ライフサイエンスコーパス: firm

1 driven by an exploratory search for newcomer firms).

2 of existing structures in selecting partner firms.

3 list and who became wealthy by founding new firms.

4 obtained through collaboration with private firms.

5 rogradation, water mobility, and bread crumb firming.

6 hence, other phenomena are involved in cake firming.

7 Additionally, a firm 1.5-cm left-sided inguinal node is palpated.

8 FIRM ablation alone at the primary source terminated AF

9 FIRM ablation at patient-specific sources acutely termin

10 FIRM ablation terminated AF to sinus rhythm or atrial fl

11 ersion of rolling interactions (step 1) into firm adhesion (step 3), yielding transendothelial migrat

12 o that cognate antigen was necessary for the firm adhesion and transendothelial migration of CD8+ eff

13 bronectin, and hyaluronan on HSECs determine firm adhesion both in vitro and in vivo as demonstrated

14 zation of MAdCAM to mediate both rolling and firm adhesion by binding to different alpha4beta7 integr

15 Transition of PMN rolling to firm adhesion critically depends on Coro1A by regulating

16 lved in T cell migration - integrin-mediated firm adhesion followed by transendothelial migration - a

17 these active nanoclusters failed to support firm adhesion in static and low shear-flow conditions be

18 ll lymphoma also underwent integrin-mediated firm adhesion involving ICAM-1 and/or VCAM-1 and demonst

19 thout a previous rolling phase and underwent firm adhesion mediated by vascular cell adhesion molecul

20 Specifically, Slit2 blocked the capture and firm adhesion of human neutrophils to inflamed vascular

21 Together, these changes translate to higher firm adhesion of infected monocytes on endothelium, whic

22 olling in Tph1(-/-) mice resulted in reduced firm adhesion of leukocytes after lipopolysaccharide tre

23 ar adhesion molecule-1 (ICAM-1) mediates the firm adhesion of leukocytes to endothelial cells and ini

24 ICAM-1 is required for firm adhesion of leukocytes to the endothelium.

25 bility to mediate either rolling adhesion or firm adhesion of lymphocytes on vascular surfaces.

26 Moreover, HLA I mIgG2a promoted firm adhesion of monocytes to ICAM-1 through Mac-1, whic

27 ents that originate from the ICAM-1-mediated firm adhesion of neutrophils that regulate VE-cadherin's

28 emonstrate that the IL-1R type 1 governs the firm adhesion of neutrophils to the inflamed spinal cord

29 nteraction of CD97 with Thy-1 is involved in firm adhesion of PMNC during inflammation and may play a

30 during complement-mediated phagocytosis and firm adhesion of polymorphonuclear neutrophils (PMN) und

31 ing site in beta2 integrins caused a loss of firm adhesion of T cells under both static and shear flo

32 onse to collagen in platelet-rich plasma and firm adhesion on VWF under arterial flow.

33 ockade in inhibiting both ICAM-1 binding and firm adhesion to activated endothelium under flow condit

34 hear flow, and prostate cancer cells exhibit firm adhesion to BMEC via beta1, beta4, and alphaVbeta3

35 elet adherence to leukocytes allows for both firm adhesion to endothelial cells and augmented transce

36 4beta1 integrin for capture, rolling on, and firm adhesion to endothelial cells, and use leukocyte fu

37 molecule 1 (ICAM-1) clustering, and monocyte firm adhesion to HLA I Ab-activated endothelium.

38 Firm adhesion to HSECs was reduced by CD29 (55% [P = 0.0

39 ated HNE-induced leukocyte rolling and their firm adhesion to the endothelium in rat cremaster muscle

40 iated by the membrane-distal D1, followed by firm adhesion to the primary binding site in D2.

41 ly of the immunological synapse and mediates firm adhesion to the target.

42 Upon their activation and firm adhesion to vascular endothelial cells (VECs), leuk

43 t integrin signaling but that LFA-1-mediated firm adhesion under conditions of shear flow requires do

44 hA2 knockdown significantly reduces monocyte firm adhesion under flow.

45 of migration on ICAM-1, as well as reducing firm adhesion under shear-flow conditions.

