ライフサイエンスコーパス: five-membered ring

1 e even mild activation sufficed to close the five membered ring.

2 t the level of oxidation in the newly formed five-membered ring.

3 e option of closing to a three-membered or a five-membered ring.

4 o a carbamate 9 by opening and reclosing the five-membered ring.

5 erred increased RARbeta specificity over the five-membered ring.

6 imes less active than its counterpart with a five-membered ring.

7 gen is incorporated into a six- instead of a five-membered ring.

8 with an imino-to-sulfur substitution in the five-membered ring.

9 p by two naphthoquinone units connected by a five-membered ring.

10 and cyano functionalities to annulate a new five-membered ring.

11 ng a fully substituted and highly oxygenated five-membered ring.

12 be a(5)-PhobPH in which the H lies over the five-membered ring.

13 oligoenes that contain both six-membered and five-membered rings.

14 th SO(2) gave 1:1 copolymers with cis-linked five-membered rings.

15 aromatic hydrocarbons (PAHs) augmented with five-membered rings.

16 indicates C-C bond length alternation in the five-membered rings.

17 he diastereotopic methylene hydrogens on the five-membered rings.

18 5]-radialene-like structures at the proximal five-membered rings.

19 [3 + 2] manner to give rise to seven- and/or five-membered rings.

20 dition to a strong pi-conjugation within the five-membered rings.

21 F(4)](8), given the inherent angle strain in five-membered rings.

22 difunctional compounds and oxygen-containing five-membered rings.

23 resents an oxygen at the apex of three fused five-membered rings.

24 oquinolines or benzazepines containing fused five-membered rings, a feature found in the cephalotaxus

25 catalysts are effective for the formation of five-membered rings, a ruthenium-based system that affor

26 nzo[k]tetraphene, which "unexpectedly" forms five-membered rings accompanying highly selective 1,2-sh

27 1- au charge is located in the central fused five-membered rings) allows the formation of a maximum o

28 Multinuclear NMR studies of five-membered-ring amine chelated aryllithium reagents 2

29 nase to give phosphates 1-P, 2-P, and 3-P as five-membered ring analogues of shikimate-3-phosphate.

30 a result of improved orbital overlap of the five-membered ring and a reduced steric environment of t

31 matic heterocyclic carboxylates containing a five-membered ring and various heteroatoms (X = NH, O, S

32 onsisting of 40 uranyl polyhedra linked into five-membered rings and 16 nitrate groups surrounds this

33 es a formal pentalene subunit at the central five-membered rings and [5]-radialene-like structures at

34 metalation of unactivated alkenes to produce five-membered rings and in one case a four-membered ring

35 pyrrolidone-1''-yl)doxorubicin (containing a five-membered ring) and 3'-deamino-3'-(3''-piperidone-1'

36 wed by oxygenation at C-11, formation of the five-membered ring, and a second oxygenation at C-15 to

37 dipolar cycloaddition necessarily creates a five-membered ring, and we have investigated the formati

38 ) of naphthalene is negative (-0.19 eV), the five-membered ring appendage contributes to the stabilit

39 orphyrin derivatives possessing an isocyclic five-membered ring appended with an amidinium functional

40 lso examined, and hydrogen shifts around the five-membered ring are competitive with the mechanisms l

41 mation of the tricyclic product in which all five-membered rings are formed.

42 pentacene derivatives with externally fused five-membered rings are prepared by means of a key palla

43 hthylenes, which contain four linearly fused five-membered rings, are benchtop stable and behave as h

44 Optimization studies identified a five-membered ring as the preferred conformational lock

45 In both CHCl3 and H2O, the presence of the five-membered ring attenuates the ability of PGB2-EA to

46 Suitable substitution of the five-membered ring backbone exemplarily allowed the Co-c

47 the presence of rhodium catalysts to afford five-membered rings bearing a (Z)-alkylidenylbenzylsilyl

48 enic PARP-1 inhibitors possess an additional five-membered ring between the B and C rings of 6(5H)-ph

49 linked the ketone and dipolarophile to give five-membered rings but mixtures resulted with four atom

50 d by making the three-carbon chain part of a five-membered ring, but with retention of the methylene

51 eses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction

52 ., the seven-membered ring hydrogen bond and five-membered ring C(4-5-10-13-14) cyclization, from whi

53 The five-membered ring carbodiimide is a stable structure, p

54 group was tethered to the acetal group by a five-membered ring compared to one where it was tethered

55 d and studied, all efforts to synthesize the five-membered ring compound have thus far met with failu

56 reviously proposed that beta-residues with a five-membered ring constraint promote two different type

57 n bonds and promoted by beta-residues with a five-membered ring constraint.

