ライフサイエンスコーパス: fission

1 isassembly of the dynamin polymer to trigger fission.

2 (e.g., 50 muM) used to target mitochondrial fission.

3 ons are thought to be the primary drivers of fission.

4 fects of midlife Drp1-mediated mitochondrial fission.

5 , viral resistance, and mitochondrial fusion/fission.

6 an annotated protein promoting mitochondrial fission.

7 ally increase membrane curvature, leading to fission.

8 a pattern suggesting increased mitochondrial fission.

9 d uncoupled triplet excitons through singlet fission.

10 e interrogated items were undergoing induced fission.

11 of the electronic matrix element for singlet fission.

12 assembly, calcium overload and mitochondrial fission.

13 hondrial dynamics by mediating mitochondrial fission.

14 logical and pathophysiological mitochondrial fission.

15 yto, promoting proliferation, migration, and fission.

16 cyto), aerobic glycolysis, and mitochondrial fission.

17 s into two pieces by a process called binary fission.

18 ated blockage of Drp1-mediated mitochondrial fission.

19 o different lipid signals to induce membrane fission.

20 nt inhibition of Drp1-mediated mitochondrial fission.

21 ER-endosome contacts drives endosomal tubule fission.

22 terest when used in conjunction with singlet fission.

23 ly in a dynamic process involving fusion and fission.

24 triplets (2xT1) in a process called singlet fission.

25 ck of endocytic pits, and catalyzes membrane fission.

26 in 1 (Drp1), a key mediator of mitochondrial fission.

27 otein 1) is a key regulator of mitochondrial fission.

28 10-fold reduction in bulk rates of membrane fission.

29 teins may be critical to regulated endocytic fission.

30 eaks these necks, a reaction called membrane fission.

31 eck and ultimately ILV generation by vesicle fission.

32 Singlet fission, a multistep molecular process in which one phot

33 , recent studies demonstrate that inhibiting fission also results in decreased mitochondrial function

34 n process 1 (MTFP1) to control mitochondrial fission and apoptosis.

35 ovel therapeutic target to control excessive fission and associated mitochondrial deficits.

36 e show that new pyrenoids are formed both by fission and de novo assembly.

37 ey restore active rotational diffusion after fission and eventually being transported away from the o

38 Paradigms have held that mitochondrial fission and fragmentation are the result of pathological

39 study is to determine whether mitochondrial fission and fragmentation can be an adaptive mechanism u

40 ammals when applied in midlife.Mitochondrial fission and fusion are important mechanisms to maintain

41 transport of mitochondria and mitochondrial fission and fusion contribute to this rejuvenation, but

42 the mechanisms that regulate rates of crypt fission and fusion could provide insights into intestina

43 As counteracting processes, crypt fission and fusion could regulate crypt numbers during t

44 the polymorphic regulation of mitochondrial fission and fusion in reactive microglia is mediated by

45 m extensive networks constantly remodeled by fission and fusion.

46 egulatory factors that control mitochondrial fission and fusion.

47 evealed that reduced levels of mitochondrial fission and increased fusion, biogenesis and synaptic ge

48 lications, such as water photolysis, exciton fission and novel photovoltaics involving low-dimensiona

49 Shh signaling activity reduces mitochondrial fission and promotes mitochondrial elongation, at least

50 ochondrial DLP1 complex during mitochondrial fission and provide a novel therapeutic target to contro

51 ts as a catalyst in dynamin-induced membrane fission and rationalize its adoption to meet the physiol

52 We focus on Dugesia japonica fission and show that it proceeds in three stages: a loc

53 s, overexpression of endophilin delayed both fission and transferrin uptake.

54 ologic requirement of a fast-acting membrane fission apparatus.

55 gated dimers, the time constants for singlet fission are relatively insensitive to the interplanar an

56 trate a novel role for cardiac mitochondrial fission as a normal adaptation to increased energetic de

57 ments of membrane vesiculation revealed that fission became spontaneous as steric pressure increased.

