ライフサイエンスコーパス: finely tuned

1 ndividuals but can become detrimental if not finely tuned.

2 nt lengths or TiO(2) shell thicknesses to be finely tuned.

3 ndicate that the availability of IUPs can be finely tuned.

4 regation of the triblock comicelles could be finely tuned.

5 lengthscales of phase separated morphologies finely tuned.

6 xponential to the stationary phase exhibit a finely tuned adaptive metabolic mechanism that enables s

7 print for engineering molecular anchors with finely tuned affinities to effectively enhance the barri

8 data indicate that connectivity within V1 is finely tuned and precise at the level of individual neur

9 onditions suggests that AREs are involved in finely tuned and stringent control of gene expression.

10 tween four radicals has been efficiently and finely tuned and the resulting allosteric complexation i

11 ulation of this second messenger needs to be finely tuned and well balanced in a context dependent ma

12 These channels are finely tuned, and either increased or decreased channel

13 se results show that active PFL synthesis is finely tuned, and feed-back inhibition and activation ar

14 quirements for inhibitory activity at P2 are finely tuned, and in agreement with the library work, th

15 rain functions and neurological diseases are finely tuned, and in certain cases fully determined, by

16 ds the prometaphase spindle and augments the finely tuned, antagonistic kinesin force balance to main

17 This has enabled a more finely tuned approach to the understanding of placode in

18 emonstration that the SSB-ssDNA complex is a finely tuned assembly in dynamic equilibrium among sever

19 Thus, a finely tuned balance between (pA)p suppression and usage

20 This finely tuned balance between interdomain rigidity and fl

21 fficiency of lamellipodia is determined by a finely tuned balance between lamellipodial and cytosolic

22 We conclude that a finely tuned balance between the GAG-bound dimer and fre

23 ffect variegation, providing evidence that a finely tuned balance between the levels of JIL-1 and the

24 Therefore, a finely tuned balance between the opposing forces of AC22

25 Overall, we find a finely tuned balance between thermodynamic and kinetic p

26 how that wild-type morphology results from a finely tuned balance in the expression of brlA, medA and

27 esponse to Candida infections necessitates a finely tuned balance of IFN-gamma production.

28 lized in a delocalized fashion, preserving a finely tuned balance of stabilizing interactions through

29 ount of PP1 targeted to kinetochores must be finely tuned, because recruitment of either no or one ex

30 During development, BMP activities are finely tuned by a number of modulators at the extracellu

31 s is maintained to control cell death and is finely tuned by an inducible antioxidant program.

32 probability (P(o)) of the BK(Ca) channel was finely tuned by bilayer thickness, first decreasing with

33 This process is finely tuned by both cell-autonomous and non-cell-autono

34 tructure and ionizable group composition was finely tuned by changing the pH of the dipping solution.

35 the dye dipoles and surface plasmons can be finely tuned by coupling the dye molecules to specific s

36 We conclude that some mammalian CREs are finely tuned by evolution and function through complex,

37 the vagus (DMV) neurones, whose activity is finely tuned by GABAergic and glutamatergic synaptic inp

38 chiometry in virions and that infectivity is finely tuned by host cyclophilin A expression levels.

39 produces oscillations whose frequencies are finely tuned by methylation and by phosphorylation.

40 ated that efficacy and biased agonism can be finely tuned by minor structural modifications to the he

41 Because T cell differentiation is finely tuned by multiple positive and negative regulator

42 idence suggests that cell death pathways are finely tuned by multiple signaling events, including dir

43 rotein-protein complexes whose functions are finely tuned by rapidly changing environmental condition

44 -Teller surface area of these carbons can be finely tuned by selecting proper experimental conditions

45 n enzyme dynamin-related protein 1 (Drp1) is finely tuned by several post-translational modifications

46 These conformational states are finely tuned by substrate availability and purine balanc

47 fferentiation of TCR(hi) CD8(+) cells can be finely tuned by synthetic amino acids in the peptide, wh

48 uard cell actin filaments, a process that is finely tuned by the conserved SCAR/WAVE-Arp2/3 actin reg

49 sine phosphorylation of specific proteins is finely tuned by the dynamic balance between protein tyro

50 que metallocofactor, the H-cluster, which is finely tuned by the surrounding protein environment to u

51 outflow to visceral organs is modulated and finely tuned by vagal afferent fibres.

