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1 ce of CGC motifs in Box D and its downstream flanking region.
2 mutants with T-DNA insertions in the FLDH 5' flanking region.
3 smids containing fragments of the SULT1C3 5'-flanking region.
4 05 (M67V) in exon 3 and rs11579627 in the 3' flanking region.
5 an BORIS expression, we characterized its 5'-flanking region.
6 plicing variants while characterizing its 5'-flanking region.
7 factors (e.g. AP-1 and NF-kappaB) to its 5'-flanking region.
8 gment contains the small fragment and the 5'-flanking region.
9 c5 gene along with 787 nucleotides of the 5'-flanking region.
10 acting elements found within the proximal 5'-flanking region.
11 e, we aimed to clone and characterize its 5'-flanking region.
12 on-canonical E box sequence CACGCG in the 5'-flanking region.
13 nctional allele to a 100-bp window in the 5'-flanking region.
14 ing from both within the G4 motifs and their flanking regions.
15 to recognize different DNA sequences in the flanking regions.
16 incidence of cryptic repetitive DNA in their flanking regions.
17 eported SNPs at r2 > 0.8 across RETN and its flanking regions.
18 NA substrate with subsequent ligation of the flanking regions.
19 controlled by at least three separable gene-flanking regions.
20 l-length human MYOCILIN (MYOC) gene and long flanking regions.
21 sin, may form a less stable coiled-coil than flanking regions.
22 aining the human GNLY gene and its 5' and 3' flanking regions.
23 leavage sites engineered into signal peptide flanking regions.
24 motifs with highly diverged "non-alignable" flanking regions.
25 known sequence region to its uncharacterized flanking regions.
26 ing the full-length mouse Myoc gene and long flanking regions.
27 babilities of folding for different sizes of flanking regions.
28 ias precisely at the border between CNEs and flanking regions.
29 ar between the recombination-free region and flanking regions.
30 version with partially similar but unrelated flanking regions.
31 composition within CNEs with their 5' and 3' flanking regions.
32 igh read coverage over the targets and their flanking regions.
33 ll as the bending and twisting rigidities of flanking regions.
34 ocus sequencing resources on genes and their flanking regions.
35 signals that distinguish peak sequences from flanking regions.
36 ferent conservation levels relative to their flanking regions.
37 tural accessibility of the binding sites and flanking regions.
38 otein expression via the MLL CXXC domain and flanking regions.
39 pri-mir-16 variants bearing single-stranded flanking regions.
40 include 70-nucleotide hairpins with unpaired flanking regions.
41 resequence NPR3 exons, splice junctions, and flanking regions.
42 et cleavage by AGO3 requires both 5'- and 3'-flanking regions.
43 have significantly lower density compared to flanking regions.
44 le nucleotide polymorphism (SNP) panels from flanking regions.
45 sequences, e.g. promoter, telomeric and gene flanking regions.
46 ss dense spacing (one SNP per 50 kb) for the flanking regions (117.7-126.6 and 160.2-167.5 MB) and ge
47 ficial chromosome containing 68 kb of the 5'-flanking region, 45 kb of the coding sequence, and 53 kb
49 not identified at either the 5' and 3' HMGCR flanking regions (+/-5000 bps) or at negative control ge
50 g the entire human IGF-I gene and a large 5'-flanking region, a approximately 700-bp DNA region appro
51 in rat corticostriatal brain slices, either flanking region alone sufficed to generate a neurotoxic
54 ach allows to rapidly identify the transgene flanking region and can easily be implemented by the enf
55 icity to DNA junctions possessing a 5'-ssDNA flanking region and can initiate translocation from this
56 unctional C/EBP binding site in the Gfi-1 5'-flanking region and enhances the promoter activity of Gf
57 Expression of the antisense variable region/flanking region and the S-region transcripts were found
59 ssion of reporter gene constructs for the 5'-flanking region and the variable number of tandem repeat
62 c clones, containing the complete locus plus flanking regions and permit seamless insertion of the re
63 "beta-hairpin" are needed to melt the origin-flanking regions and that the T-ag helicase domain selec
64 proven by the characterization of transgene flanking regions and the combinations of elements that a
65 ying this approach to 17 microRNAs and their flanking regions and with a reporter for miR-142 activit
66 en systematically reduced the size of the 5' flanking region, and determined that the nt-339 to nt-39
67 f DNase I hypersensitive sites within the 5' flanking region, and identified a candidate Igh regulato
68 the transcriptional level, we probed its 5'-flanking region, and we report here the identification o
69 3' ends, it was detected within genes and 3'-flanking regions, and Cdk7 inhibition delayed pausing an
70 e generally hypomethylated relative to their flanking regions, and the binding of some transcription
72 howed that the Ser74-Gly75 dipeptide and its flanking regions are highly conserved among a wide range
76 ious work identified the E2F1 marked box and flanking region as critical for the specificity in E2F1
77 CG repeats along with varying extents of DNA flanking regions as well as very small mutations includi
78 binding site accessibility, as determined by flanking region AU content, could fully explain the disc
80 deletions encompassing the NF1 gene and its flanking regions belong to the group of genomic disorder
83 hat changes in the C-terminus of the peptide-flanking region can substantially alter T-cell receptor
84 human triplet repeats and their surrounding flanking regions can be used to produce a cost-effective
85 in their carboxyl-termini, which with their flanking regions constitute a functional Polo-box domain
88 minal turn-helix-turn motif and a C-terminal flanking region containing an amphipathic Jalpha helix.
