1 g is not channeled to the subsequent enzyme,
flap endonuclease 1.
2 or recombination that may overlap with human
flap endonuclease-1.
3 Addition of
Flap endonuclease-1,
a nuclease known to remove 5' overh
4 The role of human FEN1 (
flap endonuclease-1),
an RTH1 (RAD two homolog-1) class
5 e with a 5'- and 3'-flap that was cleaved by
flap endonuclease 1 and a 3'-5' endonuclease Mus81/Eme1,
6 o profoundly altered PCNA's interaction with
Flap endonuclease 1 and DNA Ligase 1, DNA metabolism enz
7 these processes, acting in conjunction with
flap endonuclease 1 and replication protein A in DNA lag
8 ses, apurinic/aprymidinic endonuclease 1 and
flap endonuclease 1 and several other factors involved i
9 ion of Okazaki fragments escapes cleavage by
flap endonuclease-1 and anneals to a complementary ectop
10 of the related RAD2 family nucleases, FEN1 (
Flap endonuclease 1)
and EXO1 (exonuclease 1), on substr
11 provide strand displacement synthesis, human
flap endonuclease 1,
and human DNA ligase I.
12 Finally, a combination of HIV-1 RT,
Flap endonuclease-1,
and DNA ligase is capable of quanti
13 Treatment of extracts with
flap endonuclease 1 antiserum significantly reduced MHEJ
14 ivity of HEX1-N2 is similar to that of human
flap endonuclease-1,
both in terms of turnover efficienc
15 sion repair proteins DNA polymerase beta and
flap endonuclease-1 by 4-6-fold.
16 pt annealing at the ectopic site and promote
flap endonuclease-1 cleavage.
17 This resembles the mechanism of
flap endonuclease 1,
consistent with cooperation of thes
18 lymerase-1 (PARP-1) and the BER participants
flap endonuclease-1,
DNA polymerase beta, and apurinic/a
19 substrate recognition and specificity of the
flap endonuclease-1 enzymes.
20 Bacteriophage T4 RNase H, a
flap endonuclease-1 family nuclease, removes RNA primers
21 This is the first structure of a
flap endonuclease-1 family protein with its complete bra
22 acts with DNA polymerase beta (Pol-beta) and
flap endonuclease 1 (
Fen-1) and blocks Pol-beta-directed
23 replication proteins, including the enzymes
flap endonuclease 1 (
FEN-1) and DNA ligase I that comple
24 ociation of condensin I with the BER factors
flap endonuclease 1 (
FEN-1) and DNA polymerase delta/eps
25 The interaction between
flap endonuclease 1 (
FEN-1) and proliferation cell nucle
26 approach has been demonstrated that utilizes
flap endonuclease 1 (
FEN-1) fused to the Fok1 endonuclea
27 helicase-endonuclease that participates with
flap endonuclease 1 (
FEN-1) in Okazaki fragment processi
28 Human
flap endonuclease 1 (
FEN-1) is a member of the structure
29 PCNA binds to
flap endonuclease 1 (
FEN-1), a structure-specific endonu
30 ases is with the structure-specific nuclease
Flap Endonuclease 1 (
FEN-1), an enzyme that is implicate
31 Here we show that NEIL1 interacts with
flap endonuclease 1 (
FEN-1), an essential component of t
32 lly bound DNA polymerase beta (Pol beta) and
flap endonuclease 1 (
FEN-1).
33 a protein domain of WRN which interacts with
flap endonuclease 1 (
FEN-1).
