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1 be either a dose proportional to weight or a fixed dose.
2 also received s.c. injections of GM-CSF at a fixed dose.
4 ts were randomly assigned (1:1) to switch to fixed-dose 200 mg emtricitabine with 10 mg or 25 mg teno
10 rubicin and ifosfamide (AI), with rhTPO by a fixed dose and varying schedules being administered befo
11 heparins in many patients, are prescribed in fixed doses and do not need any coagulation monitoring i
12 farin (n=404), warfarin (n=408; 324 [79%] on fixed-dose and 84 [21%] on dose-adjusted) did not reduce
13 antially reduced residual albuminuria during fixed dose angiotensin-converting enzyme inhibition.
14 ere randomized 2:1 to receive abatacept at a fixed dose approximating 10 mg/kg by weight range, or pl
16 .23 mg/m(2), which was converted to a 4.0 mg fixed dose based on population pharmacokinetic results.
17 e regimen of budesonide plus formoterol with fixed-dose budesonide plus formoterol and fixed-dose flu
18 formoterol maintenance and reliever therapy, fixed-dose budesonide plus formoterol, or fixed-dose flu
19 ofemoral deep vein thrombosis treated with a fixed-dose catheter thrombolysis regimen, the addition o
21 ouble-blind, placebo-controlled, randomized, fixed-dose clinical trial evaluating the efficacy of GSK
22 manufacturing licenses for large numbers of fixed dose combination (FDC) drugs had been issued by st
23 osterone antagonist eplerenone in 2003 and a fixed dose combination of hydralazine-isosorbide dinitra
24 Dapagliflozin (Farxiga), alone, or in the fixed dose combination with metformin (Xigduo), is an or
26 blind treatment with nebivolol and valsartan fixed-dose combination (5 and 80 mg/day, 5 and 160 mg/da
27 patasvir/voxilaprevir (SOF/VEL/VOX) (Vosevi) fixed-dose combination (FDC), an interferon-free, comple
29 ir, emtricitabine, and tenofovir alafenamide fixed-dose combination [bictegravir group] and 330 with
31 afety of a 3-day supervised treatment of the fixed-dose combination artesunate-amodiaquine Winthrop((
32 assigned participants (1:1) to receive oral fixed-dose combination bictegravir 50 mg, emtricitabine
34 atistical comparison was between the highest fixed-dose combination dose and the highest monotherapy
36 med to further assess safety and efficacy of fixed-dose combination emtricitabine with tenofovir alaf
37 ears and older receiving regimens containing fixed-dose combination emtricitabine with tenofovir diso
40 ered once daily with the abacavir/lamivudine fixed-dose combination in treatment-naive human immunode
41 omes can be conveniently treated with triple fixed-dose combination inhaler therapy with an inhaled c
43 We demonstrate the safety and efficacy of fixed-dose combination ledipasvir and sofosbuvir for 12
44 ty-assured generic medicines, development of fixed-dose combination medicines, and promotion of adher
46 underwent randomization for treatment with a fixed-dose combination of 180 mg of pyronaridine and 60
47 dolutegravir with matching placebo plus the fixed-dose combination of 200 mg emtricitabine and 25 mg
48 ty of QVA149 (indacaterol/glycopyrrolate), a fixed-dose combination of a long-acting beta2-agonist (i
49 We assessed the efficacy and safety of a fixed-dose combination of a vasodilating beta blocker (n
54 ents received twice-daily treatment with the fixed-dose combination of daclatasvir (30 mg), asunaprev
56 Patients were given an oral, once-daily, fixed-dose combination of EBR/GZR 50 mg/100 mg for 12 we
59 inetics, and efficacy of this single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtr
60 eive treatment for 8, 12, or 16 weeks with a fixed-dose combination of grazoprevir, ruzasvir, and upr
61 ed for smoking status) to once-daily QVA149 (fixed-dose combination of indacaterol 110 mug and glycop
63 n SBP on the effectiveness of treatment with fixed-dose combination of isosorbide dinitrate and hydra
66 ver before treated for HCV were prescribed a fixed-dose combination of ledipasvir (90 mg) and sofosbu
69 ncluding lopinavir (LPV) ISNP granules and a fixed-dose combination of LPV/ritonavir (RTV) ISNP granu
70 termittent preventive treatment (IPT) with a fixed-dose combination of mefloquine-artesunate (MQAS) o
