ライフサイエンスコーパス: firing

1 creasing from the summation of these neurons firing.

2 asma membrane, thereby depressing NAcSh MSNs firing.

3 iety-like behaviors and basolateral amygdala firing.

4 sequent behavior via an interaction with MTL firing.

5 awake, freely licking rats show lick-related firing.

6 to synaptic integration and action potential firing.

7 firing whereas others decrease their rate of firing.

8 current and caused failures in postsynaptic firing.

9 xcitability and smaller propensity for burst firing.

10 nd the corresponding magnitude of VTA neural firing.

11 ration potentials into action potential (AP) firing.

12 and electrically and optogenetically induced firing.

13 pvBCs after a spike and inhibited repetitive firing.

14 xiolytic effects and increased DRN 5-HT cell firing.

15 eracting MOR-mediated inhibition of neuronal firing.

16 urons are endowed with conditionally Poisson firing.

17 c conductance, and intense, hypersynchronous firing.

18 axon branching in response to noncorrelated firing.

19 epending on a transient suppression of spike firing.

20 on fork restart while suppressing new origin firing.

21 ese transients summated rapidly during burst firing.

22 s increases basolateral amygdala (BLA) spike firing.

23 without a reduction in the number of origins firing.

24 and jitter during high frequency repetitive firing.

25 he onset of current injections (i.e., phasic firing), a dynamical property that can enhance the relia

26 hat successful learning increases persistent firing ability and decreases in persistent firing abilit

27 These changes in persistent firing ability are due to changes to the afterdepolariza

28 t firing ability and decreases in persistent firing ability contribute to learning impairments in agi

29 Persistent firing ability from neurons from behaviorally naive aged

30 netic downregulation of VTA-mPFC DA neurons' firing activity abolished the antidepressive-like effect

31 ve freely between a home and defeat chamber, firing activity emerged that predicted the animal's posi

32 usceptibility to social stress decreased the firing activity of 5-HT(DR->VTA) neurons.

33 We found that late neural firing after a sound ends can be tuned to how the pitch

34 Such phasic burst firing also occurs during natural attentive waking and p

35 Light application and associated firing alteration of pyramidal and interneuron populatio

36 her complexity indicating more random neural firing and a less homogeneous neuron population.

37 ceptors regulate brain-wide serotonin neuron firing and are positioned to assert large-scale effects

38 produced an inverted-U dose response on cell firing and behavioral performance when given systemicall

39 ced activation of the LC increases BLA spike firing and causes impairments in extinction learning.

40 required for time-of-day-specific effects on firing and circuit rhythmicity.

41 -excited neurons showed greater increases in firing and cue-inhibited neurons showed greater decrease

42 In rats, VNS elevates LC firing and forebrain noradrenaline levels, whereas LC le

43 We compare features of multiunit firing and high frequency LFP from microelectrodes and m

44 showed that riluzole suppressed spontaneous firing and increased the action potential firing thresho

45 raining and alters synaptically evoked spike firing and integrative properties of these neurons.

46 ulations, including decreases in spontaneous firing and neural habituation.

47 eraction process (tonic entrainment) between firing and nonfiring cells slows down the overall rhythm

48 ice reduces thalamic reticular nucleus burst firing and promotes rather than reduces seizure, indicat

49 esults constrain mechanisms for modular grid firing and provide evidence for inter-animal phenotypic

50 nal provides an indirect measure of neuronal firing and reflects slow-evolving hemodynamic activity t

51 rest from the literature: cooperative origin firing and replication fork barriers.

52 he biophysical properties required for rapid firing and signal transmission.

53 In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function.

54 contribution to the ictal decrease in total firing and the ictal increase of T-type calcium channel-

55 d to maintain high rates of action potential firing and transmitter release.

56 ips, back-propagation-activated Ca(2+) spike firing, and a shift in the critical frequency by blockin

57 synchronous GABA release, synchronous spike firing, and evoked-gamma power increase with lowered bas

58 weaken synaptic efficacy and reduce neuronal firing, and over a longer timeframe, driving calcium ove

59 l perspective that speed and precision of AP firing are crucial for sound source localization.

