ライフサイエンスコーパス: first

1 vestigations, diagnosis and outcomes for the first 100 patients who had API as part of their routine

2 n patients who started PPIs vs H2RAs for the first 12 months, either in the commercial population (we

3 cal adverse events versus placebo within the first 14 days were arm pain (57.4% [27 of 47] vs 7.4% [s

4 ychiatric Inventory (NPI) and relapse in the first 16-week phase after randomization.

5 y synthesized short RNA corresponding to the first 19 nucleotides (nt) of the rabies virus genome, we

6 .g. foam cells, extracellular lipids) in the first 200 mum of the intima provide important biochemica

7 und increased from 1514 to 1532 m/s over the first 24 h, after which time it plateaued.

8 ectroencephalography was recorded during the first 3 days.

9 rhoea, rash, and nausea) improved during the first 3 months of de-escalation, though not thereafter.

10 nomic impacts of cancer diagnosed within the first 3 years posttransplantation.

11 evel uptake in tumor with DiD-BCM within the first 3days, its accumulation, however, decreased obviou

12 subsets more gradually increased during the first 4 years of life.

13 In the construct containing the first 4 ZFs, we observed that ZFs 3 and 4 form an unusua

14 In particular, MD detected more eyes in the first 5 years of their follow-up, which were presumably

15 , most BCVA improvements occurred during the first 6 months and were maintained until the end of the

16 octor's diagnosed eczema/skin allergy in the first 6 years of life, adjusting for confounders.

17 placebo and assessed for safety through the first 7 days.

18 The IRR remained elevated during the first 90 days of treatment (IRR, 3.91; 95% CI, 1.62-9.42

19 at actin, Arp2/3, vinculin and integrin-beta first accumulated at the cell's leading edge.

20 First, after DSB formation, Mer2 is required for pairing

21 a-analysis, including, to our knowledge, the first analysis of the X chromosome.

22 ased Spatial Statistics analytic pipeline to first analyze fractional anisotropy (FA), the most commo

23 Sec incorporation at the first and downstream UGA codons occurs with variable eff

24 First and foremost, treating hearing loss should be inve

25 ct this information, we propose fitting both first and second scans simultaneously.

26 he Lumipulse G TP-N having a shorter time to first and subsequent results.

27 PVRs at two different time points during the first and the last follow-up visits.

28 long and unusual story of GO, which was the first antibody-drug conjugate approved for human use by

29 ogical niche models can provide a reasonable first approximation of the magnitude of species' potenti

30 h NADP(+) at 1.8 A resolution, providing the first bacterial FNO structure.

31 This is the first bivariate GWAS meta-analysis to demonstrate geneti

32 First, both PD patients and mice with ventral tegmental

33 degraded by DegP but were toxic because they first bound to the Bam complex, an essential heteroligom

34 I address these issues first by evaluating the extent to which the results of c

35 This is the first case in which a cycloparaphenylene derivative is i

36 Key features include the first catalytic asymmetric cyclopropanation of allene, m

37 The first cellular differentiation event in mouse developmen

38 Here, we provide the first characterization of a mutation in the gene encodin

39 iovascular disease were followed until their first CHF event, death, last follow-up date, or December

40 -label, 2-cohort clinical trial in which the first cohort assessed for the safety and efficacy of 12

41 This study is the first cohort-specific analysis to show that some childre

42 lities should inspire the development of the first combined audio-visual nanotechnologies.

43 We provide the first comparison of the skill of coupled ecological-nich

44 ionary terms, the present study provides the first comprehensive and detailed map of the catecholamin

45 Here we present the first comprehensive description and expression of both m

46 We have provided the first comprehensive machine learning based classificatio

47 Collectively, this is the first comprehensive map of TSSs in B. burgdorferi and ch

48 We present the first computational study that explicitly accounts for d

49 We first compute the thermal conductivity for the case with

50 data provide what is, to our knowledge, the first conclusive evidence that ARPKD is not a homogeneou

51 However, the first constitutional isomer of porphyrin, porphycene, wa

52 oming more irreversible within minutes after first contact with a surface.

53 Here the authors show that VWF is first converted from a compact to linear form by flow, a

54 e show that upon cooling down the resistance first decreases linearly with temperature and then passe

55 efficiently incorporating information beyond first-degree relatives and allows for the inclusion of c

56 Patients' first-degree relatives and pairwise age- and sex-matched

57 We first demonstrate that intertemporal decision making is

58 Here, we first demonstrated that breast cancer cells and pancreat

59 To our knowledge, this study is the first demonstration of an integrated approach to elucida

60 The approach, which is the first demonstration of applicability of molecular dockin

61 This is the first demonstration of H2O2 production using PS in an MP

62 These data are the first demonstration of microRNA regulation of DCC and su

63 This study is the first demonstration that an SRRP is required to bind bet

64 cated features (12 microm-50 microm) used to first deplete red blood cells and platelets.

