ライフサイエンスコーパス: first phase

1 nge (1400 mg protein in DBPCFC) at 6 months (first phase).

2 econd phase that was half the voltage of the first phase.

3 f the tool, which was modified following the first phase.

4 +/- 0.1 microM, reversing the effect of the first phase.

5 re required for the second phase but not the first phase.

6 array corresponding to positive pools in the first phase.

7 ction of the most probable isotopologue in a first phase.

8 ses 2-4 decreased to 35%, 12%, and 7% of the first phase.

9 e active and control group at the end of the first phase.

10 We conducted the first phase 0 clinical trial in oncology of a therapeuti

11 roup and none of the control group after the first phase (0 of 46; 95% CI 0-9; p<0.001).

12 Analysis of secretion kinetics identified a first phase (0-2 min) mediated by VAMP2 and second (2-10

13 In the first phase (0-20 min), p300 is recruited to ERalpha by

14 In the first phase (0-3 months), patients were randomized to re

15 t research organization were enrolled in the first phase 1 clinical trial of TGN1412, a novel superag

16 Vaccine Research Center (VRC) 004 is the first phase 1 dose-escalation study of a multiclade HIV-

17 The brains of all 8 patients in the first phase 1 ex vivo trial and of 2 patients in a subse

18 d immunogenicity of a WNV DNA vaccine in its first phase 1 human study.

19 In the first phase 1 study of any candidate subunit vaccine aga

20 stically with chemotherapy, we conducted the first phase 1 study of intraventricular immunochemothera

21 Since the publication of the first phase 1 trials of bortezomib 10 years ago, this fi

22 This first phase 1/2 trial testing bendamustine, lenalidomide

23 A triphasic decline consists of a first phase (1-2 days) with rapid virus load decline, fo

24 The first phase (28 days) included the experimental gingivit

25 ed investigational new drug approval for the first phase 2A clinical trial of ischaemia-tolerant mese

26 lood, Gill et al describe the results of the first phase 3 clinical trial evaluating recombinant von

27 We report results of the first phase 3 trial assessing long-acting intramuscular

28 Early data emerging from the first phase 3 trial of a malaria vaccine are raising hop

29 In the first phase, 363 scientists scored 480 applications.

30 subjects but decreased it in the FH+ group (first phase: +75 vs. -60%, P < 0.001; second phase: +25

31 The first phase, a flickering stepwise transition from a low

32 In the first phase, a single treatment was provided (intraperit

33 In the first phase, a solid liquid extraction procedure was opt

34 In the first phase, an apical actomyosin network is formed.

35 dy included 294 patients in 5 centers in the first phase and 65 patients in 3 centers in the second p

36 While three mutants had a shorter first phase and a longer second phase than the wild-type

37 orofacial stereotypies, TP/R emerges in the first phase and vanishes prior to the second.

38 ear waveforms had 4-, 8-, and 16-millisecond first phases and a 3.5-millisecond rectilinear second ph

39 The exponential biphasic waveform had a 60% first-phase and a 50% second-phase tilt.

40 and insulin regulation, including diminished first-phase and accentuated peak insulin secretion in re

41 lation, with a rapid (minutes) and transient first phase, and a slow and sustained (24-72 hours) seco

42 six (9-15 years) at home in a reconnaissance first phase, and nine (5-14 years) in hospital in phase

43 In the first phase, bacteria in the IBC were nonmotile, rod sha

44 cant active hemodynamic response in only the first phase, before the pain.

45 , 3 descending-ramp waveforms, 3 rectilinear first-phase biphasic waveforms, a Gurvich waveform, and

46 trite scavenger uric acid did not affect the first phase but ameliorated the second phase of endothel

47 In the first phase, Ca2+ bound to the C-ter EF hand pair in CaM

48 In the first phase, CD8+ cells remain sequestered within the ly

49 In the first phase, chains are synthesized in a unidirectional

50 The first phase, common to all RINs, is bipolar migration di

51 The first phase, completed in 2012, profiled the transcripto

52 In the first phase, consenting women aged 25-64 years presentin

53 The first phase, corresponding to prenatal development, is c

54 As a result, only the first-phase data were used in additional analyses.

55 AL-containing ART, with a longer duration of first-phase decay consistent with RAL-mediated blockade

56 ffectiveness of therapy, whereas the rate of first phase decline depends on multiple parameters inclu

57 ibavirin-particularly those with an adequate first-phase decrease (0.61 vs 0.35 log10 IU/mL/week; P =

58 The first-phase decrease in HCV RNA was similar between grou

59 ce was greatest in patients with an adequate first-phase decrease in HCV RNA.

