ライフサイエンスコーパス: finely

1 y, and therefore ROS levels must be balanced finely.

2 Our data demonstrate that Tregs can finely adapt, or even subvert, their classical inhibitor

3 ns, volume, and duration of incubations were finely adapted with respect to the surface probe density

4 enabling fluctuations in survival signals to finely adjust apoptotic sensitivity.

5 f strategies for molecular biosensing over a finely adjustable dynamic range is essential for underst

6 rphology of the bee proboscis is shown to be finely adjusted to the floral morphology and nectar prod

7 lts indicate the presence of mechanisms that finely align the cytoskeleton of the axon with the one o

8 The formation of a finely and homogeneously dispersed, high Tammann tempera

9 anocrystals, we use gentle chemical means to finely and reversibly tune the nanocrystal band gap over

10 vides a stage score that enables one to more finely annotate each embryo so that they are divided int

11 rsely, mimic 130a treated lungs had numerous finely arborized branches extending into central lung re

12 nd provide stratification mechanisms to more finely assess response to therapy.

13 Plants need to finely balance resources allocated to growth and immunit

14 at 3 months or to treat indefinitely is more finely balanced after a first unprovoked proximal DVT or

15 The success of the immune response is finely balanced between, on the one hand, the need to en

16 ted using a numerical model, demonstrating a finely balanced expression range that is essential to su

17 These competing influences must be finely balanced in order to decorrelate odor representat

18 The mechanisms by which these finely balanced mechanotransduction events occur, howeve

19 nt and maintenance of an epithelium requires finely balanced rates of growth and cell death.

20 Signalling by Wnt proteins is finely balanced to ensure normal development and tissue

21 rdered enhanceosome assembly to maintain the finely balanced transcription program underlying naive p

22 ynamically forms aggregates and disrupts the finely-balanced gene control mechanisms in neuronal cell

23 n regulatory interactions that safeguard the finely-balanced transcriptional programs underlying plur

24 ole of the miR858-MYB83 regulatory system in finely balancing gene expression patterns during H. scha

25 Our results show that Notch signaling is finely calibrated in the cochlea to produce precisely tu

26 This finely calibrated response is controlled by the photorec

27 s linear and nonlinear features were able to finely characterize the affective haptic perception, wit

28 Here we show how liquids can be used to finely control disorder in porous 3D photonic crystals,

29 Such ability to finely control the affinity and dynamic range of aptamer

30 We demonstrate a strategy to trigger and finely control the assembly of supramolecular DNA nanost

31 beam lithography offers us the capability to finely control the structure of silk proteins in two and

32 The reported dealkylation reactions are finely controlled by the annealing parameters, which gov

33 my, either by iterative treatment or through finely controlled expression of mtZFN, which limits off-

34 acid (AA) in the final block copolymer were finely controlled from 0.25 to 0.94, and the molecular w

35 astating diseases, replication is robust and finely controlled to maintain genome stability and funct

36 , mixing and mass and heat transport are all finely controlled, and are easily modulated.

37 hat the processability and band gap could be finely controlled.

38 em cells to proliferate and differentiate is finely controlled.

39 This study suggests a paradigm for finely controlling the activity of DEAD-box proteins to

40 capable of processing biochemical inputs and finely controlling the assembly of DNA-based nanostructu

41 temperature of 120 K are in-situ obtained by finely controlling the oxidation reaction.

42 regulation of MT stability by p27(kip1) and finely controlling the spatiotemporal activation of the

43 iption/translation circuits but also require finely coordinated cytoplasmic and nuclear proteostasis.

44 This thus defines a feed-forward cycle that finely coordinates plant growth and nutrition.

45 ics, especially flexible RF electronics with finely defined patterns, thereby significantly broadenin

46 teen interactions in stabilizing the system, finely depicting the time-dependent disruption of the hy

47 velop a Gaussian Field Latent Class model to finely describe the effect of streets while controlling

48 By finely designing the curvature and torsion, double-stran

49 ulus is a contrast envelope, consisting of a finely detailed pattern (carrier) whose contrast varies

50 Here we describe the growth of a finely dispersed array of anchored metal nanoparticles o

51 ng of two immiscible phases, one of which is finely dispersed into the other.