90 tional regulation of the psiBCH gene, its 5'-flanking region containing the putative promoter was fus
91 ealed that the proximal 1.4 kb of the 5'-end-flanking regions containing several consensus motifs was
94 of the extended smooth muscle alpha-actin 5'-flanking region demonstrated that assembly of the nucleo
98 cessibility increase and spread to genic and flanking regions due to destabilization of the histone d
100 ne lactoferrin gene, containing 4.4 kb of 5' flanking region, exon 1, intron 1, and exon 2, was isola
101 otated the human gene and resequenced its 5'-flanking region, exons, and splice junctions using 60 DN
102 ) promoter transcriptionally regulated by 5' flanking region extending 16 kb upstream that contains c
106 CR1 retrotranspositions were used to examine flanking regions for GC content and nucleotide bias at t
107 CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC
108 3RSS that reduces the distance between these flanking regions from >160 A in the linear substrate to
109 aracterized, together with an additional 270 flanking regions from one side alone, from a diverse col
112 s reporter gene demonstrated that the E1A 5'-flanking region had promoter activity, which contains mu
114 ns are enriched for long DNA repeats and the flanking regions have high alignment scores, suggesting
116 , CRMs are significantly more conserved than flanking regions, hence, bearing the signatures for puri
117 ion of cDNA ends) analyses of the 5' genomic flanking region identified eight conserved HuD leader ex
118 ISs, we aligned transposase genes and their flanking regions; identified the ISs' possible terminal
121 xamined sequences of the Pi-ta locus and its flanking regions in 159 accessions composed of seven AA
122 compared with other guanine residues of the flanking regions in both in vitro and in vivo footprinti
126 g of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations m
127 PL35a and RPL23, and ferredoxin, FDX1, whose flanking regions including promoters, terminators and un
128 er constructs containing deletions in the 5' flanking region, including a 94 bp promoter that lacks a
129 rized a 4868bp fragment of the human MAPT 5'-flanking region, including the core promoter region (-30
130 ed that Elf3 amino acid residues within this flanking region, including Trp361, are important for the
131 he microsatellite, base substitutions in the flanking regions, indels in the flanking regions, multip
132 from plasmids with the observed noncanonical flanking regions, indicating that piggyBac could generat
133 ng sequential 5'deletion constructs of the 5'flanking region into NIH/3T3, M12.4, and RAW264.7 cells.
136 ration of the conserved elements in ITS2 and flanking regions, it appears that there are three major
138 e, a distinct substitution in the N-terminal flanking region located 5 residues upstream of the epito
139 tochondrial genomes with a variation in gene flanking regions make S. vulgaris an excellent model for
141 tions in the flanking regions, indels in the flanking regions, multiple microsatellites within a frag
143 he full-length Hztransib inserts into the 5'-flanking region of a xenobiotic-metabolizing P450 gene C
144 an increase of H3K4me2 and H3K4me3 in the 5' flanking region of an active var locus and expand on an
145 that modification of the C-terminal peptide-flanking region of an influenza hemagglutinin (HA(305-32
147 on between PBC and rs231725, a SNP in the 3' flanking region of CTLA4 located outside of the area pre
150 nked SNPs (rs6493497 and rs7176005 in the 5'-flanking region of CYP19 exon 1.1) that were significant
151 ion of this important P450, we cloned the 5'-flanking region of CYP2C8 and investigated its transcrip
152 ut cell line, it does not insert into the 5'-flanking region of CYP6B8 in the laboratory strain.
