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1 ary rates have increased by at least four to fivefold.
2 at have drifted up in frequency by more than fivefold.
3 nalysis that increases precursor selectivity fivefold.
4 e rate of GTP hydrolysis by E. coli EF-Tu by fivefold.
5 ing due to landscape roughness is only about fivefold.
6 engrailed homeobox 1) expression is enhanced fivefold.
7 mber of promoter-associated CAGE clusters by fivefold.
8 ed expression and secretion by three-fold to fivefold.
9 ving axial symmetry that ranges from two- to fivefold.
10 ncreased pcPVN CRF(+)/AVP(+) neuronal number fivefold.
11 h that of KCNQ1 increased current density by fivefold.
12 tivity of the tombusvirus replicase by up to fivefold.
13 n of Nef would increase killing by more than fivefold.
14 GLUT6, and GLUT10 protein levels twofold to fivefold.
15 its interaction with actin by approximately fivefold.
16 recursor to cloud condensation nuclei, up to fivefold.
17 e and increases the number of live births by fivefold.
18 even after the testing current was increased fivefold.
19 mated overall risk of recurrence by four- to fivefolds.
20 proliferative rate of spinal cord OPCs rose fivefold above control levels during EAE, and numbers of
21 uct, we found that APF treatment resulted in fivefold activation of the CCN2 proximal promoter and, o
23 )CD23(-) splenic MZ B cells of approximately fivefold and a proportional decrease in splenic follicul
24 properties-its optical contrast is enhanced fivefold and it has excellent electrochemical stability,
25 on increased hepatic iron and serum hepcidin fivefold and led to a 40% increase in fasting glucose du
26 thecin, levels of Dnmt1 and Dnmt3a increased fivefold and twofold, respectively, and 5-methylcytosine
27 intain the high levels of secreted IL-1beta (fivefold) and IL-18 (10-fold) when stimulated with 1,000
28 morphology with gross enlargement (four- to fivefold) and internal membrane profiles reminiscent of
29 orylation of NKCC2 at both Ser126 (more than fivefold) and Ser874 (more than threefold) in rats in vi
30 f Ba(2+) to the Ca(2+) bowl is reduced about fivefold, and coupling of binding to activation is reduc
31 increases the stem-like side population over fivefold, and the percentage of cells expressing CD133 t
32 protein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human
33 nse peptide films bound and retained two- to fivefold as many cells as the other films, with cells ex
34 (standard-risk cytogenetics); approximately fivefold as many patients with high- or standard-risk cy
35 of 2P resolution ranging from approximately fivefold at 20 mum to approximately twofold at 90-mum de
37 etrical dimers that surround the icosahedral fivefold axes, forming pentamers of dimers that are thou
41 f the core stack relative to the icosahedral fivefold axis and propose that this tilt assists DNA spo
42 at the bottom of the canyon surrounding the fivefold axis of symmetry that was previously shown to i
45 ng 181-fold paired-end sequences assisted by fivefold BAC-to-BAC sequences and a high-resolution gene
46 erall amount of the maternal TF Bicoid (Bcd) fivefold, Bcd concentrations in cells at positions of th
47 tainably maintained an approximate three- to fivefold boost in biofuel production in our Escherichia
48 ed inside the single crystalline segments of fivefold boron-rich nanowires collectively, where they w
51 Fat fraction measurements can be accelerated fivefold by using combined compressed sensing and parall
53 We demonstrate the spontaneous formation of fivefold Ce-ligand coordination motifs, which are planar
55 etrically related VP subunits and not in the fivefold channel as observed for other parvoviruses.