60 NK cells correlated with treatment-induced, first-phase decreases in viral load (P<.05) and remained

61 on could be mainly energetically driven; the first phase deposited is hydrated ACC, which then conver

62 olar NEFO was a damped sine wave with 140 ns first phase duration at 50% height; the peak amplitude o

63 In the first phase during concentration of Gag3 into foci, intr

64 ulsatility of individual islets enhances the first-phase elevation and second-phase pulses of insulin

65 In the first phase, Elimination, transformed cells are destroye

66 The first phase, elucidation of the renin-angiotensin-aldost

67 At the single L-cell level, first-phase forskolin-induced exocytosis was reduced to

68 We report the findings from the first-phase genetic analyses in 1,227 participants from

69 in type 2 diabetes, islets exhibit decreased first-phase glucose-stimulated insulin secretion, impair

70 The increased first-phase glucose-stimulated release of insulin observ

71 ed predocked SG fusion accounted for reduced first-phase GSIS, selective reduction of exocytosis of s

72 ntactic chain in rigid serial order once the first phase has begun.

73 First-phase HCV decline (baseline/treatment day 4) was s

74 lls from patients with a less than 2 log(10) first-phase HCV RNA decline exhibited lower pSTAT1 induc

75 from patients with a greater than 2 log(10) first-phase HCV RNA decline to IFN-alpha-based therapy (

76 We report the first phase I trial to assess the safety and immunogenic

77 We now report results from the first phase II clinical trial developed exclusively for

78 This is the first phase II enzymatic product identified that can sig

79 CONCLUSION This is the first phase II study of a new agent in sarcoma to includ

80 We report, to our knowledge, the first phase II trial of pomalidomide administered in com

81 of systemic therapies and the results of the first phase III clinical trial evaluating the addition o

82 The E1496 study provides the first phase III data in untreated indolent lymphoma that

83 n Therapy Oncology Group (RTOG) 8610 was the first phase III randomized trial to evaluate neoadjuvant

84 This first phase III study on a topical inhibitor of corneal

85 ith 2 or more controller medications, in the first phase III trial of tiotropium in children with sev

86 Results of the first phase III trial of VEGF-targeted therapy (sorafeni

87 multicenter study, to our knowledge, is the first phase III trial to compare trabectedin versus daca

88 To our knowledge, this is the first phase III trial to perform prospective analysis of

89 To our knowledge, V325 is the first phase III trial to report clinical benefit in AGGE

90 f Preterm Infants: The Pre-B Project" is the first phase in a process to present the current state of

91 ay of Class I messages and the length of the first phase in decay of Class II messages.

92 During the first phase, in which NF-kappaB signaling is dispensable

93 The first phase included 1-hour qualitative telephone interv

94 We propose that the first phase, including a stepwise reduction in stiffness

95 st nNOS-2 had an opposing effect against the first phase, increasing its intensity.

96 hases, requiring ATM and NEMO/IKK-gamma: The first phase induced TNF-alpha-TNFR1 feedforward signalin

97 n murine pancreatic islets leads to impaired first phase insulin release ex and in vivo.

98 ncrease with oral glucose suggesting loss of first phase insulin release.

99 in 4-mediated granule pre-docking to support first-phase insulin exocytosis.

100 that PI4P5Kalpha(-/-) mice exhibit increased first-phase insulin release and improved glucose clearan

101 mic secretion index) was not correlated with first-phase insulin release from either the HGC or IVGTT

102 The main study group (n = 389) had first-phase insulin release on an intravenous glucose to

103 file as the main study group except they had first-phase insulin release that was lower than the thre

104 = 3) had different autoantibody profiles and first-phase insulin release threshold combinations.

105 -1 elicited significant potentiation of only first-phase insulin release.

106 We studied the change in the first-phase insulin response (FPIR) during the progressi

107 Primary endpoints were change in first-phase insulin response and insulin sensitivity as

108 First-phase insulin responses (FPIRs) during the intrape

109 2.8 mg . min(-1), respectively; P = 0.9) or first-phase insulin secretion (-21 +/- 212 compared with

110 U . L; P < 0.05) with compensatory increased first-phase insulin secretion (56.1 +/- 8.5 vs. 25.3 +/-

111 osclerosis Study (IRAS), we studied S(i) and first-phase insulin secretion (acute insulin response [A

112 rance test and meal tolerance test to derive first-phase insulin secretion (FPIR), insulin sensitivit