52 apping mechanism may be the incorporation of finely dispersed V-Mo-Nb carbides in a ferrite matrix.

53 techniques have provided the opportunity to finely dissect cellular heterogeneity within populations

54 vasive tumor cells were typically round with finely divided, granular, or smudgy chromatin without pr

55 onal catalysts, synergistic interactions are finely engineered through modulating the degree of freed

56 luorescently labeled cells rapidly transit a finely focused, frequency-modulated laser beam.

57 e capacities and behaviors allowed T. rex to finely fragment bones and more fully exploit large dinos

58 The results revealed a finely graded gaze direction code in right anterior STS

59 The second network was more finely grained and comprised laminin 332 and laminins wi

60 on reporting guidelines and facilitates more finely grained data exploration and querying of datasets

61 ted by others, with the goal of developing a finely grained portrait of postdoctoral career outcomes

62 Electron microscopy revealed finely granular electron-dense deposits coating the surf

63 In this work, finely ground and heat-treated serpentinite [Mg3Si2O5(OH

64 d standardized skin prick tests (SPTs) using finely ground tree-nut solution and basophil activation

65 Evolution finely hones IAV genes to optimally infect and be transm

66 These mechanisms all rely on the finely interdispersed nanocomposite character of the sam

67 These living stromatolites are finely laminated and therefore, in texture, may better r

68 Finely-laminated sediments were deposited from ca. 5000

69 elopment of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this

70 The ability to organize and finely manipulate the hierarchy and timing of dynamic pr

71 To finely map transcriptionally active regions of the prote

72 While touch is finely mapped in the cerebral cortex, it remains controv

73 are dependent on Rad51 complex formation, we finely mapped the Rad51 interaction domain in Rdh54, gen

74 We finely mapped the Rj4 locus within a small genomic regio

75 We have finely mapped the two DNA binding domains in RAD51AP1 an

76 DENV4 were isolated, and their epitopes were finely mapped using recombinant viruses and alanine scan

77 Our approach finely maps genomic inserts capable of supporting plasmi

78 ssessed with good efficiency, except for the finely matched nested case-control design, where matchin

79 oscopy (SEM) imaging showed a non-porous and finely meshed microstructure for the crosslinked gels co

80 development of further derivatives, able to finely modulate multiple pathways of cancer or parasite

81 This later finely modulates the strain of individual actomyosin int

82 ecific contribution of each cell type can be finely monitored by analyzing morphology, vitality, calc

83 ption defects of the JAM-C SC KO animals, on finely myelinated sensory nerve fibers.

84 may provide a platform for the discovery of finely optimized catalysts.

85 suggest that pathogen-host interactions are finely orchestrated by ETEC and are characterized by coo

86 An immune response consists of a finely orchestrated interplay between initial recognitio

87 The gradual comprehension of the finely orchestrated nature of intercellular communicatio

88 DC development and activation is finely orchestrated through transcriptional programs.

89 the view that diversity is promoted by more finely partitioned niches, although not simply by coevol

90 lb interneuron subtypes that are produced in finely patterned progenitor domains in the anterior vent

91 a continuum of cis-interaction profiles that finely position individual cells along the cell cycle.

92 Finely preserved details also reveal similarities in pro

93 HSP70 machinery with powerful, flexible, and finely regulatable disaggregase activity and a further l

94 f additional coactivator proteins, which can finely regulate HBV transcription.

95 Achieving strategies to finely regulate with biological inputs the formation and

96 acement strategies that can be triggered and finely regulated at either basic or acidic pHs.

