ライフサイエンスコーパス: first-degree relative

1 incomplete data and/or availability of only first-degree relatives).

2 ily history of sudden unexplained death in a first-degree relative.

3 Thirty-seven (70%) of the donors were first-degree relative.

4 orted a positive family history of FEVR in a first-degree relative.

5 SNCA triplication patient and an unaffected first-degree relative.

6 syndrome (51%) reported a CRC diagnosis in a first-degree relative.

7 were enrolled, 69% of whom had 1 AD-affected first-degree relative.

8 static location depending on cancer in their first degree relatives.

9 t of 26 probands with NAFLD-cirrhosis and 39 first-degree relatives.

10 for CRC in both groups, as well as in their first-degree relatives.

11 sychotic disorder probands, and 300 of their first-degree relatives.

12 DD), 110 orthopedic controls, and 1734 adult first-degree relatives.

13 d between ADHD probands and their unaffected first-degree relatives.

14 ing and their 2082 adult living and deceased first-degree relatives.

15 e ratios (SIRs) for different cancers in the first-degree relatives.

16 nancy-related factors and deaths of mothers' first-degree relatives.

17 no history of neurodegenerative disorder in first-degree relatives.

18 for NLPHL was 19 (95% CI, 8.8 to 36) in the first-degree relatives.

19 GnRH deficiency carrying L173R and their 30 first-degree relatives.

20 FSHD affected subjects and their unaffected first-degree relatives.

21 d disorders and individuals at risk, such as first-degree relatives.

22 gnature was also detected in PB from healthy first-degree relatives.

23 number of FSHD subjects and their unaffected first-degree relatives.

24 t onset, multiple affected relatives, and in first-degree relatives.

25 entive screening and surveillance in at-risk first-degree relatives.

26 luded 20,377 probands with glioma and 52,714 first-degree relatives.

27 vasculopathy is the most frequent risk among first-degree relatives.

28 individuals with bipolar disorder and their first-degree relatives.

29 bility to schizophrenia by including healthy first-degree relatives.

30 re independent of a family history of VTE in first-degree relatives.

31 be without evidence of NAFLD and 69 of their first-degree relatives.

32 ychiatric symptom information for additional first-degree relatives.

33 incomplete data and/or availability of only first-degree relatives.

34 er I with psychosis probands (BDP) and their first-degree relatives.

35 There had been 123 VTEs in 2617 first-degree relatives (0.12 per 100 person-years).

36 5% CI 1.21-4.74], P = 0.012), and for ILD in first-degree relatives (1.53 [95% CI 1.04-2.26], P = 0.0

37 Participants (n=1967; schizophrenia=369; first-degree relatives=1072; community comparison subjec

38 tients with ALS were reported, including 924 first-degree relatives, 1128 second-degree relatives, an

39 L was found for those with multiple affected first-degree relatives (13-fold; 95% CI, 2.8- to 39-fold

40 psychotic bipolar I disorder), 369 of their first-degree relatives (134 were relatives of individual

41 nificant for other autoimmune disease in the first-degree relatives (2.49 [95% CI 1.99-3.41], P = 2.4

42 In the per-protocol analysis, 28 first-degree relatives (3.9%) in the FIT group and 43 (5

43 rquartile range 354.1-]586), intermediate in first-degree relatives (402.9 microg/mL [204.7-4,850.0;

44 l testing would be considered for those with first-degree relatives (42 [72%] of 58; 95% CI, 59.8%-82

45 m buccal smears from 63 patients with BD, 74 first-degree relatives (49 relatives had no lifetime psy

46 48 [95% CI 1.34-2.39], P = 0.002), for RP in first-degree relatives (6.38 [95% CI 3.44-11.83], P = 4.

47 Of all eligible asymptomatic first-degree relatives, 782 were included in the colonos

48 site testing the POCT was positive in 12/148 first-degree relatives (8%) and all these subjects were

49 In first-degree relatives, ACPA reactivity was assessed, an

50 People with one or more first degree relative affected (FDRA) by aneurysmal suba

51 82 to 19.0) in persons age <30 years given a first-degree relative affected at age <30 years.

