ライフサイエンスコーパス: first generation

1 r nondepressed (low familiar risk) probands (first generation).

2 A first-generation 3D Light PAD was fabricated using the p

3 The first-generation ACM analogue dihydro-2-pyridone 1 maint

4 d describes how the lessons learned from the first-generation ADCs have led to improvements in every

5 First-generation adjuvant chemotherapy trials reported a

6 arent-offspring transmission and started the first generation affected by ALS (four children carry an

7 overcome the development deficiencies of the first generation ALK inhibitor 4 (TAE684).

8 h carbon number group, and is not the common first generation alkyl nitrates previously reported.

9 First-generation amperometric glucose biosensors incorpo

10 First generation analogues were potent inhibitors, effec

11 Here we describe the first generation and characterization of a mouse line hu

12 enic factors NF-kappaB and VEGFR2 in the 7-d first generation and second generation lungs.

13 Herein, we show that first generation and second generation progeny from gest

14 In contrast, first-generation and 4-1BB-costimulated CAR T cells incr

15 potential to increase the efficiency of both first-generation and next-generation biofuel production.

16 been realized with the evolution from BMS to first-generation and now second-generation DES, with the

17 lind randomised placebo-controlled trials of first-generation and second-generation antidepressants f

18 s, and the risk is further increased by both first-generation and second-generation antipsychotics.

19 eceptor (D3R) is a molecular target for both first-generation and several recently-developed antipsyc

20 solations) from 3 fragments prepared in 7-8 (first generation) and 3-8 (second generation) steps each

21 Whereas first-generation antagonists that inhibit all modes of T

22 n sensitivity, although a high prevalence of first generation anti-gliadin antibodies of IgG class ha

23 -go potassium channel (hERG) activity of the first-generation anti-Cryptosporidium BKIs triggered fur

24 ed, except in patients receiving a standard, first-generation antiandrogen agent with a falling PSA l

25 intake in patients treated with at least one first-generation antipsychotic and less progressive GM l

26 death and stroke associated with the use of first-generation antipsychotic drugs (FGAs) compared wit

27 First-line treatment with either first-generation antipsychotics (adjusted hazard ratio,

28 about the comparative benefits and harms of first-generation antipsychotics (FGAs) and second-genera

29 second-generation antipsychotics (SGAs) with first-generation antipsychotics (FGAs) regarding relapse

30 ed with second-generation antipsychotics and first-generation antipsychotics revealed a different and

31 um levels greater than 0.6 mEq/l, and use of first-generation antipsychotics were independently assoc

32 .32 (95% confidence interval, 2.17-2.47) for first-generation antipsychotics, and 2.74 (95% confidenc

33 The movement from first-generation antiretroviral therapy (ART) coformulat

34 Our first-generation approach aimed to unlock the unknown C(

35 Herein we describe our first-generation approach to the formal synthesis of las

36 The limit and range of detection of this first generation assay is 10(2) and 10(2)-10(8) plaque f

37 ree BD Max assays, including the BD Max MRSA first-generation assay.

38 In burrows built by first-generation backcross mice, entrance-tunnel length

39 Rather it was the widespread use of first generation beta-lactams such as penicillin in the

40 the effects of nebivolol with metoprolol, a first-generation beta1-selective beta-blocker, on human

41 First generation biofuels focused on food crops like cor

42 he most efficient crops in the production of first-generation biofuels.

43 A first-generation bioresorbable scaffold has been demonst

44 bodies provide many challenges compared with first-generation biosimilars, growth factors, and hormon

45 similar monoclonal antibodies in relation to first-generation biosimilars, the issues surrounding int

46 First generation bivalent and quadrivalent human papillo

47 Complete differentiation of first generation blood stages into sexual stages for sub

48 ts differential responsiveness to PLX4720, a first-generation BRAF inhibitor and research analog of v

49 First-generation bricks used to create three-dimensional

50 ned to improve on the safety and efficacy of first-generation BTK inhibitors.

