ライフサイエンスコーパス: fine-tuning of

1 how that ABHD6 inhibition in vivo allows for fine-tuning of 2-AG levels in mice, therefore reducing l

2 ng from bacteria to humans; this facilitates fine-tuning of activities from signaling to catalysis.

3 genera also contribute to microevolutionary fine-tuning of adaptive traits within some species.

4 +) T cells as an intrinsic mechanism for the fine tuning of Ag-specific CD4(+) T cell response.

5 DCs, the action of which contributes to the fine-tuning of Ag cross-presentation.

6 With fine tuning of all aspects of the patient journey we can

7 , Crem loss-of-function mutation resulted in fine-tuning of all measured adrenal clock genes (Per1/2/

8 ernatively spliced, but the significance and fine-tuning of alternative splicing in different biologi

9 We report that this fine tuning of ATP and O2(.-) levels by cooling controls

10 t-dark regulation, mothra retained wild-type fine-tuning of ATP synthase activity in response to chan

11 electromotility, enabling amplification and fine-tuning of auditory signals.

12 e multiple levels of regulation that grant a fine tuning of BCL6 expression and activity in physiolog

13 e for mounting novel responses and decreased fine-tuning of BCR specificities by somatic hypermutatio

14 Our results show that fine-tuning of BCR-ligand recognition can lead to B cell

15 ur data suggest that PIST contributes to the fine-tuning of beta1AR sorting both during biosynthetic

16 We show a strict fine-tuning of binding and sequence-dependent alteration

17 h)) plays complex and important roles in the fine-tuning of both cellular and network activity.

18 eature double covalent dynamics allowing for fine-tuning of both exchange and incorporation processes

19 to damaged chromatin, ZMYM3 facilitates the fine-tuning of BRCA1 interactions with DNA damage sites

20 rial function that negatively impacts on the fine tuning of Ca(2+) dynamics.

21 Thus, the fine tuning of Ca(2+) signals plays a key role in shapin

22 of Ca(2+) efflux is likely important for the fine-tuning of Ca(2+)-dependent effectors close to the a

23 ocannabinoids (eCBs) allows for more precise fine-tuning of cannabinoid receptor signaling, thus prov

24 nabled model provides insights into thermal "fine-tuning" of carbohydrate metabolism and a warning th

25 te complex with actin and myosin that allows fine tuning of cardiac muscle contraction.

26 This vital function is based on the fine-tuning of cardiac performance by the Frank-Starling

27 Fine-tuning of cascade activity can occur through modula

28 whether it leads to cell death or LTD, thus fine-tuning of caspase-3 activation is critical in disti

29 Such location sensitivity may reflect fine-tuning of category-specific visual processing to re

30 lar body and repair of adult tissues require fine--tuning of cell adhesion, cell mechanics, and inter

31 are water channel proteins that mediate the fine-tuning of cell membrane water permeability during d

32 ion pathways results in tight regulation and fine tuning of cellular responses to various extracellul

33 material properties of the cell wall and the fine-tuning of cellular biophysical parameters in the mu

34 of KSRP destabilizes CX3CL1 mRNA, providing fine-tuning of cellular inflammatory reactions in respon

35 egration, as well as in the coordination and fine-tuning of cellular processes.

36 TIP isoforms allow the spatial and temporal fine-tuning of cellular water transport, which is critic

37 eful properties that can be tailored through fine-tuning of certain parameters, such as size, shape a

38 the Weyl semimetal state does not depend on fine-tuning of chemical composition or magnetic order, w

39 This provides a mechanism for acute fine-tuning of cholesterol transporter activity in respo

40 The fine-tuning of circuits in sensory cortex requires senso

41 ase pathways and drug exposure, allowing for fine-tuning of clearance in response to specific conditi

42 Sensing membrane curvature allows fine-tuning of complex reactions that occur at the surfa

43 Fine-tuning of compound properties was achieved by small

44 Fine tuning of conditions will be needed for other amino

45 Finally, we propose that precise fine-tuning of conduction along already-myelinated axons

46 the ecdysone receptor complex influences the fine-tuning of connectivity between neuronal circuits, i

47 e of building repulsive charge relies on the fine-tuning of contacts with the RRM1-RRM2 module.