97 s of Notch signaling are highly variable and finely regulated at multiple levels, but also depend on

98 functional properties of actin filaments is finely regulated by actin-binding proteins; however, the

99 kbone, nucleobase, and ribose conformations, finely regulated by the combination of hydrogen bonds an

100 se that the activity of the ATG4 protease is finely regulated by the intracellular redox state, and i

101 efore, our data underscore the importance of finely regulated endosomal traffic in TCR signal transdu

102 mechanism by which mTORC1 activation may be finely regulated in a tissue-specific manner in response

103 f great importance to understand how YBX1 is finely regulated in cancer.

104 ults indicate that HAS2 transcription can be finely regulated not only by recruiting transcription fa

105 Small differences (e.g., <1 pH unit) and yet finely regulated physiological pH inside different endoc

106 Blood coagulation is a finely regulated physiological process culminating with

107 accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiologic

108 Production of SIgA is finely regulated, and distinct T-independent and T-depen

109 RSNO levels are finely regulated, and dysregulation is associated with t

110 f photosynthesis, requiring that its rate be finely regulated.

111 d amplitude of autophagy activity have to be finely regulated.

112 ation of extracellular matrix components are finely regulated; however, when matrix replacement goes

113 umber of parasites within a cyst, suggesting finely-regulated asynchronous replication of the parasit

114 Ca(2+) influx into the mitochondrial matrix, finely regulates metabolic energy production.

115 s, we propose that Gcn5-mediated acetylation finely regulates Rph1 protein level and that autophagic

116 Our work highlights the importance of finely regulating flavivirus polyprotein processing.

117 HB1 is deleterious for the plant and, hence, finely repressed by a translational mechanism.

118 ble molecular population genetics methods to finely resolve uncharacterized functional noncoding elem

119 uitable habitat and environment simulated by finely resolved biogeochemical models, under three IPCC

120 We leveraged finely resolved congestion data to investigate short-ter

121 traditional societies of eastern Indonesia, finely resolved cophylogenies of languages and genes rev

122 Here we use finely resolved spatial and temporal influenza disease d

123 Point-based approaches implemented with finely sampled telemetry data overestimate the presence

124 Finely-set small-scale experiments are not only very exp

125 action was carried out at 100 degrees C from finely sized particles (249 mum) in a 1:12 solute:solven

126 ability and distance sensitivity using (a) a finely spaced DNA ladder carrying a restriction site for

127 More finely stratifying the sample according to clinical judg

128 ow Alfvenic motions permeate the dynamic and finely structured outer solar atmosphere.

129 fy this balance, potentially leading to more finely tailored therapeutic strategies.

130 A new method of finely temperature-tuning osmotic pressure allows one to

131 Whisking rodents can discriminate finely textured objects using their vibrissae.

132 nematic elasticity could offer ways to tune finely the spatial organization of complex colloidal sys

133 sm or developmental delay syndromes, using a finely tiled array platform (>1 kbp) in 142 children mat

134 rther, the entire CNV load detected with the finely tiled array was contributed by common variants.

135 in the auditory neural system are optimized finely to process and discriminate behaviorally relevant

136 We sought to finely trace the temporal evolution of spatial biases by

137 and 360(+/-15) nm wide, and their period is finely tunable in situ from 500 nm to 7 mum.

138 dered actin network may allow a cell to more finely tune control of molecular release enabling a more

139 der inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sit

140 ure could modulate stability in GASright and finely tune dimerization to support biological function.

141 A variety of signals finely tune insulin secretion by pancreatic beta cells t

142 like all other persistent pathogens, has to finely tune its interplay with the host cellular machine

143 codon optimization exists as a mechanism to finely tune levels of mRNAs and, ultimately, proteins.

144 ting and vasoconstricting systems that could finely tune local blood flow depending on neuronal activ

145 on cycling can be deliberately controlled to finely tune mesoporous structure of the metal oxide sphe

146 The capability to finely tune multimetallic nanoparticle morphology stems

147 precedented employment of a chemical tool to finely tune specific mechanisms underlying telomere main

148 lexity of input signals that can converge to finely tune the activity of the PhoP/PhoQ system.