65 Cumulative SMN incidence at 25 years after first diagnosis was 3.9% (95% CI, 3.4% to 4.6%) and did

66 onserved RNA-binding protein, represents the first documented protein known to stimulate transforming

67 The recent discovery of the first doubly charmed baryon , which contains two charm q

68 These results provide the first dynamic view of corticostriatal activity during bo

69 x with a melon eIF4G peptide and propose the first eIF4E-eIF4G structural model for plants.

70 Paper-based microfluidic diagnostics first emerged in 2007 as a low-cost alternative to conve

71 The first enantioselective synthesis of (-)-himalensine A ha

72 The first enantioselective total synthesis of (-)-deoxoapodi

73 After the first English language report on LSD in 1950, psychedeli

74 Phenylalanine ammonia-lyase (PAL) is the first enzyme of the general phenylpropanoid pathway cata

75 Recent work, however, showed that the first enzyme of the glyoxylate shunt, isocitrate lyase (

76 lterations are present in individuals with a first episode of psychosis who have not been exposed to

77 Patients with first-episode psychosis had lower regional FA in multipl

78 very on structured activity in patients with first-episode psychosis who received social recovery the

79 hopulmonary aspergillosis relies on criteria first established in 1977.

80 For this purpose, we introduce the first ever dynamic NA method, DynaMAGNA ++.

81 The first evidence of prostate cancer lesion visualization i

82 To our knowledge, this is the first evidence that some mammals can use an inverted ord

83 In this study, we present the first evidence that using a BCI-FES system, a human with

84 First, evidence that thrombin may be as important as pla

85 To our knowledge, this represents the first example of a MOF capable of separating chiral pola

86 This cooperativity converts the BC into the first example of an aborted [3,3] sigmatropic shift wher

87 ead domain; 1 variant was identical with the first, except for an amino acid exchange in the stalk re

88 In our first experiment, chicks begged significantly longer in

89 nd postoperative ophthalmic examinations for first eye and second eye cataract surgeries.

90 Compared with second eyes, first eyes had worse mean preoperative BCVA (0.55 vs. 0.

91 based whole exome sequencing analysis in the first family detected a homozygous frameshift change [c.

92 showed small early favorable changes in the first few months post-TAVR, with a decrease of -2.9 mm H

93 ry nut allergy presents most commonly in the first five years of life, often after the first known in

94 assess variables obtained at baseline and at first follow-up RHC.

95 as then applied to 291 food samples from the first French total diet study on infants and toddlers.

96 demonstrate that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d

97 Here, we report the first functional characterization of PRX17 (At2g22420),

98 We performed the first genome-wide association study for molar shape and

99 In this study, we provide the first genome-wide, base pair-resolution map of 6mA in Te

100 We present the first geometric morphometric study using ontogenetic ser

101 ormational states of the enzyme, providing a first glimpse of what an active TAM receptor kinase may

102 n-droplet cell concentrator that operates by first gradually focusing cells inside a droplet to one s

103 We first group multiple features arising from the same anal

104 stallography to medicine was evident, as the first high-resolution structures emerged in the 50s and

105 ian delay from neurological symptom debut to first hospital contact was 20 days and significantly lon

106 The candidates are first identified by focusing on structures with methane-

107 MERS-CoV was first identified in June 2012 and has since spread in hu

108 They support the first impression hypothesis that suggests xenophilia can

109 Vismodegib, a first-in-class Hedgehog-pathway inhibitor, is approved f

110 Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates th

111 bines coronary heart disease, defined as the first incident myocardial infarction or death owing to c

112 ologic therapy without trying triple therapy first increases costs while providing minimal incrementa

113 orate the costs of generic ZA and one of the first independent CE analyses not sponsored by either No

114 from the distributions of its components, by first independently, and then simultaneously, mutating a

115 Here, we provide first insight into the key step of MSP-mediated phosphot

116 ing Aedes aegypti, do not develop beyond the first instar when fed a nutritionally complete diet in t

117 First, interference should occur between alternating dyn

118 ified since the 1960s when madC mutants were first isolated.

