ライフサイエンスコーパス: first-degree relative of

1 assessed through family informants in 6,660 first-degree relatives of 1,049 nondemented probands age

2 The study population comprised 9,705 first-degree relatives of 1,951 adults with epilepsy asc

3 ee relatives of 5918 CLL cases and in 28 876 first-degree relatives of 11 778 controls.

4 A cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed b

5 ee relatives of 162 patients with PD and 850 first-degree relatives of 147 controls.

6 A family study of 838 adult first-degree relatives of 152 probands in 3 diagnostic g

7 Of 37 first-degree relatives of 16 sensitive patients, 23 (62%

8 d, historical cohort study, we included 1000 first-degree relatives of 162 patients with PD and 850 f

9 conducted a historical cohort study of 1,001 first-degree relatives of 162 probands with PD and of 85

10 odifying the risk of rheumatoid arthritis in first degree relatives of 165 cases ascertained from Jan

11 From a total of 634 first degree relatives of 186 biopsy-proven celiac disea

12 imated the degree of increased risk of PD in first-degree relatives of 221 PD probands with age of on

13 sonality disorder by direct interview of 106 first-degree relatives of 23 patients with generalized s

14 tients with generalized social phobia and 74 first-degree relatives of 24 comparison subjects without

15 The authors interviewed 888 first-degree relatives of 300 overweight or obese proban

16 Of 147 first-degree relatives of 32 people who died of SADS, 10

17 Eighty-three nonpsychotic first-degree relatives of 38 patients with schizophrenia

18 onset older than 50 years compared with the first-degree relatives of 409 control probands.

19 In addition, we studied 2,713 first-degree relatives of 411 probands with PD referred

20 A total of 124 of 213 (58%) available first-degree relatives of 47 patients with AS in Iceland

21 es from 1958 to 1998 were assessed in 14 336 first-degree relatives of 5918 CLL cases and in 28 876 f

22 ML, MDS, and other malignancies among 24,573 first-degree relatives of 6,962 patients with AML and 1,

23 ly increased risk of breast cancer, untested first-degree relative of a gene mutation carrier, family

24 % mutation carriers [92% plakophilin-2]; 28% first-degree relatives of a mutation-negative proband).

25 Among first-degree relatives of a nationwide MGUS cohort, we f

26 erall lifetime cumulative risk (CR) of HL in first-degree relatives of a patient with HL was 0.6%, wh

27 sed cohort revealed that the rate of EoE, in first-degree relatives of a proband, was 1.8% (unadjuste

28 First-degree relatives of ADHD probands were at elevated

29 First-degree relatives of adults with psychotic experien

30 monozygotic twins (30-50%) and high risks to first-degree relatives of affected individuals (risk rat

31 First-degree relatives of affected individuals have a mo

32 146 probands, known affected relatives, and first-degree relatives of affected individuals.

33 dentified through cascade genetic testing of first-degree relatives of affected mutation carriers.

34 lifetime morbid risk was estimated in adult first-degree relatives of affected probands and control

35 First-degree relatives of African Americans with AD have

36 Among first-degree relatives of an index case with factor V Le

37 9 patients with inactive CD and 35 controls (first-degree relatives of and in the same age bracket as

38 Deficits were also found in unaffected first-degree relatives of attention deficit hyperactivit

39 on, characteristic of autism, extends to the first-degree relatives of autistic individuals, implying

40 (95% confidence interval [CI] 13.1-22.0) in first-degree relatives of BDI patients, higher than that

41 ORs of BDII were 13.6 (95% CI 10.2-18.2) in first-degree relatives of BDII patients and 9.8 (95% CI

42 ves of schizophrenia probands (n = 264), and first-degree relatives of bipolar disorder I with psycho

43 in euthymic bipolar patients and unaffected first-degree relatives of bipolar patients to define the

44 rostate cancer, and all other cancers in the first-degree relatives of carriers and non-carriers.

45 ncreatic, and prostate cancer occurred among first-degree relatives of carriers of BRCA2 mutations on

46 ts diagnosed in Sweden, 43 550 controls, and first-degree relatives of cases (n = 24 577) and control

47 ve-, six- and threefold, respectively, among first-degree relatives of cases carrying BRCA1 mutations

48 ET was present in 25 (22.5%) of the 111 first-degree relatives of cases compared to 6 (5.6%) of

49 erformed a kin-cohort analysis on the 14 704 first-degree relatives of cases for each SNP associated

50 In first-degree relatives of cases with </=17, 18-21, and >

51 isk for JIA was significantly elevated among first-degree relatives of cases with JIA (OR 30.4).