58 to long CNE "deserts." This corresponds with fission being the rarest type of rearrangement in avian

59 Furthermore, not only mitochondrial fission but also fusion is regulated through Mff and Drp

60 tes, which do not divide by canonical binary fission but undergo unconventional cycles.

61 smic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved and consequences of

62 suggesting that TRPML1 may promote lysosome fission by activating CaM.

63 y domain (ENTH), previously thought to drive fission by hydrophobic insertion, our results show that

64 ondrial redox status increased mitochondrial fission by increased ubiquitination of AKAP121 (A-kinase

65 tween turns of the dynamin helix and impairs fission by preventing trans interactions between dynamin

66 he hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filame

67 Failure of fission caused defective sorting of mannose 6-phosphate

68 hat interventions that promote mitochondrial fission could delay the onset of pathology and mortality

69 evel can be used to drive macroscale droplet fission.Coupling compartmentalisation and molecular repl

70 Mitochondrial fusion-fission cycles ensure independent genome segregation, im

71 ly rescues the impaired insulin secretion of fission-deficient beta-cells, demonstrating that defecti

72 C balances antagonistic forces of fusion and fission determining mitochondrial and cell fates.

73 mical properties for exploitation in singlet fission devices.

74 fission during osmotic stress, but blocking fission did not affect AMPK activation.

75 The large GTPase dynamin mediates membrane fission during clathrin-mediated endocytosis (CME).

76 Dynamin, which mediates membrane fission during endocytosis, binds endophilin and other m

77 We observed mitochondrial fission during osmotic stress, but blocking fission did

78 gy domain (PHD) and engage in rapid membrane fission during synaptic vesicle recycling.

79 ), a putative inhibitor of the mitochondrial fission Dynamin-Related Protein-1 (Drp1).

80 Further, fission efficiency remained equally potent when helices

81 fluorescent protein (GFP) was able to drive fission efficiently when bound to the membrane at high c

82 Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments

83 rther droplet shrinkage leads to a series of fission events, which includes the loss of some Cl(-) io

84 e dynamic organelles that undergo fusion and fission events.

85 ergo shape changes as a result of fusion and fission events.

86 It asserts that fission execution is a mechanical process.

87 e MOM resident adaptor protein mitochondrial fission factor (Mff).

88 s through interaction with the mitochondrial fission factor Drp1 in fed cells and in autophagy throug

89 chanisms involved and consequences of tubule fission failure are incompletely understood.

90 , which has been proposed to mediate singlet fission, forms on ultrafast timescales (in 300 fs) and t

91 ing cascade, ultimately resulting in vesicle fission from the trans-Golgi network (TGN).

92 -body theory, we show that the thermodynamic fission-fusion balance of excitons and electron-hole pla

93 other mammals, including societies with high fission-fusion dynamics, male philopatry, female dispers

94 oncert, enables the normal occurrence of the fission-fusion process.

95 Abnormal fission-fusion processes result in disrupted mitochondri

96 uctural analyses, we show that mitochondrial fission/fusion in reactive microglia is differentially r

97 timuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis, a

98 g postnatal development, crypts multiply via fission, generating 2 daughter crypts from 1 parental cr

99 RNA expression and reduced protein levels of fission genes, and increased levels of mitochondrial fus

100 ylation and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1).

101 uron-specific isoform of the large, membrane fission GTPase, can be activated in nonneuronal cells do

102 etic resonance spectroscopy to probe singlet fission in a pentacene dimer linked by a non-conjugated

103 peutic treatment of disrupting mitochondrial fission in cocaine addiction.

104 atherosclerosis by inhibiting mitochondrial fission in endothelial cells.

105 detect neutrons and gamma rays from induced fission in HEU.

106 with a role for ER-mediated endosomal tubule fission in lysosome function, similar lysosomal abnormal

107 ia, and show that induction of mitochondrial fission in midlife, but not in early life, extends the h

108 n mitochondria and the role of mitochondrial fission in mitophagy.

