ライフサイエンスコーパス: fitness

1 new functional properties that enhance viral fitness.

2 to feeding have direct consequences for its fitness.

3 immunization is accompanied by loss of viral fitness.

4 y, and, at least in animals, on reproductive fitness.

5 eterious mutations may severely decrease its fitness.

6 ize can promote worker efficiency and colony fitness.

7 itness is similar to that of non-competitive fitness.

8 ity, spur tumor evolution and increase tumor fitness.

9 adaptive landscape that relates genotype to fitness.

10 ons over time suggesting differential allele fitness.

11 n of proteins, a process vital to organismal fitness.

12 e were able to directly measure evolutionary fitness.

13 evolution of these regions may reflect their fitness.

14 ects for viruses with increased transmission fitness.

15 manipulate host metabolism to improve viral fitness.

16 function of the spatial variance and skew in fitness.

17 design, using seedling growth as a proxy for fitness.

18 s show that mutational load can reduce tumor fitness.

19 unterparts and that correlated with improved fitness.

20 efense in the lung without compromising host fitness.

21 ase is an evolutionary driver for organismal fitness.

22 s, and adult male offspring exhibited higher fitness.

23 c trait that correlates with performance and fitness.

24 ate the effects of social immunity on colony fitness.

25 ed immune pressure, yet possess contemporary fitness.

26 ic lethality) or results in profound loss of fitness.

27 oduction of outcrossed individuals with high fitness.

28 spatial structuring that can be critical for fitness.

29 ngineered escape variants had high levels of fitness.

30 fferences influence respective developmental fitness.

31 ease and that are expected to maximize their fitness.

32 decisions, which ultimately can impact plant fitness.

33 sion noise influences organism evolution and fitness.

34 or due to an improvement in overall physical fitness.

35 y of animals and may serve critical roles in fitness [1, 2].

36 linator visitation to the detriment of plant fitness [1, 5-8].

37 could disrupt the mutualism and reduce plant fitness [4].

38 strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range o

39 dites because of the different ways in which fitness accrues in the two sexes.

40 in migratory behaviour influences individual fitness across a population.

41 nsequential "passengers," some will confer a fitness advantage to a cell and be selected as "drivers.

42 tition dynamics resulting in a mitigation of fitness advantages.

43 on over a 7-day period and reduced microbial fitness after exposure to heat shock.

44 st be finely tuned to maintain host organism fitness and allow for transposon propagation.

45 onger LTL was associated with higher aerobic fitness and better trunk muscle endurance in models incl

46 hytobacteria suggests that the T6SS provides fitness and colonization advantages in planta and that t

47 to identify stable and reliable measures of fitness and complexity.

48 hormone cross talk for improvement of plant fitness and crop production.

49 portance for leaf growth and hence for plant fitness and crop yield.

50 NPEP3 have implications toward mitochondrial fitness and cystic kidney disease.

51 tanding human effects on microbial activity, fitness and distribution is an important component of Cr

52 interactions based on both mutation rate and fitness and find that these parameters are not connected

53 roles of reassortment and mutations in virus fitness and have implications for assessing the potentia

54 ut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial comm

55 ted mutations have no discernible effects on fitness and less than 1% are deleterious.

56 frequent in cancer and modulate competitive fitness and MEK dependency.

57 We examined the association between aerobic fitness and neurocognitive outcomes at young adult age,

58 res of selection translate into variation in fitness and phenotypes.

59 lutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and

60 cross-sectional and longitudinal changes in fitness and risk for hypertension, diabetes, and metabol

61 f mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of

62 g of how belowground microbiota impact plant fitness and species coexistence.

63 nd find that they have reduced proliferative fitness and stably rewired cell cycle control pathways.

64 clinical finding of improved cardiovascular fitness and survival in some overweight or obese patient

65 sms are likely nearly neutral with regard to fitness and that standard population genetic models in f

66 termine the effects of vitamin B12 or MTX on fitness and the epigenome.

67 rates the dissociation between the metabolic fitness and the suppressive function of Foxp3-expressing

68 jor factor that determines influenza A virus fitness and therefore transmissibility is the interactio

69 of antibiotic resistance modulate bacterial fitness and virulence potential, thus influencing the ab

70 d as the most likely explanation for reduced fitness, and most studies to date have focused on findin

71 of obtaining measures of physical activity, fitness, and sleep from smartphones and to gain insights

72 real-world assessment of physical activity, fitness, and sleep using mobile devices may be a useful

73 Genes essential for cell fitness are enriched within 53 communities representing

74 (VM) for male mating success and competitive fitness are not significantly different from zero, where

75 sistant cells, and identifies their relative fitness as a critical determinant of the clinical benefi

76 n of a heterogeneous tumour, we evaluate its fitness as a weighted effect of dominant neoantigens in

77 ne segments within coinfected cells, and the fitness associated with reassortant genotypes.