149 range of different halide precursors, we can finely tune the chemical composition and the optical pro

150 Cells finely tune the generation and amplification of [Ca(2+)

151 an epitaxial perovskite film can be used to finely tune the lattice symmetry by modifying the local

152 were investigated and optimized in order to finely tune the performance of the MIP-based sensor.

153 in which a neighbouring functional group can finely tune the reactivity of the isocyano group or can

154 ine whether the structural adjustments could finely tune the release kinetics in the range of minutes

155 The possibility to finely tune the stiffness, size and shape of this simple

156 ysiological functions and various mechanisms finely tune their activity, including the Ca(2+) ion its

157 BAA receptors, which provides a novel way to finely tune their function in physiological and pathophy

158 processed and integrated, and their numerous finely tuneable bandgaps that cover a broad spectral ran

159 xponential to the stationary phase exhibit a finely tuned adaptive metabolic mechanism that enables s

160 print for engineering molecular anchors with finely tuned affinities to effectively enhance the barri

161 data indicate that connectivity within V1 is finely tuned and precise at the level of individual neur

162 tween four radicals has been efficiently and finely tuned and the resulting allosteric complexation i

163 Thus, a finely tuned balance between (pA)p suppression and usage

164 fficiency of lamellipodia is determined by a finely tuned balance between lamellipodial and cytosolic

165 We conclude that a finely tuned balance between the GAG-bound dimer and fre

166 ffect variegation, providing evidence that a finely tuned balance between the levels of JIL-1 and the

167 Therefore, a finely tuned balance between the opposing forces of AC22

168 Overall, we find a finely tuned balance between thermodynamic and kinetic p

169 s is maintained to control cell death and is finely tuned by an inducible antioxidant program.

170 This process is finely tuned by both cell-autonomous and non-cell-autono

171 the dye dipoles and surface plasmons can be finely tuned by coupling the dye molecules to specific s

172 We conclude that some mammalian CREs are finely tuned by evolution and function through complex,

173 the vagus (DMV) neurones, whose activity is finely tuned by GABAergic and glutamatergic synaptic inp

174 ated that efficacy and biased agonism can be finely tuned by minor structural modifications to the he

175 Because T cell differentiation is finely tuned by multiple positive and negative regulator

176 rotein-protein complexes whose functions are finely tuned by rapidly changing environmental condition

177 n enzyme dynamin-related protein 1 (Drp1) is finely tuned by several post-translational modifications

178 These conformational states are finely tuned by substrate availability and purine balanc

179 uard cell actin filaments, a process that is finely tuned by the conserved SCAR/WAVE-Arp2/3 actin reg

180 sine phosphorylation of specific proteins is finely tuned by the dynamic balance between protein tyro

181 que metallocofactor, the H-cluster, which is finely tuned by the surrounding protein environment to u

182 the reactivity of these electrophiles can be finely tuned by varying the substituents on the aryl rin

183 napses called memristors, conductance can be finely tuned by voltage pulses and set to evolve accordi

184 sodium ions over other cations, enabling the finely tuned cascade of events associated with action po

185 opting specific conformations in response to finely tuned changes in Ca(2+)-concentration.

186 nism in which Tc17 cells are controlled by a finely tuned collaboration between the different types o

187 sis is a tightly regulated process requiring finely tuned complex interactions between different cell

188 Triton X-100 is employed at finely tuned concentrations to render RBCs highly permea

189 The finely tuned control of SCL's regulatory functions (line

190 at JUB1 constitutes a central regulator of a finely tuned control system that modulates cellular H(2)

191 This occurs in finely tuned cortical microcircuits whose functions are

192 tructure, hence the ferroelectricity, can be finely tuned depending on the anisotropy of the rare ear

193 ophisticated plant immune system, suggesting finely tuned discrimination of mutualists and commensals

194 provide promising new avenues to direct the finely tuned engineering of crop yield and traits.

