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1 performance of metal-oxide catalysts can be fine-tuned.
2 ether, our findings reveal how signaling can fine-tune a committed chromatin state by phosphorylation
3 erate daily rhythms in hormone activity that fine-tune a range of plant processes, enhancing adaptati
5 hat their properties during synthesis can be fine tuned and optimized to further enhance their antimi
7 biological function, these findings point to fine-tuned and interdependent functional roles of specif
8 ial band-pass structures that do not require fine-tuning and are robust against environmental and cel
9 to-eukaryote transition allows for increased fine-tuning and broadening of Hsp70 function in eukaryot
12 logical plasticity mechanism for dynamically fine-tuning AP conduction velocity, which potentially ha
14 obably determined by hydrophobicity, but the fine tuning appears to arise from the distribution of ca
17 tigens, the 3'RR distal part, including hs4, fine-tuned B-cell receptor expression in newly formed an
20 l, although the level of T6SS transcripts is fine-tuned by AmrZ, all T6SS mRNAs are silenced by RsmA.
22 d polystyrene content of the material can be fine-tuned by controlling the duration of heating styren
24 ked activation of NAc shell (NAcSh) MSNs was fine-tuned by GABAergic monosynaptic innervation from ad
25 e the first evidence that HTR4 expression is fine-tuned by miRNAs, and that this regulation is impair
26 levels of ESX-1 substrates in M. marinum are fine-tuned by negative feedback control, linking the exp
27 chemical and pharmacological properties were fine-tuned by structural modifications in the arylacetam
28 magnitude of this multiorbital effect can be fine-tuned by variations in the pi-electron releasing/ac
29 rature; moreover, the rate of release can be fine-tuned by varying the solution pH and/or the APBA co
30 ent activity-sensors infers that this region fine-tunes calcium responsiveness and drug sensitivity o
33 hway is a vital regulator of organ size that fine-tunes cell proliferation, apoptosis, and differenti
35 of TCR complexes are orchestrated by several fine-tuned cellular processes that encompass (a) synthes
36 des specific modules that enable the user to fine-tune classification accuracy, to formalize the anno
39 ng protein, shedding light to understand the fine-tuning control of the different vesicle fusion even
40 .SIGNIFICANCE STATEMENT The cerebellum helps fine-tune coordinated motor actions via signaling from p
43 nal modification of steroid receptors allows fine-tuning different properties of this family of prote
45 l specification, the underlying mechanism of fine-tuning double flower formation remains largely uncl
46 et, sensory cortical area size appears to be fine tuned during development to respond to functional a
48 ed here indicate that EWNS properties can be fine-tuned during synthesis resulting in a multifold inc
50 us and heterogeneous catalyst design through fine-tuned edge-site environments of the Co centers.
52 e molecular details of this synchronized and fine-tuned energy conversion mechanism are not fully und
53 plants to adapt to changing environments by fine-tuning energy production in leaves and the availabi
55 ltiple genes, often within the same pathway, fine-tuning expression of key factors and stabilizing ge
57 F6 in vivo suggests that this interaction is fine-tuned for efficient HIV-1 replication in physiologi
60 ng site, the Tyr-541 residue participates in fine-tuning Gd(3+)-sensitivity, and that the Asn-584 res
61 n tRFs and other sRNAs might be important to fine tune gene expression and protein biosynthesis in pl
62 regulation by different splicing factors to fine tune gene expression programs during these physiolo
63 n tRFs and other sRNAs might be important to fine-tune gene expression and protein biosynthesis in pl
64 sh a post-transcriptional mechanism that can fine-tune gene expression during different physiological
65 onal activity is differentially recruited to fine-tune gene expression levels in each cardiac chamber
66 bed here is rapidly reversible, adaptable to fine-tune gene expression, and relies on Set2 and the Se
67 sing the expression of GA2ox2, HDT1/2 likely fine-tune gibberellin metabolism and they are crucial fo
69 rylation, in response to hormonal signaling, fine-tunes glycogenolysis to fulfill energetic and metab
71 ntrabodies and provide a novel framework for fine-tuning GPCR functions with potential therapeutic im
73 nase Gilgamesh (Gish)/CK1gamma and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/
74 ntroduces a hybrid approach for creating and fine tuning high-Q nanocavities, involving the local dep
78 -terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an alloster
80 udy identifies a novel role for microRNAs in fine-tuning immune homeostasis and thereby maintaining t
81 nd prevent immune complications early and to fine-tune immunosuppression, with the overall goal to im
83 ment for numerous optical elements and their fine tuning in conventional design, paving the way for r
84 d originate in cone-driven retinal pathways, fine-tuned in relay thalamic neurons outside the main vi
87 the urgent question about their role in the fine-tuned interplay between the pathogen and its mammal
88 mechanical regulation may enable the cell to fine tune its mechanotransduction via membrane receptors
89 unique (function in trans) features, able to fine-tune its own circadian oscillation, and consequentl
90 to a resolution of 1.9 A shows that Msd has fine-tuned its active site such that it is a hybrid of a
92 through TRalpha1 and TRbeta1, respectively, fine tune levels of SHH and IHH and, thereby control the
93 doplasmic reticulum enables the root cell to fine-tune lipid biosynthesis to increase the production
94 m its normal function in uninfected cells to fine-tune lipid raft cholesterol that regulates innate i
95 ump regulator repurposed during infection to fine-tune lipoprotein processing and host responses.