46 lular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion mo

47 Lack of vinculin at the IS impairs firm adhesion, promoting, in turn, cell migration with A

48 sclerotic inflammation by promoting monocyte firm adhesion, whereas smooth muscle EphA2 expression ma

49 hibiting enhanced slow rolling but decreased firm adhesion.

50 for its ability to mediate both rolling and firm adhesion.

51 , Jurkat and primary MS patient-derived PBMC firm adhesion.

52 ' surface, MBDual enhanced the percentage of firm adhesion.

53 q-VWF complexes induced platelet rolling and firm adhesion.

54 FIRM analysis revealed sources in the right atrium in 85

55 tcome measure was time to balance failure on firm and foam surface testing.

56 The gels produced with LBA were less firm and released less volatile aroma compounds than the

57 The margin of the subretinal abscess became firm and the central area resolved after the operation.

58 tributions are similar to those observed for firms and are consistent with a Bose-Einstein preferenti

59 retailers) and discusses the impact of lead firms and key intermediaries on smallholders in differen

60 ical model simulating the whole ecosystem of firms and showed that the system is already in an unstab

61 with CMX + CAF sites tending to be "equally firm" and CTG + CAF sites "more firm." Patient satisfact

62 associations with known hallmarks of cancer, FIRM, and the inferred cancer miRNA-regulatory network w

63 source (focal impulse and rotor modulation [FIRM]) and then conventional ablation in 27 patients (FI

64 Furthermore, it provided firm answers to several lingering questions in chloropla

65 Distally, it has a firm anterior insertion at the femoral intertrochanteric

66 the ablation results in latest studies using FIRM are discussed.

67 aper investigates the conditions under which firms are able to develop and implement innovations with

68 nopoly state in which growth of middle sized firms are suppressed.

69 zing slow cell rolling and the transition to firm arrest.

70 The WHO engaged a bank and an accounting firm as DDM partners to support disbursement of and acco

71 tolerance, although encouraging, are not as firm as they could have been if we had used randomizatio

72 nformation with all four domains packed in a firm assembly, whereas at acidic pH, the three IgG-bindi

73 roscopy were carried out as needed to obtain firm assignments for the observed conformers of the thre

74 We establish a firm association between IDH mutations and serum 2HG con

75 near the spokehead were restored, but their firm attachment to the spokestalk required the DPY-30 do

76 partial IVC ligation revealed that leukocyte firm attachment was increased in WT mice compared to mic

77 analyzed with the elasticity models assuming firm attachment.

78 Firm attachments between kinetochores and dynamic spindl

79 The existing molecular knowledge forms a firm backbone upon which hypotheses connecting genetic v

80 transmembrane proteome of CyHV-3 provides a firm basis for further research on alloherpesvirus VTPs.

81 se to injury and infection and established a firm basis for our understanding of inflammation and tis

82 ing pathways in normal retina will provide a firm basis for targeting their roles in retinal patholog

83 Our findings create a firm basis for the development of EVs as smart drug carr

84 It also provides a firm basis for the further research on alloherpesvirus v

85 Combined, this evidence provides a firm basis for understanding the age-dependent incidence

86 conventional ablation alone in 65 patients (FIRM blinded).

87 ed in 86% of FIRM-guided cases versus 20% of FIRM-blinded cases (p < 0.001).

88 9%; p < 0.001) after a single procedure than FIRM-blinded cases with rigorous, often implanted, elect

89 ble (85.2% of FIRM-guided patients, 23.1% of FIRM-blinded patients).

90 rtile range: 224 to 1,563 days), compared to FIRM-blinded therapy, patients receiving FIRM-guided abl

91 36), or conventional ablation alone (n = 71; FIRM-blinded).

92 ld, suggesting that it may contribute to the firm bonds between kinetochores and the flared plus ends

93 ublic health leaders with a kind heart and a firm, but gentle, hand.

94 odel that incorporates realistic features of firms' buyer-supplier relationships and estimate the mod

95 We demonstrate the utility of FIRM by inferring a cancer-miRNA regulatory network thro

96 ispatchable source with zero contribution to firm capacity.

