ライフサイエンスコーパス: firmly

1 ion of anything to which one can attach them firmly.

2 endothelium where it activates leukocytes to firmly adhere engaging integrin clustering, a process of

3 ed as the likelihood for a blood-borne NP to firmly adhere to the vessel walls, is a fundamental para

4 r cells tethered and rolled on BMEC and then firmly adhered to and traversed BMEC via sequential depe

5 ormal animals, fixed CNS myelin lamellae are firmly adherent and resist separation; PLP-null myelin l

6 are sheet-like, leading edge protrusions in firmly adherent cells that contain Arp2/3-generated dend

7 digestive tract, for example, is lined by a firmly adherent mucus layer that is typically devoid of

8 l first rolls over the vessel wall, becoming firmly adherent on activation, and then transmigrates th

9 polarize and start crawling, only few remain firmly adherent over time.

10 Double-conjugated MSs specifically detected firmly adhering leukocytes (P<0.01), allowing in vivo qu

11 Conjugated MSs specifically interacted with firmly adhering leukocytes, allowing quantification of t

12 lays femtomolar binding affinity, placing it firmly alongside the CB[7].Diam(NMe3)2 complex.

13 positioned histidine residue contributes to firmly anchor, via a dative bond, a biotinylated rhodium

14 mily in which flavin mononucleotide (FMN) is firmly anchored to the protein.

15 In the same reaction step, the monoliths are firmly anchored to the surface of the capillary.

16 11 genes, the expression of which correlated firmly and universally with that of MT1-MMP (P < 0.00001

17 lematic Polypodium, a parasite of fish eggs, firmly as sister taxon to Myxozoa within the Cnidaria.

18 Our data firmly assign THEMIS to the TCR-proximal signaling casca

19 We provide evidence to firmly associate KMT2C, ASH1L, and KMT5B haploinsufficie

20 ehyde, is neither molecularly identified nor firmly associated to an encoding gene.

21 on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of papillary thyroid carcino

22 lifelong activity helps the zebra mussel to firmly attach to substrata underwater, thereby causing s

23 The inability of biofilm to firmly attach to the surface and its effective removal u

24 modulus of both poorly attached (round) and firmly attached (close to flat) cells.

25 ing cells in addition to those that are more firmly attached and migrating in random directions.

26 d to circumvent this problem is to fabricate firmly attached metal species onto the voids of a mesopo

27 to tear or crush its contents, or a tool is firmly attached to a table or free to be lifted.

28 However, many cells cannot be firmly attached to many substrates.

29 ng the other is allowed because one motor is firmly attached to one microtubule while it is stepping

30 hizosphere, which consists of soil particles firmly attached to roots, engage in symbiotic associatio

31 , only a fraction of the cell population was firmly attached to S(0) globules.

32 ompass a series of microenvironments and are firmly attached to teeth.

33 lop enough adhesion with the substrate to be firmly attached to the substrate.

34 A 'staple-pin' architecture firmly attaches the scaffolding silk to the substrate an

35 A key additional piece of evidence that firmly authenticated the established chronology was the

36 target fear memories, placing these memories firmly behind the crosshairs of neurobiologically inform

37 It is, however, firmly believed that this polymerization method will bec

38 find that the nonpolar groups of protein can firmly bind to TMD layers or graphene to expose polar gr

39 Our simulation results reveal that EGCG firmly binds to HMGB1 near Cys106, which supports previo

40 t rather with surface changes induced by the firmly bound Be(2+) and an accompanying Na(+) cation.

41 e assembly factor N7BML (NDUFAF2), was found firmly bound instead.

42 trary to all known competitive technologies, firmly bound part of arsenic preventing its leaching bac

43 ing isotherms indicating that these proteins firmly bound pelargonidin at both pH 7.0 and 3.0 (bindin

44 on the initial concentration of AgNO(3), are firmly bound to Fe NPs, which prevents their release eve

45 the seal to form and the substrate to remain firmly bound, but blocked its passage, perhaps via elect

46 Sea stars adhere firmly but temporarily to various substrata as a result

47 volves Glu192 in binding, thus succeeding in firmly capping the S1 pocket.