96 ype inactivation in potassium channels helps fine-tune long-term channel activity through conformatio
97 stem can simply alter leukocyte stiffness to fine tune margination/demargination and therefore leukoc
98 lation of BMP signal transduction provides a fine-tuning mechanism based on the two major enzymes tha
99 te that O-GlcNAcylation of DELLAs provides a fine-tuning mechanism in coordinating multiple signaling
102 for conferring stability to the NEFs, helped fine-tune mitochondrial protein quality control, and reg
103 integrate information from both pathways to fine-tune motor procedures and to acquire complex habits
105 supports host protection during infection by fine-tuning NF-kappaB activity, suggesting that SP110b m
106 d in vivo, and identify a ZNRF4-RIP2 axis of fine-tuning NOD2 signalling to promote protective host i
109 nominal M n+1AX n compounds enables not only fine tuning of existing properties but also entirely new
111 n underscores the importance of SLC25A46 and fine tuning of mitochondrial fission and fusion in ponto
112 ranscription factors and coregulators in the fine tuning of organismal metabolism.HDAC3 is a critical
114 unique, quantized activation process enables fine tuning of PANX1 channel activity and may be a gener
115 ays between pump and probe pulses allows for fine tuning of spectral resolution, bandwidth and imagin
117 of a Nedd8-moiety to Cullin proteins) in the fine tuning of the NF-kappaB response (via Cullin-1).
119 lar body and repair of adult tissues require fine--tuning of cell adhesion, cell mechanics, and inter
120 e for mounting novel responses and decreased fine-tuning of BCR specificities by somatic hypermutatio
122 to damaged chromatin, ZMYM3 facilitates the fine-tuning of BRCA1 interactions with DNA damage sites
125 material properties of the cell wall and the fine-tuning of cellular biophysical parameters in the mu
126 TIP isoforms allow the spatial and temporal fine-tuning of cellular water transport, which is critic
127 ase pathways and drug exposure, allowing for fine-tuning of clearance in response to specific conditi
129 calization and activity, suggesting that the fine-tuning of DA homeostasis involves multiple mechanis
130 al stresses that require the involvement and fine-tuning of different stress signaling pathways.
133 based EWNS platform was developed to enable fine-tuning of EWNS properties by modifying synthesis pa
135 our results demonstrate for the first time a fine-tuning of FACT by a ubiquitin proteasome system in
136 ent advances in the design, preparation, and fine-tuning of fluorophores by means of multicomponent r
138 , in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide ran
141 ively stimulate abortive termination without fine-tuning of kinetic rate parameters at ribosome stall
142 NHCs and provides a guide to the structural fine-tuning of ligand requirements and stereochemical mo
144 he body of work on the synthesis and optical fine-tuning of meso-aryl-substituted bacteriochlorins.
145 for a variety of processes, ranging from the fine-tuning of motor skill learning to important social
146 s without requiring any form of learning, or fine-tuning of neuronal parameters to replicate these re
148 icity and anisotropy, can further permit the fine-tuning of plasmon behaviors in borophene, potential
149 osine modulation may provide a mechanism for fine-tuning of plasticity and learning according to brai
150 criptome diversification is required for the fine-tuning of protein expression in monocytes, suggesti
151 eceptor-interacting proteins also facilitate fine-tuning of receptor activity and tissue specificity.