60 Neocortical pyramidal neurons regulate firing around a stable mean firing rate (FR) that can di

61 NMDAR blockers mostly decreased persistent firing associated with the memory of the neuron's prefer

62 Blockers of the NMDARs decreased persistent firing associated with the memory of the neuron's prefer

63 ry significant information in their phase-of-firing at a 10-25 Hz band-limited beta frequency at whic

64 out the nervous system by neurons capable of firing at very high rates, rapidly encoding and transmit

65 Rs are particularly important for persistent firing because they exhibit long time constants.

66 In the absence of Hox5 genes, phrenic MN firing becomes asynchronous and erratic due to loss of p

67 rats are less likely to orthogonalize their firing between directions of travel on a linear track an

68 Here, however, we show reciprocal correlated firing between heterotypic ganglion cells in multielectr

69 We found desynchronized interneuron firing between the CA1 and dentate gyrus in epileptic mi

70 idual interneurons did not display sustained firing but instead transiently enhanced their activity,

71 r or oscillatory interference models of grid firing but is accounted for by models in which pure grid

72 rization and an increase in action potential firing but this stimulation of electrical activity is as

73 have been explored to characterize neuronal firings, but only analyze temporal information and not t

74 e of pyramidal neurons might determine burst-firing by setting the relative amount of distal excitato

75 ility, reducing spontaneous action potential firing by slowing maximum depolarization rate.

76 transmitters can facilitate action potential firing by suppression of a low voltage-activated potassi

77 ion forks are not stabilized, and new origin firing cannot be prevented, leading to the accumulation

78 ed animals also exhibited reduced persistent firing capacity, which may contribute to aging-related l

79 importantly, we show that the proportion of firing cells can be increased by CDR of HCN4 to efficien

80 ophysical model demonstrates that well-known firing characteristics of mammalian muscle spindle Ia af

81 Though synchronous ictal firing characterizes cortical and thalamic activity at t

82 Regular-firing cholinergic neurons (Reg-BFCNs) were found predom

83 The phase-of-firing code exceeds information that can be obtained fro

84 of HCN and SK activities mimicked changes in firing, confirming that these channels are responsible f

85 at changes in spatial stability of grid cell firing correlate with changes in a proposed speed signal

86 The sparse thalamic firing could promote an incremental integration of recen

87 rges of dopamine neurons (tonic or pacemaker firing) determine the motivation to respond to such cues

88 We compared HD cell preferred firing directions (PFDs) in different planes and address

89 reverses eye necrosis, climbing deficit, and firing discharge caused by (G4C2)-RNA repeats.

90 We conclude that telomeric origin firing does not cause telomere elongation, and the role

91 physiology to determine how action potential firing drives calcium responses within subcellular compa

92 ectivity metric) caused by abnormal neuronal firing during a seizure onset.

93 illations in spontaneous firing, with higher firing during day compared to night.

94 ts for fast repolarization and to sustain AP firing during high frequency stimulation.

95 The reduction in MTC firing during optogenetic stimulation was confirmed in r

96 ntal observations reveal cortical population firing dynamics that are relatively coordinated and occa

97 ated to the dimensionality of inferior olive firing dynamics, as measured via a principal component a

98 nt of a colony, more neurons adopt transient firing dynamics, which can facilitate neural coding of s

99 MA reduces neuronal action potential firing elicited by mechanical stimuli in mice and rat ne

100 ed to a change in the temporal pattern of AP firing, emphasizing the role of temporal code in conveyi

101 2-SPN activity, (3) autonomous PV GPe neuron firing ex vivo was upregulated, presumably through homeo

102 ors of neuronal and cardiac action potential firing (excitability) and have major roles in human dise

103 We show that individual firing fields of pure grid cells are tuned to multiple h

104 the firing rate of single grid cells across firing fields, and artificial remapping of place cells u

105 However, only MTL firing following punishment is linked to a lower probabi

106 tical neurons are capable of elevating their firing for long durations in the absence of a stimulus.

107 to identify individual motor units and their firing frequencies.

108 turn, the Na(+) current can control neuronal firing frequency in a negative feedback loop.