109 ries about the mechanistic details of binary fission in model bacteria such as Escherichia coli, Baci

110 Thus, mitochondrial fission in response to AC uptake is a critical process t

111 demonstrate a role for altered mitochondrial fission in the NAc, during early cocaine abstinence, sug

112 Promoting Drp1-mediated mitochondrial fission, in midlife, facilitates mitophagy and improves

113 an almost exact reverse phenomenon of crypt fission, in which 2 crypts fuse into 1 daughter crypt.

114 -related protein that promotes mitochondrial fission-in midlife, prolongs Drosophila lifespan and hea

115 Mitochondrial fission-induced mitochondrial function elevates mitochon

116 Mdivi-1, a demonstrated fission inhibitor, blunts cocaine seeking and locomotor

117 ision inhibitor 1 (mdivi-1), a mitochondrial fission inhibitor.

118 tion of mitochondrial transport, fusion, and fission is critical for asymmetric division and rejuvena

119 When mitochondrial fission is disabled, AC-induced increase in cytosolic ca

120 Given that lysosome fission is implicated in both lysosome biogenesis and re

121 tion and cardiac impairment, suggesting that fission is important for maintaining cardiac and mitocho

122 roplet-robot demonstrates that the extent of fission is increased as the reaction progresses, produci

123 trictly dependent on GTP hydrolysis, but how fission is mediated is still debated: GTP energy could b

124 demonstrate in this study that mitochondrial fission is necessary for glucose-stimulated insulin secr

125 valuated whether inhibition of mitochondrial fission is neuroprotective against alpha-syn overexpress

126 In the adult intestine, crypt fission is observed at a low frequency.

127 Here, we show that dynamin-mediated membrane fission is potently inhibited in vitro when an excess of

128 How endophilin influences endocytic membrane fission is still unclear.

129 Here, we show that mitochondrial fission is triggered by mechanical forces.

130 l membrane trafficking, including fusion and fission, is crucial for cellular homeostasis and normal

131 at the location of waist formation, and thus fission, is determined by physical constraints.

132 and efficient intramolecular singlet exciton fission (iSF).

133 ondria undergo repeated cycles of fusion and fission, leading to exchange of mitochondrial genetic co

134 a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites.

135 ults in the recruitment of the mitochondrial fission machinery, and subsequent division.

136 ions to mimic membrane interactions with the fission machinery.

137 OM) can alter Drp1 structure to activate the fission machinery.

138 ghly dependent on a functional mitochondrial fission machinery.

139 In addition to its role as a viable singlet fission material, single-crystalline rubrene is selected

140 existence of coherent and incoherent singlet fission may also reconcile different experimental observ

141 Suppression of mitochondrial fission may be a therapeutic approach for treating macro

142 duce a singlet exciton, spin-allowed singlet fission may produce two triplet excitons that can be use

143 -related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NAc) after repea

144 on to their canonical roles in mitochondrial fission, Mff and Drp1 also act as regulatory factors tha

145 9)Mo from the accelerator-driven subcritical fission of an aqueous solution containing low enriched u

146 ne amplifications, pervasive aneuploidy, and fission of chromosomes 30 and 36.

147 h-energy collider experiments on the induced fission of composite particles.

148 Both fusion and fission of lysosomal membrane are accompanied by lysosom

149 ir state, which mediates the spin-conserving fission of one spin-0 singlet exciton into two spin-1 tr

150 linked to their function, and fragmentation (fission) of the normally elongated mitochondria indicate

151 Singlet fission offers the potential to overcome thermodynamic l

152 spent in membrane constriction required for fission, or in disassembly of the dynamin polymer to tri

153 Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of

154 RC1) stimulates translation of mitochondrial fission process 1 (MTFP1) to control mitochondrial fissi

155 observe the key intermediates in the singlet fission process, including the formation and decay of a

156 s (DLPs) mediate various membrane fusion and fission processes within the cell, which often require t

157 re moderated to thermal energies to increase fission processes.

158 result of regulated and balanced fusion and fission processes.

