ライフサイエンスコーパス: firing

1 he mechanism underlying defective repetitive firing.

2 , phenocopies fkh alleles in terms of origin firing.

3 changed the information content of EP neuron firing.

4 ng, such as theta oscillations and grid cell firing.

5 on of resting potential and increased evoked firing.

6 l mechanisms underlying defective repetitive firing.

7 arization and ganglion cell action potential firing.

8 educed input resistance and action potential firing.

9 shaft widening induced by high-frequency AP firing.

10 ions and contribute to high-frequency neural firing.

11 oteins involved in the origin of replication firing.

12 fork slowing and reduced replication origin firing.

13 ly 40% responded to METH, mostly by rhythmic firing.

14 action potentials in response to presynaptic firing.

15 action potential generation and synchronous firing.

16 ift of the input/output curve and persistent firing.

17 both short- and long-term, between CS and SS firing.

18 two critical elements generating persistent firing.

19 tress checkpoint, promoting continued origin firing.

20 ges in pump activity also influence neuronal firing.

21 ic Ca(2+) except during prolonged repetitive firing.

22 resence of blockers of VIP, GABA or neuronal firing.

23 mbrane is necessary for their characteristic firing accommodation during maintained stimulation, and

24 of light-responsive SCN units modulate their firing according to simple spatial patterns (drifting or

25 nhibited IA , contributing in turn to higher firing activity in RVH rats.

26 T-type calcium channels (T-channels) in the firing activity of both pyramidal and inhibitory interne

27 Specifically, we investigated how the firing activity of DA neurons should behave if they were

28 phetamine-induced, DAT-mediated increases in firing activity of dopamine neurons.

29 the A-type K(+) current (IA ) influences the firing activity of hypothalamic magnocellular neurosecre

30 tes to diminished IA magnitude and increased firing activity of MNCs from hypertensive rats.

31 a-driving neurons to the theta wave, and the firing activity of theta-driving neurons shares a substa

32 present different hidden sources of upstream firing activity.

33 First, baseline firing after CTA induction was significantly higher.

34 showed higher levels of rhythmic correlated firing, after dopamine depletion.

35 neurons robustly inhibited action potential firing and Ca(2+) activity despite desensitization of th

36 locking these channels with barium increased firing and eliminated the inhibitory actions of monoamin

37 facilitate consolidation by sequencing cell-firing and encouraging plasticity.

38 ilepsy correlates with reduction of neuronal firing and enhanced interneuronal network activity.

39 4beta2-nAChR agonists increased the neuronal firing and enhanced the spatial tuning of delay cells, n

40 e of the MLF pathway in driving motoneuronal firing and evidenced compensatory mechanisms following t

41 as motor activity through regulation of cell firing and heterologous neurotransmitter release.

42 zations (AHPs); (iv) strongly enhanced burst firing and increased excitability at moderate spike rate

43 When the light was turned off motoneuron firing and locomotor frequency both transiently increase

44 lear pathway that could lead to the observed firing and morphological recovery.SIGNIFICANCE STATEMENT

45 ) to septic rats greatly improved repetitive firing and motor unit force generation.

46 ion reduced the heat-evoked action potential firing and nociceptive behavior.

47 in pump activity can also influence neuronal firing and regulate rhythmic network output.

48 ic magnocellular neurons regulate repetitive firing and spike frequency adaptation but relatively lit

49 ent suggest that changes in action potential firing and synaptic activity may be secondary to altered

50 ErgToxin-1, and E-4031) abolished persistent firing and the underlying increase in input resistance i

51 s are unchanged between LTS bursts and tonic firing and, as a result, distance-dependent dendritic at

52 y (increased responsiveness, irregular spike firing, and increased burst activity) in SNL rats.

53 membrane depolarization and wake-like tonic firing, and OFF periods, characterized by membrane hyper

54 lated visual information encoded by neuronal firing; and (2) a substantial increase in the ability of

55 First, reduced variability of place cell firing appears to indicate an impairment of attentional

56 ysregulated neuronal excitability (decreased firing at 200-300 pA and increased firing rates at 450 p

57 rentially and excessively synchronized their firing at beta frequencies.

