequencing.
49 Fine mapping and positional cloning revealed that stumpy
50 With the use of a combination of
fine mapping and sequencing of the platelet endothelial
51 Ongoing studies include
fine mapping and sequencing studies to identify causal v
52 Sequential
fine mapping and transgenic complementation demonstrated
53 Through additional
fine mapping and whole-genome sequencing, we determined
54 ources developed in this study will underpin
fine-mapping and cloning of agronomically important gene
55 decade has witnessed significant progress in
fine-mapping and cloning of genes controlling QDR.
56 Integration of WGS-based
fine-mapping and complementary epigenomic datasets provi
57 Fine-mapping and conditional analyses in the METSIM stud
58 By integrating genetic
fine-mapping and epigenomic annotation data and performi
59 For sarcoidosis,
fine-mapping and expression analysis suggest KCNK4, PRDX
60 Here we report
fine-mapping and functional analysis of one such locus r
61 complex traits that have been validated with
fine-mapping and functional analysis.
62 Further
fine-mapping and functional studies are required to iden
63 Fine-mapping and functional studies of new risk loci cou
64 In silico
fine-mapping and functional validation identified a comm
65 improved risk prediction and inform further
fine-mapping and functional work to better understand th
66 In this study, Dw2 was identified by
fine-mapping and further confirmed by sequencing the Dw2
67 technologies provide new ways to accelerate
fine-mapping and gene isolation in crops.
68 endometrial cancer, and now report extensive
fine-mapping and in silico and laboratory analyses of th
69 alleles for bladder cancer risk that require
fine-mapping and laboratory investigation, which could f
70 ent to capture causal variants, we performed
fine-mapping and re-genotyping of the three loci using 1
71 In subsequent
fine-mapping and replication association studies in appr
72 immune etiology will become more complete as
fine-mapping and sequencing data become readily availabl
73 Here we conducted
fine-mapping and targeted sequencing of the candidate lo
74 s are an essential component in identifying,
fine mapping,
and understanding their trait variability.
75 locus mapping, meta-quantitative trait locus
fine-mapping,
and association mapping, we showed that th
76 Here, we use a
fine mapping approach to determine the genetic basis of
77 Our
fine-mapping approach identified a SNP showing the highe
78 e(s) at this locus, we employed an in silico
fine-mapping approach using genotyped and imputed SNP da
79 We implemented a functional
fine-mapping approach, leveraging intermediate phenotype
80 This study shows how data from dense
fine-mapping arrays coupled with functional genomic data
81 This problem of
fine-mapping association signals predates GWAS, but the
82 Through
fine-mapping,
association analysis, expression analysis,
83 Fine mapping at the CD4bs indicated that conformational
84 t not for GTF2E2, supporting the statistical
fine-mapping at this locus and demonstrating that RBPMS
85 Statistical
fine-mapping at this locus pointed to RBPMS at this locu
86 We then combined
fine-mapping,
bioinformatics, and bench-based approaches
87 Genomewide association analysis and
fine mapping by homozygosity were used to identify the c
88 Fine mapping by local association analysis identified RE
89 We performed
fine-mapping by targeted sequencing at WLS, MEF2C, ARHGA
90 high-resolution HLA and MICA imputation for
fine mapping causal variants in the MHC.
91 ing the ability to use these annotations for
fine mapping causal variation.
92 iction models, imputing untyped variants and
fine-mapping causal variants from summary statistics of
93 the value of high-resolution imputation for
fine-mapping causal variants in the MHC.
94 Fine mapping,
conditional analyses, and exome array geno
95 Crystallography was employed for
fine-mapping conformational epitopes in binary and terna
96 uantitative immune variables, sequence-based
fine mapping,
cross-population and cross-phenotype analy
97 monstrated that integration of these genetic
fine-mapping data with genomic annotation can highlight
98 By using a combination of genetic
fine mapping,
data on DNase hypersensitivity, and electr
99 om trait-associated variants is essential to
fine mapping disease loci.