159 emodeling events including vesicle fusion or fission, processes that are regulated by coat proteins.

160 te disposal process, radioactive iodine as a fission product can be released.

161 ions (MCCIs), incorporating various airborne fission product nanoparticles, including CsOH and CsCl,

162 The high-yield fission products (99)Tc and (90)Sr are found as problema

163 Drp1 and fission promoting Drp1 are increased in D1-MSNs, consist

164 ine self-administration, while enhancing the fission promoting Drp1 enhances seeking after long-term

165 ding altMiD51, a 70 amino acid mitochondrial fission-promoting protein encoded in MiD51/Mief1/SMCR7L,

166 model that, instead of promoting mitophagy, fission protects healthy mitochondrial domains from elim

167 pharmacological inhibition of mitochondrial fission protein Drp1, we demonstrate in this study that

168 n part, via suppression of the mitochondrial fission protein dynamin-like GTPase Drp1.

169 , caused the activation of the mitochondrial fission protein, dynamin-related protein 1 (Drp1) and en

170 We also found that the mitochondrial fission proteins Drp1 and Mff negatively regulate MARCH5

171 l as aberrations of mitochondrial fusion and fission proteins, which eventually leads to neuronal str

172 This nearly-immediate post-fission randomization of sister cell fates highlights th

173 ed to conjugated dimers with similar singlet fission rates.

174 Dynamin fission reaction is strictly dependent on GTP hydrolysis

175 Many important cellular membrane fission reactions are driven by ESCRT pathways, which cu

176 r current and potentially next generation of fission reactors worldwide.

177 ocess of cross phase modulation with soliton fission, red-shifted dispersive waves were generated whi

178 at membrane coverage correlates equally with fission regardless of the hydrophobicity of insertions.

179 o the up-regulation of Drp1, a mitochondrial fission regulator and a target gene of p53, which, in tu

180 the molecular mechanism underlying lysosome fission remains uncertain.

181 Fission requires dynamin to first constrict the membrane

182 tolytic enzymes during cell constriction and fission respectively.

183 Singlet exciton fission (SF) in organic chromophore assemblies results i

184 Singlet fission (SF), a promising mechanism of multiple exciton

185 Singlet fission (SF), an efficient multiple exciton generation (

186 Singlet exciton fission (SF), the conversion of one spin-singlet exciton

187 ng forces governing mitochondrial fusion and fission, similarly affect retinal ganglion cell survival

188 ing elements (CNEs) and that the chromosomal fission sites are further limited to long CNE "deserts."

189 At fission sites, these cycles of association and dissociat

190 ad to fitness losses, particularly in fusion-fission societies.

191 vidence in crystalline rubrene for a singlet fission step that, until now, has not been convincingly

192 fs laser pulses, we resolve the full set of fission steps before the onset of spin dephasing.

193 he unambiguous identification of the various fission steps through their contributions to distinct sp

194 w that hydrophobic insertions drive membrane fission, suggesting instead that the role of insertions

195 In contrast, here we report a mechanism of fission that is independent of protein structure-steric

196 cell lines, the inhibition of mitochondrial fission that leads to a mitochondrial structure of highe

197 though best studied for its role in membrane fission, the GTPase dynamin also regulates early stages

198 hat coupling of ER-mediated endosomal tubule fission to lysosome function links different classes of

199 semiconductors that undergo singlet exciton fission to reveal the photophysical properties of entang

200 ccinate promotes DRP1-mediated mitochondrial fission via GPR91, consequently stimulating the hMSC mig

201 d that genes and proteins inducing fusion or fission were upregulated and downregulated, respectively

202 /- 0.6% of all crypts were in the process of fission, whereas 4.1 +/- 0.9% of all crypts were undergo

203 Membrane fission, which facilitates compartmentalization of biolo

204 ated protein 1 (Drp1)-mediated mitochondrial fission, which is triggered by AC uptake.

