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3 short amphipathic N- and C-terminal peptides flanking a conserved 72-residue hydrophobic hairpin, whi
5 e model that allows two interacting segments flanking a disordered loop (double sequence approximatio
10 -ray scattering (SAXS), the positions of the flanking acyl carrier protein and ketosynthase domains h
13 with their other individual preferences for flanking amino acids, greatly increases the potential su
14 e injected plasmids with sequence variations flanking an I-SceI endonuclease recognition site into I-
16 [TADs, including acidic domain 1 (AD1), the flanking Asn/Ser/Thr-rich (NST) domain and AD2] are tran
18 upport PU.1 binding as a monomer, additional flanking bases were required to invoke sequential dimeri
19 st when the speed bump was near the end of a flanking chain, and (b) macrocycle cavity size, which wa
20 different substituents (speed bumps) on the flanking chains and two macrocycles with different cavit
21 ain protein, ZMYND8, which spreads along the flanking chromatin, but is excluded from the DSB region.
26 ne amplicon sequencing revealed the dominant flanking community members in both reactors were affilia
28 ll line-based experiments have identified 5'-flanking conserved sequences that control pancreatic and
29 but significantly overrepresented in regions flanking CpG islands (shores and shelves) and gene bodie
30 ween tissues, the methylation information of flanking CpG sites and the methylation tendency of flank
31 HCC exhibit demethylation of these NF-kappaB-flanking CpG sites, and HBV replication propagates demet
32 t palindromic repeat (CRISPR) loci and their flanking CRISPR-associated (cas) genes make up RNA-guide
33 veal varying degrees of free rotation in the flanking cyclopropenylidene groups of 2 in its coordinat
36 e versus absence of congruent or incongruent flanking distracting arrows during either Pure blocks (d
37 ntrolled pharmacology study, we measured how flanking distractors influenced detection of a small con
42 Mot1 mechanism, we dissected the role of the flanking DNA segment by biochemical analysis of complexe
45 on DNA is cut precisely at its junction with flanking DNA, ensuring the transposon is neither shorten
52 within a gene desert, with the nearest gene flanking each side being MIR31HG and MTAP, neither of wh
54 r distances became more compact, with probes flanking either the motif between C1 and C2 or the Pro/A
55 at all sites, but the spread of silencing to flanking endogenous human genes is variable in extent of
65 ndicate that when ATP hydrolysis is present, flanking heterologous dsDNA regions increase the reversi
67 mapping approach, we found that nucleosomes flanking human CTCF insulation sites are similarly disru
69 e tetramer of prototype foamy virus, and two flanking integrase dimers that engage the core structure
70 are sufficient to catalyse integration, the flanking integrase dimers were necessary for mouse mamma
71 that, in addition to the globular domain, a flanking intrinsically disordered region also recognizes
72 phenotype and that a deletion of 9 bp in the flanking intron downstream of exon 5 (tae) of the gemini
75 1 exon encoding the extracellular domain and flanking intronic sequences are inserted into the switch
79 relationship of DNA methylation at exons and flanking introns with gene expression and histone modifi
83 human homolog of Ubp10, USP36, also has IDRs flanking its catalytic domain, and these IDRs similarly
84 a model in which condensin encircles the DNA flanking its loading site and then slides down, tetherin
87 hat Rad26 uses its C-terminal domain and the flanking kinase-docking motif to bind specific HEAT repe
89 elic homologous recombination events between flanking low copy repeats termed LCR22A and LCR22D, resu
90 typical recurrent rearrangements mediated by flanking low-copy repeats (LCRs), NF1 intragenic rearran
92 demonstrating that a 50-nucleotide sequence flanking m(5)C C3349 in MAIGO5 mRNA is sufficient to con
96 reactions of the morpholine moiety with the flanking meso-aryl groups leads to a sharpened, blue-shi
97 y studies on 2,6-diarylanilines that contain flanking meta/para-substituted aromatic rings adjacent t
98 Y allele in the PfK13 propeller domain, with flanking microsatellite profiles different from those ob
104 for co-ordinated repair of both target gaps flanking Mu without replicating the intervening 37 kb of
105 the catalytic domain of Aurora-A and a site flanking Myc Box I that also binds SCF(FbxW7) We determi
106 ein, and in particular about the bHLH domain-flanking N- and C-terminal segments, which are predicted
108 tion not only of the nupt itself but also of flanking nuclear DNA within one generation of transfer.
