ライフサイエンスコーパス: first-pass

1 ately 80% of the insulin is extracted during first pass.

2 d glucose metabolism as evaluated by dynamic first-pass (18)F-FDG PET and by proliferation and endoth

3 Tumor blood flow quantified by dynamic first-pass (18)F-FDG PET/CT is significantly associated

4 prostate cancer confirms the utility of the first-pass 18F-FDG blood flow analysis in tumor diagnosi

5 fast, low-sensitivity weighted keyword-based first pass algorithm to cast a wide net to gather an ini

6 sentative and highly-annotated sequences for first-pass analyses will be essential to deal with the i

7 First-pass analyses with BR55, BR38, and BR1 revealed si

8 re made with only 2 volume scans using a new first-pass analysis (FPA) technique and with 20 volume s

9 Purpose To retrospectively validate a first-pass analysis (FPA) technique that combines comput

10 First-pass analysis with BR1, BR38, and BR55 showed simi

11 obutamine followed by contrast-enhanced MRI (first pass and delayed imaging) after a bolus infusion o

12 respectively, are diagnosed by using dynamic first-pass and delayed contrast enhancement.

13 icrovascular obstruction and infarct size by first-pass and delayed contrast-enhanced magnetic resona

14 (191m)Ir first-pass angiograms were obtained at baseline, after t

15 It is possible to use (191m)Ir first-pass angiography to evaluate rapid dynamic changes

16 a genomic context; (3) perform customizable first-pass annotation of the data; and (4) present the d

17 enzymes that were incompletely annotated in first-pass annotation of the parasite genome.

18 d, there is an increasing need for automated first-pass annotation which allows timely access to impo

19 =6) of MSCs arrest and interrupt flow during first pass at the precapillary level, resulting in decre

20 First-pass attempts to explain the glutamate-elicited cu

21 The program, should be useful for first-pass automatic classification of repeats in newly

22 ypically >85%) so that they could be used in first-pass biological assays without further purificatio

23 Pulmonary blood flow (PBF), first-pass bolus kinetic parameters, and biventricular m

24 tary glutamate is extensively metabolized in first pass by the intestine.

25 CT (11% +/- 6) correlated well with those at first-pass cardiac MR imaging (7% +/- 4, R(2) = 0.72).

26 Quantitative first-pass cardiovascular magnetic resonance (CMR) perfu

27 ratio but unlike insulin experiences little first pass clearance by the liver.

28 s to be more easily studied in a model where first pass clearance is a significant obstacle.

29 Budesonide has a high hepatic first-pass clearance and metabolites virtually devoid of

30 ntration-time profiles and approximately 50% first-pass clearance by the liver.

31 ossible cellular distribution, by minimizing first-pass clearance in the lungs.

32 rior mesenteric artery, indicating increased first-pass clearance of [14C]lactate by the splanchnic o

33 in LTRvc was determined from the splanchnic first-pass clearance of [14C]lactate infused into the su

34 hort half-life that was attributable to high first-pass clearance.

35 de first an accessible technical overview of first-pass CMR perfusion imaging and contrast it with ot

36 as of method development, include developing first-pass coarse-grained models guided by experimental

37 However, if these regions demonstrate first pass contrast hypoenhancement, they are associated

38 ing the left ventricular myocardium during a first-pass contrast bolus in the presence and absence of

39 First-pass contrast MRI was consistent with perfusion of

40 First-pass contrast-enhanced MRI calf muscle perfusion a

41 uantitative cardiac magnetic resonance (CMR) first-pass contrast-enhanced perfusion imaging to qualit

42 ior descending (LAD) artery stenosis, during first-pass, contrast-enhanced helical MDCT.

43 validated extended gamma variate modeling of first-pass cortical TACs.

44 First-pass CT images and contrast-enhanced cardiovascula

45 Dynamic first-pass CT perfusion was performed in primary (n=25)

46 of a typical batch of 240 samples (including first-pass data analysis) can be accomplished within 48

47 dehydrogenase, the enzyme that brings about first-pass degradation of fluorouracil.

48 tting was used to derive the areas under the first pass dilution curves.

49 e is an increasingly well-recognized site of first-pass drug metabolism.