113 ice demonstrated that this compound restored first-phase insulin secretion and enhanced pancreatic be

114 ng alleles were associated with a measure of first-phase insulin secretion at P < 0.05 and provided n

115 n factor, was strongly associated with lower first-phase insulin secretion but has no evidence for an

116 First-phase insulin secretion decreased across NGT categ

117 From our model analysis we note that first-phase insulin secretion depends on rapid depletion

118 abetic subjects with a predominant defect in first-phase insulin secretion had levels of inflammatory

119 he OGTT together with the restoration of the first-phase insulin secretion in diabetic subjects might

120 nt starch intake significantly increased the first-phase insulin secretion in individuals at risk of

121 Loss of first-phase insulin secretion is an early sign of develo

122 t increased beta-cell apoptosis and impaired first-phase insulin secretion precede the development of

123 ut T2D, identifies the mechanisms modulating first-phase insulin secretion rate in response to basal

124 In adult NG2KO mice, first-phase insulin secretion was lost, and these glucos

125 the prevailing level of insulin resistance, first-phase insulin secretion was markedly decreased in

126 The first-phase insulin secretion was restored in type 2 dia

127 ng of the data showed significantly improved first-phase insulin secretion with resistant starch.

128 espectively), and glucose disposition index (first-phase insulin secretion x insulin sensitivity).

129 the largest genome-wide association study of first-phase insulin secretion, as measured by intravenou

130 n to defects in insulin sensitivity (SI) and first-phase insulin secretion, respectively, as assessed

131 test (OGTT), a frequently used surrogate of first-phase insulin secretion, was not associated with t

132 insulin pulse amplitudes and a reduction in first-phase insulin secretion.

133 eatment did not affect growth in children or first-phase insulin secretion.

134 lated as ATIS: (1/GlyRa x fasting insulin) x first-phase insulin secretion.

135 n, while effects on granule docking affected first-phase insulin secretion.

136 imulation, which is reflected in potentiated first-phase insulin secretion.

137 sampled intravenous glucose tolerance test (first-phase insulin secretion; acute insulin response [A

138 ion displays a biphasic profile in which the first phase involves a fast sulfur transfer reaction fro

139 can be portrayed as a two-phase process: The first phase involves the physical translocation of a can

140 In the first phase, involving 252 subjects, at 4 months, there

141 The first phase is a parasitism phase where the nematode est

142 The first phase is abolished as OmpC becomes more stable at

143 The first phase is also accompanied by the generation of a c

144 The first phase is considered the early phase of the acciden

145 The first phase is due to the presence of a Rac2-PLD2 positi

146 results in biphasic activation of PI3K; the first phase is largely dependent on PI3Kgamma, and the s

147 The first phase is marked by large transcriptome changes as

148 phase, we feel that an understanding of the first phase is now within sight, due in part to a better

149 The first phase is rapid, induces low-level production of MC

150 The first phase is redistribution of the resonance species t

151 The first phase is related predominantly to the reach locati

152 The first phase is restored by expression of mutant cofilin-

153 The rate of the first phase is second order in hydroxide ion, while that

154 compact UHS, which works in two phases: The first phase is solved optimally, and for the second we p

155 nd paw induces a biphasic pain response; the first phase is thought to result from direct activation

156 The first phase is triggered by rapid light-induced changes

157 The first phase is triggered via the TLR4 on hematopoietic c

158 ghting its role as an important amplifier of first-phase ISR in T2DM.

159 particular, the responsiveness to glucose in first-phase ISR is blunted.

160 gmented both first- and second-phase ISR but first-phase ISR more in T2DM subjects (approximately eig

161 In the first phase, it identifies small candidate subtrees from

162 second phase of PI3K activation requires the first phase; it is this second phase that is augmented b

163 In the first phase, L. donovani promastigotes induce activation

164 Unless this first phase lasted only 40 ms, this primacy effect persi

165 declined in a biphasic manner, where a rapid first phase lasting for 25 days (IQR: 23-58) was followe

166 The first phase lasts no more than 2 h.

167 harply different in these two phases; in the first phase, MDMX depletion was synergistic with DNA dam

168 In the first phase, membrane proteins from the budding yeast Sa

169 those with electric light at home (n = 97 in first phase; n = 17 in second phase).