97 AF sources were ablated directly in 100% of FIRM cases and coincidentally (e.g., left atrial roof) i

98 However, CD40L stimulation promoted the firm, CD44-mediated adhesion of CLL cells to hyaluronan,

99 12-h fast, subjects ingested 33 g fat from a firm cheese (young cheddar), a soft cream cheese (cream

100 mpared the impact of dairy fat provided from firm cheese, soft cream cheese, and butter on the postpr

101 s claiming that workplace regulations damage firms' competitiveness and destroy jobs and others argui

102 tion-delithiation hysteresis, thus providing firm conceptual foundations for future design of improve

103 port of any of these models is limited and a firm conclusion is missing.

104 ailable and methodological issues preclude a firm conclusion.

105 are heterogeneous and lacked power to draw a firm conclusion.

106 and withdrawal, limiting the ability to draw firm conclusions (particularly about safety).

107 The evidence was too limited to make firm conclusions about differences in the benefits and h

108 poisoning in the medical literature to draw firm conclusions about many aspects of the pathophysiolo

109 d for its primary endpoint, and therefore no firm conclusions about the comparative effectiveness of

110 y in the existing literature does not permit firm conclusions about the degree of risk posed, how cha

111 However, it is too early to draw firm conclusions about the uniqueness of the cognitive m

112 ome measures, the literature does not permit firm conclusions about which interventions have these ef

113 wever, the sparse number of ONJ cases limits firm conclusions and suggests that the absolute risks fo

114 of other promising interventions, precluding firm conclusions as to their effectiveness.

115 However, no firm conclusions can be drawn in respect to the most eff

116 7-14, but further follow-up is needed before firm conclusions can be reached on the efficacy and cost

117 vestigation in additional populations before firm conclusions can be reached.

118 underpowered and retrospective in nature, so firm conclusions cannot be made.

119 This uncertainty precluded firm conclusions for 53% of species and IBAs because 95%

120 k of precision in effect estimates precluded firm conclusions for many comparisons.

121 oblems have limited researchers from drawing firm conclusions from the data.

122 est productivity to NAO have so far hampered firm conclusions on its impacts.

123 sample size and case-control design preclude firm conclusions on KS risk or pathogenesis.

124 but there is insufficient evidence to reach firm conclusions on the clinical or cost-effectiveness o

125 radictory data renders it impossible to draw firm conclusions on the role of TFAs in modifying fetal

126 ons of the available studies, we cannot draw firm conclusions to inform a population level approach t

127 Although wide CIs preclude firm conclusions, the intervention may have increased ED

128 nd patient groups makes it difficult to draw firm conclusions.

129 antity and consistency among studies to draw firm conclusions.

130 udies are of insufficient quality to support firm conclusions.

131 ports, further research is needed to support firm conclusions.

132 Although there is firm consensus that anthropogenic activities have transf

133 l cadherin adhesive bond that keeps cells in firm contact.

134 In addition, we report firm correlations between Tier 2 autologous neutralizati

135 ented with a 5 mm x 7 mm x 3 mm pedunculated firm cystic lesion on the inferior palpebral conjunctiva

136 d to various degrees, although in some cases firm data are lacking with regard to certain types of in

137 easing availability of high quality business firms' data.

138 ation would be aided by setting a reasonably firm date for OPV withdrawal as far in advance as possib

139 ce in the exoplanet population has escaped a firm detection.

140 individuals aged >50 years: 1) cases with a firm diagnosis of mild cognitive impairment or dementia

141 Fourth, one now has firm, disproof-based chemical-mechanism precedent for tw

142 Setting biological control on a firm economic foundation would help to broaden its utili

143 -induced remnant magnetization spectroscopy (FIRMS) enable the binding behavior of drug molecules wit

144 us (BStA) is widely used as bread crumb anti-firming enzyme.

145 powered for a 25% relative reduction showed firm evidence (cumulative z-curve crossed the monitoring

146 adaches have been proposed, but establishing firm evidence for any of them has proved elusive.

147 However, there was no firm evidence for associations between microbiota and me

148 In summary, the present data provide firm evidence for at most, three Gsp-1 genes in wheat, a

149 odifying cardiac structure and function, yet firm evidence for either remains lacking.

