ライフサイエンスコーパス: first-line

1 t malaria infection after treatment with the first-line ACT were randomly assigned to either re-treat

2 ssigned to either re-treatment with the same first-line ACT, an alternative ACT, which were given for

3 inhibitors and beta-blockers are recommended first-line agents for heart failure.

4 therapies (ACTs) have been widely adopted as first-line agents to treat uncomplicated falciparum mala

5 Currently, after failure of first line ALK TKI therapy, another ALK TKI is administe

6 ro approaches already proved to be effective first-line analytical tools.

7 cipation in available clinical trials in the first-line and particularly in the relapse setting is hi

8 r the overall cohort (and separately for the first-line and second-line NHT cohorts) were best for CT

9 We also separately examined the first-line and second-line novel hormonal therapy (NHT)

10 This systematic review suggests that first-line antenatal management in FNAIT is weekly IVIG

11 capable of defining the killing kinetics of first line anti-TB drugs against intracellular Mycobacte

12 Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism

13 Taxol, a first-line anti-tumour drug, has low effectiveness again

14 therefore has the potential to contribute to first-line anti-viral treatments during influenza outbre

15 fampin (RMP, a Rifamycin) has been used as a first line antibiotic treatment for tuberculosis (TB), a

16 e bacterium has developed resistance to each first-line antibiotic in turn, we need an improved under

17 nced NSCLC and disease progression following first-line anticancer therapy tested for a KRAS mutation

18 curs only in a minority of individuals after first-line antidepressant treatment ( approximately 35%)

19 Although first-line antidepressants offer therapeutic benefit, ab

20 isplayed increased susceptibility to several first-line antimalarial drugs, including lumefantrine, c

21 The differential response to first-line antipsychotic drugs may reflect a different u

22 nts with schizophrenia show poor response to first-line antipsychotic treatments and this is termed t

23 sychotics, and patients who had responded to first-line antipsychotics (n=12) were recruited.

24 th clozapine (n=12) who had not responded to first-line antipsychotics, and patients who had responde

25 Cross-resistance after first-line antiretroviral therapy (ART) failure is expec

26 Antiplatelet drugs provide first-line antithrombotic therapy for the management of

27 b RNA polymerase (RNAP) is the target of the first-line antituberculosis drug rifampin (Rif).

28 hether the ERN can inform the choice between first-line anxiety disorder treatments and whether the E

29 p was 124 weeks (IQR 56-221) for patients on first-line ART and 101 weeks (IQR 51-178) for patients o

30 HIV-1-infected adults on first-line ART attending routine visits at the Manhica D

31 viduals in LMICs initiating or re-initiating first-line ART from LMICs.

32 lts or adolescents infected with HIV in whom first-line ART had failed (assessed by WHO criteria with

33 ce was near WHO's 10% threshold for changing first-line ART in southern and eastern Africa and Latin

34 g numbers of HIV-infected children receiving first-line ART in sub-Saharan Africa with limited access

35 In this study, children receiving first-line ART in sub-Saharan Africa without real-time V

36 eillance and review of national policies for first-line ART regimen composition.

37 )-infected PWUD, and assessed its impacts on first-line ART virological outcomes.

38 ded in the analysis, of whom 67 644 received first-line ART, 1476 received second-line ART, and 1810

39 were no longer responding to non-NRTI-based first-line ART, as assessed with WHO criteria, confirmed

40 ears of follow-up (95% CI 11.4-11.7), during first-line ART.

41 curred in 14 380 (22%) of 69 454 patients on first-line ART.

42 These studies provide insight into first-line bacterial defences against predation and ways

43 ly hinders the broad application of PDT as a first-line cancer treatment option.

44 INTERPRETATION: First-line ceritinib showed a statistically significant

45 artial response after four or more cycles of first-line chemoimmunotherapy, were eligible if they had

46 ymphocytic leukaemia with poor outcome after first-line chemoimmunotherapy.

47 nd commercial acne creams as well as being a first-line chemotherapeutic agent.