100 A conventional
fine-mapping effort starts by sequencing dozens of rando
101 TL and Roadmap Epigenomics data could assist
fine-mapping efforts.
102 pulation may be particularly informative for
fine-mapping efforts.
103 idate functional SNPs are first evaluated by
fine mapping,
epigenomic profiling, and epigenome editin
104 ants are non-coding, often requiring genetic
fine-mapping,
epigenomic profiling, and individual repor
105 A
fine mapping experiment, followed by marker-assisted pro
106 Fine-mapping experiments from genome-wide association st
107 Risk loci are typically dissected through
fine-mapping experiments in trans-ethnic cohorts for lev
108 My results lay the foundation for
fine-mapping experiments to identify the complete set of
109 Fine mapping followed by candidate gene analysis of erd
110 al population structure and thus can improve
fine mapping for disease gene localization.
111 Application of MR-MEGA to
fine-mapping four type 2 diabetes susceptibility loci in
112 TAC-seq can provide powerful information for
fine-mapping gene-regulatory variants and for linking di
113 one of the most racially/ethnically diverse
fine-mapping genetic studies of HDL-C, LDL-C, and trigly
114 We performed a
fine-mapping genome-wide association study of the geneti
115 Here we establish, through
fine mapping,
genome sequencing, genetic complementation
116 To extend the
fine-mapping,
genotype data from the African American st
117 ol subjects, totaling 3,134 subjects using a
fine-mapping genotyping platform was conducted.
118 Fine mapping identified 29 critical residues that, when
119 Further sequence analysis and
fine mapping identified a candidate gene for dw as a non
120 Fine mapping identified a strong association to a common
121 9, P = 0.34); however, in African Americans,
fine mapping identified a top hit in FADS2 associated wi
122 A recent high-density
fine-mapping (
ImmunoChip) study of genetic associations
123 and liver cells, including at MTNR1B, where
fine mapping implicated rs10830963 as driving T2D associ
124 These results demonstrate that
fine mapping in AAs is a powerful approach for both narr
125 own BP locus (SOX6) and provide evidence for
fine mapping in four additional validated BP loci.
126 Through
fine mapping in German and Chilean samples, an approxima
127 tamers, intracellular cytokine staining, and
fine mapping in interferon-gamma enzyme-linked immunospo
128 We used natural variation and
fine mapping in the crop Brassica oleracea to show that
129 s risk variants and illustrates the value of
fine mapping in the resolution of GWAS signals.
130 1) are mediated, we undertook transancestral
fine-mapping in 22 086 cases and 42 539 controls of East
131 Fine-mapping in African Americans highlighted missense v
132 This study highlights the importance of
fine-mapping in diverse populations.
133 The goal of
fine-mapping in genomic regions associated with complex
134 s of this study suggest that high-resolution
fine-mapping in large samples can convert many discoveri
135 trait locus (QTL) mapping of F2 hybrids and
fine-mapping in nearly isogenic lines to characterize th
136 egions using genotyping and imputation-based
fine-mapping in populations of European (cases/controls:
137 Through
fine-mapping,
in three regions (1q32, 3p24, 10q25), we i
138 Fine mapping indicated contacts within the gp120 bridgin
139 Fine-mapping indicated association closest to the PKP2 g
140 two largest additive QTLs were subjected to
fine-mapping,
indicating the action of at least two gene
141 In a previous
fine-mapping investigation of 19 breast cancer loci, we
142 Fine mapping is a widely used approach for identifying t
143 by detecting lineage-level differences when
fine-mapping is intractable.
144 arental populations are innovative tools for
fine mapping large numbers of loci.
145 corneal button, genomewide linkage analysis,
fine mapping linkage and haplotype analysis, and screeni
146 Fine mapping localized a commonly deleted 78 kb region t
147 Recent
fine mapping methods using summary-level data require th
148 causal variant(s), a variety of statistical
fine-mapping methods have been proposed to prioritize va
149 Recent
fine-mapping methods using summary data from genome-wide
150 We performed
fine mapping of 39 established type 2 diabetes (T2D) loc
151 Fine mapping of 6p21.32-p22.1 identified 6 genome-wide s
152 Ps were analyzed, followed by imputation and
fine mapping of a region of interest on chromosome 14.