50 nt-echo sequences can be used to monitor the first-pass dynamics of contrast media, thus defining sel

51 We aimed for a high first pass effect, limiting cytokine induction systemica

52 Low solubility, poor permeability, and high first-pass effect of furosemide may also have produced t

53 studied IDN6556, a caspase inhibitor with a first-pass effect, in a large animal (pig) intraportal m

54 e-dependent changes in tacrolimus intestinal first-pass effect, metabolism, or distribution play a ro

55 able bioavailability, intestinal and hepatic first-pass effects, and dermatological reactions.

56 (2.7 ejection fraction units, p < 0.01), and first-pass ejection fractions were much lower (8.0 eject

57 ation of effects of the properties on Fa and first-pass elimination (Fg and Fh).

58 (ie., hepatic extraction, fraction escaping first-pass elimination in the liver, and hepatic clearan

59 Glycine dramatically increased the first-pass elimination of ethanol in vivo but had no eff

60 ty with typically opposing effects on Fa and first-pass elimination.

61 mages (HYPER), or (3) both absence of normal first-pass enhancement and delayed hyperenhancement (COM

62 Purified progenitors were used to provide a first-pass expression profile of various haematopoiesis-

63 ing advantage of the early kinetics and high first-pass extraction by the myocardium of this radiotra

64 The goals of this study were to measure the first-pass extraction fraction (EF) of 99mTc-tetrofosmin

65 beled myocardial perfusion agent with a high first-pass extraction fraction and delayed redistributio

66 In addition, the first-pass extraction of (11)C-laniquidar was low.

67 unction and several models for the nonlinear first-pass extraction of (82)Rb by myocardium have been

68 Hepatic insulin first-pass extraction was two-thirds lower in AAs versus

69 TOF and first-pass ferumoxytol-enhanced MR angiography were perf

70 First-pass (FP) radionuclide ventriculography (RVG) and

71 Findings were correlated with first-pass gadodiamide contrast magnetic resonance imagi

72 tion of gadolinium chelate and evaluation of first-pass gadolinium chelate perfusion by using highly

73 ging was performed in 29 patients by using a first-pass gadopentetate dimeglumine T2*-weighted echo-p

74 e sequence length polymorphism markers for a first-pass genome scan in crosses involving C32 and SJD

75 te usual postabsorptive rates and that avoid first-pass hepatic clearance.

76 al but not transdermal ET increased CRP by a first-pass hepatic effect.

77 [1,3,2]-dioxaphosphonane (MB07811) undergoes first-pass hepatic extraction and that cleavage of the p

78 t female mice lacking GLUT8 exhibit impaired first-pass hepatic fructose metabolism, suggesting that

79 To address the second question, we measured first-pass hepatic insulin clearance in two recipients o

80 ing the portal insulin dose in proportion to first-pass hepatic insulin extraction.

81 desonide, a corticosteroid with an extensive first-pass hepatic metabolism appeared promising for the

82 estrogen-induced CRP elevation is related to first-pass hepatic metabolism.

83 ow systemic availability as a result of high first-pass hepatic metabolism.

84 imal systemic corticosteroid activity due to first-pass hepatic metabolism.

85 ntrast-enhanced images were defined as COMB (first pass hypoenhancement) or HYPER (normal first pass

86 The first pass identifies putative binding sites and compens

87 Visual comparisons with first-pass images were also excellent.

88 Although magnetic resonance first-pass imaging (MRFP) has potential advantages in ph

89 ionuclide therapy dosimetry imaging, cardiac first-pass imaging, and positron coincidence imaging and

90 clide therapy dosimetry imaging, and cardiac first-pass imaging.

91 than that with gadopentetate dimeglumine at first-pass imaging.

92 We investigated this first pass in patients with diffuse liver disease and in

93 The proportion of patients with successful first-pass intubation did not differ significantly betwe

94 s the proportion of patients with successful first-pass intubation.

95 In the first pass, it identifies the local similarities between

96 longitudinally assessed in mice by means of first-pass kinetics of nontargeted microbubbles (BR1, BR

97 s study evaluated the suitability of current first-pass magnetic resonance approaches for evaluating

98 MALDI-MS is used in a first pass manner to detect derivatized phosphopeptides,

99 Using our first-pass marker panel in bulked-segregant analysis, we

100 measurements of myocardial perfusion during first-pass MDCT imaging in a canine model of LAD stenosi

101 azole, 8.0% of the tacrolimus dose underwent first pass metabolism (E(H)), whereas in the presence of

102 okinetics are remarkable for almost complete first pass metabolism after oral administration, resulti

103 )), whereas in the presence of ketoconazole, first pass metabolism was 6.2% (P=0.01).