34 A and provides binding sites for polymerase,
flap endonuclease-1 (
FEN-1) and ligase during DNA replic
35 Flap EndoNuclease-1 (
FEN-1) and the processivity factor
36 replication protein A (RPA), which inhibits
flap endonuclease-1 (
FEN-1) but stimulates Dna2 nuclease
37 y transfer (FRET) analyses show that WRN and
Flap Endonuclease-1 (
FEN-1) form a complex in vivo that
38 Flap endonuclease-1 (
FEN-1) is a critical enzyme for DNA
39 Human
flap endonuclease-1 (
FEN-1) is a member of the structure
40 Human
flap endonuclease-1 (
FEN-1) is a member of the structure
41 Flap endonuclease-1 (
FEN-1) is a multifunctional and str
42 Human
flap endonuclease-1 (
FEN-1) is a structure-specific endo
43 Mammalian
flap endonuclease-1 (
FEN-1) is a structure-specific meta
44 Flap endonuclease-1 (
FEN-1) is a structure-specific nucl
45 termediates in DNA replication and repair by
flap endonuclease-1 (
FEN-1) is essential for mammalian g
46 a Caenorhabditis elegans homologue of human
flap endonuclease-1 (
FEN-1) that is normally involved in
47 Human
flap endonuclease-1 (
Fen-1) was examined for its ability
48 Flap endonuclease-1 (
FEN-1), a 43-kDa protein, is a stru
49 rimidinic endonuclease, DNA polymerase beta,
flap endonuclease-1 (
FEN-1), and PARP-1.
50 olog-1 (RTH-1) class nuclease, also known as
flap endonuclease-1 (
FEN-1).
51 ivities of DNA polymerase delta (Pol delta),
flap endonuclease 1 (
FEN1) and DNA ligase I (Lig1).
52 Flap endonuclease 1 (
FEN1) and Dna2 are responsible for
53 Flap endonuclease 1 (
FEN1) and Dna2 endonuclease/helicas
54 Flap endonuclease 1 (
Fen1) and exonuclease 1 (Exo1) have
55 Human
flap endonuclease 1 (
FEN1) and related structure-specifi
56 This flap structure was cleaved by
flap endonuclease 1 (
Fen1) and the resultant nick was li
57 onuclease 1 (APE1) physically interacts with
flap endonuclease 1 (
FEN1) and with proliferating cell n
58 DNA polymerase beta (pol beta) and
flap endonuclease 1 (
FEN1) are key players in pol beta-m
59 The Dna2 helicase/nuclease and then
flap endonuclease 1 (
FEN1) are proposed to act sequentia
60 Dna2 nuclease/helicase and
flap endonuclease 1 (
FEN1) are proposed to cleave the fl
61 Flap endonuclease 1 (
FEN1) cleaved the displaced downstr
62 uted with purified enzymes demonstrated that
Flap endonuclease 1 (
FEN1) efficiently excises a displac
63 AMP-dRP group through its lyase activity and
flap endonuclease 1 (
FEN1) excises the 5'-AMP-dRP group
64 The structure-specific endonuclease
flap endonuclease 1 (
FEN1) has also been suggested to be
65 Flap endonuclease 1 (
FEN1) is a central component of Oka
66 Flap endonuclease 1 (
Fen1) is a highly conserved structu
67 Flap endonuclease 1 (
FEN1) is a protein that plays a rol
68 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
69 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
70 Flap endonuclease 1 (
FEN1) is a structure-specific nucle
71 5'-
Flap endonuclease 1 (
Fen1) is an important enzyme involv
72 We identify that the
flap endonuclease 1 (
FEN1) is one of the interacting pro
73 that the DNA replication and repair protein
Flap endonuclease 1 (
FEN1) is required for replication o
74 DNA replication and repair enzyme
Flap Endonuclease 1 (
FEN1) is vital for genome integrity
75 Flap endonuclease 1 (
FEN1) participates in removal of RN
76 Flap endonuclease 1 (
FEN1) phosphorylation is proposed t
77 Flap endonuclease 1 (
FEN1) plays a crucial role in both
78 Flap Endonuclease 1 (
FEN1) plays important roles both in
79 nuclease 1 (FAN1), exonuclease 1 (EXO1), and
flap endonuclease 1 (
FEN1) process a substrate reminisce
80 Flap endonuclease 1 (
FEN1) processes Okazaki fragments i
81 Flap endonuclease 1 (
FEN1) proteins, which are present i
82 nent in the maturation of Okazaki fragments,
flap endonuclease 1 (
FEN1) removes the 5'-flap and maint
83 In one model for this process, the
flap endonuclease 1 (
FEN1) removes the iRNA.