48 They were firmly cell associated, resisted phosphatidylinositol-sp

49 ng intermonomer interaction, which induces a firmly closed conformation of dimers and crucially invol

50 As firmly closed dimers markedly shorten VWF's effective le

51 ately one-half of the constituent dimers are firmly closed via the strong intermonomer interaction.

52 constrict its movement and as a consequence, firmly closes the steric gate, which in wild-type enzyme

53 g reaction that leaves the 5' end of the DNA firmly complexed with its otherwise intact protein capsi

54 ed a new type of ruthenium catalyst that was firmly confined by ordered mesoporous carbons through th

55 Although studies over the last decades have firmly connected a number of genes and molecular pathway

56 Taken together, our results firmly corroborate the concept that CTMP promotes Akt ph

57 The magnetic inclusions are found to be firmly coupled to the cell membrane, enabling a direct t

58 Proton transport by FO is firmly coupled to the rotation of the c-ring relative to

59 These data firmly demonstrate that Lig4(R278H) activity renders NHE

60 Our findings firmly demonstrate that XRCC1 is not a requisite factor

61 Our results firmly demonstrated that this immunization strategy agai

62 er activity assay and DNA binding assays, we firmly demonstrated the key role of this SRE motif in SR

63 , their role in seizure control has not been firmly demonstrated.

64 dergo CSR similarly to Ku-deficient B cells, firmly demonstrating that an A-EJ pathway distinct from

65 res derived from a Syt null mutant Syt(AD4), firmly demonstrating that anti-Syt(+) puncta are presyna

66 nd its location in plant cells remains to be firmly determined.

67 Among The 96 nodules, 88 were firmly diagnosed as low-grade dysplastic nodules (LGDNs;

68 within affected regions of PD brain has been firmly documented, however no treatments exist that are

69 f 200 nm fluorescent polystyrene beads which firmly embed in the extracellular polymeric substance (E

70 n for removing such filters when they become firmly embedded along the vena cava endothelium.

71 concept has finally been realized and is now firmly embedded in ongoing drug discovery programs, and

72 til this rapidly evolving field becomes more firmly embedded into surgical research and implementatio

73 in Papua New Guinea, where surgical care is firmly embedded within national health plans and receive

74 e packaging, and pre-existing contamination (firmly enclosed into the matrix).

75 a series of stabilization steps before being firmly encoded.

76 deed, local schistosome transmission appears firmly engrained for intermediate snail hosts can be fou

77 Cyclophanes have been firmly entrenched as a distinct class of compounds for w

78 This finding goes against firmly entrenched dogma in showing that HKT proteins can

79 nt and ubiquitinated CYP3A species that were firmly ER-tethered.

80 Future studies will be necessary to more firmly establish (or refute) this hypothesis.

81 These findings firmly establish a cell-division-independent role for co

82 Our data firmly establish a previously unrecognized specific role

83 understood, and there has remained a need to firmly establish a requirement for phagosome maturation

84 These data firmly establish an endogenous role for AhR as a regulat

85 Here we firmly establish Ccr4-Not as a positive elongation facto

86 Our results firmly establish DBC1 as a critical positive regulator o

87 ogical, biochemical and pharmacological data firmly establish MCU as an essential component of the mi

88 These findings firmly establish missense mutations in HIF-2alpha as a c

89 These results firmly establish TAF4 as a bona fide E-protein coactivat

90 These findings firmly establish that alterations in innate immunity inf

91 These results firmly establish that an axonemal CK1 regulates dynein a

92 that calcium is involved in RCH, and here we firmly establish that calcium signaling mediates cold se

93 as an important new feedback regulator, and firmly establish that CN-NFAT signaling is required for