52 or lone AF in persons aged <40 years given a first-degree relative affected at age <40 years was 5.42

53 of patients having newly diagnosed AF with a first-degree relative affected by AF between 2000 and 20

54 Patients having AF with a first-degree relative affected by AF did not have more M

55 Individuals with a first-degree relative affected by AF had a relative risk

56 9 [9.2] years) had newly diagnosed AF with a first-degree relative affected by AF.

57 highest among young women (< 45 years) with first-degree relatives affected at young ages (< 45 year

58 the 1.2% risk in individuals with at least 2 first-degree relatives affected by colorectal cancer.

59 pedigree was conditioned on the proband and first-degree relatives affected with CRC to reduce ascer

60 .24 (95% CI: 2.59 to 15.0), given at least 2 first-degree relatives affected with lone AF.

61 of CRC or a documented advanced adenoma in a first-degree relative age <60 years or 2 first-degree re

62 gated with disease in all available affected first-degree relatives, although four asymptomatic paren

63 Fifty-seven percent of anti-CCP-2-positive first-degree relatives and 8% of anti-CCP-2- negative fi

64 -Hispanic, white children were included: 861 first-degree relatives and 882 general population childr

65 absent from the anergic compartment of some first-degree relatives and all prediabetic and new-onset

66 efficiently incorporating information beyond first-degree relatives and allows for the inclusion of c

67 es is significant and higher when focused on first-degree relatives and on conditions usually express

68 Patients' first-degree relatives and pairwise age- and sex-matched

69 ily histories of single or multiple affected first-degree relatives and their diagnostic ages.

70 8 patients with schizophrenia, 37 unaffected first-degree relatives, and 139 healthy controls, we det

71 omprising 20 adults with ADHD, 20 unaffected first-degree relatives, and 20 typically developing cont

72 st-episode psychosis, 25 of their unaffected first-degree relatives, and 26 healthy control subjects

73 psychotic bipolar I disorder, 1,055 of their first-degree relatives, and 459 healthy comparison subje

74 wed documented presence or absence of CFH in first-degree relatives, and 61.5% of medical records doc

75 (HP), schizophrenia probands (SZ) and their first-degree relatives, and bipolar disorder I with psyc

76 patients with NLPHL, identified their 4,280 first-degree relatives, and calculated the registry-base

77 bands with psychotic bipolar disorder, their first-degree relatives, and healthy comparison subjects.

78 young age and unprovoked VTE predict VTE in first-degree relatives, and that the influence of these

79 group of adults with ADHD, their unaffected first-degree relatives, and typically developing control

80 r (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects.

81 hat relatives of celiac patients, especially first degree relatives are at high risk of developing ce

82 ion in psychotic disorder patients and their first-degree relatives as a possible endophenotype.

83 First-degree relatives at similar genetic distances (eg,

84 The highest familial risk was observed among first-degree relatives (attempted suicide: OR = 2.42 [95

85 Despite high heritability in first-degree relatives, AV genetic determinants remain i

86 cancer history (FCH) is often collected for first-degree relatives, but more extensive FCH informati

87 tisol-producing hyperplasias, 5 (including 2 first-degree relatives) carried a germline copy-number g

88 suspected antibiotic exposure, personal and first-degree relatives' comorbidities, and history of at

89 al activation or connectivity alterations in first-degree relatives compared with healthy controls, s

90 Persons with a single first-degree relative diagnosed at >/=60 years with CRC

91 ancer in families with increasing numbers of first-degree relatives diagnosed with melanoma, includin

92 , the prevalence of family history of SCD in first-degree relatives did not differ between those with

93 The history of SCD in first-degree relatives did not differ from controls in n

94 If the first-degree relative died aged <35 years, the rate of c

95 as is greater than the risk in persons whose first-degree relatives do not have adenomas or CRC (8.3%

96 ertained cohorts, replacing cases with their first-degree relatives enables studies of diseases that

97 RA-free first-degree relatives (even those negative for RF and a

98 orrelation coefficient, 0.73 in NF1-affected first-degree relatives) exceeded that observed in the ge

99 Subjects with 1 first degree relative (FDR) with CRC (n = 238; HR, 1.23;

100 Familial PBC has been documented in first degree relatives (FDR).

101 e quantified the risk of CRC and adenomas in first-degree relatives (FDRs) and second-degree relative

102 cts differed from those of autoantibody-free first-degree relatives (FDRs) in the abundance of four t

103 atients combined with including or excluding first-degree relatives (FDRs) or different conditional l

104 ividuals based on age and number of affected first-degree relatives (FDRs) using data from publicatio

105 ing number of melanomas in either 1 or >/= 2 first-degree relatives (FDRs).