48 and Arp2/3 and suggest a mechanism for rapid fine-tuning of cortex structure and mechanics by adjusti

49 Fine-tuning of cytokine-inducing pathways is essential f

50 ein-protein interactions may contribute to a fine tuning of cytoskeletal remodelling processes during

51 ltering agonist efficacy at alpha6* provides fine tuning of DA release and locomotor responses.

52 calization and activity, suggesting that the fine-tuning of DA homeostasis involves multiple mechanis

53 ating that m(6)t(6)A plays a general role in fine-tuning of decoding in organisms from bacteria to ma

54 ery via the phloem allows for flexibility in fine tuning of developmental programs to ensure newly de

55 ally associated with condensed chromatin and fine-tuning of developmental gene expression programs, i

56 al stresses that require the involvement and fine-tuning of different stress signaling pathways.

57 common and WspR-specific mechanisms for the fine-tuning of diguanylate cyclase activity.

58 recognition and metabolizing activities for fine tuning of DNA repair processes.

59 ated learning and addiction by modifying the fine tuning of dopaminergic cell firing.

60 pose a role for this feedback circuit in the fine-tuning of dopaminergic behaviors such as locomotion

61 Fine-tuning of electron-poor aromatic rings in position

62 n which structural changes are necessary for fine-tuning of electronic properties.

63 We conclude that a fine tuning of ERK1/2 signaling strength is critically i

64 based EWNS platform was developed to enable fine-tuning of EWNS properties by modifying synthesis pa

65 and increase efficiency of neural function, fine-tuning of excitatory and inhibitory neurotransmitte

66 nominal M n+1AX n compounds enables not only fine tuning of existing properties but also entirely new

67 This may contribute to the fine tuning of expression of the denitrification respiro

68 These adjustments involve fine-tuning of expression levels and mutual interactions

69 bacterial optogenetic control, allowing the fine-tuning of expression levels, programming of tempora

70 our results demonstrate for the first time a fine-tuning of FACT by a ubiquitin proteasome system in

71 nkage may reflect a permanent adjustment and fine-tuning of fibers connecting homologous cortical are

72 This may enable fine-tuning of filament switching in the cell.

73 LC-SOC1 signaling network contributes to the fine-tuning of flowering during changing seasons.

74 ent advances in the design, preparation, and fine-tuning of fluorophores by means of multicomponent r

75 ferentiation during embryogenesis and in the fine-tuning of fundamental biological processes, such as

76 MicroRNA is responsible for the fine-tuning of fundamental cellular activities and human

77 This fine tuning of GAL1/glycan interactions may be a strateg

78 thylation, other factors are involved in the fine tuning of gene dosage compensation in neutrophils.

79 perform endogenous functions required in the fine tuning of gene expression and in maintaining genome

80 , in particular microRNAs (miRNAs), regulate fine-tuning of gene expression and can impact a wide ran

81 Instead, they control the fine-tuning of gene expression and ensure regulatory pre

82 and human populations, which likely reflect fine-tuning of gene expression regulation during evoluti

83 in function of m(6)A is post-transcriptional fine-tuning of gene expression.

84 mRNA decay mechanisms suggests selection for fine-tuning of gene expression.

85 uf3p plays a broad, but nuanced, role in the fine-tuning of gene expression.

86 criptional regulation of RNA facilitates the fine-tuning of gene expression.

87 A-mediated feedback and feedforward loops in fine-tuning of gene expression; (ii) the miRNA-target in

88 o protein is fundamentally important for the fine-tuning of gene expression; additionally, precise tr

89 ion is a network design feature that permits fine-tuning of gene regulation and maintenance of homeos

90 ese data highlight a global coordination and fine-tuning of gene regulation during stress that mostly

91 , REST is essential for experience-dependent fine-tuning of genes involved in synaptic plasticity.

92 This process plays a fundamental role in the fine-tuning of HCN channel activity and is critical for

93 The results show that conformational fine-tuning of helical pore-forming peptides is a powerf

94 nd AtPMEI7 could be partners involved in the fine tuning of HG methylesterification during plant deve

95 tions as a mucosal protective factor through fine tuning of HIF activity.

96 Thus, we have discovered that fine-tuning of HlyA expression by the CpxRA system is cr

97 rties provide the possibility for additional fine-tuning of host defense.