94 Our kinetic data firmly establish that G-triplexes are intermediates to G

95 These results firmly establish that in HIV-1, CA is a strong determina

96 Our results firmly establish that metalenses can have widespread app

97 The data firmly establish that only the extracellular amino termi

98 Thus, our studies firmly establish that polyglutamine-expanded AR must res

99 in terms of vaccine development, since they firmly establish that preexisting serum antibodies direc

100 Our results firmly establish that SAS-6 can impose cartwheel symmetr

101 Our results firmly establish that under a similar experimental condi

102 e and cleavage of the Notch S2 site and thus firmly establish the feasibility of a mechanotransductio

103 We firmly establish the link between Kras-INP1KO pancreatic

104 Further studies are required to firmly establish the link between microvascular alterati

105 Collectively, our in vitro and in vivo data firmly establish the molecular segregation between gamma

106 ies and reaction conditions was performed to firmly establish the optimized reaction conditions requi

107 Together, our results firmly establish the pathophysiologic involvement of end

108 e randomized controlled trials are needed to firmly establish the relevance of vitamin D status to ca

109 An X-ray analysis was carried out to firmly establish the stereochemistry of the products.

110 In summary, our results firmly establish the transforming potential of adult OPC

111 The experimental and computational studies firmly establish the unique low-spin, nonplanar, cyclic

112 igation on a large population is required to firmly establish their effects on breast cancer risks.

113 the structure ( approximately 4 A) does not firmly establish this bonding.

114 In this article, we firmly establish this summer CANA pattern, providing evi

115 The data firmly establish Toll-like receptor 2 as an innate immun

116 ious examination was SFM) and after FFDM was firmly established (when the previous examination was FF

117 Studies have firmly established a key regulatory role for the tumor s

118 ical studies on persistence of HPV infection firmly established a role for HPV in the etiology of cer

119 fore the benefits and risks of doing so were firmly established appears to have had unintended clinic

120 Still, no biomarker has been firmly established as a clinically useful prognostic too

121 Fractional flow reserve (FFR) is not firmly established as a guide to treatment in patients w

122 In rodents, SR-BI has been firmly established as a physiologically relevant HDL rec

123 edical therapy and attention to risk factors firmly established as fundamental aspects of management,

124 Cadmium telluride, CdTe, is now firmly established as the basis for the market-leading t

125 quitting smoking, is a heritable trait with firmly established associations with sequence variants i

126 R chemical shift (delta(29)Si = -155) and is firmly established by its experimental molecular structu

127 Although studies have not firmly established causality, onset of regular marijuana

128 ted the interaction of viperin with its most firmly established cellular target, farnesyl pyrophospha

129 ling of bacteria, work over the last century firmly established complement as a key mediator of the g

130 r, the in vivo role of NK cells has not been firmly established due to the lack of animal models with

131 While the research in the last century firmly established FGFs as key players in development, m

132 displayed by the fkbp52-deficient mice have firmly established FKBP52 as a promising target for the

133 environment for optimal activity, it is not firmly established how these enzymes are maintained in t

134 the treatment of allergic rhinitis has been firmly established in large multicenter clinical trials.

135 ical redox functions of co-enzyme NAD(+) are firmly established in metabolism, there are numerous enz

136 In contrast to hydrogen bonding, which is firmly established in organocatalysis, there are still v

137 secondary to medical conditions but are not firmly established in primary mood disorders.

138 Screening for colorectal cancer is more firmly established in PSC patients with IBD and includes

139 in adult homoeothermic vertebrates was first firmly established in songbirds.

140 is a conserved form of programmed cell death firmly established in the aetiology, pathogenesis and tr

141 or neuron degeneration, but neither has been firmly established in the pathogenesis of ALS.

142 mportance of genetic predisposition has been firmly established in these illnesses, children (offspri

143 hysical analyses of TSE infectivity have now firmly established its prion credentials.

144 led localization of par6 and aPKC, which has firmly established its role in epithelial cell polarity.

145 Quantum chemistry has firmly established itself as a reliable method for inves

146 of ETD-based fragmentation have not yet been firmly established or systematically addressed.

