ライフサイエンスコーパス: flexible region

1 are consistent with a more conformationally flexible region.

2 Trp(195), indicating the former is in a more flexible region.

3 mains of different sizes loosely linked by a flexible region.

4 ices, separated by a well-defined turn and a flexible region.

5 its complex architecture and multiple highly flexible regions.

6 tructural changes due to crowding except for flexible regions.

7 er large protein complexes with unstructured flexible regions.

8 ic characteristics compared to disordered or flexible regions.

9 tely disordered or possess long structurally flexible regions.

10 collagen molecule to the stretching of less flexible regions.

11 thorhombic crystal (0.97 A) revealed several flexible regions.

12 ombin-2 showed a similar distribution of the flexible regions.

13 that is followed by a 30-residue disordered, flexible region (609-638).

14 These flexible regions also coincide with those regions of Sem

15 aled altered charge density surrounding this flexible region although its position was unaffected.

16 at a three-helix junction constitutes both a flexible region and part of a rigid RNA superhelix.

17 The results reveal flexible regions and concerted global motions of the sub

18 The results identify flexible regions and potential conformational changes in

19 In such cases, the removal of inherently flexible regions and the addition of stabilizing ligands

20 significant differences are observed in the "flexible" region and to a lesser extent in the G-bulged

21 The results indicate that the flexible regions are not critical for SspA function, whe

22 When these flexible regions are unresolvable structurally, computat

23 c surfaces of PrPC and PrPSc identifies this flexible region as a component of the conformational rea

24 ein unfolding, and identify the emergence of flexible regions as unfolding proceeds.

25 similar to that afforded by an interspersed flexible region associated with a (TT).(TT) mispair.

26 The flexible region at the middle of the central helix (Gly9

27 n studies reveal a fifth binding site in the flexible region between the octarepeats and the PrP glob

28 example, when a hydrogen bond forms within a flexible region, both energy and conformational entropy

29 es have been located on a solvent-accessible flexible region by computational analysis of the structu

30 folic acid [1], and why mutations within the flexible region can either abolish or change the species

31 cis autoubiquitination could occur if these flexible regions come in proximity to the E2.

32 Loops in proteins are flexible regions connecting regular secondary structures

33 mere-specific interaction domain linked to a flexible region containing determinants that promiscuous

34 Adjacent to each active site is a flexible region containing three arginines positioned ap

35 nhinging of the N-terminal bundle around two flexible regions containing G39 and G65 to elongate the

36 The presence of flexible regions could allow C-RING1B to bind a variety

37 Two large, flexible regions deduced from the DeltaTm map aligned wi

38 h is fast for use with proteins that contain flexible regions for structure-based drug design.

39 Substituting charged flexible regions from two other proteins for M created v

40 omain of Atg7 (Atg7(NTD)) recruits a unique "flexible region" from Atg3 (Atg3(FR)).

41 mited proteolysis to identify an exposed and flexible region in IAPP monomer.

42 the myosin VI structure has an unfolded and flexible region in the proximal tail which makes such a

43 ation, when combined with the existence of a flexible region in the structure, which takes part in st

44 drolase domains, whilst revealing additional flexible regions in the catalytic site.

45 states of the peripheral stalk and assigned flexible regions in the enzyme.

46 gesting a common distribution of compact and flexible regions in their folding intermediates.

47 Natural proteins can contain flexible regions in their polypeptide chain.

48 76 amino acid residues are disordered; this flexible region is required for optimal activity.