205 Inhibition of fission with P110, Mdivi-1 (mitochondrial division inhib

206 ic radii yet lack a defined structure, drove fission with substantially greater potency than smaller,

207 he most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this resp

208 t during quiescence, the unicellular haploid fission yeast accumulates mutations as a linear function

209 The fission yeast actin cytoskeleton is an ideal, simplified

210 Fission yeast AMPK catalytic subunit Ssp2 is phosphoryla

211 fic manner in Schizosaccharomyces pombe Both fission yeast and human Sde2 are translated as inactive

212 s with sensitivity to DNA-damaging agents in fission yeast and reduced viability in human cells.

213 r target recognition in the TORC2 complex in fission yeast and the mTORC2 complex in mammals.

214 Using fission yeast as a model, we report here that DBAN delay

215 oles of GR in cellular stress response using fission yeast as a model.We surprisingly discovered mark

216 daptor Nro1 regulate the hypoxic response in fission yeast by controlling activity of the sterol regu

217 Using fission yeast cell cycle as an example, we uncovered tha

218 g the stability, speed and robustness of the fission yeast cell cycle oscillations.

219 s required for oxidative stress responses in fission yeast cells by promoting transcription initiatio

220 Here, we show that fission yeast cells carrying a mutation in the DNA-bindi

221 inuous replication of hundreds of individual fission yeast cells for over seventy-five generations.

222 Rod-shaped fission yeast cells grow in a highly polarized manner, a

223 erresolution localization microscopy of live fission yeast cells to improve the spatial resolution to

224 g genome-wide methods, here we show that the fission yeast CID-protein Seb1 is essential for terminat

225 The fission yeast contractile ring has been proposed to asse

226 Using in vitro reconstitution of fission yeast contractile ring precursor nodes containin

227 icient contractile ring assembly in vivo.The fission yeast cytokinetic ring assembles by Search-Captu

228 l to analyze these results, we conclude that fission yeast does not age and that cellular aging and r

229 hat during transcriptional activation of the fission yeast fbp1 gene, binding of Rst2 (a critical C2H

230 Here, we identify Fft3, a fission yeast homolog of the mammalian SMARCAD1 SNF2 chr

231 t early divergence from a common ancestor in fission yeast involved important changes in the mechanis

232 is type of non-canonical fork convergence in fission yeast is prone to trigger deletions between repe

233 for the bidirectional motility mechanism of fission yeast kinesin-5 and provide insight into the fun

234 Here, we describe a multiplexed fission yeast lifespan micro-dissector (multFYLM) and an

235 In contrast, distinct pathways activate fission yeast Mga2 and Sre1.

236 suggests a mechanistic conservation between fission yeast PAF1 repressing AGO1/small interfering RNA

237 This analysis of H3-G34R mutant fission yeast provides mechanistic insight into how G34R

238 Here, we identify new fission yeast regulatory lncRNAs that are targeted, at t

239 y, a superresolution microscopy study of the fission yeast ring revealed that myosins and formins tha

240 e a coarse-grained mathematical model of the fission yeast ring to explore essential consequences of

241 The fission yeast scaffold molecule Sid4 anchors the septum

242 Here we use the fission yeast Schizosaccharomyces pombe as a model to in

243 quest to understand the morphogenesis of the fission yeast Schizosaccharomyces pombe drove us to inve

244 Studies in fission yeast Schizosaccharomyces pombe have provided th

245 Here, using Clr4, the fission yeast Schizosaccharomyces pombe homologue of mam

246 e oxygen-responsive lipid homeostasis in the fission yeast Schizosaccharomyces pombe in a manner anal

247 re we present evidence that cell size in the fission yeast Schizosaccharomyces pombe is regulated by

248 The two PKC orthologs Pck1 and Pck2 in the fission yeast Schizosaccharomyces pombe operate in a red

249 ory element-binding proteins (SREBPs) in the fission yeast Schizosaccharomyces pombe regulate lipid h

250 sue we performed ribosome profiling with the fission yeast Schizosaccharomyces pombe under conditions

251 In the fission yeast Schizosaccharomyces pombe, the CaMKK-like

252 In the fission yeast Schizosaccharomyces pombe, the protein kin

253 study mitotic chromosome condensation in the fission yeast Schizosaccharomyces pombe.