147 In contrast to these firmly established principles of signal transduction, mu

148 s one of very few RTKs that remain without a firmly established protein ligand.

149 not related to an inability to switch from a firmly established response strategy to an allocentric p

150 The research of the past two decades has firmly established that hormones modulate numerous aspec

151 It has been firmly established that humans excrete a small but stead

152 Mounting evidence has firmly established that low levels of cardiorespiratory

153 Experiments have firmly established that magnesium is required for effici

154 It has been firmly established that many interphase nuclear function

155 The Aspreva Lupus Management Study (ALMS) firmly established that MMF is equivalent to intravenous

156 ynthesizing atrop-haouamine A, this work has firmly established that natural haouamine exists as a si

157 Although it is firmly established that neuronal activity is a prime det

158 However, it is firmly established that new neurons are generated in the

159 Theoretical and experimental studies have firmly established that protein folding can be described

160 Our data reported herein firmly established that SpnH, SpnI, and SpnK are the res

161 While it has been firmly established that the AON is a primary source of b

162 ) copper oxides two decades ago, it has been firmly established that the CuO(2) plane is essential fo

163 It is also firmly established that their aberrant generation and ac

164 It is now firmly established that this enzyme-catalyzed modificati

165 nt experimental and theoretical results have firmly established the existence of enhanced concentrati

166 ysis of genetically engineered mouse models, firmly established the gain-of-function (GOF) properties

167 If firmly established this property of Ras would require pr

168 mmon to different autoimmune diseases is now firmly established with previous studies demonstrating o

169 for fluorouracil-based chemotherapy has been firmly established, and recent data have shown further e

170 left ventricular (LV) volume and function is firmly established, and the guidelines of the American C

171 The cause for FCD has not been firmly established, and there are no explanations for it

172 and the bacterial flagellar system has been firmly established, based upon both sequence similaritie

173 itiating DNA mutations in melanocytes is now firmly established, but how the microenvironmental effec

174 origins of the actin cytoskeleton have been firmly established, but it has become clear that the bac

175 While its efficacy is firmly established, data on safety are still incomplete.

176 le the effects of fluoxetine on behavior are firmly established, debate is ongoing whether inhibition

177 wild-type p53 in tumor suppression has been firmly established, mounting evidence has demonstrated t

178 glutamate receptors in this process has been firmly established, the contribution of metabotropic GAB

179 ation of ES cells to cardiomyocytes has been firmly established, the extent to which corresponding ca

180 tone tail acetylation and gene activation is firmly established, the mechanisms by which acetylation

181 tor of apoptotic JNK signaling in neurons is firmly established, the molecular mechanism underlying t

182 whether it was acquired after resistance was firmly established, the strain temporally preceding the

183 xchange of subunits between bilayers thus is firmly established, which becomes a crucial consideratio

184 g interest in these methods and they are now firmly established, with a plethora of different techniq

185 ound at atomic steps and surface defects, is firmly established.

186 function and action mechanism are yet to be firmly established.

187 of language-to-music effects have yet to be firmly established.

188 mited and the underlying notions are not yet firmly established.

189 promoting the transformations have not been firmly established.

190 tes and direction of transport have not been firmly established.

191 e during the 2009-2010 pandemic has not been firmly established.

192 ogene possessing tumorigenicity has not been firmly established.

193 tive selection in normal mice has never been firmly established.

194 st and was subsequently lost before becoming firmly established.

195 these changes upon abstinence remains to be firmly established.

196 t this association is plausible, but not yet firmly established.

197 osis, but its association with gender is not firmly established.

198 f hematopoietic stem/progenitor cells is not firmly established.

199 d and their function in islets have not been firmly established.

200 ugh a cause-effect relationship has not been firmly established.

201 ta [x-ray computed tomography (CT)] has been firmly established.

202 ed by NMDA receptor activation have not been firmly established.

203 rotypic patterns of prediction have not been firmly established.

204 s) through which risk is conferred have been firmly established.