119 he first five years of life, often after the first known ingestion with typical rapid onset IgE-media

120 mucous barrier of our digestive tract is the first line of defense against pathogens and damage.

121 To provide a first line of protection at these entry ports, vaccines

122 This systematic review suggests that first-line antenatal management in FNAIT is weekly IVIG

123 )-infected PWUD, and assessed its impacts on first-line ART virological outcomes.

124 ly hinders the broad application of PDT as a first-line cancer treatment option.

125 days sooner than with culture-based DST for first-line drugs and 32 days sooner for second-line drug

126 ) represents the only available option after first-line failure for the majority of individuals livin

127 First-line immunotherapy consisted of steroids (n = 61/7

128 Therefore, it might be useful as first-line monotherapy for adults with newly diagnosed e

129 Patients receiving first-line or subsequent dasatinib or nilotinib who stop

130 to lapatinib or placebo after completion of first-line/initial chemotherapy for metastatic disease.

131 First, localization capabilities were demonstrated by re

132 SIGNIFICANCE STATEMENT This article offers a first look at the relationship between Tau-PET imaging w

133 d-based resorcinarene capsule represents the first man-made enzyme-like catalyst that is capable of c

134 ents with delirium than those without at the first (median, 0 vs 9.5), second (median, 3.5 vs 9), and

135 In addition, having sex upon first meeting was associated with higher odds of SDCS (O

136 % CI: 1.21, 1.83) than was not having sex on first meeting, while living/continued communication with

137 these simulation tools, we have developed a first method to evaluate the parameters of this propagat

138 ative survival is low, once they survive the first month after percutaneous coronary intervention, th

139 th retinal structure and function during the first month following iatrogenic macular detachment surg

140 s defined as receiving >/=5 doses during the first month of treatment.

141 diversity of microbial exposures during the first months and years of life have been linked with ris

142 ll-angle negative reflection occurs when the first negative order Floquet-Bloch mode dominates inside

143 Notably, the first new central nervous system (CNS)-targeted oligonuc

144 ectional data from 1932 case subjects with a first nonfatal MI and 2055 population-based control subj

145 ry heart disease, and stroke, defined as the first nonfatal stroke or death owing to stroke.

146 This is the first observation of a PVS closure in connection with an

147 This construct is a first-of-its kind theranostic that may serve as a new ap

148 The first one (possibly associated to hot spots or whole Fer

149 Women had fewer total and first or last author publications than men (total, 12.2

150 publications than men (total, 12.2 vs 17.6; first or last, 6.8 vs 10.7; P < .001 for both comparison

151 When located at the first or second codon position, N1-methyladenosine (m1A)

152 ectives are to determine if patient age, and first or second eye surgery affect intra-operative pain

153 phoblastic leukaemia who were due to receive first or second salvage treatment were randomly assigned

154 systems and solving the process in a pseudo-first order approximation.

155 haracteristics captured by angular-dependent first order reversal curve measurements indicate a stron

156 for the orientation of boundaries defined by first-order cues (luminance) as well as second-order cue

157 Ni3TeO6-type structure with low temperature first-order field-induced metamagnetic phase transitions

158 Many lithium-storage materials operate via first-order phase transformations with slow kinetics lar

159 First-order PHE transformation rates, kPHE, and half-liv

160 was informed by the development of a pseudo first-order rate constant model, and tested in a paper-b

161 s - root diameter, root branching intensity, first-order root length and mycorrhizal colonization - i

162 for rod-like colloids is a signature of the first-order thermodynamics nature of this phase transiti

163 First, our field experiments showed that the mean number

164 In this first paper of the Series on health, equity, and women's

165 In this first part of a 2-part review, we describe indications,

166 red with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associat

167 The first patient's tumor tissue was investigated for secret

168 the average image area with a loss less than first-percentile confidence interval of the variability

169 We first performed a microarray analysis of mPFC gene expre

170 First, PFP appearance was evaluated in an anatomic speci

171 2.8 mg . min(-1), respectively; P = 0.9) or first-phase insulin secretion (-21 +/- 212 compared with

172 Time to first physical therapy evaluation in the intensive care

173 As primary care is the first point of healthcare contact for most children, we

174 Polyladderane, the first polymer to contain the ladderane functional group,

175 ycerol class and containing palmitate at the first position) were significantly genetically correlate

176 (22% vs 3%) and be rehospitalized within the first posttransplant year (78% vs 57%), all P < .001.

177 precise in-situ alignment detection, for the first practicable realisation of 3D photonic microstruct

178 To identify active sites, we first predict the CO binding at a large number of sites

179 First, previously published qualitative research was use

180 c properties of ternary FeSexTe1-x, based on first principle calculations.