51 Mouse T cells engrafted with a first-generation CAR failed to develop such autotoxicity

52 rganic transformations and compared with the first generation catalyst.

53 mmersing the samples in a solution of Grubbs first-generation catalyst in cyclohexane, a nonsolvent f

54 can be performed efficiently with the Grubbs first-generation catalyst or [(Ph)3P]3RuCl2 in a sealed

55 imethyl-imidazolidin-4-one (11a, MacMillan's first-generation catalyst) gives the corresponding cyclo

56 ene isomerization that was observed with our first-generation catalyst, providing vastly improved yie

57 e scaffold is structurally distinct from the first-generation CB1 inverse agonists.

58 om enriched CD8(+) TCM subsets, expressing a first-generation CD19 CAR containing only the CD3zeta en

59 tivity, thus avoiding problems observed with first generation CDK inhibitors.

60 The first-generation CDK inhibitors demonstrated broad activ

61 tissue specificity precluded clinical use of first-generation, centrally acting CB1 receptor blockers

62 ophylaxis for vascular procedures includes a first generation cephalosporin.

63 ccal penicillin (oxacillin and nafcillin) or first-generation cephalosporin (cefazolin).

64 antibiotic amoxicillin/clavulanic acid and a first-generation cephalosporin cefazolin.

65 Furthermore, patients who had received a first-generation cephalosporin in the 30 days prior to s

66 Thus, we advance first generation chemical biology tools to aid in the id

67 We show that this first-generation chemical tool for fluorescence Fe(2+) d

68 nd of optogenetic inhibition; however, these first-generation chloride-conducting channels displayed

69 gh activity or reasonably long scan times, a first-generation clustered-pinhole system can provide im

70 molecular libraries is often used to develop first-generation compounds, but subsequent target identi

71 ation molecules and increasing production of first-generation compounds.

72 As with these first-generation consortia efforts, the GLIOGENE Consort

73 ture that addresses important limitations of first-generation consortia efforts, which comprised a po

74 n, may overcome the "therapeutic ceiling" of first-generation correctors.

75 has better cooling properties compared with first-generation cryoballon.

76 The first generation cultivated from seeds obtained from reg

77 triazene activation, a dodecaiodo-terminated first generation dendrimer, which was transformed by ano

78 nds reported here share an architecture with first-generation dendrimeric constructs, making the conv

79 cationic self-assembling multivalent (SAMul) first generation dendrons based on L or D lysine, which

80 itions where complex tooth shapes develop in first generation dentitions that lack the capacity for l

81 To study SAR of this scaffold, first-generation derivatives were synthesized and evalua

82 ibuted as follows: bare metal stent (n=388), first-generation DES (n=425), and second-generation DES

83 CI: 0.96 to 2.47]) compared with the use of first-generation DES (OR: 3.94 [95% CI: 2.20 to 7.05]; p

84 risk of stent thrombosis when compared with first-generation DES and BMS with no increase in very la

85 For bare metal stent, first-generation DES and second-generation DES, ACS was

86 rior clinical outcomes compared with BMS and first-generation DES and similar rates of cardiac death/

87 Pathological studies have shown that first-generation DES are associated with delayed arteria

88 (ST) emerged as a major safety concern with first-generation DES early after their adoption in clini

89 y syndrome) were randomly assigned to have a first-generation DES implanted.

90 eneration DES to BMS) and indirect evidence (first-generation DES with BMS and second-generation DES)

91 Of these, 38% received BMS, 15% received first-generation DES, and 47% received second-generation

92 d into 3 groups according to stent use: BMS, first-generation DES, and newer generation DES group.

93 patients receiving bare-metal stents (BMS), first-generation DES, and newer generation DES in a larg

94 interval, 0.38-0.68; P<0.001), but not with first-generation DES, compared with BMS-treated patients

95 ted with second-generation DES, but not with first-generation DES, compared with the patients treated

96 zed controlled trials comparing stent types (first-generation DES, second-generation DES or BMS) were

97 ath or MI only in patients with DM receiving first-generation DES.