52 nd calendar-specific CRC rates in the 50,924 first-degree relatives of cases.

53 Although it is known that first degree relatives of celiac patients have an increa

54 irtually all the excess risk of cancer among first-degree relatives of children with cancer can be ac

55 ds with generalized social phobia than among first-degree relatives of comparison probands.

56 First-degree relatives of compulsive buyers were more li

57 relatives of patients with PD compared with first-degree relatives of controls (hazard ratio [HR], 1

58 latives of cases compared to 6 (5.6%) of 107 first-degree relatives of controls [relative risk (RR) =

59 4.4; p = 0.0002) when each was compared with first-degree relatives of controls.

60 gnosed adenomas compared with the risk among first-degree relatives of controls.

61 -onset schizophrenia (AOS) by determining if first-degree relatives of COS probands have an increased

62 rvosa and bulimia nervosa were determined in first-degree relatives of diagnostically pure proband gr

63 First- degree relatives of early-onset COPD probands had

64 Reduced spirometric values in first-degree relatives of early-onset COPD probands were

65 Among the entire group of first-degree relatives of early-onset COPD probands, uni

66 approximately three in current or ex-smoking first-degree relatives of early-onset COPD probands.

67 3.4% predicted for both control subjects and first-degree relatives of early-onset COPD probands.

68 chronic bronchitis in current or ex-smoking first-degree relatives of early-onset COPD probands.

69 Risk of PD was similar among first-degree relatives of early-onset PD probands (risk

70 [OR], 7.19; 95% CI, 5.65-9.14), particularly first-degree relatives of EoE cases diagnosed <18 years

71 Seventy-five asymptomatic first-degree relatives of FIP patients (mean age, 50.8 y

72 selves sensitive, compared with 1 (7%) of 15 first-degree relatives of four patients with normal resp

73 006) to measure excess cases of cancer among first-degree relatives of glioma probands.

74 A genetic effect was assessed in first-degree relatives of HS-TLE subjects who did not ha

75 First-degree relatives of IBD patients have a 10-fold in

76 are significantly increased in frequency in first-degree relatives of IIM patients, affect more wome

77 We analyzed 12-lead ECGs of 401 first-degree relatives of individuals who had died from

78 mined gene expression profiles in unaffected first-degree relatives of individuals with autoimmune di

79 risk for developing the disorder (unaffected first-degree relatives of individuals with bipolar disor

80 raphic and electrocardiographic screening of first-degree relatives of individuals with IDC and FDC i

81 Evidence is beginning to show that screening first-degree relatives of individuals with several famil

82 First-degree relatives of individuals with T1DM were rec

83 First-degree relatives of individuals with type 2 diabet

84 of data from 2,164 (1,329 women and 835 men) first-degree relatives of individuals with type 2 diabet

85 ing case-control study, we evaluated whether first-degree relatives of lung cancer cases are at incre

86 y tract cancers, occurred more frequently in first-degree relatives of lung cancer patients than in c

87 ,388 patients with MDS compared with 106,224 first-degree relatives of matched controls.

88 Among first-degree relatives of melanoma cases diagnosed befor

89 ed risks for five additional cancer types in first-degree relatives of melanoma cases suggest that in

90 The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies sh

91 S and lymphoproliferative malignancies among first-degree relatives of MGUS patients.

92 of 5- to 7-fold elevated risk of MPNs among first-degree relatives of MPN patients support the hypot

93 I 0.86-1.23, chi(2)=0.47, p=0.49), or in the first-degree relatives of MS probands compared with cont

94 termined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS

95 By considering the cancer risk in first-degree relatives of mutation-positive and -negativ

96 nced fibrosis screening may be considered in first-degree relatives of NAFLD-cirrhosis patients.