98 that IL-15 has a negative regulatory role in fine-tuning of IL-17A production and Th17-mediated infla

99 Therefore, precise fine-tuning of IL-2 expression is crucial for adjusting

100 , cell trafficking to sites of inflammation, fine-tuning of immune responses leading to activation or

101 ral circuits, which often requires exquisite fine-tuning of inhibitory connections.

102 topes on the same target molecule may enable fine-tuning of intracellular delivery based on the hemod

103 ing osteoblast differentiation, allowing for fine-tuning of intricate cellular processes.

104 c26 proteins, allowing for dynamic and acute fine tuning of ion transport for various epithelia.

105 oped by cytochrome c for the solvent driven, fine-tuning of its redox functionality.

106 that this expansion of the JAZ family allows fine-tuning of JA-mediated transcriptional responses.

107 to regulation at multiple levels that allow fine-tuning of key biological responses.

108 ively stimulate abortive termination without fine-tuning of kinetic rate parameters at ribosome stall

109 uggest a mechanism for the tension-dependent fine-tuning of kinetochore-microtubule interactions.

110 Fine-tuning of Kv1.1 surface expression by RNA editing m

111 NHCs and provides a guide to the structural fine-tuning of ligand requirements and stereochemical mo

112 Fine tuning of light signaling is crucial to plant devel

113 -red- and blue/UV-sensing pathways, enabling fine-tuning of light responses to different spectral inp

114 HY5, downregulating BBX22 expression for the fine-tuning of light-mediated seedling development.

115 ntiation and offer a potential mechanism for fine tuning of lineage-restricted transcription factors

116 in the developing limb may contribute to the fine-tuning of local Hox activity that leads to proper m

117 findings provide a framework for structural fine-tuning of LOV scaffold proteins to maximize their p

118 ate the method's accuracy and to demonstrate fine-tuning of marker density as needed.

119 Tissue modulation is dependent on the fine-tuning of mechanical forces that are transmitted in

120 he body of work on the synthesis and optical fine-tuning of meso-aryl-substituted bacteriochlorins.

121 ation by promoting Tnfaip3 transcription and fine-tuning of metabolic reprogramming in macrophages.

122 The fine tuning of metabolism and hERG followed by different

123 icate that RASSF1A is a key regulator in the fine tuning of microtubule dynamics in interphase cells

124 n underscores the importance of SLC25A46 and fine tuning of mitochondrial fission and fusion in ponto

125 the tissue-specific regulation of OXPHOS and fine tuning of mitochondrial translation accuracy.

126 miRNAs are crucial for fine-tuning of molecular mechanisms.

127 noaminergic and peptidergic signaling in the fine-tuning of most behaviors.

128 ubiquitinase interactions and imply that the fine tuning of motion has played a key role in the evolu

129 for a variety of processes, ranging from the fine-tuning of motor skill learning to important social

130 tive valorisation of lignin requires careful fine-tuning of multiple "upstream" (i.e., lignin bioengi

131 s that MYB182 plays an important role in the fine-tuning of MYB134-mediated flavonoid metabolism.

132 8.0, a property likely to participate in the fine tuning of neuronal membrane potential and to neuron

133 ynaptic properties most likely underlies the fine-tuning of neuronal circuitry.

134 s without requiring any form of learning, or fine-tuning of neuronal parameters to replicate these re

135 cular and cellular events, resulting in the "fine-tuning" of neuronal circuitry.

136 ceptors, signal integration, and the dynamic fine-tuning of NK cell responses are discussed.

137 overlapping use of multiple adaptors permits fine-tuning of NK-cell ITAM responses over the course of

138 Fine-tuning of NP size and drug release kinetics was fur

139 d suggests that the Paf1C contributes to the fine tuning of nuanced levels of regulation that exist a

140 in this compound correlates closely with the fine-tuning of one of the band-edge singularities to wit

141 ensures site-specific NCP ubiquitination and fine-tuning of opposing enzymatic activities.

142 The fine-tuning of optical and switching properties relies o

143 ranscription factors and coregulators in the fine tuning of organismal metabolism.HDAC3 is a critical

144 en ITAM and RANK/TNFR signaling and allowing fine tuning of osteoclastogenesis during bone homeostasi

145 echanism refined by evolution to allow for a fine tuning of p38alpha kinase activity.