57 emonstrate that it can be enhanced more than fivefold compared to state-of-the-art platinum catalysts
58 trols) and tensile properties (approximately fivefold compared with controls) of neocartilage were al
59 ncreased transgene integration efficiency by fivefold compared with conventional PNI or intracytoplas
60 nation prolonged the median overall survival fivefold compared with the control-treated group and two
61 y and joint-family QTL analysis methods with fivefold cross-validation for 6 diverse traits using the
62 eiver operating characteristic curves from a fivefold cross-validation were used to determine the mod
65 ive hematopoietic potential, but exhibited a fivefold decrease in multilineage definitive hematopoiet
69 in the Republic of Korea despite a more than fivefold decrease in the prevalence of the disease over
71 hed the tau-MT interaction by a greater-than-fivefold decrease of the association rate with no major
72 st and hyphal cell lengths differ by two- to fivefold, demonstrating that spindle length regulation a
73 icroliter in patients with sarcoidosis and a fivefold depletion of the slan-positive monocytes in pat
74 able HF, circulating miRNAs showed less than fivefold differences compared with normal, and myomir an
75 (DCPs), defined as greater than or equal to fivefold differences in half-maximum inhibitor concentra
76 s the presence of between one and six excess fivefold disclinations in the cross-sectional order.
78 m by 1,000-km transect spanning the State's fivefold east-west precipitation gradient ( 1,500 to 30
82 E catalyst particles and the pyridine, up to fivefold enhancements were observed in the (1)H NMR spec
84 contralesional cortex, which itself formed a fivefold expanded connection to the ipsilateral spinal c
85 tral signatures of individual cells at least fivefold faster than spontaneous Raman microspectroscopy
86 lected plants, I show that hexaploids have a fivefold fitness advantage over tetraploids in dune habi
88 ometres from the epicentre) increased nearly fivefold for six days after the 2012 event, and extended
89 rization rate of vitamin A--by approximately fivefold for the vitamin A dimer A2E--and subsequent lip
92 is because precipitation variability varies >fivefold globally resulting in a wide range of ecosystem
93 presented 66% of transfected cells) produced fivefold greater activation of the renal nerve than the
94 affinity in the absence of quinine and with fivefold greater affinity (K(D) approximately 2.2 x 10(-
95 itive hematopoietic potential, but conferred fivefold greater definitive hematopoietic potential, sim
97 range of noradrenaline diffusion was nearly fivefold greater in the locus ceruleus than dopamine in
98 luenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic
100 tumour uptake of the CP-PTX nanoparticle was fivefold greater than free drug and twofold greater than
101 rom 1 to 6 Hz generated Ca(2+) signals up to fivefold greater than predicted by linear summation of s
103 ired and fused cells over the entire device, fivefold greater than with a commercial electrofusion ch
104 wever, the glucagon response was fourfold to fivefold greater when circulating insulin did not increa
106 Brain lactate concentrations were more than fivefold higher (P < 0.05) during hypoglycemia in the T1
108 d to Trx reductase 1 (TrxR1) using NADPH was fivefold higher compared with Trx1 (418 min(-1)microM(-1
109 loading than mammalian heavy chain Ft, over fivefold higher contrast in magnetic resonance imaging,
114 because (1) Mecp2-null microglia released a fivefold higher level of glutamate, (2) blockage of micr
117 ing toxicity, SQ-Dox nanoassemblies showed a fivefold higher maximum-tolerated dose than the free dru
118 of the DeltarpfF mutant was associated with fivefold higher numbers of OMVs recovered from xylem sap
119 soluble (average 98%), was characterised by fivefold higher oil holding capacity (average 5.4 cm(3)/
120 animal interactions; herbivory was more than fivefold higher on trees influenced by tree holes relati
121 efold in abundance, 22 proteins showed up to fivefold higher oxidation, and 22 proteins increased in
122 predicted future diabetes (with a more than fivefold higher risk for individuals in top quartile).