109 ype channels are required for normal daytime firing frequency in SCN neurons and circuit rhythms.

110 enotypically, Ecm29 KO mice showed increased firing frequency of action potentials at early postnatal

111 or learning and control to cope with the low firing frequency of inferior olive neurons, which form o

112 lease from basket cells (BCs) attenuates the firing frequency of Purkinje neurons (PNs) in the cerebe

113 ciency is associated with a reduction in the firing frequency of simple and complex spikes and an inc

114 OXTRs in the CeL increased action potential firing frequency recorded from neurons in this region vi

115 ation of action potentials and regulation of firing frequency(1,2).

116 ains glutamatergic projection cells at their firing frequency, whereas GABAergic neurons are only inh

117 t, DNQX, which might suppress local neuronal firing, generate either appetitive or defensive motivati

118 erexpression (1) increased cortically-evoked firing in a subpopulation of identified striatonigral MS

119 y revealed cleft alkalinization during burst firing in both males and females.

120 Since firing in bursts has been associated to neuropeptide rel

121 Kv3.1, attenuated capacity of high-frequency firing in dentate gyrus PV cells, and altered short-term

122 ward currents and increases action potential firing in hippocampal neurons.

123 egulation, of alpha2delta3 enhances neuronal firing in immature cultures, whereas later in developmen

124 reduced both the spontaneous and the evoked firing in response to current injections in SCI-nocicept

125 tive (paradoxical) suppression of inhibitory firing in response to optogenetic inhibitory stimulation

126 rats to control levels without affecting DA firing in SAL rats, which persisted following 14d repeat

127 nism that produces rhythmic action potential firing in SCN.

128 halamocortical relay neurons; however, burst firing in thalamocortical relay neurons remains essentia

129 cuits of pyramidal neurons enable persistent firing in the absence of sensory input, maintaining info

130 nvestigate the relationship between neuronal firing in the basal ganglia and cortical gamma activity

131 NE regulates stress-induced changes in spike firing in the BLA and consequent extinction learning imp

132 g effects wear off, accompanied by increased firing in the lateral habenula (LHb) that contributes to

133 eral seconds requires sustained cue-elicited firing in the prelimbic cortex (PL).

134 oscillations in spontaneous action potential firing in the suprachiasmatic nucleus (SCN) translate ti

135 ewarded navigation task and compared spatial firing in the two areas.

136 otentially mediated by normalizing excessive firing in the ventral hippocampus without affecting anxi

137 hip THC treatment also decreased spontaneous firing in these organoids.

138 rents have been identified that regulate SCN firing, including voltage-gated Ca(2+) currents, but the

139 the same developmental profile, with maximal firing increasing and excitability decreasing into the t

140 x tend to operate in an asynchronous regime, firing independently of each other.

141 sequence of pre- and post-synaptic neuronal firing into corresponding synaptic weights.

142 s and addressed the issue of whether HD cell firing is commutative-does the order of the animal's rou

143 in thalamic reticular nucleus neurons, burst firing is impaired accompanied by attenuated IT.

144 d the hypothesis that hippocampal place cell firing is impaired after PAE by performing in vivo recor

145 n, and the role of Rif1 in regulating origin firing is separable from its role in regulating telomere

146 nly hypothesized explanation of asynchronous firing is that excitatory and inhibitory synaptic inputs

147 G1-deficient cells revealed increased origin firing mediated by the prelicensing protein, CDC6.

148 - a single-cell based, multistable mnemonic firing mode experimentally observed in several brain reg

149 ance to goal, and licking) in sustained slow firing modulation.

150 3 +/- 1% of larval neurons may be capable of firing Na(V)-dependent APs.

151 C) and entorhinal cortex (MEC) that increase firing near boundaries of space.

152 stsynaptic density to promote the persistent firing needed to maintain, manipulate, and store informa

153 ion observed in a population of periodically firing neurons and reversible conduction block that occu

154 in vivo pGABA neurons were found to be fast-firing neurons with the capacity to burst when depolariz

155 xcitability, such that myotonia triggered by firing of action potentials (electrically induced myoton

156 in the axon initial segment to regulate the firing of action potentials.