97 First-degree relatives of NHL, HL, and CLL patients have

98 and von Willebrand factor (vWF) occur (1) in first-degree relatives of NIDDM patients and (2) in asso

99 Fasting blood samples were taken from 132 first-degree relatives of NIDDM patients and 151 age mat

100 First-degree relatives of NIDDM patients have an approxi

101 Compared with adult first-degree relatives of normal controls, the risks of

102 s inhibitory control processes in unaffected first-degree relatives of OCD patients for the first tim

103 authors assert that the affection status of first degree relatives of patients with rheumatoid arthr

104 the risk of amyotrophic lateral sclerosis to first degree relatives of patients with sporadic amyotro

105 tients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and contr

106 atives, 16,658 matched control subjects, and first-degree relatives of patients (n = 17,991) and cont

107 s in age-matched islet autoantibody-negative first-degree relatives of patients (n = 392; P = 0.00001

108 Although first-degree relatives of patients exhibit a two-fold in

109 Among first-degree relatives of patients who were 50 years of

110 RR, 4.36 [CI, 2.24 to 8.51]) than that among first-degree relatives of patients who were older than 6

111 First-degree relatives of patients with adenomas did not

112 Many first-degree relatives of patients with AS appear to hav

113 rn of subclinical intestinal inflammation in first-degree relatives of patients with AS.

114 First-degree relatives of patients with AVNRT presented

115 lly abnormal and dilation is common (32%) in first-degree relatives of patients with BAV.

116 by applying the same protocol to 22 healthy first-degree relatives of patients with BD1 and 22 perso

117 eir control groups, BD1 patients and healthy first-degree relatives of patients with BD1 showed signi

118 The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder

119 y is the recommended screening procedure for first-degree relatives of patients with colorectal cance

120 In a prospective study, 1918 first-degree relatives of patients with CRC were randoml

121 nography is an effective screening method in first-degree relatives of patients with CRC.

122 lonoscopy in detecting advanced neoplasia in first-degree relatives of patients with CRC.

123 While first-degree relatives of patients with MM show an incre

124 de that autoimmune disease is more common in first-degree relatives of patients with multiple scleros

125 ated (RR, 1.74 [95% CI, 1.24 to 2.45]) among first-degree relatives of patients with newly diagnosed

126 First-degree relatives of patients with newly diagnosed

127 First-degree relatives of patients with non-insulin-depe

128 The risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fat

129 sed risk of several psychiatric disorders in first-degree relatives of patients with PD compared with

130 We assessed the risk for VTE in 915 first-degree relatives of patients with provoked VTE, co

131 relative-control sample, 58 were unaffected first-degree relatives of patients with schizophrenia (m

132 We examined 58 unaffected first-degree relatives of patients with schizophrenia an

133 First-degree relatives of patients with schizophrenia ap

134 Studies of first-degree relatives of patients with schizophrenia ov

135 renia who were taking medication, 23 healthy first-degree relatives of patients with schizophrenia, a

136 In this study, first-degree relatives of patients with SCZ and their re

137 evious studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate

138 First-degree relatives of patients with SCZ showed signi

139 ted by the presence of cognitive deficits in first-degree relatives of patients with SCZ; however, un

140 of developing Alzheimer's disease among the first-degree relatives of patients with this disorder.

141 4 (IL-4) in anti-islet autoantibody-positive first-degree relatives of patients with type 1A diabetes

142 ) by radioassay, in addition to ICAs, in 882 first-degree relatives of patients with type I diabetes,

143 isease (AD), and it is also increased in the first-degree relatives of patients with typical late-ons

144 ked VTE, compared this with the risk in 1752 first-degree relatives of patients with unprovoked VTE,

145 When counseling first-degree relatives of patients with venous thromboem

146 ired from 25 patients with schizophrenia, 25 first-degree relatives of patients, and 29 healthy volun

147 whether such abnormalities occur in healthy first-degree relatives of patients, indicating they may

148 s of SZ probands (SZREL), and 206 unaffected first-degree relatives of PBP probands to identify DMNs

149 Targeting the first-degree relatives of people with a particular compl

150 MS) project is a prospective cohort study of first-degree relatives of people with MS.

151 de patients with MEN1 or its phenocopies and first-degree relatives of persons with MEN1.

152 he early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia.