170 se living without electric light (n = 243 in first phase; n = 25 in second phase) to those with elect

171 In the first phase, nitrergic nerve fibers lose some of their n

172 1 activates ERK1/2 in a biphasic manner: the first phase occurs in response to StxB1 subunit, while t

173 Typically, the first phase of a genome wide association study (GWAS) in

174 The data generated here comprise the first phase of a genome-wide association analysis in pat

175 or Americans--the B-24 Project." This is the first phase of a larger project designed to develop diet

176 They are dispensable for the first phase of A13 development but are required for the

177 assessed the population-level effect of the first phase of Avahan (2003-08).

178 of the RNA occurs rapidly and dominates the first phase of compaction during which the observed radi

179 model of PGC DNA demethylation in which the first phase of comprehensive 5mC loss does not involve 5

180 We studied the first phase of decay of human immunodeficiency virus typ

181 ses eye rotation during acceleration and the first phase of deceleration.

182 We designated the first phase of dissemination "adherence-mediated migrati

183 hen activity of this pathway is reduced, the first phase of elongation growth is absent, and this is

184 The first phase of extinction was coincident with a slow inj

185 le for early hydrophobic interactions in the first phase of folding in apomyoglobin, and that these e

186 During a first phase of glycosylation, the conformation of GtfB i

187 nsistently, STING was necessary to mount the first phase of IFN-I production and curb CMV replication

188 stently, in mice, STING is necessary for the first phase of IFN-I production that limits early CMV re

189 In the first phase of in silico sequencing, we explore the vici

190 leted mice (M4K4 iKO) as well as an impaired first phase of insulin secretion from islets derived fro

191 incretins on beta cells, and focused on the first phase of insulin secretion to capture the early pa

192 establish that Munc18-1 is required for the first phase of insulin secretion.

193 comitant downregulation of Bcl2a1 during the first phase of involution.

194 The first phase of major neuronal rearrangements in the brai

195 ) postnatally both in vitro and during their first phase of natural cell death in vivo.

196 te the number of SN DA neurons surviving the first phase of natural cell death, but it is not suffici

197 increased number of SN DA neurons after the first phase of natural cell death.

198 IkappaBalpha-that define the duration of the first phase of NF-kappaB activity.

199 We observed a first phase of parallel evidence integration for multipl

200 ta (SNpc) by regulating the magnitude of the first phase of postnatal natural cell death which occurs

201 ous manner to control dendrite severing, the first phase of pruning.

202 elease generated by the mitochondria fuels a first phase of purinergic signaling that boosts Ca(2+) s

203 In the first phase of Shahroud Eye Cohort Study, the 40-64 year

204 st that Msh6 plays a scaffolding role in the first phase of SHM, in addition to its enzymatic role in

205 e essential function of PIWI proteins in the first phase of somatic development.

206 e of transcallosal inhibition, and a reduced first phase of spinal reciprocal inhibition (RI) in subj

207 The first phase of study was a method development to effect

208 Although the first phase of T-cell reconstitution after UCB transplan

209 monkey showed delay of gratification in the first phase of testing.

210 In the first phase of the 1000 bull genomes project, we sequenc

211 eared from STN to sensorimotor cortex in the first phase of the adaptation, when a constant rotation

212 The first phase of the algorithm involved the modeling of th

213 The first phase of the catalytic cycle involves generation o

214 Gly bonds of the gamma-Glu-Cys donors in the first phase of the catalytic cycle is conserved through

215 We report here the results of the first phase of the Centers for Disease Control and Preve

216 For our first phase of the clinical trial, patients were schedul

217 eals that it is biphasic in nature, with the first phase of the delay occurring before gastrulation,

218 een 1996 and 2001 in the American arm of the first phase of the Dialysis Outcomes and Practice Patter

219 lication of this method to the data from the first phase of the International HapMap project resulted

220 This implies that the first phase of the mammalian radiation--associated with

221 The first phase of the Marine Resiliency Study (MRS-I) inclu

222 We would seem to be witnessing the first phase of the molecular delineation of these cation

223 In the first phase of the reliability study, 123 adult myositis

224 In the first phase of the study, 3 pathologists held a consensu

225 In the first phase of the study, 32 farms were surveyed using m

226 In the first phase of the study, only GDH-positive stool sample

227 In the first phase of the study, participants with longer stop

228 In the first phase of the study, patients (n = 77) were include

229 In the first phase of the study, the mean percentage of free fe

230 In the first phase of the study, the wound complication rate in

231 The first phase of the total synthesis of thiostrepton (1),

232 We present findings from the first phase of the trial and report on uptake of home-ba

233 in the intention-to-treat population of the first phase of the trial, for which the primary endpoint

234 7, 2016, we enrolled 90 participants for the first phase of the trial.