78 ith host dependence, with reductions in host fitness being greatest when nutrient-provisioning, verti

79 gene transcriptional memory confers a strong fitness benefit in Saccharomyces cerevisiae adapting to

80 % (95% CrI 53%-99%) of cases, representing a fitness benefit of resistance.

81 n turn, we need an improved understanding of fitness benefits and costs of antibiotic resistance to i

82 l migration, despite its risks, has to yield fitness benefits compared with year-round residency.

83 ree mate choice on the relative magnitude of fitness benefits has been examined among various species

84 heir exudates but 2) there are no consistent fitness benefits of breeding alongside mites.

85 ved with nectar availability to maintain the fitness benefits of specialized plant-pollinator relatio

86 operative behaviour and the individual-level fitness benefits to being a skilled storyteller.

87 etition between types, and variation in type fitness between host subpopulations.

88 s how huddling can introduce correlations in fitness between individuals and thereby constrain evolut

89 orrhizal fungi, which are critical for plant fitness, biogeochemical cycling and other processes.

90 ver four logs of strength without detectable fitness burden within the gut over 14 days.

91 founding sizes reduced genetic variation and fitness but did not prevent adaptation if the founders o

92 mmunity, and cross-generational reproductive fitness, but its mode of action is unknown.

93 nock-down of cathepsin B genes reduced aphid fitness, but only on the host that induced upregulation

94 ies of mammals have profound effects on host fitness, but the processes that generate and maintain gu

95 influence or manipulate insect behavior and fitness by altering plant quality and defense.

96 ociated microbes can favor or improve insect fitness by suppressing plant defenses and detoxifying de

97 critical missing term in classical inclusive fitness calculations (the "reproductive conflict hypothe

98 However, to what extent fitness captures the range of other phenotypes that show

99 present review focuses on cardiorespiratory fitness (commonly measured by maximal oxygen uptake, VO2

100 sistance resulted in an enhanced replicative fitness compared to the less resistant starting populati

101 to early cleavage results in decreased viral fitness compared to wild-type HIV.

102 and 76% lower among increasing quintiles of fitness compared with the least-fit subjects (P<0.001).

103 lated for each cross as the product of these fitness components.

104 supported by the evidence that there were no fitness consequence of any EE trait nor the trade-off it

105 o understand the functional significance and fitness consequences for the beetle of mite-associated c

106 However, little work explores the fitness consequences of variation in behavior within ind

107 outer membrane exchange among clonemates and fitness consequences.

108 higher burdens of a common ectoparasite with fitness consequences.

109 in animal populations and may have important fitness consequences.

110 of top-down and bottom-up forces on consumer fitness, considering multiple predictors that can modula

111 to our knowledge, the first estimates of the fitness cost and benefit associated with resistance of t

112 of the siderophore pyoverdine only incurs a fitness cost and favours cheating when its building bloc

113 revealing the mutant enzyme complex incurs a fitness cost but does not prevent inhibitor binding.

114 ntly, while these ribosomal mutations have a fitness cost in antibiotic-free medium, in a multidrug e

115 ctionality in virus replication and the high fitness cost of amino acid substitutions in capsids to H

116 The fitness cost of cefixime resistance in the absence of ce

117 sed by acquired drug resistance, assuming no fitness cost of resistance from 2000 to 2040 in India, t

118 urther show that AS rates correlate with the fitness cost of splicing errors.

119 rk, modulating its activity and limiting the fitness cost of unnecessary immune responses.

120 rced maintenance of CRISPR targets induces a fitness cost that can be exploited to alter heterogeneou

121 lts were less sensitive to assumptions about fitness costs and test characteristics with increasing t

122 The principle of nutrient-dependent fitness costs has implications for the stability of coop

123 emy challenged, and resulted in constitutive fitness costs in the absence of parasitism.

124 was to examine the relationship between the fitness costs of immunity, pathogen resistance and the s

125 nd that resource complexity strongly buffers fitness costs of mutations, and that anabolic rather tha

126 ssenger load that can accurately predict the fitness costs of passengers in cell lines and in human b

127 most plausible parameter range, namely when fitness costs of resistance are small.

128 ong-term effects are usually ascribed to low fitness costs of resistance in absence of the drug.