58 cleus that preserves the temporal pattern of firing at high frequency.

59 ursting at moderate spike rates but reducing firing at high rates; (ii) enhancing after-depolarizatio

60 odors, piriform neurons exhibit spontaneous firing at mean rates that vary systematically among neur

61 Comparison of LHb neural firing before and after CTA induction revealed four main

62 The mechanisms underlying such firing behaviour are not known although activation of pe

63 h1 to Dbf4 restores the Fkh-dependent origin firing but interferes specifically with the pericentrome

64 yramidal neurons by chronic manipulations of firing, but it is unknown whether they are coinduced by

65 Efficient control of principal neuron firing by basket cells is critical for information proce

66 rse axis, powerfully regulating granule cell firing by imposing inhibition during a specific time win

67 equency was nearly doubled and inhibition of firing by monoamines or ML297 was lost.

68 cally express parvalbumin (PV)) show greater firing coherence with CA1 network oscillations.

69 We demonstrate that vS1 firing correlated with the local features of the vibrati

70 local features of the vibration, whereas vM1 firing correlated with the percept: the final vM1 popula

71 annel inhibitors blocked the ethanol-induced firing decrease.

72 ting membrane potential and action potential firing, decreased synaptic activity and reduced synaptic

73 Origin firing depends on MCM engagement of Cdc45 and GINS to fo

74 ory synapses, whereas more prolonged (24 hr) firing depressed both AMPAR and NMDAR EPSCs and eliminat

75 lterations in the timing of action potential firing differentially regulates hundreds of genes, acros

76 olarization at rest is replaced by irregular firing during functional network activity.

77 We assessed the role of motoneuron firing during ongoing locomotor-like activity in neonata

78 Thus, our results suggest that coordinated firing during sleep is essential for establishing sparse

79 eferentially enhanced temporal summation and firing elicited by gamma frequency inputs.

80 , provides excellent age constraints for the firing event of these artifacts.

81 excitatory drive was boosted to the adapting-firing excitatory lamina II interneurons while GABAergic

82 ver, has shown that these cells repeat their firing fields across visually identical maze compartment

83 CA1 place cell firing fields are preserved under PCP, but the drug disc

84 Whereas the place-specific firing fields are small and precise at the dorsal end of

85 ask, including activity that formed discrete firing fields at particular sound frequencies.

86 Grid cell firing forms a hexagonal array of firing fields, a pattern that is largely thought to refl

87 Grid cell firing forms a hexagonal array of firing fields, a patte

88 w presynaptic terminals to translate complex firing frequencies and tune the amount of neurotransmitt

89 ed, while glutamate cotransmission at phasic firing frequencies was reduced, enabling a selective foc

90 ion, leading to spike broadening at moderate firing frequencies.

91 Furthermore, ProTx II decreased firing frequency in human DRGs with spontaneous action p

92 can reach a bistable region, between the low firing frequency network state (L) and a quiescent one (

93 2 in the CA1 area specifically increases the firing frequency of CCK-positive but not parvalbumin-pos

94 at are seen in patients, including decreased firing frequency of cerebellar Purkinje cells and a decl

95 Notably, the firing frequency of Purkinje cells returned to normal ev

96 the modulation of Purkinje cell simple spike firing frequency, which has implications for controlling

97 g is restored, although at a greatly reduced firing frequency.

98 olarization of late spikes during repetitive firing; (ii) enhanced the after-depolarization (ADP); (i

99 ough which paracrine ATP signalling enhances firing in a cell-specific and tonotopically-determined m

100 n LHb-induced inhibition of midbrain DA cell firing in anesthetized rats.

101 hat prior cocaine self-administration had on firing in dorsal lateral striatum (DLS), a brain area kn

102 uld not evoke the sustained action potential firing in FGF13-deficient DRG neurons.