146 unique, quantized activation process enables fine tuning of PANX1 channel activity and may be a gener

147 lead to scale-invariant dynamics without any fine tuning of parameters or other model-specific constr

148 s to realize MF, however, generally requires fine-tuning of parameters.

149 lude that Suv39 activity is required for the fine-tuning of pericentric heterochromatin replication r

150 nctional conformations, this enzyme exerts a fine-tuning of phosphorylation signals.

151 ciated with the immune synapse, indicating a fine tuning of PKD responsiveness to DAG by additional r

152 icity and anisotropy, can further permit the fine-tuning of plasmon behaviors in borophene, potential

153 osine modulation may provide a mechanism for fine-tuning of plasticity and learning according to brai

154 s protein recoding by RNA editing allows for fine tuning of protein function.

155 criptome diversification is required for the fine-tuning of protein expression in monocytes, suggesti

156 tudy was to demonstrate the optimization and fine-tuning of quantitative and nonselective analysis of

157 a, the class I preQ(1) riboswitch allows the fine-tuning of queuosine biosynthesis in response to the

158 The importance of the FeS cluster for the fine-tuning of Rad3-DNA interactions is illustrated by s

159 crutinity of polymerization outcomes and the fine-tuning of reaction conditions.

160 eceptor-interacting proteins also facilitate fine-tuning of receptor activity and tissue specificity.

161 m memory, which is robust to noise and where fine-tuning of recurrent excitation or inclusion of sub-

162 ortant role in accelerating the evolutionary fine-tuning of regulatory networks.

163 the malleability of the active site with the fine-tuning of residue orientations and thermodynamic si

164 rved physiological role for Oma1 protease in fine-tuning of respiratory function.

165 d suggests that HS could regulate fusion via fine tuning of RhoA and Cdc42 activities.

166 e, to our knowledge, for the first time that fine-tuning of ROS production by RhoA, through a delicat

167 frequency of specific T cells depends on the fine-tuning of several parameters, the structural determ

168 ambiguity by IGF-binding proteins, reflects fine-tuning of signal transduction.

169 robust, rather than strategies that rely on fine tuning of specific behavioral parameters.

170 roles in RNA processing, contributing to the fine-tuning of specific signaling pathways.

171 ays between pump and probe pulses allows for fine tuning of spectral resolution, bandwidth and imagin

172 The fine-tuning of stoichiometry and organization is realize

173 l pathways have been suggested to accomplish fine-tuning of stress responses at the expense of growth

174 natural environment requires cross-talk and fine-tuning of stress signalling pathways.

175 However, rational fine-tuning of such responsive properties is very desira

176 n many interacting components that allow for fine-tuning of switching and memory properties.

177 central role of AMPARs in neurobiology, the fine-tuning of synaptic AMPA responses by endogenous mod

178 The regulatory pathways essential for the fine-tuning of synaptic inhibition have also emerged as

179 alternative splicing is thought to modulate fine-tuning of synaptic plasticity.

180 privation, 2-AG signaling may play a role in fine-tuning of synaptic strengths via presynaptically-ex

181 that FPN1 expression in erythroblasts allows fine-tuning of systemic iron utilization to ensure that

182 going autoimmune responses through the local fine tuning of T-cell-receptor-proximal activation event

183 epresent molecular tools for transcriptional fine tuning of target genes.

184 potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulati

185 unctional characteristics now allows for the fine-tuning of targeting strategies.

186 The dynamic fine-tuning of tendon ECM composition and assembly thus

187 al search efficiency but enables rapid local fine-tuning of TF search parameters.

188 roteolysis thus provide mechanisms for rapid fine-tuning of TFAM function and abundance in mitochondr

189 e novel mechanism proposes the DDB2-mediated fine-tuning of TGF-beta signaling and its downstream eff

190 Thus, the fine tuning of TGFbeta signalling derives from positive

191 e grooves on an amyloid fibril, resulting in fine tuning of the binding affinities for a specific amy

192 bond-breaking elementary steps and thus the fine tuning of the biological repair function for optima

193 While allowing for a fine tuning of the catalytic properties through ligand d

194 ls whose synthesis critically depends on the fine tuning of the crystal growth and error correction r

195 Fine tuning of the emission characteristics through stru

196 ed regions of imprinted genes, an additional fine tuning of the expressed allele is achieved by a mod

197 nd TFPI-dependent biologic responses and for fine tuning of the hemostatic balance in the vascular sy

198 ence suggests that galectin-3 is involved in fine tuning of the inflammatory responses at the periphe

199 of a Nedd8-moiety to Cullin proteins) in the fine tuning of the NF-kappaB response (via Cullin-1).