106 patients with breast cancer and their female first-degree relatives (FDRs).

107 The 205 previously negative first degree relatives from Group II that underwent new

108 It has recruited 2,632 first-degree relatives from across the USA.

109 WES was performed in 2 affected first-degree relatives from each family.

110 dent AF patients with vs without an affected first-degree relative had similar MACE-free survival.

111 Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabe

112 The POCT was found to be positive in 8/9 first-degree relatives having coeliac-type mucosal lesio

113 tients with hypoplastic left heart and their first-degree relatives identified 5 individuals with rig

114 Cascade genetic testing in first-degree relatives identified 6 additional individua

115 tics, age at onset, history of depression in first-degree relatives, impairment in role functioning,

116 asia was detected in 33 (4.2%) and 44 (5.6%) first-degree relatives in the FIT and colonoscopy groups

117 774 individuals (the exposed cohort) with a first-degree relative (index case patient) previously ho

118 action was observed regarding the sex of the first-degree relative (interaction P for parents = 0.85;

119 Cognitive dysfunction in first-degree relatives is more closely related to psycho

120 riteria for serrated polyposis, and in their first-degree relatives, is similar to that of patients d

121 Three hundred four first-degree relatives (median age, 47 years; age range,

122 0001) and family history of breast cancer in first-degree relatives (n = 7,472; ptrend = 0.0003).

123 psychotic bipolar probands, their respective first-degree relatives (n = 70 and 52), and 118 healthy

124 ipolar probands, their respective unaffected first-degree relatives (n = 70, and n = 52), and 118 hea

125 itions: bipolar disorder (n = 9), unaffected first-degree relatives (n = 8), and clinical high risk (

126 order (manic, N=110; depressed, N=55), their first-degree relatives (N=316, N=259, N=133, and N=64, r

127 polar disorder with psychosis (N=711), their first-degree relatives (N=883), and demographically comp

128 The risks for first-degree relatives (odds ratio [OR], 18.69; 95% CI,

129 ks of EoE were significantly increased among first-degree relatives (odds ratio [OR], 7.19; 95% CI, 5

130 From a total of 634 first degree relatives of 186 biopsy-proven celiac disea

131 Although it is known that first degree relatives of celiac patients have an increa

132 the risk of amyotrophic lateral sclerosis to first degree relatives of patients with sporadic amyotro

133 ly increased risk of breast cancer, untested first-degree relative of a gene mutation carrier, family

134 A cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed b

135 ML, MDS, and other malignancies among 24,573 first-degree relatives of 6,962 patients with AML and 1,

136 % mutation carriers [92% plakophilin-2]; 28% first-degree relatives of a mutation-negative proband).

137 erall lifetime cumulative risk (CR) of HL in first-degree relatives of a patient with HL was 0.6%, wh

138 sed cohort revealed that the rate of EoE, in first-degree relatives of a proband, was 1.8% (unadjuste

139 First-degree relatives of ADHD probands were at elevated

140 First-degree relatives of adults with psychotic experien

141 First-degree relatives of affected individuals have a mo

142 dentified through cascade genetic testing of first-degree relatives of affected mutation carriers.

143 Among first-degree relatives of an index case with factor V Le

144 9 patients with inactive CD and 35 controls (first-degree relatives of and in the same age bracket as

145 on, characteristic of autism, extends to the first-degree relatives of autistic individuals, implying

146 (95% confidence interval [CI] 13.1-22.0) in first-degree relatives of BDI patients, higher than that

147 ORs of BDII were 13.6 (95% CI 10.2-18.2) in first-degree relatives of BDII patients and 9.8 (95% CI

148 ves of schizophrenia probands (n = 264), and first-degree relatives of bipolar disorder I with psycho

149 in euthymic bipolar patients and unaffected first-degree relatives of bipolar patients to define the

150 In first-degree relatives of cases with </=17, 18-21, and >

151 nd calendar-specific CRC rates in the 50,924 first-degree relatives of cases.