153 ovel genetic risk loci for CAD and performed
fine mapping of all 161 risk loci to obtain a credible s
154 Fine mapping of AQP4 p201-220 and p135-153 epitopes iden
155 l type-specific H3K4me3 peaks can inform the
fine mapping of associated SNPs to identify causal varia
156 uropean and Asian populations may facilitate
fine mapping of causal variants at loci shared across po
157 nsethnic meta-analysis for the discovery and
fine mapping of complex trait loci and have provided ini
158 Fine mapping of conformational epitopes is a powerful to
159 Fine mapping of cpRNP-RNA interactions in vivo suggests
160 Fine mapping of epitopes by surface plasmon resonance al
161 results provide a foundation for the further
fine mapping of genome regions that harbor loci that int
162 ce (TS) consortia focused on gene discovery,
fine mapping of loci, and functional genomics using stat
163 n is associated with quantitative traits, or
fine mapping of meiotic recombination, which is a key de
164 itional and village chicken populations, for
fine mapping of Mendelian traits using genome-wide singl
165 We also report the
fine mapping of metabolic traits such as plasma lipids.
166 , but GAL4 expression is often too broad for
fine mapping of neural circuits.
167 ubstantial improvements in the resolution of
fine mapping of potential causal variants by leveraging
168 th the use of these resource populations for
fine mapping of QTL is the reduced number of founding in
169 The map constructed will facilitate QTL and
fine mapping of quantitative traits, map-based cloning,
170 Fine mapping of several loci for LDL-cholesterol demonst
171 Genetic
fine mapping of sex-specific asthma association signals
172 Previous
fine mapping of the 10q22-23 locus in schizophrenia iden
173 Fine mapping of the 161 CAD loci generated lists of cred
174 enetic evidence, as well as resequencing and
fine mapping of the CD58 locus in patients with MS and c
175 Fine mapping of the chromosome 12 locus confirmed signif
176 s and independent case-control data sets for
fine mapping of the common variant association signal us
177 Fine mapping of the harlequin locus revealed a 25 kb int
178 Fine mapping of the HLA region identified association wi
179 Fine mapping of the interaction unexpectedly revealed a
180 Fine mapping of the mutation showed that the esd6 phenot
181 We performed haplotype analyses and
fine mapping of the ORMDL3 locus in a cross-sectional (I
182 Fine mapping of the region in this study and the EVE Ast
183 distachyon were exploited for saturation and
fine mapping of the Snn3-D1 locus.
184 In this study, we present a
fine mapping of the structural determinants that allow s
185 Fine mapping of these LOH regions revealed three non-ove
186 Here we report the
fine mapping of this locus using data from 101,943 subje
187 Here, we report the
fine mapping of this locus using data from 104,660 subje
188 ore of 3.1 at markers D2S393 and D2S337, and
fine mapping of this region with microsatellite markers
189 gene networks and novel cell subpopulations,
fine mapping of transcription kinetics, and the relation
190 = 57,292), we performed trans-ethnic (AA+EA)
fine-mapping of 54 established EA FG or FI loci with det
191 Here we report
fine-mapping of 94 inflammatory bowel disease loci using
192 We used SNP genotyping and imputation-based
fine-mapping of a multiethnic ALL case-control populatio
193 Fine-mapping of all loci will be required to reveal mark
194 fine a lower bound for P-values, which makes
fine-mapping of associated regions difficult because, in
195 n Mendelian randomization studies as well as
fine-mapping of causative variants.
196 nes in smaller cohorts and (ii) assisting in
fine-mapping of challenging regions, e.g. major histocom
197 Our post-GWA study highlights benefits of
fine-mapping of common disease variants in combination w
198 of the index signals found through GWAS and
fine-mapping of each locus in diverse populations will b
199 hput, saturating in situ mutagenesis permits
fine-mapping of function across genomic segments.