157 ate and dramatic increase in the spontaneous firing of BLA neurons that persisted (and in some units,

158 in dopaminergic neurons, whereas synchronous firing of ChINs induces local release of dopamine.

159 ion via decreased NMDAR currents and reduced firing of dendrite-targeting somatostatin-expressing (SS

160 The selection and firing of DNA replication origins play key roles in ensu

161 ndent induction of persistent pacemaker-type firing of dorsal raphe neurons and regulate dorsal raphe

162 e extent of the modulation of the individual firing of hippocampal neurons by an IED predicted the ex

163 hose activity can be strongly upregulated on firing of IC neurons.

164 termediate coupling strengths induce chaotic firing of inferior olive neurons and increase their info

165 We show that burst firing of mouse inner hair cells prior to hearing onset

166 ture indicating that ELA alters the rhythmic firing of neurons in brain regions associated with defen

167 n a consistent mechanism to elicit correlate firing of neurons that will process similar frequencies

168 dependent fork restart while suppressing the firing of new replication origins.

169 (CNO) activation of interneurons suppressed firing of pyramidal cells, unexpectedly the majority of

170 likely due to compensation through increased firing of replication origins.

171 ic tract revealed that arousal modulates the firing of some retinal ganglion cells.

172 ither rif1-Delta1322 nor rif1(HOOK) affected firing of telomeric origins.

173 ase of T-type calcium channel-mediated burst firing of thalamocortical neurons, though the latter is

174 ionally, TrkB activation with BDNF increases firing of these PVH neurons.

175 Burst discharges (phasic firing) of dopamine-containing neurons are necessary to

176 ch includes modulation of replication origin firing, of the architecture of replication forks, and of

177 nels does not promote Cacna1g-mediated burst firing or T-type calcium current (IT) in the thalamocort

178 that intrinsic plasticity enhances the spike firing output of Purkinje cells and persists over the co

179 We show that in both regions, repetitive firing parameters increase and excitability decreases wi

180 adoxical brain state displaying asynchronous firing pattern and high EMG activity was found unexpecte

181 ssary to achieve the high-frequency bursting firing pattern characteristic of both types of LNvs in f

182 with female athletes progressing to a slower firing pattern that was not observed in males.

183 We find that grid cell firing patterns are largely absent in rTg4510 mice, whil

184 dely held assumption that cell-type-specific firing patterns can be achieved via a vast combination o

185 central pattern generators generate similar firing patterns despite several-fold increases in size b

186 in a key cortical area adapt their intrinsic firing patterns in response to the acoustic environment.

187 nto the diversity of muscle spindle afferent firing patterns observed experimentally, particularly in

188 oidal boundary geometry distorts the regular firing patterns of entorhinal grid cells, proposedly pro

189 not considered evoking long-term changes in firing patterns of in-vitro networks by introducing trai

190 ets, we examined the impact of SPW-Rs on the firing patterns of lateral septal (LS) neurons in behavi

191 The in vivo firing patterns of ventral midbrain dopamine neurons are

192 events that cause changes in dopamine neuron firing patterns remain unknown.

193 Moment-to-moment tracking of neural ensemble firing patterns revealed that the prelimbic network acti

194 ring patterns, monitor the transition of the firing patterns, and identify neural synchronization sta

195 approach flexibly uncovers diverse dynamical firing patterns, including pulsatile responses to behavi

196 tem is successfully used to recognize neural firing patterns, monitor the transition of the firing pa

197 Therefore, 'drift' in neural firing patterns, typically construed as disruptive 'inst

198 bushy cells exhibit hyperacusis-like neural firing patterns, which are comprised of enhanced sound-d

199 signatures associated with distinct in vivo firing patterns.

200 ha-helix mutations change genome-wide origin firing patterns.

201 cells, many of which displayed two preferred firing phases in theta oscillations and preferentially p

202 on by a "soft" threshold function, such that firing probability grows as a smooth nonlinear function

203 emonstrate that baseline and stimulus-evoked firing profiles of GC neurons and their processing schem

204 f high-dose lithium in CMS mice restored the firing properties of mPFC-projecting DA neurons, and als

205 v4.3-mediated currents underlie the distinct firing properties.