205 f Cdt in the human oral cavity have not been firmly established.

206 isms, and the preferred pathway has not been firmly established.

207 glycosylation for cell wall assembly is thus firmly established.

208 ptor (IR); however, their value has not been firmly established.

209 -related outcomes in middle-aged patients is firmly established.

210 its role in other tauopathies has yet to be firmly established.

211 ue of integrated team delivery models is not firmly established.

212 though their mode of regulation has not been firmly established.

213 ty, but its possible roles in cancer are not firmly established.

214 in the pathophysiology of the liver has been firmly established.

215 ated activation within the gut remains to be firmly established.

216 and distribution of excitatory neurons were firmly established; glutamatergic neurons in the anterio

217 tin filament severing protein cofilin is now firmly established; however, the contributions of other

218 g only resting, when compared with activity, firmly establishes a neuronal origin for default network

219 cancer.Significance: This large cohort study firmly establishes an association between an index of vi

220 Our study firmly establishes ATOH7 as a retinal disease gene and p

221 This study firmly establishes kin discrimination in a bacterial mul

222 usters in these cofactor-deficient proteins, firmly establishes P*-cluster as a catalytically active

223 Detection of HO-:C-OH in the gas phase firmly establishes that it is stable to isomerization, y

224 The new evidence firmly establishes that the Al-Cu-Fe alloys (including q

225 This study firmly establishes the combination of missense, nonsense

226 Our study thus firmly establishes the functions for three of the protei

227 This finding firmly establishes the role of IFIH1 in T1D and demonstr

228 ntained at a median follow-up of 8 years and firmly establishes the role of RT in the treatment of me

229 lls than in buffer, a surprising result that firmly establishes the significance of quinary interacti

230 oundaries of the original idea of Kekule and firmly establishes the usefulness of the sigma-aromatici

231 noallelic mutations in 18 affected families, firmly establishing TGFBR1 as the causative gene.

232 XAFS) spectra and reconstitution activities, firmly establishing the M-cluster-bound NifEN (designate

233 n outgrowth in cultured neurons and in vivo, firmly establishing the role of sliding in axon outgrowt

234 utionary model of early biochemistry that is firmly grounded in phylogenomic information and biochemi

235 firing and hemodynamic response that are not firmly grounded in rigorous theory or experimental evide

236 Bayesian analysis is firmly grounded in the science of probability and has be

237 ten discount evidence that contradicts their firmly held beliefs.

238 While the U6 snRNA catalytic core remains firmly held in the active site cavity of Prp8 by protein

239 them, three isomers of feruloyl-sucrose were firmly identified and another was strongly supposed to b

240 hormone for which the receptor has not been firmly identified.

241 ts suggest that the surfactant amine head is firmly immobilized onto the nanotube surface together wi

242 Our results also firmly implicate FNIII domain-mediated interactions in T

243 Bone morphogenetic proteins (BMPs) are firmly implicated as intra-ovarian regulators of follicl

244 Human studies have firmly implicated voltage-gated sodium channels in human

245 mponent, and copy number variants (CNVs) are firmly implicated.

246 Our revised timescale more firmly implicates volcanic eruptions as catalysts in the

247 opulations of large frugivorous vertebrates, firmly in the agenda of reducing emissions from deforest

248 L phylogeny revealed that Simonsenia belongs firmly in the Bacillariaceae, with which it shares a sim

249 Our results firmly indicate that (i) the supergroup Excavata is not

250 pic, electrochemical, and inhibition studies firmly indicate that [Co4(H2O)2(PW9O34)2]10- is stable u

251 In such an orientation, the oleoyl chain is firmly inserted into the membrane.

252 site of B cell development in swine are not firmly known.

253 Our findings are important as they firmly link sleepwalking to the neuroscience of motor co

254 ions with ILK, a signal transduction pathway firmly linked to cell motility and invasion.

255 pectra identify the asteroid as F class, now firmly linked to dark carbon-rich anomalous ureilites, a

256 lution and as FOXP2 is the sole gene to date firmly linked to speech and language development.