52 m through which the activity of VGCCs can be finely tuned by various neurotransmitters, hormones and

53 the reactivity of these electrophiles can be finely tuned by varying the substituents on the aryl rin

54 napses called memristors, conductance can be finely tuned by voltage pulses and set to evolve accordi

55 This directional flux can be finely-tuned by the relative number of myosin V and VI m

56 sodium ions over other cations, enabling the finely tuned cascade of events associated with action po

57 opting specific conformations in response to finely tuned changes in Ca(2+)-concentration.

58 aken together, this study provides access to finely tuned chlorins for spectroscopic studies and dive

59 nism in which Tc17 cells are controlled by a finely tuned collaboration between the different types o

60 sis is a tightly regulated process requiring finely tuned complex interactions between different cell

61 ets in a strain-specific manner, implicating finely tuned, complex receptor systems in NK xenorecogni

62 Triton X-100 is employed at finely tuned concentrations to render RBCs highly permea

63 The finely tuned control of SCL's regulatory functions (line

64 at JUB1 constitutes a central regulator of a finely tuned control system that modulates cellular H(2)

65 opper resistance, suggesting that there is a finely tuned copper redox balance at the yeast plasma me

66 This occurs in finely tuned cortical microcircuits whose functions are

67 tructure, hence the ferroelectricity, can be finely tuned depending on the anisotropy of the rare ear

68 kely to be important for specificity and for finely tuned differences in cell-type-specific alternati

69 construction of nanoscale objects that have finely tuned dimensions, orientation, and structure with

70 cell by apoptosis, caspase activation, when finely tuned, directs alternative cellular functions ind

71 ophisticated plant immune system, suggesting finely tuned discrimination of mutualists and commensals

72 The authors conclude that finely tuned dopaminergic signaling within the dorsal st

73 cal stimulus can be directly translated into finely tuned, dynamic adjustments of optical transparenc

74 RNA editing is a finely tuned, dynamic mechanism for post-transcriptional

75 provide promising new avenues to direct the finely tuned engineering of crop yield and traits.

76 ectron transfer pathway in alpha2 suggests a finely tuned evolutionary adaptation of RNR to control t

77 amework in which control is mediated through finely tuned excitatory and inhibitory drives resonates

78 ating osteoblast and osteoclast activity and finely tuned expression of inflammatory molecules, resul

79 ve migration, but their precise role and the finely tuned expression that orchestrates this complex d

80 can limit its own generation by triggering a finely tuned "feedback" mechanism whereby A2 becomes ser

81 er, these findings suggest that the DMPFC is finely tuned for processing social interaction above oth

82 est that its role as a ubiquitin receptor is finely tuned for proteasome targeting.

83 mmunity trait space indicating that they are finely tuned for the available conditions.

84 roteomic data (realised niches), we identify finely tuned gene expression governing resource usage by

85 esults further suggest that mariners are not finely tuned genetic entities and that a greater amount

86 The mechanism of this finely tuned genetic switch depends on differential bind

87 Ibbeta3 TM heterodimer shows the hallmark of finely tuned heterodimeric interaction, while homomeric

88 ding capacity in the ER and in the ways of a finely tuned homeostat adjusts organelle abundance accor

89 ssumed that gene regulatory interactions are finely tuned, how accurate gene regulation could evolve

90 relaxation (kT1-->S0) rate constants can be finely tuned in M-(PM')n-M compounds and (ii) demonstrat

91 Light utilization is finely tuned in photosynthetic organisms to prevent cell

92 HtrA regulation appears to be finely tuned in S. mutans, since strains containing mult

93 herefore is sustained in Cx43 null mice by a finely tuned interaction between gap junction-dependent

94 cificity of the Pdr-Pdx couple may be due to finely tuned interactions at the protein-protein interfa

95 We propose that hmU preference is due to finely tuned interactions at the sites of kinking that e

96 Memories are encoded by finely tuned interactions within large-scale neuronal ne

97 que structure is critically dependent on the finely tuned interplay between disulfide bonding and N-g

98 Together, these results indicate that finely tuned levels of Lamin B1 are required for NSC dif

99 A finely tuned lipid assembly machinery is required to bui

100 sed of various tissue microenvironments with finely tuned local immunosurveillance systems, many of w

101 the development of novel metamaterials with finely tuned magnetic properties, such as reconfigurable

102 ence of excitation and inhibition, each with finely tuned magnitude and duration.