206 neurons regulate firing around a stable mean firing rate (FR) that can differ by orders of magnitude

207 slow homeostatic renormalization of the mean firing rate (MFR), concomitantly accompanied by a slow s

208 ed with frequency up to the afferent resting firing rate (~100-150 Hz) and at higher frequencies affe

209 ch that place cells return to their baseline firing rate after exploration.

210 neurons encode information by varying their firing rate and patterns precisely fine-tuned through GA

211 gered by the optogenetic modification of the firing rate and spike synchrony of cells.

212 gh-gamma power, thought to index the average firing rate around the electrode, was highest for the sm

213 based largely on models those consider only firing rate as the mechanism of information transfer.

214 The age trajectory of MU firing rate assessed at a single contraction level diffe

215 information is represented through reliable firing rate changes during unconstrained navigation.

216 rent (0.7-8.8 m/s) directions, and monitored firing rate changes in breathing and blood glucose modul

217 and postsynaptic spike pairing events and by firing rate changes of interneurons but not pyramidal ce

218 -poor environments and preferentially used a firing rate code driven by intra-hippocampal inputs.

219 Here, we have probed the firing rate coding properties of neurons in medial entor

220 mats despite considerable rescaling of their firing rate depending on the visual specificities of eac

221 cells showed an increasing gradient in mean firing rate from proximal to distal CA3.

222 Place cell firing rate increases in early stages of exploration of

223 ponse window that still contains presynaptic firing rate information before the synapse is depressed.

224 the increased synaptic density and decreased firing rate observed in germ-free mice.

225 ed astrocytes in wild-type mice enhanced the firing rate of cortical neurons and gamma oscillations,

226 und that, in dopamine-depleted mice, (1) the firing rate of D2-SPNs was elevated, especially during c

227 FC-DRN neural circuit, in vivo recordings of firing rate of DRN 5-HT neurons, cerebral 5-HT depletion

228 es a general framework for approximating the firing rate of neurons with spatial structure.

229 neurons only respond to the mean population firing rate of Purkinje cells at high frequencies.

230 mechanistic explanation: variability in the firing rate of single grid cells across firing fields, a

231 on about memory content not available in the firing rate of the neurons.

232 r extent in both sexes (P < 0.05), whilst MU firing rate progressively decreased with age in females

233 ensity of VGLUT2(+) puncta and Purkinje cell firing rate respectively, in contrast to the increased s

234 linear "ramping" component of each neuron's firing rate strongly contributes to the slow timescale v

235 Many neurons showed peaks in firing rate when a low-numbered harmonic aligned with th

236 with the modulation of the stimulus-induced firing rate, and importantly, a higher phase coherence i

237 er footshock caused smaller increases in BLA firing rate, but this could be augmented by chemogenetic

238 used to determine discharge characteristics (firing rate, variability) and biomarkers of peripheral M

239 ute expression levels increased with maximal firing rate.

240 caused an increase in the spontaneous neuron firing rate.

241 re characterized by spike waveform shape and firing rate.

242 that deep layer neurons show higher baseline firing rates (FRs) in GC with deep-layer inhibitory neur

243 mage, bushy cells show increased spontaneous firing rates across a wide-frequency range, suggesting t

244 xceeds information that can be obtained from firing rates alone and is evident for inter-areal connec

245 harmonics are represented by local maxima in firing rates along the tonotopic axis, has been characte

246 diction errors, and outcome history in their firing rates also carry significant information in their

247 ntained in adaptive conductances that reduce firing rates and can be accessed directly without cued r

248 ure the initial drop and delayed recovery of firing rates and correlations observed experimentally.

249 single-neuron level, these included ramping firing rates and cycle-specific responses.

250 Firing rates and magnitudes of responses in relation to

251 al and proximal apical dendrites, as well as firing rates and ocular dominance, were normal.