123 patients with CRC, FGFR4(arg)-carriers had a fivefold higher risk of tumors that were stage II or gre
124 ce (P301S tg mice), we found that ISF tau is fivefold higher than endogenous murine tau, consistent w
125 rs containing Na(+) with an affinity that is fivefold higher than for G-quadruplex structures formed
126 plants resulted in a DNTF efficiency of 56%, fivefold higher than in diploid plants and 50-fold highe
127 n iron-deficient waters averaged 9 pM, up to fivefold higher than in iron-rich coastal and nutrient-d
128 (SD; 8-h photoperiod) plants were three- to fivefold higher than in long-day plants (LD; 16-h photop
129 ransplant population is overall threefold to fivefold higher than the general population with poorer
130 Modeled methane concentrations were four- to fivefold higher than the preindustrial value typically a
131 0.BR cells and tissues had levels of mA3 RNA fivefold higher than those from BALB/c and C3H/HeN mice.
133 TFV and showed higher levels, reflecting the fivefold-higher concentration of this drug than of TFV.
135 ation governs the Coulomb force, we obtain a fivefold-improved limit on anisotropies in the speed of
136 bining the multimodal connectomics yielded a fivefold improvement in predicting treatment response.
138 Pt nanoparticle catalysts and is more than a fivefold improvement over pure silver nanoparticles at t
139 ponse of approximately 860 microA cm(-2) , a fivefold improvement over the best previous comparable d
140 treatment leaf, 35 proteins increased up to fivefold in abundance, 22 proteins showed up to fivefold
144 er antibodies with half-lives extended up to fivefold in human (h)FcRn transgenic mice and threefold
145 sistently higher by in average approximately fivefold in insects compared with plants and PMU1 gene e
146 s were found to be overexpressed by at least fivefold in insulitic islets from living patients with r
148 the MP compartment is increased by more than fivefold in Runx1 KO mice, with a prominent skewing towa
149 s, mini frequency was increased threefold to fivefold in syt-I KO neurons compared with wild type.
150 ty to survive intracellularly also increased fivefold in the case of the feoB1-deficient mutant.
151 found to be selectively increased more than fivefold in the hippocampus of 3xTg-AD mice relative to
152 ifferent human genomic regions vary by up to fivefold in the local density of cancer somatic mutation
153 the total excretion of flavanones increased fivefold in the triathletes compared with the control vo
156 iPS, or isogenic origins exhibited a two- to fivefold increase in a population of CD43(+)(Leukosialin
157 escence staining of these sediments showed a fivefold increase in active strain CJ2 in the sediments
160 mulates alveolar lung deposition, measured a fivefold increase in alveolar-lung deposited surface are
161 mutant human lung cancer cells resulted in a fivefold increase in ATP-binding cassette, subfamily G (
162 nterictal cardiac abnormalities, including a fivefold increase in atrioventricular (AV) conduction bl
168 alt-ferrite ( 1.24 x 10(-9) A(-1)m), while a fivefold increase in dlambda/dH was observed for magneti
169 cation of the river's runoff in the 1920s, a fivefold increase in dust loading from anthropogenically
170 st peatlands, where permafrost thaw caused a fivefold increase in emissions (0.56 +/- 0.11 vs. 2.81 +
176 of the benthic reorganization was an abrupt fivefold increase in macroalgal cover in 1995 in Kongsfj
177 all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 as an i
178 vivo stratified by cell division revealed a fivefold increase in mRNA transcription coupled to DNA h
179 amic range and detection sensitivity-about a fivefold increase in peak detection-as compared with the
180 t the invention of agriculture facilitated a fivefold increase in population growth relative to more
181 , with long-read sequencing data providing a fivefold increase in sensitivity for genetic variants ra
182 f TaLsi1 or OsLsi1 resulted in a fourfold to fivefold increase in Si accumulation in transformed plan
183 a high (75-98%) DPPC content induces up to a fivefold increase in spin depolarization time tau at 297
184 -deficient large myelinated A-axons showed a fivefold increase in susceptibility to 4-aminopyridine (
186 This compositional change was attended by a fivefold increase in the mass of the upper continental c
187 how that Apc(min/+)/Tpl2(-/-) mice exhibit a fivefold increase in the number of intestinal adenomas.