103 processes to emerge and be coordinated in a finely tuned manner.

104 extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time s

105 ulation of sclerostin levels appears to be a finely tuned mechanism by which osteocytes coordinate re

106 This study highlights a finely tuned mechanism for regulating histone demethylas

107 These results unveil a new, finely tuned mechanism for TNF-alpha-induced IKK activat

108 This model suggests a finely tuned mechanism that balances transcription speed

109 an ocular circadian clock and by light in a finely tuned mechanism that ensures that melatonin is sy

110 are necessarily highly competitive and have finely tuned mechanisms to adjust growth and development

111 These studies reveal the plasticity of this finely tuned molecular machine and represent a first ste

112 chanistic insights into the workings of this finely tuned molecular machine.

113 Nature provides highly evolved, finely tuned molecular machinery for solar energy conver

114 etabolic and physiological processes through finely tuned molecular mechanisms.

115 borate process that integrates a plethora of finely tuned molecular processes ranging from carefully

116 ular IRP1/IRP2 ratios can provide a range of finely tuned, mRNA-specific responses to the same (iron)

117 s involves generation of new neurons through finely tuned multistep processes, such as neural stem ce

118 For the trachea, where finely tuned neuromuscular activity is not an issue, tis

119 ts of Alzheimer disease is the disruption of finely tuned neuronal circuitry of discrete brain region

120 s, highly selective protein interactions and finely tuned on/off switches.

121 This finely tuned orchestra of developmental changes thus sim

122 t of a multicellular organism depends on the finely tuned orchestration of cell proliferation, differ

123 layed characteristics consistent with a more finely tuned oscillatory drive.

124 substituents at positions 4 and 6 and can be finely tuned over a broad range of conformation ratios.

125 dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in syste

126 ts that regulate diffusive processes through finely tuned particle-network interactions.

127 Using finely tuned phosphoramidite ligands, it is possible to

128 s a novel method for developing carbons with finely tuned pores for a variety of applications, such a

129 This is a very finely tuned process regulated by an emerging number of

130 l particle assembly, and nuclear export is a finely tuned process requiring the concerted actions of

131 rturbation of sodium channel inactivation, a finely tuned process that critically regulates the flow

132 cellular polysaccharide, is synthesized in a finely tuned process that involves the activity of glyco

133 wound-induced epithelial cell migration is a finely tuned process that is dependent upon the regulate

134 Capsid assembly and maturation are finely tuned processes in which viral and host factors p

135 cells maintain tissue homeostasis through a finely tuned program of responses to both physiological

136 isms contain biominerals and composites with finely tuned properties, reflecting a remarkable level o

137 res the design of enhanced fluorophores with finely tuned properties.

138 n intricately organized kinetic scheme, with finely tuned rate constants, is required to achieve high

139 We conclude that Mtb has evolved finely tuned redox and hypoxia-mediated sensing strategi

140 The results uncovered a finely tuned regulation able to shift the precursor path

141 iptional responses that maintain a balanced, finely tuned regulation of cholesterol and bile acid met

142 Our findings highlight the importance of finely tuned regulation of EDNRA signaling during human

143 and virulence, confirming that this complex, finely tuned regulation system is crucial in the interac

144 Collectively, these data reveal a finely tuned regulatory mechanism for controlling signal

145 he signaling functions of dopamine require a finely tuned regulatory network for rapid induction and

146 A finely tuned regulatory network orchestrates the biogene

147 and the wild-type F-MLV strain, suggesting a finely tuned relationship between the levels of mCAT1 in

148 geometric, and chemical properties have been finely tuned relative to the corresponding residues in w

149 The finely tuned response of mTOR to these stimuli results i

150 hanisms for T-cell activation and allows for finely tuned responses to extracellular cues.

151 employs a prion mechanism to create stable, finely tuned self-perpetuating biochemical memories.

152 A finely tuned sensory to projection neuron network secure

153 h fishes, is the result of a highly evolved, finely-tuned sensory system based on single-domain, ferr

154 set of neural oscillators for PD, but a more finely tuned set of oscillators in ET.