109 lated with ncRNA expression, suggesting that flanking nucleosomes form a barrier to pervasive transcr
111 etrotransposon presence/absence patterns and flanking nucleotide changes suggest an important influen
112 studies have only considered the immediately flanking nucleotides around a polymorphic site--the site
117 rigins by promoting the juxtaposition of DNA flanking parS sites, drawing sister origins in on themse
118 its closest relative, ERK2, three additional flanking phosphosites have been confirmed (T198, T207, a
120 triction enzyme recognition site changes and flanking primers for all SNPs and Indels in a user-defin
122 ns revealed twelve-fold symmetry, concentric flanking protrusions, and a central electron density.
123 Interestingly, the inversions are nested or flanking rather than coinciding with the deletion or dup
125 in rat corticostriatal brain slices, either flanking region alone sufficed to generate a neurotoxic
126 binding site accessibility, as determined by flanking region AU content, could fully explain the disc
128 e, a distinct substitution in the N-terminal flanking region located 5 residues upstream of the epito
131 s using deletion constructs of a proximal 5'-flanking region of miR-98 did not reveal a hypoxia-respo
134 putative regulatory sequence in the ULK1 5'-flanking region, the mutation of which increased ULK1 pr
136 proven by the characterization of transgene flanking regions and the combinations of elements that a
137 ying this approach to 17 microRNAs and their flanking regions and with a reporter for miR-142 activit
138 deletions encompassing the NF1 gene and its flanking regions belong to the group of genomic disorder
139 CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC
140 ns are enriched for long DNA repeats and the flanking regions have high alignment scores, suggesting
142 PL35a and RPL23, and ferredoxin, FDX1, whose flanking regions including promoters, terminators and un
143 Hippocampal cis-meQTL-CpGs are enriched in flanking regions of active promoters, CpG island shores,
146 Statistical machine learning revealed that flanking regions of putative DIMM binding sites contribu
148 in vivo to the pre-rRNA and to U3 sequences flanking regions that base-pair to the pre-rRNA includin
149 were collapsed across CpG islands and their flanking regions to identify variants collectively assoc
150 e generally hypomethylated relative to their flanking regions, and the binding of some transcription
161 ich lines the anesthetic-binding cavity, its flanking residues (132 to 140), and Leu-122, a pore-gati
163 nsive mutagenesis revealed the importance of flanking residues within the polyprotein in defining the
167 loading intermediate, when either one of the flanking roadblocks was eliminated, the remaining roadbl
170 gene expression, and the amount of conserved flanking sequence all correlate with retention rates.
171 e that Cas13b has a double-sided protospacer-flanking sequence and elucidate RNA secondary structure
172 ng G is not strictly required, but increased flanking sequence GC content correlates with higher inse
173 unction by DNA silencing and utilize similar flanking sequence information (PAMs) to identify invader
175 e euchromatic coordinates and identified the flanking sequence of breakpoints in heterochromatic regi
177 ene approach based on genome position of the flanking sequence of the insertional mutant CAL027_01_20
178 ragment sequence to the published SULT1C3 5'-flanking sequence revealed an 863-nt deletion (nt -146 t
181 ctual ratios for each combination of peptide/flanking sequence were measured with a multiple reaction
183 cy is also influenced by the element and its flanking sequences (i.e., small elements are more compet
187 erfering RNAs were enriched in the 5' and 3' flanking sequences of nonadditively expressed genes in t
188 a values predicted from structures, although flanking sequences of S-palmitoylated sites are enriched
189 key components of miRNA stem loops and their flanking sequences on the efficiency of mature miRNA exp
191 target and non-target demonstrated that the flanking sequences provided the specificity for enhanced
193 develops a general approach for identifying flanking sequences that can be used to drive transgene e
197 ighly expressed genes in Chlamydomonas whose flanking sequences were tested for the ability to drive
198 es in relation to genes and their associated flanking sequences, we reveal that, in normal cells, gen
199 Moreover, we identified elements of core and flanking sequences, which are of critical importance for
200 e focused on assessing the length of natural flanking sequences, which surround each peptide included
203 Here we found that unpaired DNA nucleotides flanking short base-paired DNA stretches, as in stem-loo
204 show a significant correlation with loss of flanking siRNAs, but we identified one gene supporting e
205 K1, subsequent slower phosphorylation of the flanking sites results in inhibition of the kinase.
206 ocus in detail and, by using imputation from flanking SNP genotype data, shows that it affects blood
210 thogens and whose activity is repressed by a flanking substrate-binding leucine-rich repeat (LRR) dom
211 A protospacer adjacent motif (PAM) sequence flanking target DNA is crucial for self versus foreign d
215 ated the phasing of these deletions with the flanking tens of thousands of heterozygous SNPs and inde
216 mers, with a pair of C-terminal domains from flanking tetramers completing the synaptic interface.