129 tors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selec

130 Northomicrodon parasitism can exert high fitness costs to a host colony.

131 y a combination of Biolog phenotype data and fitness data to validate and refine our KPPR1 model.

132 Our results demonstrate that gene fitness depends on habitat composition, and suggest that

133 a comprehensive genome-wide analysis of the fitness determinants for growth in vitro and in vivo of

134 rive transitions, and that arbitrarily small fitness differences among sex chromosome genotypes can d

135 Characterization of fitness differentials derived from replicated demographi

136 n the midgut tissue did not have an observed fitness disadvantage and showed reduced microbial loads

137 rent behaviors are observed depending on the fitness distribution functions).

138 nator visits, which reduces individual plant fitness due to herbivore-induced chemical defenses and s

139 ce resistance to genotoxic stress and confer fitness during aging.

140 oth high- and low-fidelity variants retained fitness during coinfection with the wild-type virus.

141 homologous gene clusters were essential for fitness during in vitro growth in three C. jejuni strain

142 ograms are selected for enhanced tumorigenic fitness during the evolution of distant metastasis.

143 Human fitness dynamics are uniquely and profoundly governed by

144 The distribution of fitness effects (DFE) of new mutations plays a fundament

145 s, type of top-down effects and how consumer fitness effects are measured.

146 ution approaches, CPR largely mitigates host fitness effects due to a relatively short expression tim

147 s are largely protected against the negative fitness effects of cancers.

148 highlighting the general need to measure the fitness effects of light pollution.

149 Tolerance aims to minimize the fitness effects resulting from incumbent pathogen popula

150 rocesses during the homing reaction, various fitness effects, and the efficacy of the effector in blo

151 fferent classes of MGE show a broad range of fitness effects, from the nearly neutral transposons to

152 y showing that it yields unbiased and robust fitness estimates in most epidemic scenarios.

153 d experiment, a subset was chosen to compare fitness (fecundity and survivorship) in the presence and

154 e, however, it is hardly possible to measure fitness for all genotypes in a natural population.

155 elation between in vitro and in vivo loss of fitness for the majority.

156 her residual nepotistic value: her expected fitness from later investments in personal reproduction

157 We draw an analogy between the fitness function and the free energy in statistical mech

158 Using an IIN sampling algorithm and a fitness function trained on the manually curated PPINs,

159 Moreover, it restored fitness, fur density, and renal function in both fast ag

160 ancestor with chimpanzees, likely expediting fitness gains during intergroup conflict.

161 One of the identified mucus-specific fitness genes encodes the rhomboid protease GlpG.

162 ead to larger improvements when distant high-fitness genotypes more readily evolve from lower-fitness

163 strength enabling populations to reach high-fitness genotypes, regardless of the distribution of eff

164 nson's Disease Rating Scale, MDS-UPDRS III), fitness, health and well-being measured.

165 ays are biased toward mutations with minimal fitness impacts and fluctuation tests typically investig

166 in a slight but significant decrease in GAS fitness in a humanized mouse model of impetigo; the Delt

167 ry used to identify genes that contribute to fitness in a murine model of infection.

168 Bacterial fitness in abscesses and in epithelial cells was studied

169 +) beige adipocytes contributed to metabolic fitness in adipocyte liver kinase b1-deficient mice, our

170 d influence physiological traits relevant to fitness in black-tailed godwits Limosa limosa limosa on

171 ts with SCT had similar baseline measures of fitness in cross-section, including exercise duration (5

172 sterilization of natural soil reduces Howea fitness in every soil-species combination except H. fors

173 Multiple genes that contribute to ExPEC fitness in mucus broth were identified, with genes that

174 Moreover, a perR mutant had decreased fitness in other host-related stress conditions, includi

175 427 offers an accessible pathway to increase fitness in rCan, reversion in K33S-GPC rCan is likely to

176 systems to provide reliable estimates of AVR fitness in real time.

177 s recognised as a significant contributor to fitness in social species, the opposite outcome is also

178 is important for the recovery of replication fitness in the chimera RNA.

179 r phenotypic diversity to improve population fitness in the face of environmental variability.

180 F-dependent LPS modification exhibit reduced fitness in vivo Here, we present investigation of AlmG,

181 identified 49 PKs with a significant loss of fitness in vivo in two independent experiments, and a st

182 LTL may relate to aspects of physical fitness in young adulthood, but replication of these fin

183 optimum memory also maximizes geometric mean fitness, in steady state.

184 ting species if selection acts to reduce the fitness inequality between competitors and/or strengthen

185 ess genotypes more readily evolve from lower-fitness intermediates.