98 (ST) and late adverse outcomes compared with first-generation DES.

99 degradable polymer DES platforms compared to first-generation DES.

100 These first-generation designs thicken beyond single PNTs.

101 The first generation device demonstrated great potential and

102 Our first-generation devices containing (PEA)2(MA)2[Pb3I10]

103 First-generation devices were pulsatile, but they had po

104 revious studies were based on less-effective first-generation devices, and analyzed only dichotomized

105 m safety and efficacy outcomes compared with first-generation devices.

106 /4A sequences might affect susceptibility to first-generation direct-acting antiviral agents.

107 Two "first-generation," directly radiolabeled anti-CD20 antib

108 beta-interferons and glatiramer acetate, the first-generation DMTs, several newer therapies are imbue

109 t, mainly because of the "always-on" mode of first-generation DNAzyme sensors.

110 e- to five-times half-life compared with the first generation), dramatically enhanced inhibition of t

111 ads could drive the design of more resilient first generation drug candidates.

112 First-generation drug-eluting coronary stents (DES) were

113 Compared with bare metal stents (BMS), first-generation drug-eluting stents (DES) have signific

114 First-generation drug-eluting stents (DES), which impart

115 First-generation drug-eluting stents were associated wit

116 olimus have been shown to be superior to the first-generation drug-eluting stents.

117 uced extrapyramidal side effects compared to first generation drugs.

118 First-generation Edwards SAPIEN valves and delivery syst

119 model that initially developed resistance to first-generation EGFR inhibitors via cMET activation.

120 The first generation ELFI prototype is simply assembled in a

121 Studies using a first-generation enzyme-linked immunosorbent assay test

122 creased activity against activating mutants, first-generation epidermal growth factor receptor (EGFR)

123 The Argus I implant is the first-generation epiretinal prosthesis approved for an i

124 il practices combined with the production of first generation ethanol and electricity (scenario s2) w

125 would not perform better than the projected first generation ethanol, although the uncertainties are

126 ignaling and could be potentially useful for first-generation (F1) hybrid breeding.

127 utations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer

128 Altered dormancy was only observed in the first generation following herbivory, whereas defence pr

129 d might be epigenetically deregulated in the first generations following allopolyploidization.

130 While generally efficacious, ACTs and the first generation fully synthetic ozonide, arterolane (OZ

131 The first generation (G1) metallo-triangles were directly ob

132 A novel first generation (G1) poly(amidoamine) dendrimer (PAMAM)

133 amine the association between grandparents' (first generation (G1)) life-course exposure to chronic p

134 In first-generation (G1) ctc1 atr mutants, enhanced telomer

135 that may be exploited to improve upon these first generation GlgE inhibitors.

136 ates the biotechnology-engineered commercial first generation glyphosate-tolerant EPSPS in corn (Zea

137 petitive interaction between AZ GSMs and the first generation GSMs (R)-flurbiprofen and sulindac sulf

138 First-generation hatchery fish had nearly double the lif

139 gene expression in the offspring of wild and first-generation hatchery steelhead trout (Oncorhynchus

140 was reached in 2011 with the approval of the first-generation HCV NS3/4A protease inhibitors.

141 First-generation HIV protease inhibitors (PIs) alter pro

142 First generation homozygous coq-3(ok506) mutants are fer

143 g between the pillars in the presence of the first generation Hoveyda-Grubbs catalyst, while favoring

144 P = .89) and drug-eluting stent generation (first generation: HR, 0.90; 95% CI, 0.68-1.20; P = .49;

145 in regions near genes and within TEs in the first-generation hybrid, intermediate in the resynthesiz

146 ple of speciation by hybridization, in which first-generation hybrids instantly attain reproductive i

147 However, the first-generation ICG-NPs have a short shelf life (<1 mon

148 A cohort of 824 662 first-generation immigrants aged 30 to 74 as of January

149 : Of the 4582 survey participants, most were first-generation immigrants from China (68.7%) and femal

150 Also, first-generation immigrants interviewed in English had h

151 Among first-generation immigrants, those migrating to Singapor

152 ndian immigrants in Singapore is higher than first-generation immigrants.