150 Together, our data provide firm evidence for involvement of NOTCH signalling in HLH

151 decrease in repeat revascularization with no firm evidence for reduction in death and myocardial infa

152 However, firm evidence for the existence and functional importanc

153 We also present firm evidence for the existence of very long-term variat

154 X-ray absorption spectroscopy provides firm evidence for the presence of Ni(0) centers, whereas

155 eduction in repeat revascularization with no firm evidence for the reduction in death or myocardial i

156 Firm evidence is lacking that prevention of CKD translat

157 To date, there is no firm evidence that meiosis, the hallmark of gametogenesi

158 No firm evidence was found for the efficacy of all early ph

159 tion led to a policy framework that places a firm focus on African leadership and capacity building a

160 subjects received targeted source ablation (FIRM) followed by conventional ablation, or conventional

161 Here we develop this idea and place it on a firm footing by employing a standard decision-theoretic

162 slated into clinical practice by providing a firm foundation for clinical laboratories to set appropr

163 blies both in vivo and in vitro, providing a firm foundation for creating tailored biomimetic nanocom

164 c basis for the biosynthesis of 1 and sets a firm foundation for querying the biosynthetic potential

165 population, we validated the procedure as a firm foundation for standardized somatic-mutation analys

166 y erythropoiesis and anemia, one must have a firm foundation of indices that accurately measure red b

167 tigations of this elusive molecule provide a firm foundation to better understand its potential physi

168 P, CNV, or PAV across the panel, providing a firm foundation to identify functional variation associa

169 erent set of pathogenic processes, providing firm foundations for studies aimed at dissecting disease

170 babilities towards newcomers and established firms from the data, we find that endogenous mechanisms

171 ework for inference of regulation by miRNAs (FIRM) from sets of coexpressed genes.

172 rast, PME expression was tightly linked with firm fruit texture.

173 10 of which are likely pathogenic, giving a firm genetic diagnosis for 2.9% of patients.

174 t requires that interpretation be based on a firm genetic, biochemical, and structural foundation.

175 ect: no contact, light grip (< 1 N) (LG) and firm grip (FG).

176 cal role of the Ska complex in maintaining a firm grip on dynamic microtubules.

177 by grip context (no contact, light grip and firm grip), as well as how they are co-ordinated with th

178 When GVS was applied during firm grip, hand and ground reaction forces were generate

179 re solved in nondonating toluene and provide firm ground for diffusion-ordered NMR spectroscopy as we

180 over the interaction length scale, providing firm ground for the applicability of statistical physics

181 Firm guidance is needed for primary care on the use of l

182 d then conventional ablation in 27 patients (FIRM guided) and conventional ablation alone in 65 patie

183 Randomized trials of FIRM-guided ablation and mechanistic studies to determin

184 FIRM-guided ablation is more durable than conventional t

185 to FIRM-blinded therapy, patients receiving FIRM-guided ablation maintained higher freedom from AF a

186 All FIRM-guided ablation procedures (n=24; 50% paroxysmal) a

187 In the Indiana University FIRM registry, FIRM-guided ablation produced high single-procedure succ

188 rted by substantially improved outcomes from FIRM-guided ablation, resulting in increased attention t

189 rs and describe acute procedural outcomes of FIRM-guided ablation.

190 : 132 to 681 days) after a single procedure, FIRM-guided cases had higher freedom from AF (82.4% vs.

191 r consistent slowing) was achieved in 86% of FIRM-guided cases versus 20% of FIRM-blinded cases (p <

192 rdiographic monitors when possible (85.2% of FIRM-guided patients, 23.1% of FIRM-blinded patients).

193 a 2-arm 1:2 design, by ablation at sources (FIRM-guided) followed by conventional ablation (n = 36),

194 Firm guidelines for bariatric surgery in adults have bee

195 alb levels also were higher in children with firm hepatomegaly [176.6 (129.6, 240.7) pg/mg] than in n

196 .0230), nodular liver appearance compared to firm (HR: = 1.61, P = 0.008), and age at KPE >/= 75 days

197 FIRM-identified rotor sites did not exhibit quantitative

198 c mapping showed no rotational activation at FIRM-identified rotor sites in 23 of 24 patients (96%).

199 ferences between humans and great apes stand firm in eight out of nine of these domains, I conclude t

200 was administered by an international polling firm in June 2014.