200 he two halves of CaM also contributes to the fine tuning of the orientation/distance between the redo

201 le of SLURP-1 in the epidermis is to provide fine tuning of the physiologic regulation of KC function

202 Fine tuning of the protein folding environment in subcel

203 (usually life history) time frames, offering fine tuning of the response to environmental context.

204 dings illustrate that Sox4 mediates critical fine-tuning of the 2 opposing forces in early B-cell dev

205 screening platform promises to enable rapid fine-tuning of the ABA sensors and engineering of plant

206 ds for RGD-recognizing integrin subtypes; 5) fine-tuning of the affinity and selectivity by additiona

207 the folding of the aptamer, allows rational fine-tuning of the affinity of our model aptamer across

208 Following fine-tuning of the anesthetic regime, stimulation elicit

209 The results showed a fine-tuning of the binding properties of [8]CPP 1 toward

210 Fine-tuning of the biophysical properties of biological

211 potential mechanism for the maintenance and fine-tuning of the BMP signaling pathway in various syst

212 Fine-tuning of the bone morphogenetic protein (BMP) path

213 , and the overall energy balance provide the fine-tuning of the Ca2+-induced conformational change in

214 This control allows for fine-tuning of the cellular phenotype, including regulat

215 n receptor trafficking and signaling for the fine-tuning of the cellular response.

216 ication and amplification may be followed by fine-tuning of the cis-regulatory element supplied by th

217 array of chemical reactions is attributed to fine-tuning of the cofactor-substrate interactions in th

218 In addition, fine-tuning of the crystal structure by changing the cry

219 Thus, fine-tuning of the cytokine expression appears to be ess

220 The fine-tuning of the degree of methylesterification of cel

221 n or peptide-based imaging probes and allows fine-tuning of the desired blood half-life, because long

222 negative feedback loops that allows for the fine-tuning of the dynamics of a mammalian signaling pat

223 The fine-tuning of the electronic properties and redox poten

224 An easy synthetic approach has enabled the fine-tuning of the electronic structure of the organobor

225 ion of excitation and inhibition and enables fine-tuning of the excitation-inhibition balance.

226 (reg) depended on PD-1 expression and that a fine-tuning of the expression of this molecule directly

227 rent solvent systems, as key factors for the fine-tuning of the extraction properties, are discussed.

228 The fine-tuning of the fatty acid flux between the acyl-CoA,

229 propose a general mechanism that enables the fine-tuning of the Fermi velocity in Dirac materials in

230 This work provides new insight into the fine-tuning of the flavin cofactor in offsetting the inn

231 hysiological and pathological conditions and fine-tuning of the flow of sensory information into the

232 We propose that progressive fine-tuning of the frequency coding and stabilization of

233 nt function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by

234 es at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination.

235 tigen insertion site and vector dose allowed fine-tuning of the in vivo growth and immunogenicity of

236 r, human LCN2-R-NTD could be involved in the fine-tuning of the interaction between NGAL and its cell

237 array can be reversibly manipulated allowing fine-tuning of the interparticle separation distance.

238 l bursting individually allows combinatorial fine-tuning of the level of MHC class I gene expression

239 In conclusion, fine-tuning of the levels of EBOV GP expressed at the su

240 ata suggest that it might be involved in the fine-tuning of the life span and function of activated D

241 bis(diphenylphosphino)amine (DPPA) allows a fine-tuning of the ligand properties and offers a consid

242 ystematic study, we show that the structural fine-tuning of the linkers allows access to variations i

243 Fine-tuning of the maintenance of lysogeny is facilitate

244 ocked a versatile toolbox for the design and fine-tuning of the material properties of these hydrogel

245 y acquisition, possibly allowing more subtle fine-tuning of the maturation process.

246 hes between hydrophilic and hydrophobic, but fine-tuning of the microenvironment is possible by adjus

247 rinciples of mu-EME transfer enabled further fine-tuning of the mu-EME process.

248 ial for improving the material properties by fine-tuning of the nanoscale architecture.