189 he formation of filamentous actin, a two- to fivefold increase in the release of endothelial cell mic
191 tor, but that free ATP in solution confers a fivefold increase in the stability of the nucleoprotein
192 pamil (threefold increase), (3)H-loperamide (fivefold increase), and (3)H-paclitaxel (fivefold increa
193 de (fivefold increase), and (3)H-paclitaxel (fivefold increase); blocking S1PR1 abolished this effect
194 ation increased from 0.33 to 1.65 million, a fivefold increase, with a compound annual growth rate of
195 lial to mesenchymal regulators, as well as a fivefold increased ALDH1 activity, a threefold enrichmen
196 nked gene expression, for example, three- to fivefold increased expression of transketolase and gluta
197 0 AM display a decreased latency and about a fivefold increased multiplicity of skin cancer (invasive
199 rs after reversal, and are associated with a fivefold increased risk for death by 1 year compared wit
200 he diabetic condition results in a three- to fivefold increased risk for fetal cardiac malformations
202 d controls, patients with TG had a more than fivefold increased risk of reaching the endpoint (adjust
203 htop bioreactors resulted in almost ten- and fivefold increases in specific titers of myo-inositol an
204 ecies quantification is unsuitable, due to a fivefold inter-tissue variation in mtDNA content per cel
205 s process is demonstrated by a high-yielding fivefold intramolecular coupling to form a helical ZrPAH
206 n MR imaging was performed at 1.5 and 3.0 T (fivefold k-t SENSE acceleration; spatial resolution, 1.3
207 f sustained tension, exhibited approximately fivefold larger deformation fields and approximately two
208 the frictional force and velocity was nearly fivefold larger than the hydrodynamic friction coefficie
209 icient tumor microenvironment were more than fivefold larger than tumors grown in a wild-type microen
210 d in the cytoplasmic membrane, resulted in a fivefold larger value of D, 0.27+/-0.06 mum2/s for antib
212 tely twofold more frequent and approximately fivefold longer processive runs, allowing them to catch
217 1) . sec(-1)) were approximately twofold and fivefold lower, respectively, compared with those of gad
219 ve and tensile strain patterns approaching a fivefold magnitude increase in some locations compared t
221 pe strain, the esxH-deficient strain induced fivefold more antigen-specific CD4(+) T-cell proliferati
222 cular, dodecamers are able to detect two- to fivefold more antigen-specific T cells in both human and
223 drives reporter gene expression tenfold and fivefold more effectively than those of rat and human, r
224 the autogenous strain produced approximately fivefold more eggs following a blood meal than through a
225 d after exposure to this cytokine were about fivefold more infectious than virions produced by other
226 STAU2 binds ~10-fold more UPF1 and ~two- to fivefold more of those SBS-containing mRNAs that were te
227 In rat striatal synaptosomes, 6c was almost fivefold more potent at inhibiting AMPH-stimulated dopam
228 quiring land and species coverage means that fivefold more threatened vertebrates could be adequately
229 pidophylla contained 14 unnamed compounds of fivefold or greater abundance than in S. moellendorffii,
230 cortex increases with cortex size, reaching fivefold or greater in primates, and (iii) that when the
231 ted that deconSTORM enables an approximately fivefold or greater increase in imaging speed by allowin
233 d in the absence of BLM, LOH is increased by fivefold or more, implying significantly increased inter
234 tection sensitivity is enhanced by three- to fivefold over previously used tracers at 11.7 T, and is
238 s, Treg and natural killer cell counts rose >fivefold (P < .001) and >fourfold (P < .001), respective
240 46 genes were specifically upregulated over fivefold (p </= 0.05) upon rhizosphere colonization and
241 methylated loci were threefold (P=0.02) and fivefold (P=0.004) higher, respectively, in adenomas ass
243 by J774A.1 macrophage-like cells by 3.5- to fivefold Plg receptors and plasmin proteolytic activity
244 ghly conserved nature of the residues at the fivefold pore, the HI loops surrounding this critical re