201 Recently, growth mechanism of firms in complex business networks became new targets of

202 iveness of several inexpensive features that firms in four industries could implement with existing o

203 ding risk, whereas dose reductions without a firm indication may decrease the effectiveness of stroke

204 ed by percutaneous drainage, and although no firm inference can be made from such a small series, we

205 rther, we highlight the specificity of using FIRM inferences to identify miRNA-regulated genes by exp

206 tion of heterogeneous nucleation and provide firm insight to the wetting of nanosized objects.

207 sion deficiency syndrome and is critical for firm integrin-dependent leukocyte adhesion.

208 ydrogels incorporating LN-511-E8 resulted in firm integrin-mediated adhesion to the scaffold and well

209 with a reduction in striatal DAT despite its firm involvement in DLB pathology.

210 hat the probability of merger between bigger firms is bigger than that between smaller ones, and such

211 Firm-juicy cultivars containing high VOC concentrations

212 Generally, firm-juicy cultivars had a shorter time to first swallow

213 pressive disorder (MDD) has not yet provided firm leads to its underlying molecular biology.

214 This study investigated the regulation of firm leukocyte adhesion to human brain endothelium by tw

215 prostheses beyond simple environments (e.g. firm level ground without load) that represent only a su

216 These results suggest firm limits on human rationality and have broad implicat

217 The results establish a firm link between fibrosis with aberrant p300 expression

218 genetic and functional studies demonstrate a firm link between SIM1 loss of function and severe obesi

219 mediated B cell motility arrest and leads to firm, long-lasting B cell adhesion to the APC.

220 xing has long been a likely explanation, but firm, long-term observational evidence has been absent.

221 dies of fibrillation, and how this motivated FIRM mapping in humans.

222 FIRM mapping revealed a median of 2 (interquartile range

223 on using focal impulse and rotor modulation (FIRM) mapping that rotors act as human atrial fibrillati

224 include focal impulse and rotor modulation (FIRM) mapping, and initial results reported with this te

225 roanatomic maps passed through AF sources on FIRM maps.

226 l under standard and tax instruments, and if firms market the abated natural gas, private net benefit

227 Physical examination revealed a palpable firm mass occupying the entire left part of the abdomen.

228 had solitary, deep, 2 cm hard and moderately firm masses, respectively.

229 mpanies the mesenchymal mode of migration on firm matrices and is facilitated by Rac1 activation.

230 Notably, firm matrices do not support microvesicle release, where

231 ination (focal impulse and rotor modulation [FIRM]) may improve outcome from AF ablation.

232 Lack of this basic information precludes a firm mechanistic understanding of TES effects.

233 of endothelial miR-126 and miR-126* enhanced firm monocyte and T cell adhesion to hCMEC/D3 cells, whe

234 While a GTP-bound FtsZ dimer retained a firm monomer-monomer contact, a GDP-bound FtsZ dimer los

235 producers and other organizations, including firms, nongovernmental organizations, and government, th

236 ge cannot solely account for the significant firming of ERO cakes and, hence, other phenomena are inv

237 nnecessary ablation, and motivate studies on FIRM-only ablation.

238 ectly by Focal Impulse and Rotor Modulation (FIRM) or coincidentally when anatomic ablation passes th

239 Four follow-up surveys tracked outcomes for firms over 2 years and showed that personal initiative t

240 These results suggest that firm particulate gels can persist longer in the GI tract

241 be "equally firm" and CTG + CAF sites "more firm." Patient satisfaction was high, with no statistica

242 tudies of reduced flavins/flavoproteins on a firm photophysical footing.

243 time of admission revealed scattered 1-3-cm firm pink hyperpigmented subcutaneous nodules, several o

244 retains certain advantages and still holds a firm place in the diagnostic evaluation.