58 The beta-residues in our systems have a five-membered-ring constraint (trans-2-aminocyclopentane

59 ene 2p-pi orbital by incorporating it into a five-membered ring, containing two double bonds, or into

60 Even though there are two five-membered ring cyclizations and several triple bond

61 c C-H activation processes proceed through a five-membered-ring cyclometallated intermediate.

62 wire contains one of three different cyclic five-membered rings: cyclopentadiene, furan, or thiophen

63 of atoms that are linked together by double five-membered rings (D5R), or 5(2)4(5) subunits, that ha

64 The five-membered ring derivative AMCPy emerged as a potent

65 of guanine is completely blocked, all of the five-membered ring derivatives incorporate the normal ba

66 acyl myo-inositol products via a 1,2-bridged five-membered ring dioxolanylium ion intermediate observ

67 ogen migration processes are observed in the five-membered ring due to the high barrier to 1,3-hydrog

68 contained amide, amine, and hetero-aromatic five-membered rings, each of which had a hetero-atom and

69 omatic ring system and cyclization to form a five-membered ring, followed by hydride loss to yield a

70 sites, five benzene rings fused to a central five-membered ring, for binding of six alkali-metal ions

71 Galactofuranose (Galf) is the five-membered ring form of galactose.

72 Five-membered ring formation proceeds less readily, but

73 n pathway proceeds via the initial step of a five-membered ring formation upon attack of the hydrazin

74 ism is proposed to account for the selective five-membered-ring formation with the rearrangement of t

75 t binding orientations of the inhibitor core five-membered rings from one series to another.

76 differentiating among these isomers in their five-membered ring furanose structure and smaller energe

77 a butenolide to produce stereoselectively a five-membered ring fused bicyclic lactone, the core stru

78 Introduction of ring strain through five-membered ring fusion at the NC bond slightly increa

79 The open-chloronium ions (E) rearrange to a five-membered-ring halonium ion during ionic chlorinatio

80 Quantum chemical calculations show that five-membered-ring halonium ion intermediates are 11 to

81 ucture optimization with the introduction of five-membered ring heterocycles at R6 resulted in compou

82 novinyl groups as acceptor and benzannulated five-membered ring heterocycles with alkyl chains of var

83 A study of ortho-substituted five-membered-ring heterocycles was undertaken and subse

84 genetic alphabet may be expanded to include five-membered-ring heterocycles.

85 s, none have shown reliable selectivity with five-membered-ring heterocycles.

86 was utilized for the synthesis of unnatural five-membered ring heterocyclic carbocyclic nucleosides.

87 t features 1,3-dipolar cycloaddition to give five-membered ring (Huisgen) intermediates, followed by

88 ond to nitrogen and the anti isomer favors a five-membered ring hydrogen bond to oxygen.

89 ring-closing metathesis to form the pendant five-membered ring; (iii) making recourse to a monothio

90 red ring in 2c than through the bonds of the five-membered ring in 15 or the six-membered ring in 12b

91 positioning the double bond internal to the five-membered ring in advance of transient ring expansio

92 ns-3,4-disubstituted carbo- and heterocyclic five-membered rings in high yields and with good to exce

93 ridine moieties with differently substituted five-membered rings in the backbone of the newly formed

94 ortho-substituted benzene units to construct five-membered rings in this work provides a unique entry

95 m metabolite, comprises a linear array of 10 five-membered rings in two pentacyclic regions that deri

96 s, intramolecular hydroacylation has favored five-membered rings, in preference to four membered ring

97 A five-membered ring indene skeleton is also prepared via

98 e for sp(3) C-H bonds of methyl groups via a five-membered ring intermediate over the sp(2) C-H bonds

99 sp(3) C-H bonds of beta-methyl groups, via a five-membered ring intermediate, over the aromatic sp(2)

100 cycloaddition with the nitrone, generating a five-membered ring intermediate.

101 ed by N-N bond formation, producing unstable five-membered ring intermediates that spontaneously dehy

102 The five-membered-ring intermediates lead to rearranged prod

103 active derivative revealed the presence of a five-membered ring intramolecular hydrogen-bonding netwo

104 emical shift (NICS) values indicate that the five-membered ring is more aromatic than the six-membere

105 A highly diastereoselective synthesis of five-membered rings is achieved from the reaction of the

106 The formation of five-membered rings is against the Baldwin's rule.

107 of the resulting bistetracene analogue with five-membered rings is comprehensively investigated by s

108 formation of the bistetracene analogue with five-membered rings is kinetically controlled while an "

109 Several five-membered-ring isoindol-1-ones displayed very high i

110 The five-membered ring lactam intermediates in these synthet

111 late directing groups may be used to furnish five-membered ring lactone products.