103 This contrasted to transient firing in hippocampus and sensory neocortex.

104 namic control of OSN-driven action potential firing in MCs through changes in gap junction properties

105 ERG) K(+) channels contributes to persistent firing in neocortical pyramidal cells.

106 dorant receptors, inhibiting the basal spike firing in olfactory sensory neurons.

107 opamine neurons recorded in vivo pause their firing in response to reward omission and aversive stimu

108 igated the basis for altered Purkinje neuron firing in SCA2.

109 Measurement of action potential (AP) firing in Scn8a(N1768D/+) pyramidal neurons in brain sli

110 Regular firing in spinal motoneurons of red-eared turtles (Trach

111 bers is sufficient to induce postsynaptic AP firing in the absence of AMPA receptors.

112 r, a pressing need to elucidate striatal SPN firing in the context of the synchronized network oscill

113 involved in generating high frequency burst firing in the subiculum, but the exact nature of these c

114 2/3) NAcc projecting neurons showed enhanced firing in toluene-exposed animals and in IL5 neurons, th

115 meostatic plasticity mechanisms to stabilize firing, including excitatory and inhibitory synaptic sca

116 Replication stress and deregulated origin firing increase the number of HO collisions leading to g

117 Burst firing induced MEF2A/D-dependent induction of the target

118 In the tonic-firing inhibitory lamina II interneurons, glutamatergic

119 We computed the firing instants of motor units identified from intramusc

120 and with decreased and delayed striatal fast-firing interneuron activity.

121 s during systole, when baroreceptor afferent firing is maximal, relative to diastole.

122 ATR-Chk1 inhibitor-induced origin firing is mediated by Cdc7 kinase through previously und

123 Although tonic firing is similar in these subpopulations, we find that

124 g rate of MEC neurons without changing their firing locations.

125 inputs to the LC with changes in LC neuronal firing, making it a highly coordinated event.

126 terpret their activity and that, while their firing may conform to predictions of these models in som

127 ChIP-Seq and RNA-Seq, GOF p53-induced origin firing, micronuclei formation, and fork protection were

128 lamocortical neurons into or out of a phasic firing mode in two freely behaving genetic rodent models

129 s the ionic mechanisms supporting persistent firing modes triggered by depolarizing stimuli following

130 enuation remains consistent across different firing modes.

131 st time that the RSC and ACA contain neurons firing more during PS than in any other state.

132 g evidence that during action potential (AP) firing, nerve terminals rely on the glucose transporter

133 erlying working memory, where the persistent firing of 'Delay cells' is mediated by N-methyl-d-aspart

134 neuroarchitecture and increased spontaneous firing of 5-HT neurons.

135 s from GPe showed that ethanol decreased the firing of a large subset of low-frequency neurons.

136 the neuronal input resistance and increased firing of action potentials, indicating an enhanced exci

137 e discovered that a new experience increased firing of active dentate granule neurons rapidly and rob

138 (alpha4beta2-nAChR) enhance the task-related firing of delay and fixation cells in the dlPFC of monke

139 The AP firing of developing central auditory neurons can be mod

140 his allowed direct observation of stochastic firing of DNA replication origins, which differs from ce

141 apping of mossy cells, in contrast to sparse firing of granule cells, suggests differential involveme

142 l regions of 9 patients, we investigated the firing of hundreds of single neurons before, during, and

143 ns, toluene exposure significantly decreased firing of IL5 neurons and this was accompanied by an inc

144 e recently identified a defect in repetitive firing of lower motor neurons as a novel contributor to

145 and in vitro In the hippocampus, sequential firing of many neurons over periods of 100-300 ms reoccu

146 sectioning the MLF or the ATD pathway on the firing of medial rectus motoneurons, as well as the plas

147 early harbinger of dysfunction and aberrant firing of motor neurons.

148 causes immediate, instructive changes in the firing of mouse lateral geniculate nucleus (LGN) neurons

149 o identify currents that trigger spontaneous firing of muscle in the setting of reduced ClC-1 current

150 a2 subunits (alpha4beta2-nAChR) enhanced the firing of neurons in the primate prefrontal cortex that

151 ed replication forks thereby suppressing the firing of new replication origins.