252 ucleus output neurons, bushy cells show high firing rates as well as lower and less variable first-sp

253 S as a function of the deviation of neuronal firing rates from a locally defined set-point, independe

254 were both necessary to explain the elevated firing rates in experienced ferrets.

255 Firing rates in the BLA were sustained throughout the tr

256 ic Purkinje neurons (PNs) resulted in low PN firing rates in the cerebellum.

257 x that is recruited to the seizure, neuronal firing rates increase and waveforms become longer in dur

258 confidence of a retrieval trial, with higher firing rates indicative of reduced confidence.

259 We examined the firing rates of CA3 neurons from young and aged, male, L

260 most of which invoke changes in spontaneous firing rates of central auditory neurons resulting from

261 Sun et al. discover that neuronal firing rates of hippocampal place cells code for periodi

262 d we fit computational models to predict the firing rates of individual neurons at the time of reward

263 behavior in Treasure Hunt, we found that the firing rates of many MTL neurons during navigation signi

264 t this connection, and action potential (AP) firing rates of PV-INs were unchanged.

265 nputs from co-aligned conjunctive cells with firing rates that differ between their fields.

266 HD cell peak firing rates were generally equivalent along each surfac

267 However, higher firing rates were sustained during the lever interaction

268 e groups (MU-modes) with parallel scaling of firing rates with changes in the muscle force, and (ii)

269 ke-encoded information is evident in average firing rates, but finer temporal coding might allow mult

270 neurons from EV-treated monkeys showed lower firing rates, greater spike frequency adaptation, and ex

271 ynaptic strength, membrane excitability, and firing rates, its role at the neural circuit and network

272 erent parameters through minor variations in firing rates, LA cells coded fewer task features with st

273 which are comprised of enhanced sound-driven firing rates, reduced first-spike latencies and wideband

274 unbalanced responses favoring increased SNr firing rates, suggesting a potential locus for cannabine

275 the running speed-dependent gain in neuronal firing rates.

276 d makes it less dependent on the presynaptic firing rates.

277 porally offset prototypic GPe and STN neuron firing results in part from increased striatopallidal tr

278 nset, showing large deviations from baseline firing shortly after image onset but relaxing back to ba

279 Although CA2 neuronal firing showed only weak spatial selectivity, it accurate

280 Glutamate typically stimulates burst firing subsequent to this hyperpolarization in normal ty

281 ulation and a longer duration of GnRH neuron firing than KP54 (115 vs. 55 minutes; P = 0.0012).CONCLU

282 us firing and increased the action potential firing threshold of patient-derived neurons to more depo

283 the white matter (inner-zone GCs) had higher firing thresholds and could sustain firing with larger c

284 ndividual IZs or occasionally by altering IZ firing time, demonstrating that IZs, rather than individ

285 ace preferentially with other IZs of similar firing time.

286 rons in the vmPFC and dmPFC exhibited phasic firing to EtOH lever presses and aborts, but only in the

287 lamus (VMH), leptin-induced action potential firing was enhanced, whereas nuclear pSTAT3 was reduced

288 Using a novel method to track neuronal firing, we analyzed microelectrode array recordings of s

289 es in Kv3 currents and action potential (AP) firing were analysed from wild-type, Kv3.1 and Kv3.3 kno

290 rane potential allows to generate persistent firing when clusters of cooperative channels are present

291 rons in visual cortex increase their rate of firing whereas others decrease their rate of firing.

292 or is coincident with rhythmic Purkinje cell firing, which alters the activity of their target cerebe

293 Rebound firing, which can have unwanted effects on neural circui

294 ited a twofold to fourfold increase in their firing, which started immediately (1 min) or up to 90 mi

295 ilure coincided with reduced dopamine neuron firing, which was not observed during antipsychotic effi

296 nduce a range of sympathetic vasoconstrictor firing while measuring beat-by-beat blood pressure and f

297 d higher firing thresholds and could sustain firing with larger current inputs than GCs closer to the

298 These new analyses showed continued neuronal firing with widespread intense activation and stereotype

299 ons exhibit 24 h oscillations in spontaneous firing, with higher firing during day compared to night.

300 - and R-type channels also decreased daytime firing, with little effect at night, and decreased circu