48 In this study, we evaluate benefit from first-line chemotherapy and characterize imaging respons

49 Doxorubicin, a first-line chemotherapy drug, often causes myelosuppress

50 First-line chemotherapy for patients with cisplatin-inel

51 LFOXIRI-Bev) is an established and effective first-line chemotherapy regimen for metastatic colorecta

52 scan result, number of metastatic sites, and first-line chemotherapy regimen.

53 treatment cycle is predictive of outcome to first-line chemotherapy with bevacizumab in patients wit

54 studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin

55 an cancer (EOC) after surgical resection and first-line chemotherapy, about 60% of patients will re-d

56 cond-line treatment in patients who received first-line chemotherapy, without prior immune checkpoint

57 plete or partial remission or no-response to first-line chemotherapy.

58 al prognosis and few treatment options after first-line chemotherapy.

59 er that had progressed following, or during, first-line chemotherapy.

60 assess the efficacy of adding bevacizumab to first-line cisplatin plus etoposide for treatment of ext

61 d urothelial cancer cannot receive standard, first-line cisplatin-based chemotherapy because of renal

62 parity between use of total B12 or holoTC as first-line clinical tests of vitamin B12 status.

63 rica in patients with virological failure of first-line combination antiretroviral therapy (ART) cont

64 Patients were randomly assigned to first-line contact aspiration (n = 192) or first-line st

65 LARC devices constitute first-line contraceptive methods for adolescents.

66 ropharynx, hypopharynx, or larynx undergoing first-line curative treatment.

67 sease and treatment course including current first-line curative treatment: liver resection, radiofre

68 esulted from earlier diagnosis and access to first-line curative treatments, among which RFA provided

69 , 36 patients were enrolled and treated with first-line dabrafenib plus trametinib.

70 Compared with the first-line dacarbazine treatment strategy, NIVO followed

71 play a major role in anti-viral immunity as first line defense during hepatitis B infection, particu

72 ises a large surface area and functions as a first-line defense against noxious insults.

73 ausing variants, using exome sequencing as a first-line diagnostic approach in consanguineous familie

74 Colonoscopy and blood tests were the "first line" diagnostic tools.

75 INTERPRETATION: Addition of custirsen to first-line docetaxel and prednisone was reasonably well

76 at screening, disease progression following first-line docetaxel treatment established by radiograph

77 i-cancer activity as compared to the current first line drug gemcitabine after heat mediated controll

78 ases had additional resistance to >/=1 other first-line drug (n = 66 [81%]) and one-third had resista

79 Among the compounds tested, the first-line drug fluconazole was the weakest inhibitor, w

80 ling miRNA modulation with temozolomide, the first-line drug for GBM therapy.

81 he antineoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive.

82 Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB

83 L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute Lymphoblastic Leuk

84 days sooner than with culture-based DST for first-line drugs and 32 days sooner for second-line drug

85 Opioids are first-line drugs for moderate to severe acute pain and c

86 ts with a history of treatment resistance to first-line drugs relative to treatment responders when b

87 the standard stent retriever technique as a first-line endovascular treatment for successful revascu

88 ing EGFR mutation, disease progression after first-line epidermal growth factor receptor tyrosine kin

89 alences of primary antibiotic resistance and first-line eradication rates.

90 examine the relation between resistance and first-line eradication.

91 Plain radiography is the first-line, essential screening or diagnostic tool for d

92 The ICERs for first-line etanercept-methotrexate and triple therapy we

93 The lifetime analysis suggested that first-line etanercept-methotrexate would result in 0.15

94 ) represents the only available option after first-line failure for the majority of individuals livin

95 als of induction and maintenance regimens in first-line FL therapy published after 1990 and with suff

96 As a standard study end point for first-line FL therapy, progression-free survival (PFS) r

97 s a potential surrogate end point for PFS in first-line FL therapy.

98 hat CR30 is a surrogate end point for PFS in first-line FL treatment trials.

99 ts with RAS wild-type (wt) mCRC treated with first-line fluorouracil, leucovorin, and irinotecan (FOL

100 First-line FOLFIRI plus cetuximab clearly benefitted pat

101 A tentative diagnosis was established after first-line imaging.

102 ults Among 3,038 beneficiaries, 41% received first-line IMiDs.