257 proteins originated specifically in mammals, firmly linking this family of proteins with interferons

258 A lubricant can be firmly locked into the structures and, owing to its flui

259 d to sandwich the layer of biological sample firmly on the electrode surface.

260 candidate gene studies have placed MC4R more firmly on the human obesity map, the major breakthrough

261 , whereas Galphai2-deficient T cells adhered firmly on the sinus, which prevented their retraction, f

262 The sensitizer is anchored firmly on the surface of NiO, and the binding is resista

263 February 2012, the South-East Asia Region is firmly on track for polio-free certification in early 20

264 the auxilin J-domain, splits ATP, it clamps firmly onto its heavy-chain site and locks in place a tr

265 hesion force, water droplets could either be firmly pinned to the surface, forming various patterns o

266 Phylogenetic analyses firmly place the palmophyllalean Verdigellas peltata alo

267 ovoke many diseases, including autoimmunity, firmly positioning the unfolded protein response as a ma

268 o humans from exposure to pathogens has been firmly put into a risk assessment framework.

269 inated communication-current theories remain firmly rooted in an individualistic account and have lar

270 Although existing models of allostery are firmly rooted in the current structure-function paradigm

271 tive behavior depends on cortical structures firmly rooted in the emotional brain from which they hav

272 ys a twisted L-shaped beta-helical structure firmly stabilized by a 3D hydrogen-bonded scaffold.

273 In contrast, the antagonist epimer remained firmly stabilized in the binding pocket.

274 Our results firmly support a structural plasticity view of microtubu

275 Collectively, these data firmly support the premise that muscle carnitine availab

276 involvement of Sia in the animal strains is firmly supported by crystallographic studies, it is not

277 usly long-wavelength emission for DMP and is firmly supported by polarity-, viscosity-, and temperatu

278 otion is along the minimum energetic pathway firmly supporting the experimental results.

279 autoimmune encephalomyelitis (EAE) research firmly supports this hypothesis.

280 (N- and C-terminal) lipidated proteins that firmly tether to the surface of producing cells.

281 and adhered to antigen-presenting cells less firmly than gal3(-/-) T cells, suggesting that galectin-

282 s providing causal evidence have established firmly that face-selective brain areas are central to fa

283 This work establishes firmly the metal-doped B rings as a new class of novel a

284 dern observations--are required to establish firmly the role of the Agulhas system in a warming clima

285 Diffraction revealed that the Abeta anchors firmly to the highly charged DMPG bilayers in the interf

286 integrin-based platforms to move and adhere firmly to the surface of other cells.

287 along its backbone allowed it to attach more firmly to thin filaments than the wild-type isoform, pro

288 ions related to different scenarios, such as firmly trapped or labile guest facing the {Mo9O9} pores.

289 ARAP3-deficient cells adhere more firmly under flow conditions in vitro and to the vessel

290 However, the maxilla is firmly united with the skull, indicating an akinetic ros

291 excellent agreement with biochemical results firmly validates the MPD analyses, which, we expect, can

292 in SIFSIX materials grasp every atom of SO2 firmly via S(delta+) ...F(delta-) electrostatic interact

293 othelial cells enables neutrophils to adhere firmly, via LFA-1-mediated binding to ICAM-1 constitutiv

294 cess termed cell-autonomous immunity-equates firmly with survival of the species.

295 e produced models were assembled, positioned firmly within a 3D printed shell mold simulating the ski

296 With these structures we are now firmly within the "atomic age" of electron cryomicroscop

297 (Capnodiales, Dothideomycetes) and place it firmly within the clade Pseudocercospora s. str., now ac

298 results demonstrate that Fdg neurons operate firmly within the sensorimotor watershed, downstream of

299 hin the plane of the epithelium but are kept firmly within this plane to give a symmetric division.

300 lf-assemble, biomimetic microelectronics can firmly yet gently attach to an inorganic or biological t