152 m memory, which is robust to noise and where fine-tuning of recurrent excitation or inclusion of sub-
153 ds for RGD-recognizing integrin subtypes; 5) fine-tuning of the affinity and selectivity by additiona
158 An easy synthetic approach has enabled the fine-tuning of the electronic structure of the organobor
160 rent solvent systems, as key factors for the fine-tuning of the extraction properties, are discussed.
161 propose a general mechanism that enables the fine-tuning of the Fermi velocity in Dirac materials in
162 l bursting individually allows combinatorial fine-tuning of the level of MHC class I gene expression
163 bis(diphenylphosphino)amine (DPPA) allows a fine-tuning of the ligand properties and offers a consid
164 ystematic study, we show that the structural fine-tuning of the linkers allows access to variations i
167 hes between hydrophilic and hydrophobic, but fine-tuning of the microenvironment is possible by adjus
170 uch polyplex formulation and determined that fine-tuning of the polyplex structure is essential for e
171 this deacetylase proteome could lead to the fine-tuning of the regulation of microtubule dynamics an
173 rsity of their building blocks, which allows fine-tuning of their chemical and physical properties by
175 nabled model provides insights into thermal "fine-tuning" of carbohydrate metabolism and a warning th
176 HECs constitute a negative feedback loop to fine-tune photomorphogenesis in Arabidopsis thaliana.
179 matin remodeler and a signaling component to fine-tune plant morphogenesis in response to environment
181 study underscores the critical importance of fine-tuned presynaptic control in normal brain function.
182 plicing of Nf1 is an important mechanism for fine-tuning Ras/ERK signaling as well as learning and me
183 at microfluidic technologies can undoubtedly fine-tune reaction times and reagents concentration prof
187 intenance of pancreatic beta cells through a fine-tuned regulation of cell proliferation and apoptosi
189 rd et al. describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin s
191 timization, as each of its components can be fine-tuned separately to increase reaction rates and/or
194 ility of certain growth factors but also the fine-tuned signaling cascades that are initiated by hypo
195 may be a general mechanism used by cells to fine-tune Smad3 activity in both basal and TGF-beta-stim
196 henotyping, we propose target haplotypes for fine-tuning starch structure in rice through marker-assi
197 rgy with nebulin to reinforce and temporally fine-tune striated muscle relaxation-contraction cycles.
199 ongly correlated regime and does not require fine tuning, suggesting that this state is generic for p
200 th sexual pheromones are widely studied as a fine-tuned system of intraspecific sexual communication
203 that for G:C W:W Trans , Mg(2+) binding can fine tune the basepair geometries without compromising w
204 under certain conditions, miRNA families can fine tune the biological effects of their regulation by
207 joints for turbo machinery blades, which can fine tune the normal contact load existing between the c
208 We present a crystal engineering strategy to fine tune the pore chemistry and CH4 -storage performanc
209 ch this is employed as a molecular switch to fine tune the relative expression of structural to non-s
210 cies that facilitate water dissociation, and fine tunes the electronic structure to weaken hydrogen a
211 ivalent approach may provide a mechanism for fine tuning the efficacy of allosteric compounds in futu
212 ted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical
215 how nature evolved alternative mechanisms to fine-tune the activity of a cysteine protease dubbed RD2
216 dings provide novel insights into how phages fine-tune the activity of the host transcription machine
218 onditions were closely monitored in order to fine-tune the applied strategy as well as facilitate the
219 o envisage that mutagenesis could be used to fine-tune the balance between the endogenous metabolic n
221 2 and functions in a rheostat-like manner to fine-tune the cell-type-specific transcription of genes
223 rotein kinase C activity, and is required to fine-tune the cytokine responses that control inflammati
227 ay in both strains, the mutant was unable to fine-tune the expression and activity of oxidative phosp
228 ons not only ensure quality control but also fine-tune the gene expression process, which must adapt
231 tor kappa B kinase subunit beta (IKKbeta) to fine-tune the inflammatory response to the strength of t
233 ve feedback circuits may enable S. mutans to fine-tune the kinetics and magnitude of the competence r
234 d then adopt a transfer learning strategy to fine-tune the model on enhancers specific to a cell line
235 nterlocked DNA nanostructure that is able to fine-tune the oxidative catalytic activity of a split DN
238 general, miRNAs function synergistically to fine-tune the regulation of biological processes and to
239 signal converges with the circadian clock to fine-tune the regulation of nuclear gene expression in A
240 he results point to an increasing ability to fine-tune the structure-dependent activity of MOF-suppor
241 s of immunity through two modes of action to fine-tune the timing and amplitude of defence responses.