245 Unexpectedly, free Hb also promoted firm platelet adhesion and stable microthrombi on VWF.

246 eceptor glycoprotein VI and strongly affects firm platelet adhesion on von Willebrand factor (VWF) un

247 enabling high-affinity GPIbalpha binding and firm platelet adhesion to a partially disordered A1 doma

248 glycoprotein ligand 1 axis, followed by (2) firm platelet adhesion to the endothelium via interactio

249 pective represents a moving target, but some firm points can be made for which we are indebted to thi

250 tunities such as these likely exist wherever firms possess environmentally relevant data not accessib

251 lassical novae display nova shells, but lack firm post-eruption ages, and are also dwarf novae at pre

252 It is a firm prediction of the concordance cold-dark-matter cosm

253 Although firm prevalence data are lacking, there is a strong impr

254 On follow-up, freedom from AF after a single FIRM procedure for the entire series was 95% (PAF), 83%

255 h a simulated breakfast cereal manufacturing firm procuring grain, containerboard boxes, plastic pack

256 that personal initiative training increased firm profits by 30%, compared with a statistically insig

257 ature induced a decrease in the maximum curd firming rate and an increase in the viscosity of the inv

258 n differed with storage temperature, and the firming rate was evidently lowest during frozen storage.

259 d stored at -25 degrees C, while the highest firming rate was observed for finished bread from parbak

260 The lowest firming rate was observed for finished bread resulting f

261 However, more studies are needed before firm recommendations can be made.

262 Research is needed to inform firm recommendations on how to protect this vulnerable p

263 In the Indiana University FIRM registry, FIRM-guided ablation produced high single

264 gion well separated above Europa's limb is a firm result and not invalidated by our 2014 STIS observa

265 s are often attributable to processes in the firm's upstream supply chain.

266 gram, the Iranian cyber attack on the energy firm Saudi Aramco, the persistent cyber espionage carrie

267 te the model's parameters using microdata on firms' self-reported customers.

268 vel for an invented solar cell manufacturing firm shows Se, Te, and Cu as approximately equal, Cu has

269 s in vivo, we show that the NPC lacks such a firm size threshold; instead, it forms a soft barrier to

270 lf-employment, small business ownership, and firm startup rates.

271 at the dead body of a young male, selected a firm stem of grass, and started to intently remove debri

272 has been used for over a decade; however, a firm structural basis of this reaction has been lacking.

273 with several large ecchymoses radiating from firm subcutaneous nodules on the buttocks, arms, and thi

274 ed, were probably left earlier on relatively firm substrates that predated the deposition of soft mud

275 magnetic resonance spectroscopy, providing a firm support for the tyrosyl radical in the HCO enzymati

276 nditions or eyes-closed balance testing on a firm surface was not more common among participants with

277 nse of employment, sales, credit ratings, or firm survival.

278 n a 3-month-old infant that presented with a firm swelling in the chest wall and was histopathologica

279 pigments from PSP can be challenging due to firm texture and high polyphenol oxidase (PPO) content.

280 this sample (JPP2) was more reddish and less firm than other samples.

281 t at free on-site clinics offered by a large firm to its employees.

282 emented strategies with consulting and legal firms to access the IOM proceedings.

283 of PGMs) reflecting the rational response of firms to changing prices.

284 a competitive market provides incentives for firms to educate consumers or offer products that facili

285 technology to lower this barrier by enabling firms to inform customers of products' environmental foo

286 social media site, contracting with Chinese firms to install the same censoring technologies as exis

287 These examples illustrate the potential for firms to lower their overall carbon footprints while imp

288 here also remain continued disincentives for firms to measure and pay the full costs of their supply

289 Presentation with a firm type of chronic hepatomegaly of multifactorial etio

290 te pro-oncogenic function of PKCzeta without firm understanding of detailed molecular mechanism.

291 Therefore, a firm understanding of how stem cells maintain their prot

292 benefit of this method is that it provides a firm upper bound on the average molecular weight of DOM,

293 glutathione-Cu(I) equilibrium system sets a firm upper limit on the thermodynamic availability of in

294 We find evidence that is consistent with firms using acceleration trade-offs to achieve complianc

295 nding to the immobilized GAG brushes ensures firm virus attachment to the interface.

296 Waxy paper-like vitreous with firm vitreous adhesions beyond major arcades and along r

297 Cake crumb firming was evaluated by texture analysis.

298 to $15 billion yearly would occur if service firms were to reach median research and development fund

299 procurement organizations to participate in firm-wide environmental impact reduction targets.

300 Focal impulse and rotor modulation (FIRM) with an endocardial basket catheter was used in al