249 have predictable consequences and thus allow fine-tuning of the optoelectronic properties for special

250 hylenediamine kappa pharmacophore allows the fine-tuning of the pharmacodynamic and pharmacokinetic p

251 These modifications allowed for fine-tuning of the photoluminescence (PL) and ECL emissi

252 This modulation in turn allows for fine-tuning of the platinum center reactivity to match t

253 Fine-tuning of the pluripotency program is executed by a

254 uch polyplex formulation and determined that fine-tuning of the polyplex structure is essential for e

255 Fine-tuning of the pore opening size is critical for thi

256 antly, the ligands on the boronate allow for fine-tuning of the properties and reactivity of acylboro

257 This allows a fine-tuning of the properties of these macrocycles throu

258 gory, essential design parameters that allow fine-tuning of the properties of these magnetic responsi

259 lish successfully this challenging coupling, fine-tuning of the reaction conditions were required.

260 this deacetylase proteome could lead to the fine-tuning of the regulation of microtubule dynamics an

261 NAs that act both in cis and trans, enabling fine-tuning of the regulatory strength and dynamics.

262 on of RNA/codon-optimized gene sequences and fine-tuning of the relative expression levels of the two

263 ty of GAIT elements may provide hierarchical fine-tuning of the resolution of inflammation.

264 nd aryl boronate coupling partners, allowing fine-tuning of the resultant macrocycle conformation.

265 trolled reactivity and achieved quantitative fine-tuning of the self-assembled structures.

266 This enabled fine-tuning of the separation conditions for each indivi

267 receptive-field structures may arise from a fine-tuning of the spatial arrangement of synaptic input

268 Further fine-tuning of the substituent pattern in the sulfonamid

269 sition 7 of quinolinone ring combined with a fine-tuning of the substituents on the benzyl group in p

270 be integrated into one single 2.5 nm AuNP by fine-tuning of the surface coverage; a ratiometric pH re

271 s within the IleRS.tRNA complex, whereas the fine-tuning of the synthetic site is attained via confor

272 t procedure takes 4-6 h to perform; periodic fine-tuning of the system takes 1-2 h.

273 Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal

274 This striking cooperativity switch enables fine-tuning of the thermodynamic accessibility of the te

275 teroaromatic moiety provided a means for the fine-tuning of the UV/vis absorption and emission spectr

276 Golgi trafficking and thus contribute to the fine-tuning of the water permeability of the plasma memb

277 the cell membrane, their activation and the fine tuning of their biophysical properties are all dram

278 This allows for the fine tuning of their optical and electrochemical propert

279 en fixation systems, and that expression and fine-tuning of their activities are integrated with over

280 rsity of their building blocks, which allows fine-tuning of their chemical and physical properties by

281 ir detailed atomic structures, which enables fine-tuning of their functionalities for desired applica

282 Our results demonstrate that fine-tuning of their photophysical properties can be obt

283 Fine tuning of these hydrogels is easily accomplished by

284 The fine-tuning of these aryl substituents led to an array o

285 ering analysis, and we have demonstrated how fine-tuning of these parameters can improve the power co

286 , plays an important role in the control and fine-tuning of these stress responses.

287 aling in specific cases may have evolved for fine-tuning of this basic mechanism.

288 function of nonneuronal TRPM channels in the fine-tuning of this network activity.

289 and suggest that miRNAs are involved in the fine-tuning of this neurotrophin particularly in adultho

290 own-regulates Glut-1 and glucose uptake, and fine-tuning of this pathway may be a potential approach

291 ampal circuits throughout adulthood, and the fine-tuning of this process is likely important for effi

292 Here we explore how the fine-tuning of this unique replication system and the me

293 icroRNAs (miRNAs) has been implicated in the fine-tuning of TLR-mediated inflammatory response.

294 This mechanism likely participates in fine-tuning of transcript levels in response to differen

295 Hence, chromatin chaperone-mediated fine-tuning of transcription is crucial for driving morp

296 ssor activity and might be important for the fine-tuning of transcription regulation within this regi

297 Such a mechanism would permit the fine-tuning of transcriptional networks during different

298 offer untapped opportunities for therapeutic fine-tuning of Tregs and their all-important restraint o

299 n knowledge from the literature and requires fine-tuning of very few parameters.

300 litate host adaptation through sRNA-mediated fine-tuning of virulence gene expression.