153 in countries such as the UK and USA were the first generation in which many smoked substantial number

154 We developed the first generation in-situ pathogen detection system (Gen1

155 ly more potent in vitro and in vivo than the first generation inhibitor 14 (BIIB021) that completed p

156 nabsorbable ASBT inhibitor starting from the first-generation inhibitor 264W94 (1).

157 are 10-fold more potent toward Cif than our first-generation inhibitors and have no detectable thyro

158 First-generation insecticidal PIPs were Cry proteins exp

159 patients with virus harboring resistance to first-generation integrase inhibitors.

160 Here, we adapt the first-generation KTR for extracellular signal-regulated

161 The development of first-generation land surface models as a unifying frame

162 covery of 4 that is vastly improved from the first generation late INa inhibitor 1 (ranolazine).

163 ffold led to the discovery of 2 (AS-136a), a first generation lead with low nanomolar potency against

164 The first-generation ligands appeared to be MOR-selective, w

165 A series of first-generation light-driven molecular motors with rigi

166 First-generation liposomes have emerged as one of the fi

167 While first generation long acting/extended release (LA/ER) DD

168 dence for possible decomposition pathways of first-generation materials and guided synthetic modifica

169 e rapidly hydrolyzable Schiff-base moiety of first-generation members with a cyclic, unhydrolyzable p

170 orithms substantially outperform widely used first-generation methods, with large gains on all types

171 ctive double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role

172 effects in a population comprising primarily first-generation Mexican Americans with major depression

173 revalent among second-generation compared to first-generation migrants.

174 Using these methods, we obtained the first-generation mimetic drugs and tested these compound

175 A first-generation model, built from existing gene network

176 ers stabilized in NU-1000 provide an active, first generation MOF-based, selective methane oxidation

177 nd to be nearly 10-fold more potent than the first generation molecules.

178 HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineff

179 Among these agents, first-generation mTOR inhibitors (rapalogs) have caused

180 First-generation nanotherapies are well tolerated in hum

181 However, first generation native-like trimers expose epitopes for

182 populate the neurogenic niche containing the first-generation neuronal precursors.

183 Our first-generation nickel-based liposomes captured HIV-1 E

184 that efficiently inhibits HIV-1 resistant to first generation NNRTIs.

185 We found that the first-generation non-optimized SMIPPI, Ro-26-4550, inhib

186 al assessments we conducted, similar to the 'first generation' non-conditional A7KO mice.

187 To obtain more detailed interactions between first generation, non-covalent inhibitors and GlgE, a va

188 Second, in an in vivo comparison with first-generation (nondegradable, molecular weight below

189 Compound 2 (KU-32) is a first-generation novologue (a novobiocin-based, C-termin

190 Overall, our results suggest that "first generation" NP risk models have probably misrepres

191 19 and observe Cas9-induced mutations in the first generation of 23 % and 10 % of the lines, respecti

192 and observed that it is more potent than the first generation of Ab for controlling Ab-resistant tumo

193 A first generation of amine terminated aramide dendrimers

194 The first generation of Aurora kinase inhibitors did not far

195 have recently been overcome, leading to the first generation of autonomous motors and pumps on scale

196 ng on the small scale and have generated the first generation of autonomous self-powered nanomotors a

197 However, the first generation of CB1 inverse agonists, represented by

198 The first generation of childhood cancer survivors is now ag

199 The first generation of chloride-conducting channelrhodopsin

200 Results of the first generation of clinical trials now in progress are

201 ve design concepts, and it might lead to the first generation of deformable resonant devices.