112 th these results, the order of importance of five-membered ring lactones as competent templates for t

113 diacylglycerol (DAG) analogues embedded into five-membered ring lactones as templates III and IV are

114 The modified FAD contains a fused five-membered ring, linking the C(4a) and N(5) atoms of

115 to an N-C8 cation via the intermediacy of a five-membered ring may be operative in nitrenium ions wi

116 hose alkylidene is derived from an identical five-membered ring monomeric unit.

117 ed chemical structures around the ubiquitous five-membered ring motif, such as potentially therapeuti

118 Similarly, the five-membered ring naphthylethyl analogue, phosphorodiam

119 six-membered ring nitroxides and substituted five-membered ring nitroxides were efficient protectors.

120 ulations and NMR studies have shown that the five-membered ring of mannostatin A is rather flexible o

121 lated to compare the aromaticity in both the five-membered rings of 33, 34, 36 and 1,6-dioxa-6a-chalc

122 de chains carried by the beta-lactam and the five-membered rings of the carbapenem core.

123 Here the bent configurations of four- and five-membered rings of uranyl peroxide hexagonal bipyram

124 y reactions directed toward the syntheses of five-membered rings, other carbocycles and, finally, het

125 application of the "inside attack" model for five-membered ring oxocarbenium ions developed previousl

126 nucleophile attack for 2,3-trans-substituted five-membered ring oxocarbenium ions is strongly influen

127 ence is provided that nucleophilic attack on five-membered ring oxocarbenium ions occurs from the ins

128 f Ip/Py and Hz/Py pairs were compared to the five-membered ring pairs Im/Py and Hp/Py on a DNA restri

129 strategy provides a straightforward entry to five-membered ring products from simple, stable pi-syste

130 mplex is the first structure of PRODH with a five-membered ring proline analogue bound in the active

131 ized in the multiatom SOMOs of the three- to five-membered ring radical anions.

132 double bonds that are identical to the "all five-membered ring" species formed through cyclopolymeri

133 t is absent in all the inactive compounds: a five-membered ring structure, one of whose carbon atoms

134 All chlorophylls have similar five-membered ring structures, with variations in the si

135 which are rare examples in the class of such five-membered-ring sulfur species.

136 , the structure of 1 has parallel and planar five-membered rings symmetrically positioned about the c

137 aving the sugar residue attached to the same five-membered ring system.

138 The reaction produces substituted five-membered ring systems stereoselectively and on prep

139 contain a 2-amino-3-hydroxycyclopent-2-enone five membered ring, termed C(5)N, which is condensed via

140 iers of 19.1 and 23.0 kcal/mol, leading to a five-membered ring tetroxolane intermediate.

141 of the acyl hydrogen and addition to form a five-membered ring tetroxolane.

142 rturb much more the pi-electron structure of five-membered rings than that of the six-membered ones.

143 of a new stereogenic center on the C2 of the five-membered ring, the reaction proceeds with formation

144 des are capped by diverse amino acid-derived five-membered rings, the tetramic acids and related pyrr

145 negatively with the resonance energy of the five-membered ring; the nonaromatic cyclopentadiene deri

146 e carbon-carbon bond joining the two central five-membered rings then gave the trans isomer 26.

147 alogues have been elaborated from a panel of five-membered ring trifluoromethylated amino acids (Tfm-

148 hat the tert-butyl and p-xylyl groups in the five-membered-ring upper half may be introduced simultan

149 motor comprises a fluorene lower half and a five-membered-ring upper half; the upper-half ring is fu

150 hod is presented for pucker determination of five-membered rings using only residual dipolar coupling

151 substrate to Fe(2+)versus Ni(2+): forming a five-membered ring versus a six-membered ring, respectiv

152 ntiospecific synthesis of the functionalized five-membered ring vinyl stannane from the monoterpene R

153 otope labeling at different positions of the five-membered ring was developed.

154 ommon electrochemical oxidation, whereas the five-membered ring was formed through ring-closing metat

155 The five-membered ring was generated in a stereocontrolled f

156 onic overlapping plus the ring strain of the five-membered ring, whereas steric effects seem to be un

157 localization of 6pi-electrons over the BC2N2 five-membered ring, which thus indicates the aromatic pr

158 yl(crotyl)enolsilanes, when constrained in a five-membered ring with a 1,2-diol, react with aldehydes

159 closing metathesis strategy to construct the five-membered ring with control of both the relative and

160 bearing a terminal alkyne led to the desired five-membered ring with high enantioselectivities (up to

161 180 degrees variation in orientation of the five-membered ring within the active site.