71 s to develop a nanotechnology to formulate a fixed-dose combination of poorly water-soluble drugs in
72 sis were randomly assigned to groups given a fixed-dose combination of SOF and LDV, with RBV (n = 9)
73 rhosis were randomly assigned to an all-oral fixed-dose combination of sofosbuvir (400 mg) and velpat
74 atients with decompensated cirrhosis given a fixed-dose combination of sofosbuvir and velpatasvir wit
77 y, we evaluated the efficacy and safety of a fixed-dose combination of sofosbuvir-velpatasvir (400 mg
79 itive participants to trial clinics for ART (fixed-dose combination of tenofovir, emtricitabine, and
80 sess the efficacy and safety of an all-oral, fixed-dose combination of the hepatitis C virus NS5A inh
81 and safety of an interferon-free regimen--a fixed-dose combination of the nucleotide polymerase inhi
82 nofovir-emtricitabine in a 245 mg and 200 mg fixed-dose combination once daily, plus 800 mg darunavir
84 he growing body of clinical evidence for the fixed-dose combination regimen of elbasvir plus grazopre
85 ive sofosbuvir-velpatasvir, in a once-daily, fixed-dose combination tablet (134 patients), or sofosbu
86 andomly (1:1) to receive 12 or 24 weeks of a fixed-dose combination tablet containing ledipasvir and
87 merase inhibitor sofosbuvir in a once-daily, fixed-dose combination tablet for 12 weeks, ledipasvir-s
89 ive and 22 treatment experienced) received a fixed-dose combination tablet of 90 mg of ledipasvir and
91 ype 3 were randomly assigned to groups given fixed-dose combination tablet of ledipasvir and sofosbuv
93 e III studies, treatment with the once-daily fixed-dose combination tablet of ledipasvir/sofosbuvir (
94 were randomized to receive treatment with a fixed-dose combination tablet of sofosbuvir-velpatasvir-
95 io to receive ledipasvir and sofosbuvir in a fixed-dose combination tablet once daily for 12 weeks, l
96 grazoprevir 100 mg plus elbasvir 50 mg in a fixed-dose combination tablet once daily for 12 weeks.
97 NS5A inhibitor velpatasvir in a once-daily, fixed-dose combination tablet or matching placebo for 12
98 ceived sofosbuvir-velpatasvir (400 mg/100 mg fixed-dose combination tablet) and GS-9857 (100 mg) once
99 th trimethoprim-sulfamethoxazole in a single fixed-dose combination tablet), 12 weeks of fluconazole,
103 emtricitabine and tenofovir alafenamide as a fixed-dose combination to dolutegravir administered with
104 emtricitabine and tenofovir alafenamide as a fixed-dose combination versus coformulated dolutegravir,
106 olving children with asthma, salmeterol in a fixed-dose combination with fluticasone was associated w
107 to assess the efficacy and safety of SOF/LDV fixed-dose combination without RBV in patients with HCV
108 d sofosbuvir-velpatasvir (400 mg/100 mg in a fixed-dose combination) plus GS-9857 (100 mg) once daily
113 e, zidovudine, or abacavir as dual or triple fixed-dose-combination paediatric tablets with lamivudin
119 rst-line treatment for HIV, and coformulated fixed-dose combinations are preferred to facilitate adhe
122 lability of polypills remain limited, unlike fixed-dose combinations in other diseases such as HIV, t
125 s kind of novel nanotechnology for pediatric fixed-dose combinations of poorly water-soluble drugs.
126 stable, and flexible pediatric granules for fixed-dose combinations that can be used as sachets and
128 e of external-beam radiation with concurrent fixed-dose continuous-infusion doxorubicin followed by s
130 of sertraline daily, or placebo in a 6-week fixed-dose, double-blind, double-dummy, parallel-group,
135 semaglutide (doses reached after following a fixed dose-escalation regimen) or once-daily insulin gla
136 EC-Asnase, administered as a 25,000 IU/m(2) fixed dose (FD) or individualized dose (ID) starting at
137 y, fixed-dose budesonide plus formoterol, or fixed-dose fluticasone plus salmeterol for 6 months.
138 th fixed-dose budesonide plus formoterol and fixed-dose fluticasone plus salmeterol for 7 months.
139 ponse duration of low-dose rituximab (100 mg fixed dose for 4 weekly infusions) together with a short
141 or placebo given at 0, 24, and 48 h, with a fixed-dose furosemide regimen as background therapy.