254 Similar to the human shelterin, fission yeast shelterin is composed of telomeric sequenc

255 The fission yeast specific chaperone Rng3 was thus not requi

256 genic suppressors of a temperature-sensitive fission yeast strain mutated in the exocyst subunit Sec3

257 Therefore, knowledge from the budding and fission yeast systems illuminates highly conserved molec

258 sight into the role of H3-G34R, we generated fission yeast that express only the mutant histone H3.

259 We show in fission yeast that, at low Cdc20 concentrations, Cdc20(M

260 Here, we use fission yeast to investigate how phosphatase activity pa

261 and FPALM superresolution microscopy of live fission yeast to investigate the structures and assembly

262 From fission yeast to mammals, heterochromatin assembly at DN

263 Here, we report the crystal structure of the fission yeast Tpz1(475-508)-Poz1-Rap1(467-496) complex t

264 antified the localization pattern of Mcp5 in fission yeast zygotes and show by perturbation of phosph

265 We examine the function of Swi1 and Swi3, fission yeast's primary FPC components, to elucidate how

266 pe in mammals, spindle pole body dynamics in fission yeast, and surveillance of defective nuclear por

267 points contributes to kinetochore capture in fission yeast, but the relative contributions of dynamic

268 similar structures appear to be conserved in fission yeast, computational modeling and analysis of hi

269 In fission yeast, cytokinesis involves the type II myosins

270 In fission yeast, force balance is restored when both kines

271 ith each other in vitro, and at least in the fission yeast, heterologous Oxs1 and Pap1-homologues can

272 In fission yeast, histone H3 lysine 9 (H3K9) is methylated

273 In fission yeast, Mcp5 is the anchor protein of dynein and

274 In fission yeast, meiosis-specific transcripts are selectiv

275 , we discovered that the myosin I protein in fission yeast, Myo1, which is required for organization

276 parts list of genes important for meiosis in fission yeast, providing a valuable resource to advance

277 atalog of genes important for meiosis in the fission yeast, Schizosaccharomyces pombe Our genome-wide

278 In fission yeast, Schizosaccharomyces pombe, interactions b

279 To characterize R-loops in fission yeast, we used the S9.6 antibody-based DRIPc-seq

280 l1p, the main eisosome BAR-domain protein in fission yeast, we visualized whole eisosomes and, after

281 cytokinesis arrest in the erg11-1 mutant of fission yeast, which has a partial defect in the biosynt

282 rding the human gene homologs in budding and fission yeast, worm, fly, fish, mouse, and rat on a sing

283 and constriction of the contractile ring in fission yeast.

284 RNAs), suggesting that dsRNAs form widely in fission yeast.

285 ion and influences cell cycle progression in fission yeast.

286 e isoform level in the sexual development of fission yeast.

287 ic tubule elongation and vesicle scission in fission yeast.

288 physical mechanism for typical conditions in fission yeast.

289 subunit and, thereby, controls exocytosis in fission yeast.

290 function of PS in the rod-shaped, polarized fission yeast.

291 ner similar to what has been demonstrated in fission yeast.

292 are coordinated to maintain lipid balance in fission yeast.

293 sure proper splicing of certain pre-mRNAs in fission yeast.

294 acterize the transcriptome in the meiosis of fission yeast.

295 ysical model of kinetochore capture in small fission-yeast nuclei using hybrid Brownian dynamics/kine

296 studies of Cdc42 polarization in budding and fission yeasts and demonstrate that models describing sy

297 f meiotic drive genes on chromosome 3 of the fission yeasts Schizosaccharomyces kambucha and S. pombe

298 Mer2, identified so far only in budding and fission yeasts, is in fact evolutionarily conserved from

299 se transcript landscapes between budding and fission yeasts.

300 which are absent or divergent in budding or fission yeasts.