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1 flank led to regression in the contralateral flank.
2 gions within the repeat but not close to the flanks.
3 ins bind to TAZ1 through helical motifs that flank a conserved LP(Q/E)L sequence that is essential fo
6 short amphipathic N- and C-terminal peptides flanking a conserved 72-residue hydrophobic hairpin, whi
9 -ray scattering (SAXS), the positions of the flanking acyl carrier protein and ketosynthase domains h
10 e injected plasmids with sequence variations flanking an I-SceI endonuclease recognition site into I-
13 locus (WNT10B(R)) within intron 1 (IVS1) and flanked at the 5' by non-human sequences whose origin re
14 olling for nucleotide composition; moreover, flanks at the 5' end of the exons have significantly low
16 upport PU.1 binding as a monomer, additional flanking bases were required to invoke sequential dimeri
21 that the N-terminal membrane-spanning domain flanked by a few positively charged or neutral residues
22 quences specified by guide RNA molecules and flanked by a protospacer adjacent motif (PAM) and is wid
24 a large 10-stranded, antiparallel beta-sheet flanked by alpha-helices on each side, representing a un
25 ation, consisting of a catalytic core domain flanked by amino- and carboxy-terminal domains essential
27 oteins characterized by a central tryptophan flanked by aspartic/glutamic acid residues (W-acidic).
28 orter gene cassette inserted into the vector flanked by boundary elements from the viral latency locu
32 c enhancement improves detection of a target flanked by distractors, consistent with sharpened visuos
34 presented whereby split intein sequences are flanked by endoplasmic reticulum retention/retrieval mot
35 receptive field has an excitatory ON center, flanked by excitatory OFF regions, a structure similar t
36 nucleoporin RanBP2 at a binding site that is flanked by FG-repeats and Ran-binding domains, and overl
38 nd its two paralogs PDIA8 and PDIA2 are each flanked by genes encoding Rho guanine-dissociation inhib
40 ontain a non-conserved linker (NCL) sequence flanked by highly conserved N- and C-terminal sequences,
42 ce of a guide RNA and repairing DNA template flanked by homology DNA fragments to the target site, we
43 d of a stable oligomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs)
44 ntegrated DNA encoding the viral proteins is flanked by long terminal repeat (LTR) regions from the r
46 Combined with phenotypic data, a major QTL flanked by marker AHGS4584 and GM672 was identified on c
50 overhangs, and it unwinds duplexes that are flanked by only a few nucleotides, as in the folded HCV
55 ure of sgs1Delta reveals copy number changes flanked by repetitive regions with high R-loop-forming p
56 The other two constructs, an exact monomer flanked by ribozymes and a trihelix-forming RNA with req
57 another to deliver an EGFP-HSV1-tk construct flanked by sequences homologous to those surrounding the
58 , located on three separate transcripts, are flanked by sequences that fold to form the conserved str
59 labeled with unique oligonucleotide barcodes flanked by sequencing primer targets enables quantitativ
60 e show that a double cut HDR donor, which is flanked by single guide RNA (sgRNA)-PAM sequences and is
63 A. boonei casposon as well as mini-casposons flanked by the TIR inserted preferentially at a site rec
64 d of a randomized nucleic acid sequence core flanked by translational start, stop, and cysteine-encod
66 mble on a Cas2 domain dimeric core, which is flanked by two Cas3 domains forming a groove where the p
67 train CBDB1 preferentially removed Cl doubly flanked by two Cl or by one Cl and NH2, whereas strain 1
68 cyclobutane beta- or gamma-amino acid being flanked by two d- or l-proline residues, have been synth
69 zed by two hemiprotonated C:C(+) base pairs, flanked by two minor groove tetrads resulting from the a
70 sed of a central anthraquinone (AQ) acceptor flanked by two Ru(bpy)3(2+) photosensitizers and two per
71 rom ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved
73 hese linker DNA regions with 6mA are usually flanked by well-positioned nucleosomes and/or H2A.Z-cont
74 st when the speed bump was near the end of a flanking chain, and (b) macrocycle cavity size, which wa
75 different substituents (speed bumps) on the flanking chains and two macrocycles with different cavit
76 ain protein, ZMYND8, which spreads along the flanking chromatin, but is excluded from the DSB region.
81 sin removal of short nonhelical regions that flank collagen's triple helix, known as telopeptides.
83 ne amplicon sequencing revealed the dominant flanking community members in both reactors were affilia
85 ll line-based experiments have identified 5'-flanking conserved sequences that control pancreatic and
87 ween tissues, the methylation information of flanking CpG sites and the methylation tendency of flank
88 HCC exhibit demethylation of these NF-kappaB-flanking CpG sites, and HBV replication propagates demet
89 t palindromic repeat (CRISPR) loci and their flanking CRISPR-associated (cas) genes make up RNA-guide
90 veal varying degrees of free rotation in the flanking cyclopropenylidene groups of 2 in its coordinat
94 e versus absence of congruent or incongruent flanking distracting arrows during either Pure blocks (d
95 ntrolled pharmacology study, we measured how flanking distractors influenced detection of a small con
96 sed to mediate the excision and loss of loxP-flanked DNA sequences in a rapamycin controlled manner.