152 [OR], 7.19; 95% CI, 5.65-9.14), particularly first-degree relatives of EoE cases diagnosed <18 years

153 Seventy-five asymptomatic first-degree relatives of FIP patients (mean age, 50.8 y

154 006) to measure excess cases of cancer among first-degree relatives of glioma probands.

155 A genetic effect was assessed in first-degree relatives of HS-TLE subjects who did not ha

156 We analyzed 12-lead ECGs of 401 first-degree relatives of individuals who had died from

157 risk for developing the disorder (unaffected first-degree relatives of individuals with bipolar disor

158 Evidence is beginning to show that screening first-degree relatives of individuals with several famil

159 First-degree relatives of individuals with T1DM were rec

160 ,388 patients with MDS compared with 106,224 first-degree relatives of matched controls.

161 S and lymphoproliferative malignancies among first-degree relatives of MGUS patients.

162 nced fibrosis screening may be considered in first-degree relatives of NAFLD-cirrhosis patients.

163 First-degree relatives of NHL, HL, and CLL patients have

164 tients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and contr

165 s in age-matched islet autoantibody-negative first-degree relatives of patients (n = 392; P = 0.00001

166 Although first-degree relatives of patients exhibit a two-fold in

167 First-degree relatives of patients with AVNRT presented

168 by applying the same protocol to 22 healthy first-degree relatives of patients with BD1 and 22 perso

169 eir control groups, BD1 patients and healthy first-degree relatives of patients with BD1 showed signi

170 The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder

171 y is the recommended screening procedure for first-degree relatives of patients with colorectal cance

172 In a prospective study, 1918 first-degree relatives of patients with CRC were randoml

173 nography is an effective screening method in first-degree relatives of patients with CRC.

174 lonoscopy in detecting advanced neoplasia in first-degree relatives of patients with CRC.

175 While first-degree relatives of patients with MM show an incre

176 The risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fat

177 We assessed the risk for VTE in 915 first-degree relatives of patients with provoked VTE, co

178 relative-control sample, 58 were unaffected first-degree relatives of patients with schizophrenia (m

179 We examined 58 unaffected first-degree relatives of patients with schizophrenia an

180 renia who were taking medication, 23 healthy first-degree relatives of patients with schizophrenia, a

181 In this study, first-degree relatives of patients with SCZ and their re

182 evious studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate

183 First-degree relatives of patients with SCZ showed signi

184 ted by the presence of cognitive deficits in first-degree relatives of patients with SCZ; however, un

185 ked VTE, compared this with the risk in 1752 first-degree relatives of patients with unprovoked VTE,

186 When counseling first-degree relatives of patients with venous thromboem

187 ired from 25 patients with schizophrenia, 25 first-degree relatives of patients, and 29 healthy volun

188 s of SZ probands (SZREL), and 206 unaffected first-degree relatives of PBP probands to identify DMNs

189 MS) project is a prospective cohort study of first-degree relatives of people with MS.

190 he early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia.

191 ries of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples-populati

192 otyped familial cohort, we demonstrated that first-degree relatives of probands with NAFLD-cirrhosis

193 ols, the odds of advanced fibrosis among the first-degree relatives of probands with NAFLD-cirrhosis

194 The prevalence of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis

195 vely assess the risk of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis.

196 Lower cancer rates in first-degree relatives of schizophrenia patients suggest

197 Z (n = 229) and BDP (n = 188), HP (n = 284), first-degree relatives of schizophrenia probands (n = 26

198 A total of 54 healthy first-degree relatives of schizophrenic patients and 80

199 Healthy first-degree relatives of schizophrenic patients show al

200 No differences were demonstrated between first-degree relatives of SCZ patients and healthy subje

201 Z probands, 300 PBP probands, 179 unaffected first-degree relatives of SZ probands (SZREL), and 206 u

202 In our model, first-degree relatives of the patients with detected PTE

203 an American and 76.3% were white; 76.1% were first-degree relatives of their recipient.