153 e sequence containing C-6530>G SNP in the 5' flanking region of ERCC6 from Sp1 on the C allele to SP1
154 paB binding motifs were identified on the 5' flanking region of exon 1b of the human L-type calcium c
156 All exons, splice junctions, and the 5'-flanking region of GSTP1 were resequenced using 60 DNA s
158 this STAT5-binding site-containing distal 5'-flanking region of IGF-I gene may be an enhancer mediati
160 and rs6835457 located in the 3'-untranslated flanking region of IL21 (odds ratio 1.11 [95% confidence
161 regulatory enhancer element found in the 5' flanking region of many phase II detoxification enzymes.
162 micro-RNA target sequence in the downstream flanking region of MC4R as a strong, probable functional
163 s using deletion constructs of a proximal 5'-flanking region of miR-98 did not reveal a hypoxia-respo
164 regulated, we isolated and sequenced the 5'-flanking region of mouse caspase-12 gene by a PCR-mediat
167 33 base pairs of upstream sequence of the 5'-flanking region of mVGLUT2 complementary DNA was cloned.
168 response to 7-ketocholesterol within the 5'-flanking region of profilin-1 was dependent on a single
174 tructural association between the N-terminal flanking region of the A1 domain (amino acids Gln(1238)-
175 ence, Gln(1238)-Glu(1260), in the N-terminal flanking region of the A1 domain, together with the asso
176 A detailed analysis of the 14-kb long 5'-flanking region of the ACT gene indicated the presence o
180 Here, we examined the sequence of the 5'-flanking region of the BCRP gene and found a putative es
182 ns, the promoter region, and 60 bp of the 3' flanking region of the canine FGFR3 gene were sequenced
183 trol chicken EF-2 gene transcription, the 5'-flanking region of the chicken EF-2 promoter was analyze
185 defined nucleotide sequence in the distal 3' flanking region of the CP27 proximal promoter CCAAT box.
188 e determined that another CpG site in the 5'-flanking region of the Fgf-1.A isoform was also methylat
192 putative NFI and AP-1 elements within the 5'-flanking region of the GFAP gene also diminished basal e
193 of the coding sequence, and 53 kb of the 3'-flanking region of the hAT1R gene was employed to genera
196 naturally occurring polymorphisms in the 5' flanking region of the human angiotensinogen (AGT) gene,
197 ing to the NF-kappaB motif present in the 5' flanking region of the human IFN-gammaR2 promoter that w
198 ts using a reporter vector containing the 5'-flanking region of the human IL-1beta gene revealed that
200 We recently demonstrated that the 3-kb 5'-flanking region of the human ROBO4 gene directs endothel
204 e beta cell, areas of identity within the 5' flanking region of the mouse, human, and rat mafA genes
206 nstructs driven by the approximately 5 kb 5'-flanking region of the murine SerpinB2 gene and several
207 esponse element (CRE)-like element in the 5'-flanking region of the MuSK gene binds to CREB1 (CRE-bin
208 results indicate that a variation in the 5' flanking region of the myostatin gene is associated with
209 Loss of repressive activity within the 5' flanking region of the NK1 partly accounts for constitut
210 ors containing different fragments of the 5'-flanking region of the Pde3b gene, we identified a dista
212 e Sp3 promoter, we isolated 2.1 kb of the 5'-flanking region of the Sp3 gene, which contains Sp1/Sp3
216 the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the
219 pping we interrogated SNPs within +/- 250 kb flanking regions of 14 previously reported index SNPs fr
220 . populations, by resequencing the exons and flanking regions of 3,873 genes in 154 chromosomes from
221 Hippocampal cis-meQTL-CpGs are enriched in flanking regions of active promoters, CpG island shores,
222 in the sequences with low CpG density in the flanking regions of Alu repeats, rather than within the
224 orms of OI, we sequenced the coding and exon-flanking regions of COL1A1 and COL1A2 in a cohort of 63
225 agen I polymerized without telopeptides (the flanking regions of collagen molecules) can differential
226 lymorphisms (SNPs) located in the coding and flanking regions of ENPP1 were genotyped in 577 African-
228 actors have putative binding sites in the 5'-flanking regions of genes coding for the channel protein
231 EC2 specifically binds RY motifs from the 5' flanking regions of LEC2-induced genes provides strong e
232 in and displacement of the N- and C-terminal flanking regions of LOV2 (404-546), both of which consti
234 eural network), and given input of symmetric flanking regions of N-terminus and C-terminus half-cysti
238 Statistical machine learning revealed that flanking regions of putative DIMM binding sites contribu
240 searched for ChoRE-like sequences in the 5'-flanking regions of several genes that responded rapidly
241 ng cis-acting regulatory sequences in the 5' flanking regions of Snai1 and Wnt4, thereby inhibiting d
243 intly estimating dates of recombination from flanking regions of the breakpoint and further illustrat
245 ng the physical interaction of the 5' and 3' flanking regions of the FLC locus using chromosome confo
247 into consideration the weak signals from the flanking regions of the motifs; and (iv) analyze co-occu
248 p to 1 kb past the poly(A) sites into the 3' flanking regions of the nematode genes before it termina
249 tion indicating that charged residues in the flanking regions of the peptide are not the major determ
251 ds to increase with the genome size; (c) the flanking regions of the recently active IS elements are
252 the C-terminal alpha-helix and two immediate flanking regions of the S-loop of the SDH molecule.