186 hosphorylating ribozymes and translate their fitnesses into absolute estimates of catalytic activity

187 eneration; that of hermaphrodite competitive fitness is 0.11%/generation.

188 rate of mutational decay of male competitive fitness is 0.17%/generation; that of hermaphrodite com

189 ants (HLCRMs) show reduced fitness (relative fitness is 0.41-0.78) and highly attenuated virulence in

190 Darwinian fitness is a central concept in evolutionary biology.

191 ychiatric disorders that reduce reproductive fitness is an evolutionary paradox.

192 In evolutionary birth-death processes, fitness is at best a derived quantity, and owing to the

193 Our data suggest that viral fitness is correlated with in vitro assembly kinetics an

194 tion is related to other components of their fitness is critical to understanding disease impacts at

195 1.5X faster rate of mutational decay of male fitness is nearly identical to the same ratio in Drosoph

196 However, fitness is rarely linked to both climatic conditions and

197 ro, whereas VM for hermaphrodite competitive fitness is similar to that of non-competitive fitness.

198 eterious and cause a reduction in population fitness known as the mutational load.

199 peed of regime shifts for models that detail fitness landscape dynamics, we find that our quantitativ

200 set of chaotic dynamics is the result of the fitness landscape reversibly alternating between epochs

201 Instead of postulating a particular fitness landscape, we address this problem by considerin

202 ng the need to have full knowledge about the fitness landscape.

203 roles in adaptive evolution depending on the fitness landscape; however, direct experimental support

204 notion of fitness and related ideas such as fitness landscapes and evolutionary optima.

205 generate near-comprehensive single-mutation fitness landscapes comprising >96.3% of all possible sin

206 Exploration of fitness landscapes in the context of a protein fold prov

207 further demonstrate the dependence of local fitness landscapes on substrate identity and provide an

208 cultural makeup of species by affecting the fitness landscapes on which they evolve.

209 ared these scans with published experimental fitness landscapes.

210 This evidence suggests that aerobic fitness levels are associated with hippocampal DG-relate

211 ten associated with substantial penalties to fitness, making the resulting products undesirable for a

212 l, but detectable, contributions to genotype-fitness maps.

213 s evolutionary trajectories through genotype-fitness maps.

214 densities, Bragg peaks, and guided algorithm fitness metrics as a function of signal-to-noise ratio.

215 Here we present a fitness model for tumours based on immune interactions o

216 nriched in neoantigen qualities defined by a fitness model, and neoantigens in the tumour antigen MUC

217 gth (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using da

218 Importantly, low-fitness neoantigens identified by our method may be leve

219 ) variants) revealed reduced population-wide fitness, numerous individual variants were found to have

220 r redox-active metabolites can influence the fitness of a biofilm-forming microorganism.

221 We measured fitness of approximately 14,000 E. coli strains, each ex

222 We defined the fitness of AVR strains as their reproductive number rela

223 g MELK with CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines

224 , suggesting that passenger load reduces the fitness of cancer cells and slows or prevents progressio

225 al pathways in carbon metabolism to maximize fitness of cells facing periodic energy limitations.

226 r plasticity could lead to higher population fitness of ctenophores under adverse conditions such as

227 Prolonging care may increase fitness of current offspring, but it can also reduce opp

228 uclear incompatibility, leading to increased fitness of F1 hybrids and recovery in the F2 generation.

229 underscores the incremental contributions to fitness of individual surface protein genes and the mult

230 uences of these changes for the behavior and fitness of insect herbivores.

231 mpact the composition of a community and the fitness of its members, as well as the fitness of their

232 duced by a partner species that enhances the fitness of P. gingivalis while diminishing its virulence

233 Furthermore, fitness of S. aureus in these sites of replication is no

234 nferred by the resistance mechanism, (c) the fitness of the antibiotic-resistant mutant bacteria as a

235 s that infect cyanobacteria and increase the fitness of the cyanophage.

236 that correlate with compromised reproductive fitness of the generation that experienced the stress, b

237 e structures that play a role in the overall fitness of the organism.

238 Next, we monitored the lifetime fitness of the terrestrial adults in an insectary.

239 tive details of the community (e.g. relative fitness of the two species, initial conditions).

240 d the fitness of its members, as well as the fitness of their hosts when communities are living on or

241 nclear what selective pressure maintains the fitness of this developmental program, composed of hundr

242 st discrimination mechanisms that reduce the fitness of uncooperative symbionts can stabilise mutuali

243 tio is determined by the relative number and fitness of X- vs. Y-bearing sperm.