195 ectron transfer pathway in alpha2 suggests a finely tuned evolutionary adaptation of RNR to control t

196 amework in which control is mediated through finely tuned excitatory and inhibitory drives resonates

197 ating osteoblast and osteoclast activity and finely tuned expression of inflammatory molecules, resul

198 ve migration, but their precise role and the finely tuned expression that orchestrates this complex d

199 er, these findings suggest that the DMPFC is finely tuned for processing social interaction above oth

200 mmunity trait space indicating that they are finely tuned for the available conditions.

201 roteomic data (realised niches), we identify finely tuned gene expression governing resource usage by

202 The mechanism of this finely tuned genetic switch depends on differential bind

203 relaxation (kT1-->S0) rate constants can be finely tuned in M-(PM')n-M compounds and (ii) demonstrat

204 Light utilization is finely tuned in photosynthetic organisms to prevent cell

205 Memories are encoded by finely tuned interactions within large-scale neuronal ne

206 que structure is critically dependent on the finely tuned interplay between disulfide bonding and N-g

207 Together, these results indicate that finely tuned levels of Lamin B1 are required for NSC dif

208 A finely tuned lipid assembly machinery is required to bui

209 sed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of w

210 the development of novel metamaterials with finely tuned magnetic properties, such as reconfigurable

211 extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time s

212 This study highlights a finely tuned mechanism for regulating histone demethylas

213 This model suggests a finely tuned mechanism that balances transcription speed

214 are necessarily highly competitive and have finely tuned mechanisms to adjust growth and development

215 Nature provides highly evolved, finely tuned molecular machinery for solar energy conver

216 etabolic and physiological processes through finely tuned molecular mechanisms.

217 borate process that integrates a plethora of finely tuned molecular processes ranging from carefully

218 s involves generation of new neurons through finely tuned multistep processes, such as neural stem ce

219 s, highly selective protein interactions and finely tuned on/off switches.

220 t of a multicellular organism depends on the finely tuned orchestration of cell proliferation, differ

221 layed characteristics consistent with a more finely tuned oscillatory drive.

222 substituents at positions 4 and 6 and can be finely tuned over a broad range of conformation ratios.

223 dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in syste

224 ts that regulate diffusive processes through finely tuned particle-network interactions.

225 s a novel method for developing carbons with finely tuned pores for a variety of applications, such a

226 This is a very finely tuned process regulated by an emerging number of

227 l particle assembly, and nuclear export is a finely tuned process requiring the concerted actions of

228 cellular polysaccharide, is synthesized in a finely tuned process that involves the activity of glyco

229 Capsid assembly and maturation are finely tuned processes in which viral and host factors p

230 cells maintain tissue homeostasis through a finely tuned program of responses to both physiological

231 res the design of enhanced fluorophores with finely tuned properties.

232 The results uncovered a finely tuned regulation able to shift the precursor path

233 Our findings highlight the importance of finely tuned regulation of EDNRA signaling during human

234 and virulence, confirming that this complex, finely tuned regulation system is crucial in the interac

235 Collectively, these data reveal a finely tuned regulatory mechanism for controlling signal

236 A finely tuned regulatory network orchestrates the biogene

237 and the wild-type F-MLV strain, suggesting a finely tuned relationship between the levels of mCAT1 in

238 geometric, and chemical properties have been finely tuned relative to the corresponding residues in w

239 The finely tuned response of mTOR to these stimuli results i

240 hanisms for T-cell activation and allows for finely tuned responses to extracellular cues.

241 employs a prion mechanism to create stable, finely tuned self-perpetuating biochemical memories.

242 A finely tuned sensory to projection neuron network secure

243 set of neural oscillators for PD, but a more finely tuned set of oscillators in ET.

244 tions also exist for perioral exploration, a finely tuned skill requiring the combination of motor an

245 than previously assumed and rather involves finely tuned surface-water interactions.

246 This finely tuned system is responsive to developmental and p

247 re states of the organism and the world in a finely tuned system to control ingestion.

248 mucosa of the intestinal tract represents a finely tuned system where tissue structure strongly infl

249 le changing the nature of the Xaa side chain finely tuned the conformers ratio.