219 high coverage genomes and find that regions flanking the amylase locus show notable depression of ge
220 el conformation, suggesting that the residue flanking the amyloidogenic peptide contributes to the st
221 s tandem array, and heterozygous for markers flanking the array, we measured interhomolog recombinati
222 "sensory motif" and two loops, RL1 and RL2, flanking the ATP-binding site playing a significant role
223 te NLS at the N terminus of large terminase, flanking the ATPase domain, that is conserved only in al
224 es circRNA biogenesis by binding the introns flanking the back-splicing junctions and that this contr
228 We found that the density of SNPs/indels flanking the breakpoints of deletions (in-phase variants
229 electronic variation of the aromatic groups flanking the C horizontal lineO of the cyclopentadienone
230 with the dipole of the acceptor substituent flanking the carbene center being the major selectivity
231 ssure due to substituents on the heteroatoms flanking the carbene center, as well as inductive electr
232 We also found that the C-terminal extension flanking the catalytic core of Dbp4 plays an important r
233 ements, which are 5-15 amino acid extensions flanking the central PXXP motif for high affinity bindin
236 brane domain; the four transmembrane helices flanking the channel lumen alone seem to determine the p
237 perfect cyclin-dependent kinase (Cdk) sites flanking the CHD promotes actin ring formation, using si
239 The specificity of AR extends to the regions flanking the core 15-bp site, where isothermal calorimet
240 on the sequence or DNA shape of the regions flanking the core binding site are highly predictive of
241 Here we show that the nucleotides directly flanking the core-binding site, differ depending on the
243 ing affinity is greatly enhanced by residues flanking the crystallographically-defined recognition mo
244 catalyst 1, containing trimethylsilyl groups flanking the cyclopentadienone ketone, gave the best res
245 , two copies of a 146-bp direct repeat motif flanking the deleted region were found in the self-ferti
246 required for the binding of BRCA1 to regions flanking the DSB, whereas BRCA1 binding directly to DNA
247 the same morphology, with negative curvature flanking the edges and with no visible protein structure
250 eotides complementing the 5'- and 3'-regions flanking the G4 have been connected by an abasic linker
255 ver, the analysis of the enhancer landscapes flanking the HoxD cluster reveals that the bimodal regul
258 with a clear preference for the nucleotides flanking the integration site at the leader-repeat 1 bou
259 ntified sequences cover most of the sequence flanking the junction between the bacterial and human DN
260 Binding of an antibody to epitope sequences flanking the linker disrupts the interaction between the
261 We have identified two CTCF binding sites flanking the locus and two associated with a super-enhan
262 parasubiculum appears as a linear structure flanking the medial entorhinal cortex mediodorsally.
263 t maintaining longer, poly-A-containing arms flanking the miRNA stem-loop markedly enhanced transgeni
264 endonucleases coupled with paired guide RNAs flanking the mutated Dmd exon23 resulted in excision of
265 the Neurexin2 AS4 exon, compared with those flanking the Neurexin1 and Neurexin3 AS4 exons under joi
266 hylated in liver tumors at CpG dinucleotides flanking the NF-kappaB-binding sequence, supporting that
267 flexibility to wedge the RCC1 beta-propeller flanking the NLS against its lateral surface, preventing
268 sliding has been shown to depend on the DNA flanking the nucleosome, transcription factor binding at
274 omic microarray chips covering about 8000 bp flanking the predicted transcription start sites in Xeno
280 tes with the levels of histone crotonylation flanking the regulatory elements of activated genes.
281 ation and activity are mediated by sequences flanking the RNA-binding domain that bind specific molec
283 n target pri-miRNAs, including the sequences flanking the stem-loop region, contributed to high affin
285 of a short protospacer adjacent motif (PAM) flanking the target site, and subsequent R-loop formatio
288 e promoter elements, which are DNA sequences flanking the transcription start site (TSS) that help di
290 oprotein regions embedded in and immediately flanking the viral membrane dictate active incorporation
294 eases because they suggest that the residues flanking these repetitive sequences may represent viable
297 ntain a nuclear localization signal sequence flanking to the K1 segment and a novel conserved region
298 based on liberation of sgRNAs by processing flanking tRNAs, permits highly efficient multiplexing of
299 ation-the addition of subsidiary cells (SCs) flanking two dumbbell-shaped guard cells (GCs)-is linked
300 gene conversion-like mechanism that employs flanking variable leucine-rich repeat sequences as templ
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