103 For patients who received a prior first-line immune checkpoint inhibitor, clinicians shoul

104 , we suggest that Rtx might replace St-Cp as first-line immunosuppressive therapy in patients with id

105 First-line immunotherapy consisted of steroids (n = 61/7

106 onfidence interval, 3.32-78.64; for combined first-line immunotherapy with steroids and intravenous i

107 to lapatinib or placebo after completion of first-line/initial chemotherapy for metastatic disease.

108 These findings support TIPS as the first-line intervention in such patients.

109 Psychological therapies are first-line interventions for depression, but existing pr

110 psychological treatments are recommended as first-line interventions for depression, only a small fr

111 psychological treatments are recommended as first-line interventions for harmful drinking, only a sm

112 patients whose condition does not respond to first-line interventions.

113 tate neoplasms, hence USG (TRUS) remains the first line investigation due to its low cost, easy avail

114 RI and MRS is currently not recommended as a first line investigation for detecting prostate neoplasm

115 vel plasma cell-directed chemotherapy beyond first line may be those patients who are either relapsin

116 Hypothermia as a first line measure to reduce intracranial pressure to le

117 PICU site explained 6.5% of the variation in first-line mechanical ventilation group (95% CI, 2.0-19.

118 with those receiving invasive ventilation as first-line mode of mechanical ventilation following unpl

119 Use of noninvasive ventilation as first-line mode of mechanical ventilation in critically

120 on, rather than invasive ventilation, as the first-line mode of mechanical ventilation.

121 Therefore, it might be useful as first-line monotherapy for adults with newly diagnosed e

122 ost effectiveness ratio of $90,871/QALY, and first-line NIVO + IPI followed by carboplatin plus pacli

123 every 3 weeks followed by second-line IPI or first-line NIVO followed by second-line IPI are the most

124 e years (QALYs) for treatment sequences with first-line NIVO, IPI, NIVO + IPI, PEM every 2 weeks, and

125 INTERPRETATION: In NSCLC, first-line nivolumab plus ipilimumab had a tolerable saf

126 In an open-label phase 3 trial, we compared first-line nivolumab with chemotherapy in patients with

127 Virological failure of the WHO-recommended first-line NNRTI-based regimen was higher in the presenc

128 ocalyx on mucosal surfaces and represent the first line of cellular defense against infection and inj

129 The skin barrier is the body's first line of defence against environmental assaults, an

130 est organ in the human body and provides the first line of defence against environmental attack and p

131 Antiviral therapy is a first line of defence against new influenza strains.

132 Neutrophils are the first line of defense against bacterial infections, and

133 tion of thermosensitive client proteins in a first line of defense against cellular stress.

134 It represents the first line of defense against infection and is involved

135 s, including monocytes and macrophages, is a first line of defense against infectious diseases and pl

136 Neutrophils are responsible for the first line of defense against invading pathogens.

137 rs in E. coli, ubiquinone acts as the cell's first line of defense against LCFA-induced oxidative str

138 mucous barrier of our digestive tract is the first line of defense against pathogens and damage.

139 roduce natural Abs which provide an integral first line of defense against pathogens while also perfo

140 s rely on antimicrobial peptides (AMPs) as a first line of defense against pathogens.

141 infection in vivo Macrophages are a critical first line of defense against respiratory pathogens.

142 The first line of defense against viral infections is the in

143 d type III IFNs (IFN-lambda) function as the first line of defense against virus infection and regula

144 a A viruses, antiviral treatment becomes the first line of defense during pandemics because there is

145 A first line of defense is the expression of the innate ge

146 s the largest human organ, and it provides a first line of defense that includes physical, chemical,

147 Human gammadelta T cells comprise a first line of defense through T-cell receptor (TCR) reco

148 physical barrier, but also as an immunologic first line of defense.