235 count </= 350 cells/mul) contributed to the first phase of the trial.

236 er the second vaccine dose to the end of the first phase of the trial.

237 The first phase of the undertaking consists of an assessment

238 The first phase of this bioinformatic analysis implements a

239 The first phase of this method elicited 413 open-ended respo

240 This article describes the first phase of this national initiative, the Family Asse

241 In the first phase of this pathway, ten Fe/S cluster (ISC) asse

242 During the first phase of this procedure, one auditory stimulus was

243 We find that DLP1 is dispensable for the first phase of this process but essential for the second

244 The first phase of this protocol involves identification of

245 In the first phase of this research, standardized approaches we

246 In the first phase of this study, in-depth, semistructured inte

247 The first phase of this trial was designed to determine the

248 s-stimulus association was formed during the first phase of training.

249 bstates of the bacterial ribosome during the first phase of translocation, characterized by intermedi

250 ed with Ag and supplemental tocopherols in a first phase of treatment followed by a 4-wk clearance ph

251 In the first phase of UEM, it was possible to obtain snapshot i

252 centrifugation experiments indicate that the first phase of unfolding involves dissociation of the te

253 about the organization and evolution of the first phases of color processing, the filtering of light

254 trinsic factors that are responsible for the first phases of embryonic patterning.

255 ipation of specific water molecule(s) in the first phases of the reaction mechanism of catalase-perox

256 Among 52 studies selected in first phase, only renin-angiotensin-aldosterone-system b

257 In the first phase, participants were randomly assigned (1:1:1)

258 In the first phase, perivascular nitrergic nerve fibers remain

259 For the first phase, pooled relative risks for renal endpoints w

260 ergo a two-phase conformational cascade: the first phase progresses from a metastable prefusion state

261 In the first phase, pseudopods extended rapidly, with actin pol

262 The first-phase reduction of ISP starts as early as 100 micr

263 The first phase relies on the assembly of a wide contractile

264 In the first phase, replicating spirochetes, positioned at vary

265 The first phase resulted from Ca2+ influx through AMPA recep

266 The first phase revealed c-Jun as a direct substrate of Cdk5

267 In the first phase, RNA molecules that are initially in an exte

268 ed two stage assessments; which consisted of first phase screening of the children for neurodevelopme

269 the human whole blood assay is an efficient first-phase screening model for inflammation, and a guid

270 ing is a good candidate for amplification of first-phase secretion by glucose, cyclic adenosine 3':5'

271 ulin secretion with a trend toward increased first-phase secretion.

272 Although the first phase seemed to be independent of TNFR1 signaling,

273 In the first phase, sentinel cells gather Ags present in tissue

274 tments of 100 and 250 U/ml revealed that the first-phase sg1b RNA decline began approximately 12 h po

275 The first phase shows adaptation at low concentrations of et

276 In the first phase, small pools of AD strains are mated with th

277 In the first phase, starch and metabolites provided a transient

278 in subjects with low thymic scores, whereas first-phase T cell increases (perhaps mediated by redist

279 In the first phase (the cyclase phase), simple linear hydrocarb

280 During the first phase, the actin cytoskeleton promotes mechanotran

281 In a first phase, the adherence at 4 months was directly asse

282 To accomplish the objectives of this first phase, the Pre-B Project organizers established 4

283 In the first phases, the bacteria, decorated with hypoacylated

284 ystem improved from 86%, 92%, and 67% in the first phase to 96%, 94%, and 83%, respectively, in the s

285 n) reform plan, launched in 2009, marked the first phase towards achieving comprehensive universal he

286 e-derived or blood dendritic cells, but only first phase transfer was observed with Mutz-3 LCs.

287 The first phase transition involves an initial formation of

288 In the first phase, type I genes (hCGbeta3, -5, -7, and -8) acq

289 In the first phase, vaginal and cervical swab specimens were ob

290 Median first-phase viral decay rates were significantly faster

291 d was independent of the correlation between first-phase viral decline efficiency and RVR.

292 In the first phase, viruses carrying various combinations of mu

293 The first phase was a 65-million-year (My) interval from 425

294 The first phase was characterized by limited T-cell immunity

295 The first phase was mainly influenced by vegetation recovery

296 Our results indicate that the first phase was mediated by dsRNA-induced phosphorylatio

297 In the first phase, we compared allele frequencies of 150,080 S

298 For the first phase, we develop an algorithm which transforms th

299 In the first phase, we retrospectively reviewed the clinical an

300 mixing of the eluted nucleic acids from the first phase with loading buffer which is facilitated by