152 In drinking monkeys, evoked firing of OFC pyramidal neurons was reduced, whereas the

153 omplex behaviors emerge from the coordinated firing of prefrontal neurons.

154 coincide with a significant decrease in the firing of PrL pyramidal neurons and did not seem to prop

155 across the septo-temporal axis, phasing the firing of specific CA3 interneurons, thereby contributin

156 We further show that suppressing the firing of these neurons across the transition prevents n

157 aptic inhibition is unaffected by changes in firing or CaMKIV signaling in individual neurons.

158 h levels during high rates of auditory nerve firing, or that calcium-dependent processes involved in

159 s likely operate synergistically to maximize firing output during locomotion.SIGNIFICANCE STATEMENT N

160 (ChR2) in brain tissue, and consequently the firing pattern of neurons, by manipulating the phase of

161 ls and influences action potential waveform, firing pattern, and rate.

162 term alterations in medial rectus motoneuron firing pattern, which were more drastic in MLF of animal

163 neurons encode both modalities with similar firing patterns (stimulus-synchronized or nonsynchronize

164 They differ in their connectivity and firing patterns and, therefore, in their functional prop

165 ral tegmental area (VTA) where they regulate firing patterns critical for movement control, reward, a

166 is currently unknown whether these temporal firing patterns critically rely on upstream cortical inp

167 : The capability to disentangle superimposed firing patterns in upstream networks, and to represent t

168 regulation of their AP shape during natural firing patterns in vivo.

169 potentials that are critical to shaping the firing patterns of these cells.

170 h switch, but did not develop anticorrelated firing patterns or predict choice accuracy.

171 perirhinal cortex of rats generate sustained firing patterns that discriminate large segments of the

172 atial cells and confirmed that their spatial firing patterns were unrelated to running speed and high

173 by mossy fiber inputs with a wide variety of firing patterns.

174 e to the temporal nature of action potential firing patterns.

175 rons display considerable diversity in their firing patterns.

176 uspected heterogeneity and adaptivity in MEC firing patterns.

177 the elevated action potential and repetitive firing phenotype.

178 icity that persistently eliminates the burst firing potential of Re neurons.

179 ity that eliminates the high-frequency burst firing present in many Re neurons.

180 ect their neuronal calcium and in some cases firing profiles in wake-behaving flies.

181 we tested the effect of ReRh lesions on the firing properties and spatial activity of dorsal hippoca

182 Intrinsic firing properties were only slightly enhanced.

183 ptic drive in the maturation of PV(+) neuron firing properties, the fast-spiking phenotype showed dif

184 induction revealed four main differences in firing properties.

185 e strength of SA1 responses - the population firing rate - rather than their spatial layout.

186 ng" activity, a monotonic change in neuronal firing rate across time, is observed throughout frontost

187 yers exhibit attention-mediated increases in firing rate and decreases in variability.

188 eceptors on LC neurons, resulting in reduced firing rate and norepinephrine release.

189 free choice protocol for 8 weeks), the basal firing rate and the excitability of LHb neurons in brain

190 central node can be tuned to have a certain firing rate and variability, or to allow for an optimal

191 d changes in MU force, contraction time, and firing rate associated with sustained voluntary contract

192 lar layer interneurons exhibit bidirectional firing rate changes during whisking, similar to PCs.

193 remaining afferent inputs, thereby restoring firing rate codes for rudimentary sound features.

194 Specific forms of firing rate correlations can limit efficient information

195 ng neurons which is not captured by standard firing rate equations.

196 increase in the single-unit action potential firing rate in vivo in VTA dopamine neurons, which was b

197 r space, we discovered that each face cell's firing rate is proportional to the projection of an inco

198 ness under all tested conditions whereas the firing rate model does not.