104 Based on this difference in first pass metabolism, an increase of 2% in bioavailabil

105 aempferol to cultured hepatocytes, mimicking first pass metabolism, greatly diminished the inhibitory

106 r deliver drugs systemically without hepatic first pass metabolism.

107 and extensive distal binding in all tissues, first-pass metabolism and activation of NNK in the airwa

108 Intranasal administration avoids first-pass metabolism and provides a reproducible, easil

109 There is debate regarding the site of first-pass metabolism and specifically whether the stoma

110 rful new tool for preclinical predictions of first-pass metabolism for new drugs in development.

111 thanol from reaching the liver by activating first-pass metabolism in the stomach.

112 First-pass metabolism is a common cause of incomplete an

113 aining monooxygenase enzymes involved in the first-pass metabolism of drugs and foreign chemicals in

114 The effect of glycine on the first-pass metabolism of ethanol was also examined in vi

115 The first-pass metabolism of foreign compounds in the lung i

116 tients with TIPS, there was a marked loss in first-pass metabolism of midazolam as a result of dimini

117 intestinal P450 expression and capacity for first-pass metabolism of oral drugs.

118 en et al. show in this issue of the JCI that first-pass metabolism of the anticancer agent docetaxel

119 and poor oral bioavailability, due to rapid first-pass metabolism of the phenol moieties.

120 9 was not active orally, likely due to rapid first-pass metabolism of the phenol moiety.

121 y influencing either the absorption phase or first-pass metabolism of TVR.

122 henols undergo extensive modification during first-pass metabolism so that the forms reaching the blo

123 Astemizole undergoes extensive first-pass metabolism, and its dominant metabolite, desm

124 substrates that undergo extensive intestinal first-pass metabolism.

125 , by inhibiting intestinal (but not hepatic) first-pass metabolism.

126 f verapamil, a drug that undergoes extensive first-pass metabolism.

127 ufficient alcohol to account for the bulk of first-pass metabolism.

128 sm in keeping with its inhibition of in vivo first-pass metabolism.

129 ministered alcohol is incomplete, indicating first-pass metabolism.

130 ch has the metabolic capacity to account for first-pass metabolism.

131 ain barrier-permeant, but suffers from rapid first-pass metabolism.

132 pectrometry (FIE-MS) is finding utility as a first-pass metabolite fingerprinting tool in many resear

133 correlation with those obtained by using the first-pass method (Pearson r = 0.80) and gamma variate a

134 F(V) was also calculated by using the first-pass method and gamma variate analysis for model v

135 ulated from this short dynamic image using a first-pass model.

136 ial perfusion reserve can be quantified with first-pass MR imaging.

137 as a percentage of left ventricular mass) at first-pass multidetector CT (11% +/- 6) correlated well

138 ed and normal myocardium were comparable for first-pass multidetector CT and cardiac MR imaging, card

139 First-pass multidetector CT and MR imaging demonstrated

140 Arrhythmia-insensitive, first-pass, multisection, T1-weighted MR imaging with co

141 netic resonance (cine, T2* iron, vasodilator first pass myocardial perfusion, and late gadolinium enh

142 racer uptake, K1 (K1 (mL/g/min) = MBF.E; E = first-pass myocardial extraction of 1-11C-acetate) and w

143 values were converted to MBF values using a first-pass myocardial extraction/flow relationship measu

144 ronary MR angiography performed as part of a first-pass myocardial perfusion and viability assessment

145 First-pass myocardial perfusion cardiovascular magnetic

146 imaging for assessment of cardiac function, first-pass myocardial perfusion imaging at rest and duri

147 a "notched" section profile for T1-weighted first-pass myocardial perfusion magnetic resonance (MR)

148 First-pass myocardial perfusion MR imaging was performed

149 First-pass myocardial signal intensity-time curves were

150 We postulated that the hepatic first pass of a bolus of an ultrasound contrast agent in

151 ortical layers and thus are extracted in the first pass of activity through the anteroventral tempora

152 Multidetector CT was performed during the first pass of contrast material to assess myocardial per

153 e diversity of the sequences detected in the first pass of database screening and the ability of a gi

154 CMR perfusion imaging during the first pass of gadolinium-based contrast agents has under

155 s was observed in images acquired during the first pass of gadopentetate dimeglumine in coronary arte

156 lood (18)F-FDG activity, consistent with the first pass of labeled cells in the systemic circulation.