149 This finding provides the first line of evidence in a new framework for understand

150 This discovery provides the first line of evidence to suggest that AD-associated neu

151 hereby G. duodenalis evades and disrupts the first line of host defense by degrading human mucin-2 (M

152 To provide a first line of protection at these entry ports, vaccines

153 gression, and ablation of AR activity is the first line of therapeutic intervention for disseminated

154 diagnosis and 82 patients at the end of the first line of treatment (EOT).

155 ter than 95%, and opioids are considered the first line of treatment for pain management.

156 emisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infect

157 is of Weibel-Palade body (WPB) is one of the first lines of defence against vascular injury.

158 These findings have provided first lines of evidences that PDZK1 expression is negati

159 As one of the first lines of host defense, monocytes play important ro

160 of the host innate immune system and define first-line of defence against pathogens.

161 olymeric IgM antibodies provide an efficient first-line of defense against pathogens.

162 any point during chemotherapy (>4 cycles of first-line or 2 cycles of later-line therapy) or relapse

163 20 antibody, chlorambucil, or alemtuzumab as first-line or second-line treatment; and had an Eastern

164 In conclusion, discontinuation of first-line or subsequent 2G-TKI yields promising TFR rat

165 Patients receiving first-line or subsequent dasatinib or nilotinib who stop

166 reducing the relative risk of progression in first-line patients with chronic lymphocytic leukaemia w

167 ment-naive BRAF wild-type advanced melanoma, first-line PEM every 3 weeks followed by second-line IPI

168 INTERPRETATION: First-line pembrolizumab has antitumour activity and acc

169 We assessed the activity and safety of first-line pembrolizumab in cisplatin-ineligible patient

170 f selective serotonin reuptake inhibitors as first-line pharmacologic interventions for OCD; however,

171 ctivity disorder (ADHD) and is currently the first-line pharmacological treatment for children.

172 fe and successful in improving the uptake of first-line Pneumocystis pneumonia prophylaxis in renal t

173 Thus, avoiding food waste should be a first-line priority, while optimizing the method of trea

174 mized control trials (RCTs) that reported on first-line pulmonary tuberculosis therapy between June 2

175 f different intermittent dosing schedules in first-line pulmonary tuberculosis therapy.

176 insomnia (CBT-I) has been established as the first-line recommendation for the millions of adults wit

177 Non-ASCT first-line regimen changed with 65% of patients in 2010-

178 A transition to use of a dolutegravir as a first-line regimen in all new ART initiators is the opti

179 ing levels, compromising the WHO-recommended first-line regimen.

180 INTERPRETATION: A future transition from first-line regimens containing efavirenz to regimens con

181 c resistance to H pylori and the efficacy of first-line regimens in the Asia-Pacific region.

182 of drugs is a component of most recommended first-line regimens.

183 This first line response of astrocytes to myelin injury may e

184 De-escalation is the recommended first-line response to potential violence and aggression

185 sion or complete remission unconfirmed after first-line rituximab plus cyclophosphamide, doxorubicin,

186 ty of the generated stable cell systems as a first-line screening tool for SCs in urine was also demo

187 significant activity of chemotherapy in the first-line setting and beyond, its limitations are refle

188 Pembrolizumab in the first-line setting is being further assessed in the phas

189 Although 5-year survival rates in the first-line setting range from 60% to 70%, up to 50% of p

190 trial have been completed so far, all in the first-line setting.

191 mors who have had disease progression during first-line somatostatin analogue therapy have limited th

192 for chemotherapy, and might represent a new first-line standard of care for PD-L1-expressing, advanc

193 o first-line contact aspiration (n = 192) or first-line stent retriever (n = 189) immediately prior t

194 cept-methotrexate versus triple therapy as a first-line strategy.

195 Gemcitabine has been the first line systemic treatment for pancreatic cancer.

196 generative and anti-inflammatory agents, and first-line systemic pharmacotherapy includes tricyclic a

197 Multiple effective first-line systemic treatment options are available for

198 , TAM16 showed in vivo efficacy equal to the first-line TB drug isoniazid, both as a monotherapy and

199 Widespread resistance to first-line TB drugs is a major problem that will likely

200 assess the diagnostic accuracy of PMCTA as a first-line technique in post-mortem investigations.