153 related to risk of islet autoimmunity among first-degree relatives of persons with type 1 diabetes (

154 ries of schizophrenia or bipolar disorder in first-degree relatives of probands in 3 samples-populati

155 First-degree relatives of probands with (vs without) IC

156 tudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's dise

157 tudinal study of 330 initially asymptomatic, first-degree relatives of probands with Alzheimer's dise

158 Chronicity was assessed in 37.8% of affected first-degree relatives of probands with chronic depressi

159 First-degree relatives of probands with comorbid alcohol

160 arkedly higher (approximately 10-fold) among first-degree relatives of probands with generalized soci

161 ated the prevalence of autoimmune disease in first-degree relatives of probands with multiple scleros

162 ols, the odds of advanced fibrosis among the first-degree relatives of probands with NAFLD-cirrhosis

163 The prevalence of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis

164 otyped familial cohort, we demonstrated that first-degree relatives of probands with NAFLD-cirrhosis

165 vely assess the risk of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis.

166 ntrols, the risks of panic disorder in adult first-degree relatives of probands with panic disorder o

167 s a 30-50-fold increased incidence of VUR in first-degree relatives of probands, compared with the ge

168 udies have found an increased rate of SAH in first degree relatives of SAH patients (relative risk 3.

169 Lower cancer rates in first-degree relatives of schizophrenia patients suggest

170 althy comparison subjects, and 19 unaffected first-degree relatives of schizophrenia patients were st

171 have evaluated verbal working memory in the first-degree relatives of schizophrenia patients, who li

172 Z (n = 229) and BDP (n = 188), HP (n = 284), first-degree relatives of schizophrenia probands (n = 26

173 Thirty-two first-degree relatives of schizophrenic patients (13 wit

174 A total of 54 healthy first-degree relatives of schizophrenic patients and 80

175 Healthy first-degree relatives of schizophrenic patients show al

176 Some unaffected first-degree relatives of schizophrenics also manifest c

177 No differences were demonstrated between first-degree relatives of SCZ patients and healthy subje

178 lta SaO2) were significantly lower among the first-degree relatives of SDB families than among contro

179 theses, mood disorder was not more common in first-degree relatives of subjects with depressive perso

180 us, abnormal glucose metabolism is common in first-degree relatives of subjects with type 2 diabetes.

181 ate of suicide attempts was increased in the first-degree relatives of suicide probands compared with

182 Z probands, 300 PBP probands, 179 unaffected first-degree relatives of SZ probands (SZREL), and 206 u

183 y increased in prevalence (21.9%) in the 151 first-degree relatives of the 21 IIM probands compared w

184 family history data were available for 6430 first-degree relatives of the cases and 4936 first-degre

185 Genotyping first-degree relatives of the cases identified potential

186 first-degree relatives of the cases and 4936 first-degree relatives of the controls.

187 tibody- and/or insulin autoantibody-negative first-degree relatives of the IDDM subjects, and in 28 a

188 In our model, first-degree relatives of the patients with detected PTE

189 hen including sex and the number of affected first-degree relatives of the proband (N(aff)) as covari

190 ng the clinical severity of LQTS in affected first-degree relatives of the proband.

191 93 to 1997 for 685 family members, including first-degree relatives of the probands and spouse contro

192 f 133 probands and 273 directly interviewed, first-degree relatives of the probands were included in

193 Among the first-degree relatives of the probands with acute schizo

194 c treatment as well as clinically unaffected first-degree relatives of the schizophrenia patients.

195 an American and 76.3% were white; 76.1% were first-degree relatives of their recipient.

196 RC also did not differ significantly between first-degree relatives of these groups (serrated polypos

197 lsive disorder (OCD) patients, 18 unaffected first-degree relatives of these OCD patients and 49 heal

198 Z or schizoaffective disorder, 30 unaffected first-degree relatives of these SCZ patients, 13 obsessi

199 Finally, first-degree relatives of those with DS shared volume ab

200 nce of ADHD and learning disabilities in 679 first-degree relatives of three groups of index children

201 are rates of familial psychopathology in the first-degree relatives of three proband groups: 1) patie

202 We assessed uptake of screening by first-degree relatives of two groups of index cases: peo

203 , 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients.

204 First-degree relatives of type 1 DM individuals were rec

205 muscle from 10 insulin-resistant nondiabetic first-degree relatives of type 2 diabetic families and 6

206 Nondiabetic first-degree relatives of type 2 diabetic patients have

207 c screening revealed abnormalities in 30% of first-degree relatives of UCA or sudden unexplained deat

208 ion Fraction Registry prospectively assessed first-degree relatives of UCA or sudden unexplained deat

209 f B-cell lymphoproliferative disorders among first-degree relatives of WM patients, has been reported

210 mily studies have suggested that some female first-degree relatives of women with polycystic ovary sy