143 bil at 12 weeks was 200 (SD 71) ng/mL in the fixed-dose group and 318 (129) ng/mL in the pharmacokine
144 e 25 mg oral omecamtiv mecarbil twice daily (fixed-dose group), 25 mg twice daily titrated to 50 mg t
146 stically significant decreases in the use of fixed-dose ICS-LABA agents in children (-0.98 percentage
147 pen-label noninferiority study that compared fixed-dose idraparinux with adjustable-dose oral vitamin
149 and angiotensin II receptor antagonists) in fixed doses in which data on headache were reported.
150 oterol maintenance and reliever therapy with fixed-dose inhaled corticosteroid/long-acting beta2-agon
151 % women) were randomly assigned to receive a fixed-dose intravenous bolus, followed by a 72-hour infu
154 an oral factor Xa inhibitor administered in fixed doses, may simplify the treatment of venous thromb
157 Once-daily dolutegravir in combination with fixed-dose NRTIs represents an effective new treatment o
161 -intensified treatment with (131)I-MIBG at a fixed dose of 11.1 GBq (300 mCi) per cycle is safe and o
162 by slow intravenous injection, followed by a fixed dose of 15 000 IU/m(2) bleomycin by intravenous in
163 challenged on day 0, 14 and 28 with a single fixed dose of 2.5 grams of the following (random order):
176 ion of CTLA-4-deficient cells responded to a fixed dose of Ag compared with CTLA-4-expressing cells,
178 ed that increasing amounts of SAM added to a fixed dose of BUP resulted in dose-dependent reductions
182 A group of 54 patients were treated with a fixed dose of decitabine (15 mg/m(2) by IV daily for 10
183 th total body irradiation (TBI) were given a fixed dose of donor T cells (HSCT step 1), followed by c
184 ng doses of GGTI in conjunction with a high, fixed dose of FTI causes a dose-dependent inhibition of
185 In the context of CY tolerization, a high, fixed dose of haploidentical T cells was associated with
187 r stage IV melanoma were randomly assigned a fixed dose of ipilimumab of either 10 mg/kg (n=73), 3 mg
188 ntricles were randomly assigned to receive a fixed dose of isosorbide dinitrate plus hydralazine or p
191 ss device using a dose of 180 mg/m2/d with a fixed dose of oral L at 5 mg/m2/d for 21 out of 28 days.
194 umab, coadministration of trastuzumab with a fixed dose of T-DM1 at 3:1 and 8:1 ratios dramatically i
196 lfilled the criteria for noninferiority to a fixed dose of zidovudine and lamivudine plus efavirenz a
198 5 volunteers were inoculated at 3 sites with fixed doses of 35000HP on one arm and at 3 sites with va
199 fety of pharmacological prevention with low, fixed doses of anticoagulant drugs, prophylaxis remains
201 of 40, 50, 60, and 80 mg/m(2) was given with fixed doses of cyclophosphamide, vincristine, and predni
202 daunorubicin (DNR) and etoposide (ETOP) and fixed doses of cytarabine were evaluated with (ADEP) or
203 response technology, to receive one of three fixed doses of deutetrabenazine (12 mg/day, 24 mg/day, o
204 ss the efficacy, safety, and tolerability of fixed doses of deutetrabenazine-a novel vesicular monoam
205 day for 3 days), coupled with our historical fixed doses of fludarabine and rituximab (BFR), as a non
206 ophrenia randomly assigned to four different fixed doses of haloperidol decanoate and treated for 1 y
208 andomly assigned in a 3:1:1 ratio to receive fixed doses of investigational drug, placebo, or haloper
209 s study evaluated the efficacy and safety of fixed doses of once-daily extended-release (XR) venlafax
210 1.45% [CI, -1.80% to - 1.10%]) compared with fixed doses of oral agents but much less when compared w
211 nd treatment of either placebo or one of two fixed doses of oral, once-daily bitopertin (10 or 20 mg
212 This study assessed the efficacy of two fixed doses of paroxetine in the treatment of generalize
214 revention, some have advocated administering fixed doses of statins based on a person's estimated net
215 zumab who were switched directly to 8-weekly fixed dosing of aflibercept without a loading phase.
216 of 0.4 mg/m(2)/d to 16 mg/m(2)/d and 25 mg/d fixed dosing, of which 67 were assessable for toxicity.