181 e origins of life from chemical and physical first principles.

182 electron diffraction analysis combined with first-principles calculation allows us to determine that

183 Here, based on first-principles calculations, anisotropic Eliashberg th

184 ator-metal transition using a combination of first-principles density-functional and many-body calcul

185 This study is the first proof of concept that targeting a lncRNA to transc

186 To our knowledge, this is the first propensity score-matched analysis of robotic vs op

187 roups, such as women who experience PPD as a first psychiatric episode.

188 In this study, we present the first quantitative human genome-wide map of DNA lesions

189 increased risk of death during TB treatment [first quintile, referent; second quintile hazard ratio (

190 We conducted the first randomized trial of behavioral weight loss for HIV

191 By first reacting a bifunctionalized peptide with the more

192 It has been postulated that the amygdala first receives visual input via a rapid subcortical rout

193 most taxa even show increases in the rate of first records over time.

194 Live-cell imaging reveals that Rab8a is first recruited to the plasma membrane and dorsal ruffle

195 This is the first report describing the ability of the pH1N1 NS1 pro

196 To our knowledge, this is the first report of nucleolar functions for NSs within the B

197 This is the first report of TA receptor function in a native tissue

198 This first report of the large combined experience with DCDD

199 It also affords the first reported [8]AGNR, which can now be synthesized on

200 Conclusion To our knowledge, this is the first reported anti-PD-L1 plus olaparib or cediranib com

201 In the first reported pediatric case series of virologically co

202 as been an important open question since the first reports of the strong modulation of electrical pro

203 In this review article, we will first review the key role of Ca(2+) in normal cardiac fu

204 th different levels of expertise (1-9 years) first reviewed only a fraction of the full multiparametr

205 ca, deposited during the early stages of the first rise in atmospheric oxygen on the Earth (the Great

206 Experiments were carried out in piglets first sensitized by three intra-peritoneal injections of

207 n the rate of successful cardioversion after first shock (AOR, 0.73; 95% CI, 0.51-1.06; P=0.10).

208 usted rate of successful cardioversion after first shock (from 12.3% to 13.8%; P=0.13).

209 of TMA oxidation by marine bacterial Tmm and first show that NADP(+) undergoes a conformational chang

210 Health Insurance Act of 1883 established the first social health insurance system in the world.

211 Patients presenting with their first STEMI and early QW in the ECG had smaller myocardi

212 hanges appear possible, suggesting this is a first step in developing a simple way of controlling pla

213 Here, we undertake a first step in this direction by focussing on the pressur

214 good to excellent yield, and represents the first step towards a general transition metal catalysed

215 These data are important first steps toward implementation of precision head and

216 Current experiments are taking the first steps toward noise-resilient logical qubits.

217 This contemporary review first strives to understand the diverse roles of immune

218 To our knowledge, this is the first study to investigate the long-term association of

219 To examine this system, we first tested thiram, a DTC pesticide known to display ne

220 ely connected model of MCs and GCs, we found first that interglomerular synchrony was generally quite

221 First, the motor domain attains the poststroke conformat

222 ults in an ancient vertebrate reveal for the first time a collection of brain targets of Galphat-S-ir

223 Herein, we report for the first time a series of novel, potent, and selective inhi

224 of the hits are chemotypes described for the first time as late-stage gametocyte-targeting molecules.

225 egisters on all women who gave birth for the first time between January 1, 1993, and December 31, 201

226 Here we for the first time demonstrate this extreme localization of BISE

227 Here, we test for the first time how early-life stress drives developmental pr

228 nnel magnetocapacitance (TMC) effect for the first time in Fe/AlOx/Fe3O4 magnetic tunnel junctions (M

229 Here we demonstrate for the first time that harmonic nanomechanical resonators with

230 Results indicated for the first time that luminescence switchable CNPs can be synt

231 ed to bind beta-1,4-linked galactose and the first time that one of these adhesins has been shown to

232 This is the first time that RE-MOFs based on 12-c molecular building

233 Herein, we demonstrate by the first time that the Igf1r plays an important role in mur

234 In this study, we report for the first time that the primary cilium acts as a crucial sen

235 Our results reveal for the first time the dynamic connection between FTO RNA bindin

236 Especially, for the first time the fully tunable conductivity of ReS2x Se2(1

237 We report for the first time the high sorption properties of a molecular r

238 In the present study, we describe for the first time the presence of ACSL6 mRNA in human skeletal

239 We report here for the first time the temperature dependences of LSSE voltage (

240 We report for the first time the use of hexavalent chromium (Cr(VI)) as an

241 l molecule with inherent properties, for the first time, as the redox probe in the development of HCV

242 d indoles and H2O that is catalyzed, for the first time, by a complex of earth-abundant iron.