84 s in concert with alternate flap cleavage by
flap endonuclease 1 (
FEN1) to mediate CAG repeat expansi
85 s derived from Xenopus laevis, we found that
flap endonuclease 1 (
FEN1) was a factor responsible for
86 Recently,
Flap endonuclease 1 (
FEN1) was shown to contribute to te
87 Most flaps are cleaved by
flap endonuclease 1 (
FEN1) while short, and the remainin
88 Here, we demonstrate that
flap endonuclease 1 (
FEN1), a canonical lagging strand D
89 Human
flap endonuclease 1 (
FEN1), an essential DNA replication
90 Polymorphisms and somatic mutations in
Flap Endonuclease 1 (
FEN1), an essential enzyme involved
91 se 1 (APE1), DNA polymerase beta (pol beta),
flap endonuclease 1 (
FEN1), and DNA ligase I (LigI).
92 n genes involved in DNA replication, such as
flap endonuclease 1 (
FEN1), can cause single-stranded DN
93 p21 disrupts PCNA-directed stimulation of
flap endonuclease 1 (
FEN1), DNA ligase I, and DNA polyme
94 AP endonuclease, replication factor C, PCNA,
flap endonuclease 1 (
FEN1), DNA polymerase delta, and DN
95 Flap endonuclease 1 (
Fen1), has an endonuclease activity
96 In most cases, the flap was removed by
flap endonuclease 1 (
FEN1), in a reaction required to re
97 Flap endonuclease 1 (
FEN1), involved in the joining of O
98 d cancer avoidance of the structure-specific
flap endonuclease 1 (
FEN1), its cellular compartmentaliz
99 , which is removed by the structure-specific
flap endonuclease 1 (
FEN1), leaving a nick for ligation.
100 is via long-patch BER (LP-BER) dependent on
flap endonuclease 1 (
FEN1), not previously known to be p
101 and handoff of DNA-editing enzymes, such as
flap endonuclease 1 (
FEN1), with sliding clamps are key
102 brogated two of three nuclease activities of
flap endonuclease 1 (
FEN1).
103 age of the flap by Dna2 nuclease followed by
flap endonuclease 1 (
FEN1).
104 he primer into a flap that is cleaved off by
flap endonuclease 1 (
FEN1).
105 Flap endonuclease-1 (
FEN1) belongs to the Rad2 family of
106 Flap endonuclease-1 (
FEN1) is a multifunctional, structu
107 Flap endonuclease-1 (
FEN1) is proposed to participate in
108 The prototypical 5'-nuclease,
flap endonuclease-1 (
FEN1), catalyzes the essential remo
109 cture- and strand-specific phosphodiesterase
flap endonuclease-1 (
FEN1), the prototypical 5'-nuclease
110 isomer of RECQL5, RECQL5beta, with the human
flap endonuclease 1,
FEN1, which plays a critical role i
111 Human
flap endonuclease 1 (
h-FEN1) mutations have dramatic eff
112 ase/endonuclease, called RAD2 homologue 1 or
flap endonuclease 1,
has a unique cleavage activity, dep
113 Interaction between human
flap endonuclease-1 (
hFEN-1) and proliferating cell nucl
114 Human
flap endonuclease-1 (
hFEN-1) is highly homologous to hum
115 Human
flap endonuclease-1 (
hFEN1) catalyzes the essential remo
116 cates a back-up function of exonuclease 1 to
flap endonuclease-1 in RNA primer removal during lagging
117 In most cases, FEN1 (
flap endonuclease 1)
is able to efficiently cleave short
118 long flap (20 nucleotides) by M. acetivorans
flap endonuclease 1 (
MacFEN1).
119 Instead,
flap endonuclease 1 must recognize and bind to the inter
120 Flap endonuclease-1 or FEN-1 is a structure-specific and
121 es lacking genes encoding the orthologues of
flap endonuclease-1,
PCNA, and MutS.
122 Until cleaved by FEN1 (
flap endonuclease 1),
such flaps can initiate homologous
123 We further demonstrate that hDNA2 and
flap endonuclease 1 synergistically process intermediate
124 Coordinating with
flap endonuclease 1,
the APE1 3'-5' exonuclease activity
125 a long flap that was efficiently cleaved by
flap endonuclease 1,
thereby leading to repeat deletion.
126 Flap endonuclease 1,
which preferentially cleaves unanne
127 ssed by DNA polymerase beta and processed by
flap endonuclease 1 with different efficiency.
128 beled the eukaryotic DNA replication protein
flap endonuclease 1 with mKikGR and added it to replicat