217 rch 5, 2015, we enrolled 150 patients in the fixed-dose omecamtiv mecarbil group and 149 in the pharm
218 as a significant increase in the impact of a fixed dose on extracellular dopamine, indicating that ne
220 ponse system to 26 weeks of monotherapy with fixed-dose oral cariprazine (3 mg, 4.5 mg [target dose],
221 All participants received the available fixed-dose oral formulation of elvitegravir 150 mg, cobi
222 large clinical trials have demonstrated that fixed-dose oral ximelagatran, 36 mg twice daily, adminis
227 ridol for 14 weeks (an 8-week escalation and fixed-dose period followed by a 6-week variable-dose per
228 s in glucose levels at the end of the 8-week fixed-dose period for patients given clozapine (N=27) an
229 vels were increased at the end of the 8-week fixed-dose period for the patients given clozapine (N=27
230 niazid should also be combined into a single fixed-dose pill, along with pyridoxine (vitamin B6), tha
231 se heterogeneity, gamma irradiation (using a fixed dose prescription) appears to deliver a sufficient
234 nts was simulated for 5 warfarin protocols-a fixed-dose protocol, a clinically guided protocol, and 3
236 etry-guided RAI therapy may be preferable to fixed-dose RAI treatment strategies in older patients wi
239 tastatic soft tissue sarcomas, we compared a fixed dose rate infusion of gemcitabine versus a lower d
241 nd toxicity of gemcitabine administered at a fixed dose rate or in combination with cisplatin, doceta
251 For patients with disseminated disease, fixed-dose-rate gemcitabine plus docetaxel is an appropr
252 Providers noted the inflexibility of the fixed dose regimen, with dosages sometimes inappropriate
254 on and cirrhosis who received a 12-week oral fixed-dose regimen of daclatasvir, asunaprevir, and becl
255 received 12 weeks of treatment with the oral fixed-dose regimen of daclatasvir, asunaprevir, and becl
258 he level of anticoagulation in response to a fixed-dose regimen of warfarin is difficult to predict d
259 g to a single inhaler regimen (SMART) with a fixed-dose regimen with salbutamol as reliever ('Standar
260 ibitor that can be administered in a simple, fixed-dose regimen, may be an option for the extended tr
265 omized to full-dose CsA (microemulsion) plus fixed-dose SRL (2 mg/day; group A, n=97) or reduced-dose
266 n (ACC/AHA) cholesterol guidelines recommend fixed-dose statin therapy for those at risk and do not r
268 e-blind, placebo-controlled, parallel-group, fixed-dose study in adult patients with bipolar I disord
269 hm to intravenous rituximab (375 mg/m(2)) or fixed-dose subcutaneous rituximab (1400 mg), stratified
270 okinetic non-inferiority of 3 week cycles of fixed-dose subcutaneous rituximab versus standard intrav
272 To evaluate the efficacy and safety of a fixed-dose tablet containing sumatriptan succinate and n
273 release bupropion 360 mg per day combined in fixed-dose tablets (also known as NB16), or matching pla
274 release bupropion 360 mg per day combined in fixed-dose tablets (also known as NB32), sustained-relea
275 12 weeks followed by once daily combination fixed-dose tablets of 90 mg ledipasvir and 400 mg sofosb
276 The visual and anatomic improvements after fixed dosing through week 24 and PRN dosing with monthly
277 andomized, double-blind, placebo-controlled, fixed-dose trial using a sequential parallel comparison
279 ; and regimen C (to evaluate the safety of a fixed dose two-thirds the MTD of regimen A given every 2
281 mized clinical trials of statins vs placebo, fixed-dose vs titrated statins, and higher- vs lower-int
284 ng chemotherapy through CVCs to no warfarin, fixed-dose warfarin 1 mg per day, or dose-adjusted warfa
287 t that is given as an intravenous bolus at a fixed dose, with less undesirable side effects including
291 ction and the capacity to be administered in fixed doses without routine coagulation monitoring, NOAC
292 cal care because they can be administered in fixed doses without routine coagulation monitoring.
293 acological basis for their administration in fixed doses without routine coagulation monitoring.
295 l fibrillation were developed to be given in fixed doses without the need for the routine monitoring
296 coagulant agents that can be administered in fixed doses, without laboratory monitoring and dose adju
298 For prophylaxis of venous thromboembolism, fixed-dose ximelagatran started the morning after total
299 V), have compared the efficacy and safety of fixed-dose ximelagatran without anticoagulation monitori
300 nofovir-emtricitabine group) or a regimen of fixed-dose zidovudine and lamivudine twice daily plus ef
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