200 ions have led to improved identification and
fine-mapping of genetic variants associated with adaptat
201 Fine-mapping of genomic regions implicated in genome-wid
202 plotypes in African genomes have facilitated
fine-mapping of loci discovered in other human ancestry
203 Here, we show that
fine-mapping of pancreatic and testicular cancer GWAS wi
204 We perform
fine-mapping of PCa risk across TET2 using genotypes fro
205 Fine-mapping of that gene was performed, and 10 SNPs wer
206 We performed
fine-mapping of the 21 risk regions (including 250 kb on
207 Detailed
fine-mapping of the 23-Mb region of replicated linkage h
208 Fine-mapping of the association signals identifies speci
209 uely powered design, we investigated whether
fine-mapping of the HLA region could narrow the missing
210 ilibrium between the two populations allowed
fine-mapping of the locus to a 7 kb region overlapping e
211 Fine-mapping of the promoter activity revealed that two
212 We performed a
fine-mapping of the region in order to search the 6q23 r
213 Fine-mapping of these components in southern African pop
214 Additional
fine-mapping of this gene and functional genomic studies
215 Fine-mapping of this mutated modifier gene (M-locus) and
216 e need for functional studies and additional
fine-mapping of variants in the 1q12-locus.
217 thnic association analysis for discovery and
fine-mapping offers a framework for further follow-up an
218 f GWAS is that it always requires subsequent
fine-mapping or sequencing to pinpoint causal mutations.
219 tory marks) can be integrated for increasing
fine-mapping performance within single-population studie
220 Fine mapping placed the locus between markers at positio
221 0 recombination events in a large (N = 6153)
fine-mapping population.
222 Bivariate
fine mapping provided evidence that the individual varia
223 bined three distinct approaches: multiethnic
fine-mapping,
putative functional annotation (based upon
224 Although
fine-mapping reduced the genomic intervals and gene cont
225 Fine mapping,
resequencing, imputation, and haplotype an
226 We observed improvements in the
fine-mapping resolution at many susceptibility loci.
227 y modeling pleiotropic risk regions improves
fine-mapping resolution compared to standard single trai
228 ave demonstrated that our approach increases
fine-mapping resolution over existing methods.
229 ional annotation data, fastPAINTOR increases
fine-mapping resolution relative to existing methods.
230 We also demonstrate improved
fine-mapping resolution, in loci containing a single cau
231 71% of signals reside within genes and
fine mapping resolves 23 signals to one or two likely ca
232 nome sequences and combined with the genetic
fine mapping results to identify a list of candidate gen
233 Our
fine-mapping results indicate that in nine of 24 shared
234 However,
fine mapping revealed subtle and strong differences in h
235 led levels of genetic diversity, and further
fine mapping revealed that the control elements of mutat
236 Fine mapping revealed that the cysteine-rich domain of M
237 Fine mapping reveals that two variants correlated with r
238 to combine meta-analysis results and aids in
fine-mapping shared variants at these locations.
239 from the region where RSB1 was identified by
fine-mapping showed that a specific allele of AGAMOUS-Li
240 ished as a valuable tool for identifying and
fine-mapping signals of disease association in the MHC.
241 Further associated and
fine-mapping single nucleotide polymorphisms (SNPs) (n=
242 Forty-four SNPs (21 for discovery and 23 for
fine-mapping)
spanning 300 kilobases in and around COL5A
243 red to standard single trait and pleiotropic
fine mapping strategies.
244 we undertook an iterative and complementary
fine mapping strategy using family-based CL/P samples fr
245 Lastly, we described a
fine-mapping strategy for these 42 eQTL target-gene asso
246 eotide polymorphisms (SNPs) used in GWAS and
fine mapping studies have causal effects through their i
247 er prioritized potential loci for downstream
fine mapping studies in the search for CCLE specific sus
248 These results provide the basis for
fine mapping studies to narrow the disease interval and
249 r prioritized targets for downstream genetic
fine mapping studies.