204 RC also did not differ significantly between first-degree relatives of these groups (serrated polypos

205 lsive disorder (OCD) patients, 18 unaffected first-degree relatives of these OCD patients and 49 heal

206 Z or schizoaffective disorder, 30 unaffected first-degree relatives of these SCZ patients, 13 obsessi

207 Finally, first-degree relatives of those with DS shared volume ab

208 , 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients.

209 c screening revealed abnormalities in 30% of first-degree relatives of UCA or sudden unexplained deat

210 ion Fraction Registry prospectively assessed first-degree relatives of UCA or sudden unexplained deat

211 f B-cell lymphoproliferative disorders among first-degree relatives of WM patients, has been reported

212 icantly with breast cancer in the proband or first-degree relative (P < .01), and with colorectal can

213 and with colorectal cancer in the proband or first-degree relative (P < .01), but not family history

214 from recent-onset patients and GADA-positive first-degree relatives participating in the Bart's-Oxfor

215 234 psychotic bipolar (PBP) probands and 231 first-degree relatives (PBPR), and 200 healthy control s

216 est risk of having >/=1 tender joint seen in first-degree relatives positive for >/=9 ACPAs (OR 5.00,

217 r whether these abnormalities are present in first-degree relatives, possibly representing genetic pr

218 In this sample of first-degree relatives receiving genetic susceptibility

219 %, 87.4%, and 91.0% for third-, second-, and first-degree relatives, respectively).

220 ata revealed no difference in mean number of first-degree relatives screened between nonfamilial and

221 ore cost-effective given that the decedent's first-degree relatives should only need minimal cardiolo

222 Compared with controls, healthy first-degree relatives showed a highly significant decre

223 n during their lifetime, or as a result of a first-degree relative signing a donor card, or consentin

224 S aureus bacteremia was observed among these first-degree relatives (SIR, 2.49 [95% CI, 1.95 to 3.19]

225 eosinophilic esophagitis (EoE) mostly among first-degree relatives, suggesting a genetic contributio

226 bsessive-compulsive disorder (OCD) and their first-degree relatives, suggesting involvement of the fr

227 of results between SDIs and their unaffected first-degree relatives, suggesting that the proposed end

228 severity and are also apparent in unaffected first-degree relatives, suggesting that they represent a

229 esting state EEGs of 225 SZ probands and 201 first-degree relatives (SZR), 234 psychotic bipolar (PBP

230 individual ADs was consistently higher among first-degree relatives than among second- and third-degr

231 ounders, infants of mothers who had lost any first-degree relative the year before or during pregnanc

232 sed 100-fold; given >/=2 premature deaths in first-degree relatives, the rate increased more than 400

233 complete ANGPTL3 deficiency and 3 wild-type first-degree relatives using computed tomography angiogr

234 ere at risk of carrying a mutation because a first-degree relative was a known symptomatic carrier.

235 The prevalence of SCD in >/=1 first-degree relative was significantly higher in victim

236 y group, the family history of SCD among the first-degree relatives was determined and verified from

237 The risk for VTE in first-degree relatives was higher if the index cases had

238 The risk for first-degree relatives was significantly higher than tha

239 Using prospectively registered data on their first-degree relatives, we evaluated the impact of paren

240 history of premature cardiovascular death in first-degree relatives were 1.72 (95% confidence interva

241 ives (5.4%), increasing to 7% (6/85) if only first-degree relatives were assessed.

242 % male) who had received a diagnosis of CUP, first-degree relatives were at an elevated risk of CUP t

243 The lifetime risk of HL was higher when first-degree relatives were diagnosed at early ages (bef

244 Nonbipolar first-degree relatives were impaired on 5 of these, and

245 First-degree relatives were invited for clinical and gen

246 Available first-degree relatives were invited to undergo noncathar

247 All remaining 135 healthy first-degree relatives were negative for both POCT and E

248 ree relatives and 8% of anti-CCP-2- negative first-degree relatives were positive for >/=9 ACPAs.

249 First-degree relatives were submitted to cardiac screeni

250 erosis, but who subsequently had an affected first degree relative, were identified.

251 ree relative with PCa (FH); and those with a first-degree relative who had died of PCa (FHD).

252 ontrol subjects with tetramer(+) cells was a first-degree relative who had insulin-specific cells wit

253 undergoing radical prostatectomy, those with first-degree relatives who died of PCa did not have an i

254 lepsy from 1935-94 (probands) and their 2439 first-degree relatives who resided in Olmsted County.