201 TAM) in patients with virological failure of first-line tenofovir-containing ART.

202 s are common in patients who have failure of first-line tenofovir-containing regimens in sub-Saharan

203 Of 712 individuals with failure of first-line tenofovir-containing regimens, 115 (16%) had

204 stic challenge because echocardiography as a first-line test may be limited.

205 anti-cervical cancer effects of metformin, a first-line therapeutic drug for type 2 diabetes mellitus

206 alcium channel blocker ingestion (1D); 2) as first-line therapies (prioritized based on desired effec

207 for inclusion in the analysis of efficacy of first-line therapies.

208 ies were included in analysis of efficacy of first-line therapies.

209 agent, MitoQ, alone and in combination with first line therapy for DKD.

210 immunotherapy 2-5 months after completion of first-line therapy and who were assessed as having a hig

211 rtion of complete hematologic response after first-line therapy compared to patients with a dFLC leve

212 e addition of evofosfamide to doxorubicin as first-line therapy did not improve overall survival comp

213 The first-line therapy for acute TTP is based on daily thera

214 ifestyle modification, metformin remains the first-line therapy for adolescents with type 2 diabetes,

215 fit of adding evofosfamide to doxorubicin as first-line therapy for advanced soft-tissue sarcomas.

216 n thiazides and thiazide-like diuretics as a first-line therapy for any outcome.

217 Lithium is a first-line therapy for bipolar affective disorder.

218 While benzodiazepines are a first-line therapy for Dravet syndrome, they are limited

219 omycin-based regimens are commonly used as a first-line therapy for Helicobacter pylori-positive pati

220 in the Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRY

221 costeroids (CSs) and cyclosporine A (CsA) as first-line therapy for newly diagnosed cGVHD after allo-

222 of combination nivolumab plus ipilimumab as first-line therapy for NSCLC.

223 e only Food and Drug Administration-approved first-line therapy for patients with advanced hepatocell

224 dermal growth factor receptor (EGFR) are the first-line therapy for patients with metastatic colorect

225 the addition of ipatasertib to paclitaxel as first-line therapy for triple-negative breast cancer.

226 (SABA) delivered by metered-dose inhaler as first-line therapy for younger and older children (hospi

227 ns, and outline options for patients in whom first-line therapy has failed.

228 irinotecan (FOLFIRI) regimen is superior as first-line therapy in advanced or metastatic KRAS wild-t

229 D-1 inhibitors supports using this option as first-line therapy in circumstances where rapid response

230 Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndro

231 S and ORR over standard-of-care sunitinib as first-line therapy in patients with intermediate- or poo

232 ated cabozantinib compared with sunitinib as first-line therapy in patients with mRCC.

233 r to standard ATRA and chemotherapy (CHT) in first-line therapy of low- or intermediate-risk acute pr

234 alysis found that etanercept-methotrexate as first-line therapy provided marginally more QALYs but ac

235 CLRT-SLT may be offered as first-line therapy to patients with HCC and well-compens

236 ion who had locally defined viral failure on first-line therapy with tenofovir plus a cytosine analog

237 addition of either pertuzumab or placebo to first-line therapy with trastuzumab and docetaxel for pa

238 y cholangitis have an inadequate response to first-line therapy with ursodeoxycholic acid.

239 Among 82 patients evaluable for response to first-line therapy, 31 patients received neoadjuvant che

240 with nonsteroidal anti-inflammatory drugs as first-line therapy, or tramadol or duloxetine as second-

241 After 16 weeks of first-line therapy, patients with stable or responding t

242 inimal residual disease level achieved after first-line therapy.

243 patients achieved a complete response after first-line therapy.

244 he use of raltegravir 1200 mg once daily for first-line therapy.

245 astric cancer and progressed during or after first-line therapy.

246 nefits and harms compared with each other as first-line therapy?