202 ositions for radiofluorination, leading to a first generation of fluoroalkyl-substituted quinoline ta

203 The first generation of forest free-air CO2 enrichment (FACE

204 ertain rare variants that were missed in the first generation of GWAS.

205 agenda should draw on the experience of the first generation of innovations that underlie the countr

206 In the 1940s, the first generation of modern computers used vacuum tube os

207 Here, we tested the first generation of soluble, native-like envelope trimer

208 rm are presented with the aim to achieve the first generation of specific urinary tests for the detec

209 The first generation of synthetic vaccines has been largely

210 Deletion of the mTert gene in the first generation of Tert null mice compromised tumor gro

211 on-genetic inheritance is not limited to the first generation of the progeny, but can involve the gra

212 ned with transition state analogs produced a first generation of triple-helical peptide inhibitors (T

213 Google Earth, and the functionality of this first generation of virtual globes, are reviewed against

214 panel for robust inferences of parental and first generations of admixed ancestries.

215 A first-generation of luminescent MCs was presented previo

216 agents for patients following the approved "first generation" of DNA methylation (e.g., Dacogen, Vid

217 They were first-generation offspring of parents with neovascular A

218 Among first-generation offspring of parents with neovascular A

219 o increase the density of macular pigment in first-generation offspring of parents with neovascular A

220 The frequency of first-generation offspring of patients affected by EoE o

221 her potency than compound 1 and verapamil, a first-generation P-gp modulator.

222 -eluting stent (CoCr-EES) is superior to the first-generation paclitaxel-eluting stent (PES) and is n

223 (EES) with outcomes of patients treated with first-generation paclitaxel-eluting stents (PES) for unp

224 First-generation pan-Jak inhibitors can be useful for a

225 The evolved octapeptides, but not first-generation peptides, discriminated one-way blinded

226 Expansion of the first-generation PEQ consensus epitope via in vitro evol

227 promise to improve the clinical outcomes of first-generation PES.

228 method by retracing the transition from the first-generation, phosphine-based Grubbs olefin metathes

229 The wafer-based first-generation photovoltaic devices have been followed

230 a leads to Cas9-induced mutations in 10 % of first generation plants screened.

231 PLGA-b-PEG-b-PLGA sol-gels are a first-generation platform for the localized multi-drug d

232 PEG-b-PLA micelles are a first-generation platform for the systemic multi-deliver

233 However, the first-generation precursors that produce adult-born neur

234 Taken together, first-generation product yields parametrized with a vola

235 del with explicit, a priori treatment of the first-generation products for each precursor molecule, f

236 cterizing the reactivity and kinetics of the first-generation products of these reactions, carbonyl o

237 missense mutations revealed by sequencing in first-generation progeny of N-ethyl-N-nitrosourea-treate

238 ed TT may be a cost-effective alternative to first-generation protease inhibitors depending on pricin

239 ated G(1) CHC patients age 50 years, TT with first-generation protease inhibitors is cost-effective c

240 o interferon-based therapies (which includes first-generation protease inhibitors) before treatment.

241 Bortezomib is a first generation proteasome inhibitor that is the frontl

242 eft ventricular assist devices have replaced first-generation pulsatile devices.

243 n exon 21 are associated with sensitivity to first generation quinazoline reversible EGFR tyrosine ki

244 loline alkaloids is reported and extends our first-generation (racemic) synthesis of this alkaloid fa

245 n limited by high nonspecific binding of the first-generation radioligand, low-resolution scanners, s

246 om patients treated with RAF inhibitors, the first-generation RAF inhibitor vemurafenib stimulated in

247 Although ATP-competitive, first-generation RAF inhibitors (vemurafenib/PLX4720, RA

248 al and thyroid BRAF(V600E) cancers, in which first-generation RAF inhibitors have been ineffective.

249 First-generation RAF inhibitors paradoxically induce ERK

250 proved safety and more durable efficacy than first-generation RAF inhibitors, a concept currently und

251 me several known mechanisms of resistance to first-generation RAF inhibitors.