250 Post-GWAS
fine-mapping studies are challenging, but the use of mul
251 Fine-mapping studies are required to determine whether t
252 Fine-mapping studies determined that nonneutralizing mAb
253 Although previous HLA
fine-mapping studies have identified amino acid polymorp
254 After
fine-mapping studies, the results were replicated in 1,1
255 (LD), and have been proposed to be useful in
fine-mapping studies.
256 o pinpoint the causal variants in subsequent
fine-mapping studies.
257 functional score that can be incorporated in
fine-mapping studies.
258 10(-5)), we performed a peakwide association
fine mapping study by using 1414 SNPs across approximate
259 This
fine-mapping study confirmed previous associations and i
260 A
fine-mapping study in a 110-kb region at 19q13 among CAP
261 We performed a
fine-mapping study of 14,551 subjects from multi-ancestr
262 Here, we conducted a large-scale
fine-mapping study of PsV risk in the MHC region in 9,24
263 Our trans-ethnic HLA
fine-mapping study reveals that (i) a common set of amin
264 potential causal variations, we performed a
fine-mapping study using 77 SNPs in a 194 kb segment of
265 Here we conduct the first
fine-mapping study, which thoroughly investigates the SL
266 00-fold larger, traditional imputation-based
fine-mapping study.
267 ng disease-associated variants in human, but
fine-mapping the causal variants remains a challenge.
268 Fine-mapping the primary MHC association through high-re
269 Finally,
fine-mapping the smallest subtelomeric rearrangements ha
270 Fine mapping these QTL can lead towards the identificati
271 Fine mapping these regions will likely identify novel ge
272 (1) demonstrates the utility of trans-ethnic
fine mapping through integration of GWASs involving dive
273 able for additional investigations including
fine mapping to elucidate the biological basis of the fi
274 allelic expression analysis and trans-ethnic
fine mapping to identify transcript-specific cis-acting
275 interrogating local population structure for
fine mapping to more accurately locate true casual genes
276 s (HS) facilitate gene discovery by allowing
fine mapping to only a few megabases, significantly decr
277 First, we performed
fine-mapping to define critical intervals that included
278 Fine-mapping to identify causal variants in genome-wide
279 The family data were used in the
fine-mapping to identify SNPs that showed novel associat
280 r locus using a single trait to 12 SNPs when
fine-mapping two traits simultaneously.
281 Fine-mapping uncovers a motif-disrupting common variant
282 Fine mapping using sequence and imputed genotype data ha
283 tion analysis Program (HAPRAP), that enables
fine mapping using summary statistics and haplotype info
284 ining cell types associated with disease and
fine mapping variants.
285 The panel of SNPs used for
fine mapping was also tested for association with transc
286 e region in which association was confirmed,
fine-mapping was performed (654 cases and 1,847 controls
287 For
fine mapping we interrogated SNPs within +/- 250 kb flan
288 With high-resolution Bayesian
fine mapping,
we identified five regions where one varia
289 Using linkage analysis and
fine mapping,
we identified the disease-causing gene, MC
290 Through genetic
fine mapping,
we prioritized rs9349379, a common SNP in
291 Here, through genetic
fine-mapping,
we define a set of tightly linked variants
292 Through
fine-mapping,
we identified markers in four regions that
293 RESEARCH DESIGN AND For
fine-mapping,
we sequenced WFS1 exons, splice junctions,
294 Linkage and
fine mapping were used to identify a region of interest
295 in the cold sore susceptibility region using
fine mapping with 45 SNP markers.
296 Fine mapping with microsatellite markers was compatible
297 statistical methods have been developed for
fine-mapping with the use of summary statistics from gen
298 ture mapping identified 5 significant peaks;
fine mapping within these peaks identified 2 rare varian
299 Fine-mapping within the 6q25 and possibly the 11p15 loci
300 Further
fine-mapping within those areas was generally unhelpful