199 e then implemented the spatial variation and firing rate models of roughness based on these simulated

200 hermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression i

201 In contrast, both manipulations altered the firing rate of MEC neurons without changing their firing

202 umin-positive interneurons and decreases the firing rate of pyramidal neurons, phenomena mimicked by

203 The time-averaged firing rate of the SCN is modestly increased under these

204 spikelets/CS correlated with the average SS firing rate only for Z+ cells.

205 disease symptoms on the basis of changes in firing rate or firing synchronization/rhythmicity.

206 s in postsynaptic excitability, occlusion of firing rate potentiation, and reductions in BK currents

207 the idea that PICs contribute to non-linear firing rate profiles during ascending but not descending

208 Firing rate profiles for the descending phases of the co

209 e of the triangular contractions, 93% of the firing rate profiles were best fitted by rising exponent

210 With stimulation, however, firing rate profiles were best fitted with linear functi

211 ed a remarkable form of temporal invariance: firing rate profiles were temporally scaled to match the

212 relationship between neuronal morphology and firing rate showed that dopaminergic neurons function as

213 It was found that THC left firing rate unaltered and only slightly reduced theta os

214 RH excitability, a key determinant of neural firing rate using laboratory and computational approache

215 otential (AP) generation, measured as higher firing rate, shorter EPSP-AP delay in vivo and shorter A

216 Furthermore, when correlations covary with firing rate, this relationship is reflected in low-rank

217 explain why covariation of correlations with firing rate-a relationship previously explained in feedf

218 nt and underlie the steep initial rise in MU firing rate.

219 ientation or direction by suppression of the firing rate.

220 e for the initial sharp rise in motor neuron firing rate.

221 with a subsequent reduction in simple spike firing rate.

222 d changing repetition frequency by increased firing rate.

223 orrelations can increase systematically with firing rate.

224 ease, and, consequently, reduced spontaneous firing rate.

225 athway might curb this initial steep rise in firing rate.

226 o hypoxia by either increasing or decreasing firing rate.

227 uniform in size, number of spikes, and peak firing rate.

228 , which also exhibited increased spontaneous firing rate.

229 he autocorrelogram, waveform parameters, and firing rate.

230 V1 neurons preferring low SF (mean change in firing rate: -8.0%), whereas silencing PM L5 feedback su

231 The firing-rate response increased indefinitely with injecte

232 A sensitivity analysis for the firing-rate response to the different stimuli revealed t

233 nucleus (LGN) neurons, leading to increased firing-rate responses to the presented stimulus orientat

234 iched with cells with small RFs, high evoked firing rates (FRs), and sustained temporal responses, wh

235 ically-quiescent, muscles, the instantaneous firing rates (IFRs) of muscle spindles are associated wi

236 on of iSPNs, which often displayed excessive firing rates and aberrant phase-locked firing to cortica

237 for joint alterations in the observed neural firing rates and correlations; (2) Neural circuit functi

238 their neurites, and increasing POMC neuronal firing rates and excitability.

239 bility in basic neuronal properties, such as firing rates and inter-spike interval distributions.

240 MU population model was used to simulate MU firing rates and isometric muscle forces and, to that mo

241 d the effects of adaptation on single-neuron firing rates and local field potentials; this mechanisti

242 are by looking at the distribution of field firing rates and reproducibility of this distribution ac

243 The high convergence, firing rates and strength of Purkinje inputs predict pow

244 decreased firing at 200-300 pA and increased firing rates at 450 pA), whereas insignificant morpholog

245 ) and "indirect pathway" SPNs (iSPNs); their firing rates became imbalanced, and they disparately eng

246 pikelets are preceded by higher simple spike firing rates but, following the complex spike, simple sp

247 They have stable firing rates during prolonged periods of stimulation and

248 and laminar organization of decision-related firing rates in dorsal premotor cortex.

249 ced CTA caused significantly higher baseline firing rates in LHb neurons, as well as elevated firing

250 lationship between pairwise correlations and firing rates in recurrently coupled excitatory-inhibitor

251 ng rates in LHb neurons, as well as elevated firing rates in response to cue presentation, lever pres

252 ny was higher, excitation increased CbN cell firing rates more effectively.