244 and pathways can contribute to an organism's fitness on such complex and variable natural resource la

245 These asymmetric fitness outcomes suggest conflicts between parents and o

246 mental modifications shape developmental and fitness outcomes, how their influences may differ among

247 and achieving relatively increased levels of fitness over 20 years were associated with preservation

248 Seasonal phenology, life history, and cohort fitness over multiple generations depend strongly upon i

249 Decline in both telomere length and physical fitness over the life course may contribute to increased

250 itions that enable them to quickly reach the fitness peak as a function of the number of sites under

251 he time it takes for a population to reach a fitness peak, circumventing the need to have full knowle

252 that tumour spatial structure amplifies the fitness penalty of resistant cells, and identifies their

253 ondary analyses addressing impacts on growth fitness, photosynthetic pigments, and total cellular pro

254 complete graph, and vary assumptions on the fitness probability distributions.

255 a need to rapidly adjust their virulence and fitness program to prevent eradication by the host.

256 interactions, including estimating relative fitness ratios and fitting a generalized linear model.

257 of Foxo1 function, but not restored survival fitness, rectified the dysregulated gene expression and

258 diminished the impact of AT-rich DNA on host fitness reduced transcription from constitutive, but not

259 a general model that shows these individual fitness reductions from herbivore-induced changes in pla

260 To test fitness related benefits of migration, we studied a part

261 rence in attractiveness preferences, nor the fitness-related outcomes of attractiveness; (2) the negl

262 to self-turn after falling on its back, is a fitness-related trait.

263 consistently shape scaling relationships in fitness-related traits, (3) are necessary for the mainte

264 ategy for elucidating the sequence-structure-fitness relationships in other common motifs.

265 tin resistance mutants (HLCRMs) show reduced fitness (relative fitness is 0.41-0.78) and highly atten

266 ly inherited epigenetic states to organismal fitness remains unknown as well-documented examples are

267 ation is solely a manifestation of increased fitness resulting from random amplification mechanisms,

268 tive, real-world physical activity patterns, fitness, sleep, and cardiovascular health.

269 ggest that germ plasm targeting represents a fitness strategy adopted by some retrotransposons to ens

270 rient and light availability, shapes species fitness, succession and selection.

271 specific infectivity and decreased relative fitness, suggesting that ExoN(-) virus generated during

272 val adaptation to achieve a higher 'cellular fitness' that may be also associated with chemoresistanc

273 antee that there is a simple scalar, such as fitness, that would describe long-term evolutionary outc

274 vironment and epistatic interactions control fitness, the influences of epistasis x environment inter

275 a positive association between body mass and fitness, there has been a genetic change towards lower b

276 The process of selecting for cellular fitness through competition plays a critical role in bot

277 orrelated among whorls, selection to improve fitness through female (or male) function typically favo

278 ntensity parasite infections can reduce host fitness through negative impacts on reproduction and sur

279 underwent a graded exercise test of aerobic fitness to measure maximal oxygen uptake (VO2Max).

280 formation about the consequences of seasonal fitness trade-offs for population dynamics.

281 harbour stress-tolerant subgroups, and thus fitness tradeoffs may govern Cu-tolerant strain distribu

282 t of potted rice plants and their effects on fitness traits of the brown planthopper (BPH) [Nilaparva

283 iting in 22 steps; synV strains exhibit high fitness under a variety of culture conditions, compared

284 SynX exhibited good fitness under a wide variety of conditions.

285 of the whole brood, suggesting a beneficial fitness value of cross-over of stress.

286 The fitness value of leaves varies greatly and leaves are pr

287 The effect is largest when the fitness values of the mutants and wild types are anti-co

288 We show that for a range of fitness values of the mutants, the Comet and Comet-swarm

289 ld site, the impact of epistasis on relative fitness varied significantly over 2 yr, showing that epi

290 The concept of fitness varying with respect to both genotype and enviro

291 rimary routes to the rapid evolution of high-fitness virus genotypes.

292 Greater decline in fitness was associated with greater annual decline in lu

293 e probability that it would retain wild-type fitness was correlated with evolutionary conservation an

294 To determine whether cardiorespiratory fitness was longitudinally associated with preservation

295 t genetic constellations may relate to viral fitness, we compared the pathogenesis and transmission i

296 -enhancing mutations that maintain wild-type fitness with an accuracy of 90%.

297 ecome host to tumours have otherwise greater fitness, with higher survival and fecundity rates prior

298 an interact to influence seasonal timing and fitness within generations.

299 t carrying serve to increase individual male fitness, yet are uncommon phenomena in the animal kingdo

300 shed the importance of physical activity and fitness, yet limited data exist on the associations betw