98 Mot1 mechanism, we dissected the role of the flanking DNA segment by biochemical analysis of complexe
104 The polymorphic fibrils differ in their flanking domains rather than the polyglutamine amyloid s
106 r distances became more compact, with probes flanking either the motif between C1 and C2 or the Pro/A
111 sequencing was performed using primers that flanked germline mutations, whose design did not rely on
112 oof-of-principle use of multiplexed ribozyme flanked gRNAs to induce mutations in vivo in Drosophila
113 ndicate that when ATP hydrolysis is present, flanking heterologous dsDNA regions increase the reversi
114 mapping approach, we found that nucleosomes flanking human CTCF insulation sites are similarly disru
117 that, in addition to the globular domain, a flanking intrinsically disordered region also recognizes
119 1 exon encoding the extracellular domain and flanking intronic sequences are inserted into the switch
123 hat Rad26 uses its C-terminal domain and the flanking kinase-docking motif to bind specific HEAT repe
124 ion of virus directly into the tumors on one flank led to regression in the contralateral flank.
126 elic homologous recombination events between flanking low copy repeats termed LCR22A and LCR22D, resu
127 demonstrating that a 50-nucleotide sequence flanking m(5)C C3349 in MAIGO5 mRNA is sufficient to con
130 reactions of the morpholine moiety with the flanking meso-aryl groups leads to a sharpened, blue-shi
131 y studies on 2,6-diarylanilines that contain flanking meta/para-substituted aromatic rings adjacent t
132 llers bind one or both full nucleosomes that flank micrococcal nuclease (MNase)-defined nucleosome-fr
133 Y allele in the PfK13 propeller domain, with flanking microsatellite profiles different from those ob
136 the catalytic domain of Aurora-A and a site flanking Myc Box I that also binds SCF(FbxW7) We determi
137 ein, and in particular about the bHLH domain-flanking N- and C-terminal segments, which are predicted
138 ive thionation of thiophene- and selenophene-flanked NDIs using microwave irradiation and excess Lawe
139 tion not only of the nupt itself but also of flanking nuclear DNA within one generation of transfer.
141 etrotransposon presence/absence patterns and flanking nucleotide changes suggest an important influen
142 studies have only considered the immediately flanking nucleotides around a polymorphic site--the site
147 southward heat transport follows the eastern flank of the Filchner Depression and is found to be dire
148 ssion (MTCT) was dependent on the C-terminal flank of the V3 crown and particularly on amino acid pos
151 and in invasion assays, and/or injected into flanks of severe combined immunodeficient mice; xenograf
153 organs, particularly leaves, initiate at the flanks of the shoot apical meristem (SAM) following auxi
154 s, stomatal cell files are positioned at the flanks of underlying longitudinal leaf veins, rather tha
155 ound to the neopentyl center C-1si, which is flanked on each neighboring carbon by syn-axial substitu
157 its closest relative, ERK2, three additional flanking phosphosites have been confirmed (T198, T207, a
159 ns revealed twelve-fold symmetry, concentric flanking protrusions, and a central electron density.
161 Interestingly, the inversions are nested or flanking rather than coinciding with the deletion or dup
162 in rat corticostriatal brain slices, either flanking region alone sufficed to generate a neurotoxic
163 binding site accessibility, as determined by flanking region AU content, could fully explain the disc
166 putative regulatory sequence in the ULK1 5'-flanking region, the mutation of which increased ULK1 pr
168 proven by the characterization of transgene flanking regions and the combinations of elements that a
169 ying this approach to 17 microRNAs and their flanking regions and with a reporter for miR-142 activit
170 CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC
171 ns are enriched for long DNA repeats and the flanking regions have high alignment scores, suggesting
172 PL35a and RPL23, and ferredoxin, FDX1, whose flanking regions including promoters, terminators and un
173 Hippocampal cis-meQTL-CpGs are enriched in flanking regions of active promoters, CpG island shores,
176 were collapsed across CpG islands and their flanking regions to identify variants collectively assoc
177 e generally hypomethylated relative to their flanking regions, and the binding of some transcription
181 ich lines the anesthetic-binding cavity, its flanking residues (132 to 140), and Leu-122, a pore-gati
184 loading intermediate, when either one of the flanking roadblocks was eliminated, the remaining roadbl
186 gene expression, and the amount of conserved flanking sequence all correlate with retention rates.
187 e that Cas13b has a double-sided protospacer-flanking sequence and elucidate RNA secondary structure
189 ragment sequence to the published SULT1C3 5'-flanking sequence revealed an 863-nt deletion (nt -146 t
193 erfering RNAs were enriched in the 5' and 3' flanking sequences of nonadditively expressed genes in t
194 a values predicted from structures, although flanking sequences of S-palmitoylated sites are enriched
195 key components of miRNA stem loops and their flanking sequences on the efficiency of mature miRNA exp
197 target and non-target demonstrated that the flanking sequences provided the specificity for enhanced
198 develops a general approach for identifying flanking sequences that can be used to drive transgene e
201 ighly expressed genes in Chlamydomonas whose flanking sequences were tested for the ability to drive
202 es in relation to genes and their associated flanking sequences, we reveal that, in normal cells, gen
203 Moreover, we identified elements of core and flanking sequences, which are of critical importance for
206 show a significant correlation with loss of flanking siRNAs, but we identified one gene supporting e
207 K1, subsequent slower phosphorylation of the flanking sites results in inhibition of the kinase.
209 ocus in detail and, by using imputation from flanking SNP genotype data, shows that it affects blood
211 thogens and whose activity is repressed by a flanking substrate-binding leucine-rich repeat (LRR) dom
213 mers, with a pair of C-terminal domains from flanking tetramers completing the synaptic interface.