49 xibility of dipeptide sequences found in the flexible regions is about a factor of five higher than t

50 A flexible region, known to interact with cpn60, extends f

51 hannel from Magnetococcus marinus includes a flexible region linking the TM domains to a four-helix c

52 We used an AF-2 flexible region mutant and an AF-2 static region mutant.

53 This conformationally flexible region of gp41 assumes mostly helical conformat

54 ication of the ATG12 binding sequence in the flexible region of human ATG3 and the crystal structure

55 ly that the double mutation L55S/L56S in the flexible region of RhoGDI drastically decreases its affi

56 e occurs within a serine-rich, intrinsically flexible region of TbSP1, does not involve the phospholi

57 ing to backbone 1H-15N NOE results, the most flexible region of the apoprotein, except for the termin

58 correlated with residues located in the most flexible region of the G-loop, the major cytosolic gate

59 e amino terminus is an extended and possibly flexible region of the protein, allowing it to efficient

60 The kinks coincide with a relatively flexible region of the sequence, and this is probably a

61 on the conditions, are separated by a highly flexible region of undefined conformation.

62 significant conformational rearrangements in flexible regions of alpha-bungarotoxin, mainly loops I,

63 RelB-p105 complex formation, all domains and flexible regions of each protein are engaged in the RelB

64 active site cleft where it may interact with flexible regions of Pol II and the general factor TFIIB

65 ECD fragmentation is not limited only to the flexible regions of protein complexes and that regions l

66 ooperative binding interactions in specific, flexible regions of protein structure.

67 ese ILMs might play a functional role in the flexible regions of proteins and in proteins in a non-na

68 are a possible indication of the role of the flexible regions of proteins for the biological function

69 ation about the dynamic behavior of the most flexible regions of proteins.

70 n for structure-based drug design, elucidate flexible regions of the AR LBD, and provide insight as t

71 We consider a method that treats multiple flexible regions of the binding site independently, reco

72 e are due to a change from the stretching of flexible regions of the collagen molecule to the stretch

73 tions, we present the first NMR study on the flexible regions of the E1 component from Escherichia co

74 rameters, indicating that these are the most flexible regions of the molecule.

75 n the trigger loop and bridge helix, the two flexible regions of the Pol II subunit Rpb1 that partici

76 and gamma(t) time-series] were found only in flexible regions of the protein for a few residues which

77 ament, focusing on conformational changes in flexible regions of the troponin I subunit.

78 uggest a critical role for the structurally 'flexible' region of PrP in agent replication and targeti

79 5-Lys404), indicating that this represents a flexible region on the protein surface.

80 in responsible for RNA binding activity by a flexible region on which lie two functionally critical s

81 with hypotheses that envision the linkers as flexible regions, or as looping away from one another, a

82 impossible to identify independent subunits, flexible regions, or hinges simply by visual inspection

83 tures of multidomain proteins, proteins with flexible regions, or protein complexes obtained by X-ray

84 Many structurally flexible regions play important roles in biological proc

85 We conclude that the cytoplasmic domain is a flexible region poised for stabilization by small change

86 Problems with internal flexible regions ranging from one or more loops or hinge

87 steines were introduced at the interfaces of flexible regions remote from the active site.

88 A flexible region (residues 60-85) couples the structured

89 a reveal the beta5-alpha11 loop of PBPA as a flexible region that appears important for acylation and

90 is not attached to F1 suggests that it has a flexible region that can serve as a stator during both A

91 These phosphates lie in an unstructured flexible region that functions as the allosteric effecto

92 ilizes the middle of Tm, resulting in a more flexible region that is important for the cooperative ac

93 ises an autonomous, functionally active, and flexible region that plays a key role in alpha polymer f

94 been found that some assemblies contain long flexible regions that adopt multiple structural conforma

95 Remarkably, apart from minor differences in flexible regions, the backbone tertiary structure of the

96 , the distance and disorder in the protein's flexible regions using TR-FRET and DEER.

97 onstrates that SVHP lacks a conformationally flexible region (V-loop) present in all other villin-typ

98 ailed biophysical studies of the exposed and flexible region, we synthesized three peptides including

99 Replacement of a flexible region with alpha-helical residues (residues 59

100 e the two trefoil domains are connected by a flexible region with the monomer units being at variable

101 Interestingly, a flexible region within the N-terminal domain, which unde

102 We identified a flexible region within the rigid beta-subdomain that giv

103 vide suggestive evidence for the location of flexible regions within 23S rRNA.