255 uated, and those who agreed to contact their first-degree relatives who were at least 40 years old we

256 sotypes), and sera from 99 antibody-negative first-degree relatives who were never autoantibody posit

257 mutation that results in AD and 115 (38.5%) first-degree relatives who were noncarrier controls.

258 ate ACPAs in sera from 111 antibody-positive first-degree relatives who were positive on at least 1 v

259 ion and of new cases of celiac disease among first degree relatives with negative results at a first

260 Eight patients had first degree relatives with visual snow.

261 controlled trial in infants with at least 1 first-degree relative with allergic disease.

262 : N=13; noncarriers: N=13) with at least one first-degree relative with Alzheimer's disease and 25 su

263 .82 x 10(-7)) and were more likely to have a first-degree relative with AMD (P = 5.38 x 10(-6)).

264 used to answer the question, "Does having a first-degree relative with an adenoma increase the risk

265 rticipants, 71 individuals with at least one first-degree relative with BD (at-risk), and 80 control

266 iduals aged 18 to 30 years with at least one first-degree relative with bipolar disorder were compare

267 tion task: 24 with BP, 29 at risk based on a first-degree relative with BP, and 53 healthy, low-risk

268 was 1.3-fold higher for HL survivors with a first-degree relative with cancer ( P < .001), with 3.3-

269 We randomly assigned 832 newborns who had a first-degree relative with celiac disease to the introdu

270 for HLA-DQ2 or HLA-DQ8 and had at least one first-degree relative with celiac disease.

271 iduals between ages 45 and 65 years with one first-degree relative with CRC age < 50 years or two fir

272 ers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to

273 r monoallelic MUTYH mutation carriers with a first-degree relative with CRC diagnosed by 50 years of

274 instead answer the question, "Does having a first-degree relative with CRC increase the risk for an

275 Of 430 young CRC cases, 111 (26%) had a first-degree relative with CRC.

276 nors with (n = 1245) vs. without (n = 757) a first-degree relative with ESRD.

277 men), and 94 were healthy controls without a first-degree relative with mental illness (mean [SD] age

278 y of PAD was defined primarily as having any first-degree relative with PAD.

279 o men with no family history of PCa (NFH); a first-degree relative with PCa (FH); and those with a fi

280 subjects at risk of RA by virtue of having a first-degree relative with RA.

281 om the general population and those having a first-degree relative with T1D were enrolled if they had

282 ctively), adjusting for the HLA-DR genotype, first-degree relative with T1DM, maternal education, and

283 h HLA-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited fro

284 ted case-control study of 67 children with a first-degree relative with type 1 diabetes: 27 with isle

285 ter than the risk in persons who do not have first-degree relatives with adenomas (2.31% vs. 0.53%; r

286 ed that the risk for CRC in persons who have first-degree relatives with adenomas is greater than the

287 cancer (CRC) is unclear for persons who have first-degree relatives with adenomatous polyps (adenomas

288 n 1 year of age at high risk of atopy (>/= 2 first-degree relatives with allergic disease) but with n

289 ts from our institution, of whom 20 had >/=1 first-degree relatives with AVNRT.

290 ; RR, 2.5; 95% CI, 1.1 to 5.3) or women with first-degree relatives with bilateral disease (RR, 3.6;

291 95% CI, 50 to 66) for those with two or more first-degree relatives with breast cancer at 50 years of

292 Extremely dense breasts on mammography or first-degree relatives with breast cancer were associate

293 Extremely dense breasts and first-degree relatives with breast cancer were each asso

294 a of any size, or an adenoma of any size and first-degree relatives with colorectal cancer.

295 gree relative with CRC age < 50 years or two first-degree relatives with CRC were selected.

296 athogenic mutations of the RET gene, or were first-degree relatives with histologically proven medull

297 study included patient age, body mass index, first-degree relatives with history of breast cancer, nu

298 large adenomas (>/=1 cm) in persons who have first-degree relatives with large adenomas is greater th

299 n a first-degree relative age <60 years or 2 first-degree relatives with these findings at any age ar

300 Serum samples were obtained from first-degree relatives without RA according to the 1987