245 t regulate opening and closing of the capsid fivefold portals have evolved in different viral lineage
246 (I(KA)/I(Glu) ratio 0.4) and a greater than fivefold potentiation of kainate responses by cyclothiaz
247 0.01 mg kg(-1), was also conducted following fivefold pre-concentration of QuEChERS extracts prior to
249 activities showed little or no change over a fivefold range of dietary NSP intake, although alpha-glu
251 matic inhibition of interstitial fibrosis, a fivefold reduction in alpha-smooth muscle actin expressi
252 secondary hemorrhage, yielded a threefold to fivefold reduction in lesion volume and produced a subst
253 er, these changes resulted in a threefold to fivefold reduction in the time needed to precisely encod
254 in Arabidopsis thaliana pdTPI resulted in a fivefold reduction in transcript, reduced TPI activity,
255 e dimensions, kinked nanopores exhibit up to fivefold reduction in translocation velocity, which has
256 thal ancestry, and there is an approximately fivefold reduction of Neanderthal ancestry on the X chro
257 al than in the axial direction can lead to a fivefold reduction of the minimal plate height compared
258 r cell expansion in the lymph node (four- to fivefold reduction) but not Th1 programming, independent
260 vage, increases HDR efficiency by twofold to fivefold relative to circular plasmid donors at one geno
262 -) mice were increased more than 10-fold and fivefold, respectively, compared with those in wild-type
263 d tolerance to the low flow state by two and fivefold, respectively, normalized arterial pressure dur
264 ding, but rather enhanced refolding kinetics fivefold, resulting in a 0.9 kcal/mol stabilization in t
265 , mice placed on diet enriched in magnesium (fivefold) showed no evidence of connective tissue minera
268 n average an approximately three-, four-, or fivefold stronger effect than rainfall, solar radiation,
269 ubulin relative to MT walls by approximately fivefold, suggesting that it may contribute to the firm
270 prohead by interacting specifically with the fivefold symmetric capsid structures that surround the h
271 egion is positioned between two neighboring, fivefold-symmetrically related VP subunits and not in th
272 ntify regular shapes, including species with fivefold symmetry and surprisingly large aspect ratio up
273 ments of the network were localized near the fivefold symmetry axis and included those connecting the
274 We introduce a model in which the degree of fivefold symmetry can be tuned by favouring arrangements
279 e amount of locally favoured structures with fivefold symmetry, which bear great structural similarit
282 d TIMP-1 were significantly upregulated from fivefold to 375-fold by microarray and from threefold to
284 ly 67% of advanced melanomas, accompanied by fivefold to six-fold higher levels of secreted protein i
286 pentacle gold-copper alloy nanocrystals with fivefold twinning, the size of which can be tuned in the
287 (fourfold underestimation), and 8% and 37% (fivefold underestimation) (P < 0.001), respectively.
288 thways in the developing kidney, including a fivefold up-regulation of Foxd1, a known regulator of ne
289 during vegetative growth, but they increase fivefold upon starvation, protecting cells from oxidativ
290 ermined experimentally are reproduced within fivefold using potential of mean force calculations.
291 eling studies have demonstrated a twofold to fivefold variation of intrinsic and synaptic parameters
292 that interact with PhiX174 at an icosahedral fivefold vertex and induce single-stranded (ss) DNA geno
294 t hexameric capsomers is greatest around the fivefold vertices, where there is the largest deviation
297 LLN-COPD, indicating risks between two- and fivefold, were observed for all occupational exposures a
298 sed HCT116 cell migration and invasion up to fivefold, whereas cell mobility was abolished by STAT3-D
299 on and transiently increased in number up to fivefold, which depended in part on hedgehog signaling.
300 ity of CbbR at the cbb(I) promoter three- to fivefold while CbbRR2 appeared to stabilize CbbR binding
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