250 perties of reactive ferryl intermediates are finely tuned through hydrogen bonding interactions betwe

251 ability to stabilize gas microbubbles can be finely tuned through variation of the surface-modificati

252 Thus, finely tuned TMS treatment has great potential to become

253 nditions, the activity of these receptors is finely tuned to effectively mediate host defense yet con

254 all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance between fi

255 rstanding how HECT ubiquitin ligases must be finely tuned to ensure normal cellular behavior.

256 The architecture of Kepler-223 is too finely tuned to have been formed by scattering, and our

257 otic genomes, but their mobilization must be finely tuned to maintain host organism fitness and allow

258 rotein family that have affinity differences finely tuned to mediate their biological roles.

259 However, because ILCs are finely tuned to perturbations within tissue microenviron

260 Our data illustrate how excitability can be finely tuned to provide specific firing templates by the

261 We propose that tynA and feaB expression is finely tuned to provide the FeaB activity that is requir

262 affinity and transcription factor levels are finely tuned to regulate stochastic expression, setting

263 detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their h

264 fabrication of such particles are typically finely tuned to specific monomer or polymer species, siz

265 OR effector translational repressor 4E-BP is finely tuned to the nutritional requirements of the fema

266 que transients of bar-fixation saccades were finely tuned to the speed of bar motion and were trigger

267 l black hole, but requires an accretion rate finely tuned to the thermodynamic state of the hot gas.

268 Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific rep

269 al in embryonic stem cells (ESCs) requires a finely tuned transcriptional circuitry wherein the pathw

270 The data presented here indicate that the finely tuned transcriptional control upon salt stress is

271 llary bridges and resulting particles can be finely tuned using several addressable parameters: (i) t

272 d and interrupted pericyclic pathways can be finely tuned via a combination of structural and electro

273 e, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, s

274 Second, these DA events are finely tuned within and between frequency domains as bui

275 conditions (concentration, pH, etc.) can be finely tuned without cross-contamination, allowing the s

276 se results show that active PFL synthesis is finely tuned, and feed-back inhibition and activation ar

277 rain functions and neurological diseases are finely tuned, and in certain cases fully determined, by

278 ount of PP1 targeted to kinetochores must be finely tuned, because recruitment of either no or one ex

279 cal stimulus can be directly translated into finely tuned, dynamic adjustments of optical transparenc

280 RNA editing is a finely tuned, dynamic mechanism for post-transcriptional

281 ssumed that gene regulatory interactions are finely tuned, how accurate gene regulation could evolve

282 results show that functional connectivity is finely tuned, with important implications for signal pro

283 lengthscales of phase separated morphologies finely tuned.

284 nt lengths or TiO(2) shell thicknesses to be finely tuned.

285 ndividuals but can become detrimental if not finely tuned.

286 regation of the triblock comicelles could be finely tuned.

287 This directional flux can be finely-tuned by the relative number of myosin V and VI m

288 us uncover a ciliopathy protein complex that finely tunes dishevelled levels, thereby modulating plan

289 DA finely tunes its own synthesis and release by activating

290 The results demonstrate that attention finely tunes neuronal communication at the synaptic leve

291 It is also found that hydration finely tunes the electric field distribution between AuN

292 These results demonstrate that the thalamus finely tunes the frequency of slow waves during non-REM

293 Together, our results reveal that PKR finely tunes the network activity that must be maintaine

294 ignature, whereas the residue at position 19 finely tunes the regulator/operator interaction.

295 These applications illustrate the benefit of finely tuning nanoscale conduit geometries, which can be

296 These are constructed for finely tuning the delivery of chemical or biochemical sp

297 The possibility of finely tuning the macrocycle properties by synthetic mod

298 sses close to the surface can be achieved by finely tuning the relative concentration of the alloy co

299 design of efficient electrocatalysts through finely tuning their electrical conductivities.

300 sfer between host CdS QDs and dopants can be finely turned in a wide range by dopant migration toward