214 ction was greater on the previously infected flank than on the naive flank for wild-type and rag1(-/-
215 at both the viral DNA +1 and -1 bases, which flank the 3'-processing site, play a critical role for 3
217 variants on the alpha3 and L3 regions, which flank the di-Zn(II) active site, were selectively (19) F
222 , far fewer SLM2 and Sam68 RNA binding sites flank the Neurexin2 AS4 exon, compared with those flanki
223 two sites for ST8Sia-IV autopolysialylation flank the PBR, we evaluated the role of PBR residues in
225 translocations between three linkage groups flanked the deleted fragments, which, according to segre
227 high coverage genomes and find that regions flanking the amylase locus show notable depression of ge
228 el conformation, suggesting that the residue flanking the amyloidogenic peptide contributes to the st
229 s tandem array, and heterozygous for markers flanking the array, we measured interhomolog recombinati
230 "sensory motif" and two loops, RL1 and RL2, flanking the ATP-binding site playing a significant role
231 es circRNA biogenesis by binding the introns flanking the back-splicing junctions and that this contr
235 We found that the density of SNPs/indels flanking the breakpoints of deletions (in-phase variants
236 electronic variation of the aromatic groups flanking the C horizontal lineO of the cyclopentadienone
237 with the dipole of the acceptor substituent flanking the carbene center being the major selectivity
238 ssure due to substituents on the heteroatoms flanking the carbene center, as well as inductive electr
240 The specificity of AR extends to the regions flanking the core 15-bp site, where isothermal calorimet
241 Here we show that the nucleotides directly flanking the core-binding site, differ depending on the
243 ing affinity is greatly enhanced by residues flanking the crystallographically-defined recognition mo
244 catalyst 1, containing trimethylsilyl groups flanking the cyclopentadienone ketone, gave the best res
245 , two copies of a 146-bp direct repeat motif flanking the deleted region were found in the self-ferti
246 the same morphology, with negative curvature flanking the edges and with no visible protein structure
249 eotides complementing the 5'- and 3'-regions flanking the G4 have been connected by an abasic linker
254 ver, the analysis of the enhancer landscapes flanking the HoxD cluster reveals that the bimodal regul
256 ntified sequences cover most of the sequence flanking the junction between the bacterial and human DN
257 Binding of an antibody to epitope sequences flanking the linker disrupts the interaction between the
258 We have identified two CTCF binding sites flanking the locus and two associated with a super-enhan
259 parasubiculum appears as a linear structure flanking the medial entorhinal cortex mediodorsally.
260 t maintaining longer, poly-A-containing arms flanking the miRNA stem-loop markedly enhanced transgeni
261 endonucleases coupled with paired guide RNAs flanking the mutated Dmd exon23 resulted in excision of
262 the Neurexin2 AS4 exon, compared with those flanking the Neurexin1 and Neurexin3 AS4 exons under joi
263 hylated in liver tumors at CpG dinucleotides flanking the NF-kappaB-binding sequence, supporting that
264 flexibility to wedge the RCC1 beta-propeller flanking the NLS against its lateral surface, preventing
265 sliding has been shown to depend on the DNA flanking the nucleosome, transcription factor binding at
269 omic microarray chips covering about 8000 bp flanking the predicted transcription start sites in Xeno
273 ation and activity are mediated by sequences flanking the RNA-binding domain that bind specific molec
275 n target pri-miRNAs, including the sequences flanking the stem-loop region, contributed to high affin
277 of a short protospacer adjacent motif (PAM) flanking the target site, and subsequent R-loop formatio
280 e promoter elements, which are DNA sequences flanking the transcription start site (TSS) that help di
282 oprotein regions embedded in and immediately flanking the viral membrane dictate active incorporation
283 ngly, the pseudo-repeat region of tau, which flanks the core microtubule-binding domain of tau, contr
287 ntain a nuclear localization signal sequence flanking to the K1 segment and a novel conserved region
288 based on liberation of sgRNAs by processing flanking tRNAs, permits highly efficient multiplexing of
292 ation-the addition of subsidiary cells (SCs) flanking two dumbbell-shaped guard cells (GCs)-is linked
293 G 20 treatment of mice bearing contralateral flank UM-UC-3 and RT112 xenografts selectively arrested
294 gene conversion-like mechanism that employs flanking variable leucine-rich repeat sequences as templ
299 mice bearing PSMA+ PC3 PIP and PSMA- PC3 flu flank xenografts at a 740-kBq dose and in mice bearing P
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