242 ously inhibiting mTOR-regulated autophagy to fine-tune the timing and magnitude of this process and t
243 length, temperature and endogenous hormones fine-tune the timing of flowering for reproductive succe
245 suggest that Mule uses various mechanisms to fine-tune the Wnt pathway and provides multiple safeguar
246 y/hydrophilicity around the active sites and fine-tuned the selectivity in photocatalytic oxidation o
247 The CCAT2 interaction with the CFIm complex fine-tunes the alternative splicing of Glutaminase (GLS)
248 Therefore, the Kv1.3/PSD-95 association fine-tunes the anti-inflammatory response in leukocytes.
250 remains unknown, these data suggest that FAS fine-tunes the cell's response to stress and injury by r
251 GbetaL-ubiquitination-dependent switch that fine-tunes the dynamic organization and activation of th
253 ap opening through protease-Gag interactions fine-tunes the lifetime of the productive complex and he
254 rm heteromeric CRAC channels, in which ORAI2 fine-tunes the magnitude of SOCE to modulate immune resp
255 rai N terminus is essential for STIM1, as it fine-tunes the open Orai channel gating, thereby establi
256 nt that RCL-localized Asn(347) glycosylation fine-tunes the RCL cleavage rate by human neutrophil ela
257 potential role for a 'housekeeping' gene in fine-tuning the development of an ecologically important
259 ycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine si
260 ugh a feedback loop that might contribute to fine-tuning the expression of more than a thousand of MY
261 urther demonstrate the general importance of fine-tuning the integrative properties of neuronal dendr
262 with G1 progression may thus be critical for fine-tuning the orientation of the polarity axis in yeas
263 ategy allowed us to establish principles for fine-tuning the properties of fluorophores and to develo
264 the S1 helix also play an important role in fine-tuning the voltage dependence of activation, regula
267 iosis, providing clues as to how plant cells fine-tune their biology to enable symbiosis, and an exci
270 nts encounter a variety of stresses and must fine-tune their growth and stress-response programs to b
272 sensitive ion channels may use to detect and fine-tune their responses to different mechanical stimul
276 a versatile modification that can be used to fine-tune these cell cycle events, frequently through pr
277 a nexus for sleep and mood regulation while fine-tuning these processes to adapt to seasonal changes
278 ves, and their photophysical properties were fine-tuned through the incorporation of electron-withdra
280 nown about how transcriptional processes are fine-tuned to adjust to different environmental conditio
281 hypoxia is critical for cell survival and is fine-tuned to allow cells to recover from hypoxic stress
284 ssociation of the MTS with the beta-sheet is fine-tuned to balance MinE's need to sense MinD on the m
285 ulti-enzyme complexes, has been continuously fine-tuned to efficiently deconstruct recalcitrant carbo
287 cellular Ca(2+) application, the sensors are fine-tuned to physiological sensing range, and live-cell
288 arly indicates that plant stress response is fine-tuned to protect against stress-induced damages.
289 or activity of CXCL1 monomers and dimers are fine-tuned to regulate neutrophil trafficking for succes
290 o migrating through a moving flow, which are fine-tuned to the respective flight capabilities of each
292 incoherent feed-forward loops or networks to fine-tune transcription and thereby control diverse biol
293 f one or more genes from a distance but also fine-tune transcription of their host gene through trans
294 multiple regulatory layers for Hox genes to fine-tune transcriptional programs essential for develop
295 -regulatory elements in specific settings to fine-tune transcriptional regulation in response to envi
296 that CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 signaling in ECs, sugges
297 Retinal neurons use multiple strategies to fine-tune visual signal transduction, including post-tra
299 nstream of PINK1 and HTRA2 for mitochondrial fine tuning, whereas TRAP1 loss of function leads to red
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