157 ves in 122 subjects, with correction for the first pass of the initial bolus.

158 oscopy increases the frequency of successful first-pass orotracheal intubation compared with direct l

159 red with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associat

160 29), time to peak (P = .008), upslope of the first-pass peak (P = .011), and late-phase washout slope

161 k-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement.

162 cardiac volumes, function, oxygenation, and first-pass perfusion (0.03 mmol/kg Gd-DTPA bolus) at str

163 mural extent of microvascular obstruction at first-pass perfusion (intraclass correlation coefficient

164 hypothesis that transcatheter intraarterial first-pass perfusion (TRIP) magnetic resonance (MR) imag

165 n = 7) and subacute (1 week, n = 6) resting first-pass perfusion and late gadolinium-enhanced cardio

166 Patients also underwent quantitative first-pass perfusion cardiac magnetic resonance to measu

167 First-pass perfusion images at rest were acquired in 3 s

168 Semi-quantitative evaluation of the first-pass perfusion images was completed to determine m

169 BOLD and first-pass perfusion images were acquired at rest and st

170 atial resolution of 1.5 x 1.2 x 5.0 mm3, and first-pass perfusion images were acquired for visual com

171 ased maximum signal intensity and upslope at first-pass perfusion imaging and reduced infarct size at

172 Cardiovascular magnetic resonance first-pass perfusion imaging was performed before and 5

173 First-pass perfusion imaging was performed during hypere

174 es before and after intravenous contrast and first-pass perfusion imaging were acquired, and assessed

175 s been shown to reduce dark-rim artifacts in first-pass perfusion imaging.

176 ersistent decline in myocardial perfusion at first-pass perfusion imaging.

177 d-enhancement magnetic resonance imaging and first-pass perfusion magnetic resonance imaging at rest

178 First-pass perfusion MR imaging was performed 1 hour and

179 First-pass perfusion MRI is a safe and accurate test for

180 oxide, producing remote vasodilation during first-pass perfusion of the opposite limb; (3) nitrite i

181 We applied BOLD imaging and first-pass perfusion techniques to: 1) examine the patho

182 MR imaging were used to assess LV function, first-pass perfusion, and delayed contrast enhancement i

183 Cardiac MR imaging consisted of cine, rest first-pass perfusion, and late gadolinium enhancement im

184 R protocol consisted of T2-weighted imaging, first-pass perfusion, cine function, delayed-enhancement

185 respectively), showing expected patterns of first-pass perfusion.

186 I (r = 0.88, slope = 0.79, s.e.e. = 6.0) and first-pass planar scintigraphy (r = 0.86, slope = 1.2, s

187 ed tRNA detection programs are used as fast, first-pass prefilters to identify candidate tRNAs, which

188 vestigation examined the prognostic power of first-pass radionuclide angiocardiography (RNA) ejection

189 ombosis was discovered accidentally from the first-pass radionuclide angiogram that is routinely perf

190 First-pass radionuclide angiographic (FPRNA) analysis, u

191 Conventional gated first-pass radionuclide angiography (FP) and planar gate

192 including 45 biplane and 9 single plane) and first-pass radionuclide angiography (n = 38) in patients

193 Good correlation was also observed between first-pass radionuclide angiography and both contrast ve

194 roducible and correlate well with results of first-pass radionuclide angiography but are closer in va

195 sion computed tomography (SPECT) imaging and first-pass radionuclide angiography during a single exer

196 Ninety-two patients underwent first-pass radionuclide angiography using a multicrystal

197 The rest study was combined with first-pass radionuclide angiography using the multicryst

198 asive tests--the Duke treadmill score (DTS), first-pass radionuclide angiography with calculation of

199 ew demonstrates the importance of performing first-pass radionuclide cardioangiography routinely befo

200 right heart hemodynamics, gas exchange, and first-pass radionuclide ventriculography at rest and wit

201 Hemodynamic monitoring and first-pass radionuclide ventriculography were performed

202 ing with invasive hemodynamic monitoring and first-pass radionuclide ventriculography.