252 e, is more severe than that seen with use of first generation rapalogs and is mediated by a TORC1- an

253 y up to 64-fold increase in sensitivity over first-generation reagents.

254 Use of first-generation recombinant adenovirus serotype 5 (rAd5

255 In at least two cases we found first-generation recombinant offspring of parents whose

256 One of these approaches is a first-generation recombinant vesicular stomatitis virus

257 rate approximately 100 times faster than the first generation ReOx-Pd/C catalyst prepared from perrhe

258 of genotoxicity caused by the integration of first-generation retroviral vectors.

259 were more effective than treatment with the first-generation reversible inhibitors in inhibiting gro

260 Median longevity of the first generation S-ICD system was 5.0 years.

261 tients who underwent imaging with a previous first-generation scanner.

262 terpyridine-based architecture that mimics a first-generation Sierpinski triangle has been synthesize

263 generation everolimus-eluting stent with the first-generation sirolimus-eluting stent in patients wit

264 eration everolimus-eluting stents (EES) with first-generation sirolimus-eluting stents (SES) in prima

265 Many first-generation Smac-mimetics such as compound A (2) we

266 six combustion sources form 0.7 Tg y(-1) of first-generation SOA in the United States, almost 90% of

267 For a first-generation solution, we describe a low-cost, easy-

268 control despite receiving high doses of the first-generation somatostatin analogues octreotide or la

269 megaly who are inadequately controlled using first-generation somatostatin analogues.

270 Our previous study showed that some of our first-generation spiro-oxindoles undergo a reversible ri

271 These 16 amines were used to synthesize five first-generation spiroligomer-peptoids hybrids.

272 un, suggesting that the mass distribution of first-generation stars might extend to 100 solar masses

273 rom low-energy supernovae would have enabled first-generation stars to form over an extended period.

274 I and II clinical trials with autologous and first-generation stem cells have yielded inconsistent be

275 A highly convergent first generation synthesis led to the complete stereoche

276 rahydropyran core (13 steps) compared to the first-generation synthesis (22 steps).

277 o heading within families demands roguing in first generation synthetics.

278 rformance for newer systems as compared with first-generation systems, with notable improvements in s

279 k," it is initiated by formation of separate first-generation teeth that line the embryonic pufferfis

280 Here, we demonstrated that first-generation TERT-null mice, unlike Terc-null mice,

281 ked to the acquired resistance against those first generation therapeutics.

282 The present study sought improvements in the first generation THPIs by enhancing thermal stability an

283 e evolution of catheter-based treatment from first-generation thrombectomy devices to the game-changi

284 homozygous TIN2(DC/DC) mice were not viable, first-generation TIN2(+/DC) mice were healthy and fertil

285 ESKM was superior to the first-generation TKI, imatinib.

286 Recent insights indicate that 'first-generation' TNFRSF agonists lack efficacy as they

287 coverage, describe our efforts to develop a first-generation total-body PET/CT scanner, discuss sele

288 The first generation transgenic crops used strong constituti

289 AD) research community has historically used first-generation transgenic (Tg) mouse models that overe

290 t autologous tier-2 neutralization, unlike a first-generation trimer.

291 t and 13.2 mGy (IQR, 10.2-18.6 mGy) with the first-generation unit (P < .0001).

292 t and 2.67 mSv (IQR, 1.68-4.00 mSv) with the first-generation unit (P < .0001).

293 the second-generation unit compared with the first-generation unit.

294 vaccine-associated viraemia compared to the first-generation vaccine and both provided complete, sin

295 ll as the phylogenetic relationships of this first-generation vaccine.

296 ecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection.

297 First-generation vaccines used to eradicate smallpox had

298 mV) and improved photostability relative to first-generation voltage sensors.

299 cond-generation immigrant group than between first-generation vs second-generation immigrants, and th

300 s, however, biological effects found for the first generation were commonly similar in magnitude to t