253 lity across cortical layers, with changes in firing rates most important in the upper layers and chan

254 Tutor similarity predicted firing rates most strongly during early stages of learni

255 ded while the inhibitory reflex was engaged, firing rates no longer increased steeply, suggesting tha

256 n caused significant changes in the relative firing rates of individual grid fields, reconfiguring th

257 s of neural activity in that it assumes that firing rates of neurons are sensitive to multiple discre

258 for by differences in running speed, as the firing rates of PER interneurons did not show significan

259 Here, we show a similar effect in the firing rates of primary motor cortical cells.

260 Firing rates of some neurons were phasically selective f

261 mRNA counts, Pol II density and Pol II firing rates of the Ccnb1 promoter transgene resembled t

262 errors and are not due to differences in SS firing rates or variability.

263 tifying a population-wide increase in neural firing rates that corresponded with the hand being near

264 ural population responses and predict neural firing rates to faces.

265 Finally, we found that spontaneous firing rates were shifted up or down by dnCaMKIV or caCa

266 Finally, firing rates were significantly higher during consumptio

267 his elevated excitation results in increased firing rates, and abnormal coding of frequency and binau

268 where the major effect is the increasing of firing rates, and in layer V, where the major effect is

269 lity was improved, even for fixed population firing rates, because of a decrease in noise correlation

270 The result was consistent across varying firing rates, network sizes, and topologies.

271 rrelations for different correlation levels, firing rates, network sizes, network densities, and topo

272 alysis over a wide range of AP waveforms and firing rates, owing in part to the use of an iterative a

273 tation within CA1, thus leading to unaltered firing rates.

274 he negative feedback mechanism that controls firing rates.

275 l visuomotor continuum based on task-related firing rates.

276 ip emerged between pairwise correlations and firing rates.

277 showed reduced spontaneous and sound-evoked firing rates.

278 ulation, including decreasing and increasing firing reliability, respectively.

279 GnRH intrinsic conductances can produce the firing response in positive feedback, suggesting the bra

280 n and excitation may contribute to irregular firing.SIGNIFICANCE STATEMENT Neurons embedded in active

281 naptic vesicle recycling during sustained AP firing, similar to what is observed during acute glucose

282 of correlated neural networks with realistic firing statistics indicate that this change in the corre

283 ms on the basis of changes in firing rate or firing synchronization/rhythmicity.

284 story-dependent transients of muscle spindle firing that are not uniquely related to muscle length an

285 , we observed a decrease in the motor neuron firing that could be explained by the reduction in the e

286 ynaptic scaling that senses perturbations in firing through changes in calcium influx, and translates

287 population level, each origin has a distinct firing time and frequency of activation within S phase.

288 addition to neurons displaying synchronized firing to CI stimuli, a large population of A1 neurons i

289 ssive firing rates and aberrant phase-locked firing to cortical beta oscillations, preferentially and

290 exhibited higher incidences of phase-locked firing to ongoing cortical oscillations, and SPN ensembl

291 ate a cell type-selective entrainment of SPN firing to parkinsonian beta oscillations.

292 y controls the information present in the SS firing, triggering robust and rapid changes in the SS en

293 neurons, greatly decreases SWA and cortical firing, triggers short OFF periods in NREM sleep, and in

294 uits transition between periods of sustained firing (UP state) and quiescence (DOWN state), a pattern

295 a strong alteration of overdispersion (i.e., firing variability).

296 Spontaneous firing was observed in subsets of neurons in CA1 and CA3

297 g neurons generates sparse and orthogonal AP firing, which may support sparse coding during hippocamp

298 the hippocampus that gate information flow, firing while phase-locked to theta rhythms.

299 In contrast, inhibition of CIN firing with the mu/delta selective opioid [Met(5)]enkeph

300 uggests that blocking thalamocortical phasic firing would treat absence seizures.