247 nterior circulation undergoing thrombectomy, first-line thrombectomy with contact aspiration compared

248 Recommended first-line topical treatments include neuroregenerative

249 First line treatment is radiotherapy, which many patient

250 Currently, the first line treatment, gemcitabine, is only effective in

251 capacity than patients who have responded to first-line treatment (Cohen's d=0.9191 (whole striatum),

252 he purpose of this article was to inform the first-line treatment choice between cognitive-behavioral

253 First-line treatment consisted of either an 8-week alter

254 tered to 92% of patients, mostly as standard first-line treatment corresponding to stage; 8% of patie

255 citabine and docetaxel versus doxorubicin as first-line treatment for advanced or metastatic soft-tis

256 d brief therapy and might be considered as a first-line treatment for children with anxiety problems.

257 Fluoropyrimidines are the first-line treatment for colorectal cancer, but their ef

258 iptase inhibitors (NRTIs) are recommended as first-line treatment for HIV, and coformulated fixed-dos

259 consider with their patients when selecting first-line treatment for locally advanced or metastatic

260 For many years, first-line treatment for locally advanced or metastatic

261 is percutaneous minimally invasive therapy a first-line treatment for many patients at extreme risk f

262 Although fluid restriction remains the first-line treatment for most forms of chronic hyponatre

263 TION: Doxorubicin should remain the standard first-line treatment for most patients with advanced sof

264 Cetuximab Versus FOLFIRI Plus Bevacizumab as First-Line Treatment For Patients With Metastatic Colore

265 Regarding first-line treatment for patients with non-squamous cell

266 inib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma (RCC).

267 was more common among those who discontinued first-line treatment for this reason.

268 del(17p) and relapsed CLL from 2014, and for first-line treatment from 2016 onward.

269 Cladribine was used as the first-line treatment in 9 patients and as later-line tre

270 first such study to address the question of first-line treatment in a randomized trial.

271 LY2828360 may be useful as a first-line treatment in chemotherapy-induced neuropathic

272 -directed small molecule therapy to standard first-line treatment of acute myeloid leukemia (AML) has

273 nd CsA appeared to be safe and effective for first-line treatment of cGVHD.

274 evacizumab to cisplatin and etoposide in the first-line treatment of ED-SCLC had an acceptable toxici

275 lus chemotherapy is the standard of care for first-line treatment of HER2-positive advanced gastric c

276 nd safety of nintedanib plus chemotherapy as first-line treatment of malignant pleural mesothelioma (

277 R tyrosine kinase inhibitor gefitinib in the first-line treatment of patients with advanced EGFR-muta

278 progression-free survival over gefitinib in first-line treatment of patients with EGFR-mutation-posi

279 sinin-based combination therapy (ACT) is the first-line treatment of Plasmodium falciparum malaria.

280 acin-based sequential quadruple therapies as first-line treatment options and determine factors assoc

281 ility of remission or treatment failure with first-line treatment options for major depression.

282 Cladribine therapy in first-line treatment or later.

283 First-line treatment with a vascular endothelial growth

284 First-line treatment with either first-generation antips

285 n-containing regimens could be an option for first-line treatment, but its efficacy should be evaluat

286 ational guidelines recommend azithromycin as first-line treatment, rapid spread of macrolide resistan

287 Oral propranolol is now the first-line treatment, which should be administered as ea

288 etastatic NETs and disease progression after first-line treatment.

289 re EGFR-blocking antibodies are approved for first-line treatment.

290 ing ART, in line with nationally recommended first-line treatment.

291 eak and PLPS and, thus, should be considered first-line treatment.

292 best tolerated of the three and the standard first-line treatment.

293 significant treatment-related toxicities of first-line treatment.

294 rease) as oral targeted therapies become the first-line treatment.

295 re more prevalent in the rotating arm during first-line treatment.

296 sone (CHOP), nowadays represent the standard first-line treatment; for patients who achieve a satisfa

297 e exercise or psychological interventions as first-line treatments for CRF.

298 bance (2D); 3) in patients refractory to the first-line treatments, we suggest incremental doses of h

299 011 national shortage of norepinephrine, the first-line vasopressor for septic shock.

300 al vs atypical) and line of study treatment (first line vs others).

301 61 (31.3%), and 84 (43.1%) had been treated first-line with argatroban, lepirudin, danaparoid, and f