203 ing (primary sensory receiving areas) mature first, passing relatively stable outputs about sensorimo

204 As a first-pass scan for novel imprinted genes, we performed

205 consisting of an early 2-min uptake scan-or first-pass scan-and 3 sequential 15-min late 18F-FDG upt

206 tabolite fingerprinting is widely used as a 'first pass' screen for compositional differences, where

207 h for post-hoc normalization of quantitative first-pass screening data in the absence of explicit in-

208 rchaeological and geological field work as a first-pass screening device which obviates the necessity

209 Although the ABCA4 array remains a good first-pass screening option, the NGS platform is a time-

210 As a first-pass screening probe for forensic crime scenes, Ra

211 accuracy needed to limit false positives in first-pass screening.

212 in organizing sequencing data and to provide first-pass sequence analysis in an automated fashion.

213 h parameters to provide the most informative first-pass sequence analysis possible.

214 protein data base searching, and (4) limited first-pass sequence annotation, making it difficult to d

215 5.9% in nondiabetic patients, P < 0.001) and first-pass SGU (4.7+/-1.7 vs. 26.5+/-5.1% in nondiabetic

216 0.94, P < 0.01 for nondiabetic patients) and first-pass SGU (r = 0.87, P < 0.05 for NIDDM patients; r

217 For OG-CLAMP, SGU was calculated as first-pass SGU by subtracting the integrated decrease in

218 g the OG-CLAMP is well-correlated to SGU and first-pass SGU during HVC in NIDDM.

219 LAMP technique in NIDDM by comparing SGU and first-pass SGU during HVC with SGU during the OG-CLAMP e

220 e performed with a 22-gauge needle after the first pass showed minimal or no aspirate.

221 first pass hypoenhancement) or HYPER (normal first pass signal enhancement).

222 t-pass signal enhancement (HYPO), (2) normal first pass signal followed by hyperenhanced signal on de

223 rdial infarction (MI): (1) absence of normal first-pass signal enhancement (HYPO), (2) normal first p

224 d endogenously produced glucose and a higher first-pass splanchnic glucose uptake (SGU).

225 erted to urea, with kinetics indicative of a first-pass splanchnic phenomenon.

226 om an adenoma had already been detected with first-pass standard forward-viewing colonoscopy; none of

227 pid manner and also were able to provide the first-pass structure evidence of a newly discovered natu

228 were further investigated using correlative first-pass studies.

229 Intraosseous had significantly higher first-pass success rates and faster placement compared w

230 First-pass success was significantly higher for intraoss

231 myocytes, and blood cell progenitors without first passing the cells through a pluripotent state.

232 ell-dependent, humoral immune responses must first pass through germinal centers (GCs) within the cor

233 lexes to read through this region during the first pass through net.

234 ed insertion alleles for 1976 genes during a first pass through the genome including, unexpectedly, a

235 For water to evaporate, it must first pass through the tight lipid-lipid barrier.

236 ompatible with consciousness, the brain must first pass through these hubs in an orderly fashion.

237 in cells treated with aqueous humor that was first passed through a 3-kDa or a 30-kDa, but not a 100-

238 ng through a double-gated "check-in" system, first passing through a pore on the hexamer surface and

239 The first-pass time course of signal enhancement was measure

240 Parameters of a first-pass time intensity curve were calculated for quan

241 for information extraction can form a useful first-pass tool for assisting human annotation and maint

242 limit peak dead-time losses during the bolus first-pass transit.

243 These results suggest that the first-pass uptake of 18F-FDG may provide an estimate of

244 Hypoxic first-pass uptake was 78.2% +/- 7.2% for (64)Cu-ATS and

245 ent entry to the circulation, because of its first-pass urinary excretion.

246 ia Screening Studies project, men provided a first-pass urine specimen, which they returned by post f

247 s, 55 SNPs were successfully analyzed in the first pass using this assay format and all 181 genotypes

248 monstrated better agreement with independent first-pass values (r = 0.90) than did manual measurement

249 ion fraction from tomography correlated with first-pass values with r = 0.82, and end diastolic and e

250 olic volumes from tomography correlated with first-pass values with r = 0.85 and r = 0.91, respective

251 c-sestamibi SPECT (gated SPECT, n = 88) with first-pass ventriculography.

252 k yet informative comparative analyses and a first pass visualization of both annotation and analysis

253 , the small amount of dietary lysine used in first pass was oxidized almost entirely.