243 Our platform, for the first time, demonstrates the detection of hybridization

244 lent glycooligomers on solid support for the first time, demonstrating the utility of this approach f

245 In the proposed study, for the first time, sensitive electrochemical detection of a bre

246 The present study revealed, for the first time, that Rodentia associated UMRV emerged from a

247 We report, for the first time, that the excitation of a peripheral nerve ca

248 We find, for the first time, that the model thalamic network is capable o

249 ress this issue, our paper presents, for the first time, the integration on a single glass substrate

250 ingle-particle EM analysis revealed, for the first time, the overall architecture of the MCM-MeaB com

251 For the first time, this study reports a ddHRMS/MS method capabl

252 MALDI-MS allowed these two epitopes, for the first time, to be directly identified on the polylactosa

253 For the first time, variations in miscanthus cell wall glycan co

254 Here, for the first time, we report carious lesions preserved in speci

255 Here, for the first time, we show robust evidence of a decrease in hai

256 ion transport of biological samples for the first time.

257 etal and carbon sources is presented for the first time.

258 The findings are the first to demonstrate an association between ketamine's c

259 This study is the first to identify active isoprene degraders in estuarine

260 This analysis was one of the first to incorporate the costs of generic ZA and one of

261 These results are the first to reveal the neurocomputational mechanisms underl

262 e, the largest trial of CIDP to date and the first to study two administrations of immunoglobulins an

263 Here we present the first, to our knowledge, in vivo therapeutic micromotors

264 we provide the TSIS R package, which is the first tool for detecting significant transcript isoform

265 The first total syntheses of members of these natural produc

266 d its subsequent elaboration to complete the first total synthesis of the juvenimicin, M-4365, and ro

267 The supervised machine-learning model was first trained with 1037 individual compounds that adopt

268 Altogether our work provides the first transcriptome comparison between cork oak and holm

269 During cooling, the compound first transits into a magnetically distinguishable HS-LS

270 or pregnancy, maternal, and paternal traits, first-trimester antidepressant exposure was associated w

271 d global monitoring data reported during the first two decades of transgenic crops, with each case re

272 The first two talks discuss novel developmental and neuronal

273 We show that SiO2 first undergoes a change in Si-O coordination number fro

274 We describe here the first use of thiosemicarbazone exchange to form dynamic

275 Thus, vDeltaK1L is the first vaccinia virus construct reported that caused a mu

276 First validated with standard synthetic membranes and th

277 The discovery cohort had 306 patients, the first validation cohort had 216, and the second validati

278 no difference in mean visual outcome of the first versus second NAION events (standardized mean diff

279 With these advances, the first vertical GaN metal-insulator-semiconductor field-e

280 ther to abundance or rarity, thus offering a first view on how it varies across space and time and re

281 the most popular candidate materials for the first wall/blanket applications in fusion reactor.

282 First, we find that across three etiologically distinct

283 First, we identified the optimal NP formulation through

284 First, we investigate a variety of intron sequence-deriv

285 First, we observed a constrained, horseshoe-shaped subst

286 First, we report that UL8 alone forms protein filaments

287 First, we theoretically model the importance of multiple

288 f newborns with the S187A mutant died in the first week due to failure to undergo the peroxisome prol

289 i reaches high parasitemia levels during the first week of infection in all three mice strains before

290 ethodology for burden estimation and present first WHO global and regional estimates of the annual nu

291 nabaptist Genome Reference Panel (AGRP), the first whole-genome catalogue of variants and phased hapl

292 F injections for an eye with mCNV during the first year after diagnosis was 2.8 (standard deviation,

293 f humoral immunity was most outspoken in the first year after lung transplantation.

294 slight initial increase in the IG during the first year and smaller decline afterward.

295 ciated with lower mortality hazard after the first year compared with the waitlist including KDPI 0%

296 offspring of chow-fed dams throughout their first year of life, an effect not present in the offspri

297 status, with normalization of weight in the first year of life.

298 F was defined by any HF encounter during the first year, and incident HF with either 1 inpatient or 2

299 Warming reduced limber pine first-year recruitment in the forest, but had no net eff

300 Our results support two major first, young eels distinguish among magnetic fields corr