253 GC content in conversion tracts compared to flanking regions of the same genes nor in conversion tra
254 scovered elements are likely to exist in the flanking regions of this and other functional RNAs, and
256 earch for a genetic modifier within POLG and flanking regions potentially involved in the regulation
258 A central question is whether and how these flanking regions regulate ATP hydrolysis or the coupling
260 duplication CNVs into their transcribed and flanking regions, respectively, supporting a role for tr
263 tionary context of the less rapidly evolving flanking regions, revealing the complexities of the muta
264 hese maturation RNAs all possess in their 5' flanking regions RY motifs, DNA elements bound by other
265 Analysis of a 1.8 kb fragment of the 5'-flanking region showed that the classical TATA-box motif
266 in class II epitopes was not different from flanking regions, so CD4 T cells rarely exert selection
268 ands and 5' CAGE tags mapped in the upstream flanking region surrounding the precursor miRNA (pre-miR
269 ed 3' and/or 5' single-stranded (ss)-(dT)(n) flanking regions (tails) (n ranging from zero to 20 nt)
270 recognition, but escape mutations arising in flanking regions that alter antigen processing have not
271 consists of 11 tandem HAT repeats and short flanking regions that are also predicted to form helical
272 in vivo to the pre-rRNA and to U3 sequences flanking regions that base-pair to the pre-rRNA includin
274 distinguish recombination-free regions from flanking regions that recombine suggest that recombinati
276 single HMG box, as well as basic and acidic flanking regions that vary greatly in length and charge.
277 putative regulatory sequence in the ULK1 5'-flanking region, the mutation of which increased ULK1 pr
278 al region was reversed with respect to these flanking regions, the origin was still able to replicate
280 were collapsed across CpG islands and their flanking regions to identify variants collectively assoc
281 Bioinformatic analyses of the human RPGR 5'-flanking region uncovered potential transcription factor
283 ells through transcription control in the 5'-flanking region upstream from the Pax6 P0 promoter.
284 gene and the other targeting a hypervariable flanking region upstream of the 16S rRNA gene, are compl
286 enes drop away quite rapidly in the external flanking regions (upstream of the 5' paralog and downstr
289 solated promoter is functional, 4.4 kb of 5' flanking region was inserted upstream from the firefly l
290 rter construct containing 120 kb of RANKL 5'-flanking region was stimulated by dibutyryl-cAMP in stro
291 In silico PCR analysis based on conserved flanking regions was also used to interrogate hotspots i
293 entire Ctcf-bounded Wnt4 locus, but not the flanking regions; we term this mode of action "chromatin
294 reveals that it also has enhancers in the 3' flanking region which contain RAREs and have the potenti
296 ce revealed the putative lpm cluster and its flanking regions which harbor 43 open reading frames.
297 we present the first survey of promoter (5'-flanking) regions, which are rich in cis-regulatory sequ
299 bp duplex with a 3'-(dT(20)) single-stranded flanking region, with apparent affinity in the micromola
300 y proteins that bind the E2F1 marked box and flanking regions, with a potential role in E2F1 apoptosi
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