155 tions also exist for perioral exploration, a finely tuned skill requiring the combination of motor an

156 Human face perception is a finely tuned, specialized process.

157 in protein-protein interactions mediated by finely tuned structural instability and coupled with mol

158 antage conferred upon a biological system by finely tuned structural instability.

159 t the metal-binding His cluster in TraI is a finely tuned structure that achieves a sufficient affini

160 isolate rare enzyme variants that displayed finely tuned substrate specificity.

161 than previously assumed and rather involves finely tuned surface-water interactions.

162 This finely tuned switch is conferred by a naturally variable

163 This finely tuned system is responsive to developmental and p

164 re states of the organism and the world in a finely tuned system to control ingestion.

165 mucosa of the intestinal tract represents a finely tuned system where tissue structure strongly infl

166 le changing the nature of the Xaa side chain finely tuned the conformers ratio.

167 perties of reactive ferryl intermediates are finely tuned through hydrogen bonding interactions betwe

168 he core histones and the linker histones are finely tuned through interactions with transcriptional r

169 ability to stabilize gas microbubbles can be finely tuned through variation of the surface-modificati

170 on could explain the experimentally observed finely tuned timing between parallel fiber and climbing

171 Thus, finely tuned TMS treatment has great potential to become

172 eparate classes of taste receptor cells each finely tuned to a single taste quality.

173 to ATF4 expression, allowing anabolism to be finely tuned to amino acid availability.

174 y by these specific editing reactions and is finely tuned to any perturbation of these reactions.

175 cells in mammalian primary visual cortex are finely tuned to binocular disparity.

176 nditions, the activity of these receptors is finely tuned to effectively mediate host defense yet con

177 all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance between fi

178 rstanding how HECT ubiquitin ligases must be finely tuned to ensure normal cellular behavior.

179 size and signaling output of niches must be finely tuned to ensure proper tissue homeostasis.

180 The architecture of Kepler-223 is too finely tuned to have been formed by scattering, and our

181 otic genomes, but their mobilization must be finely tuned to maintain host organism fitness and allow

182 rotein family that have affinity differences finely tuned to mediate their biological roles.

183 nd functional properties of mitochondria are finely tuned to meet cell-specific energetic, metabolic,

184 e physical properties of these polymers were finely tuned to optimize their photovoltaic effect.

185 However, because ILCs are finely tuned to perturbations within tissue microenviron

186 in response to inflammatory stimuli must be finely tuned to promote an effective immune response whi

187 review we illustrate how excitability can be finely tuned to provide contrasting firing templates in

188 Our data illustrate how excitability can be finely tuned to provide specific firing templates by the

189 We propose that tynA and feaB expression is finely tuned to provide the FeaB activity that is requir

190 results suggest that the locus coeruleus is finely tuned to regulate organismal arousal and that bur

191 affinity and transcription factor levels are finely tuned to regulate stochastic expression, setting

192 detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their h

193 Sensory neurons in the airways are finely tuned to respond to reactive chemicals threatenin

194 fabrication of such particles are typically finely tuned to specific monomer or polymer species, siz

195 show that stabilization of HO-1 mRNA can be finely tuned to the NO exposure, and that the effect in

196 OR effector translational repressor 4E-BP is finely tuned to the nutritional requirements of the fema

197 que transients of bar-fixation saccades were finely tuned to the speed of bar motion and were trigger

198 l black hole, but requires an accretion rate finely tuned to the thermodynamic state of the hot gas.

199 Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific rep

200 al in embryonic stem cells (ESCs) requires a finely tuned transcriptional circuitry wherein the pathw

201 The data presented here indicate that the finely tuned transcriptional control upon salt stress is

202 llary bridges and resulting particles can be finely tuned using several addressable parameters: (i) t

203 mosquito vector Anopheles gambiae depends on finely tuned vector-parasite interactions.

204 d and interrupted pericyclic pathways can be finely tuned via a combination of structural and electro

205 e, in pyramidal neurons, the AIS location is finely tuned with the somatodendritic capacitive load, s

206 results show that functional connectivity is finely tuned, with important implications for signal pro

207 Second, these DA events are finely tuned within and between frequency domains as bui

208 conditions (concentration, pH, etc.) can be finely tuned without cross-contamination, allowing the s