ライフサイエンスコーパス: floxuridine

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1 Floxuridine (5-fluorodeoxyuridine, FdUrd), a U.S. Food a

2 nts 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite.

3 um-labile prodrug of the nucleoside analogue floxuridine, a potent antineoplastic drug used in the cl

4 is through other mechanisms (hydroxyurea and floxuridine) also act synergistically with AZT.

5 ates with the phosphorylated 5-FU nucleoside Floxuridine and demonstrated their enhanced activity aga

6 six cycles of hepatic arterial infusion with floxuridine and dexamethasone plus intravenous fluoroura

7 re enrolled onto a phase I protocol with HAI floxuridine and dexamethasone plus systemic chemotherapy

8 combination of hepatic arterial infusion of floxuridine and intravenous fluorouracil improves the ou

9 ition of chemotherapy, such as capecitabine, floxuridine, and vinblastine, may increase the effective

10 its metabolite 5-fluorodeoxyuridine (FdUrd, floxuridine) are chemotherapy agents that are converted

11 Patients received floxuridine at doses previously demonstrated as safe in

12 patients) or postoperative hepatic arterial floxuridine combined with intravenous continuous-infusio

13 dengue virus replication in the presence of floxuridine, consistent with thymidine-less stress trigg

14 CONCLUSION The combination of regional HAI floxuridine/dexamethasone and systemic oxaliplatin and i

15 ) or combined with regional hepatic arterial floxuridine (FUDR) (n = 28).

16 followed by hepatic artery infusion (HAI) of floxuridine (FUDR) alternating with systemic fluorouraci

17 every 2 weeks concurrent with 2 weeks of HAI floxuridine (FUDR) and dexamethasone (Dex) every 28 days

18 biliary toxicity may permit salvage HAI with floxuridine (FUDR) in patients whose liver tumors fail t

19 MTD) of systemic irinotecan (CPT-11) and HAI floxuridine (FUDR) plus dexamethasone (DEX) as combinati

20 efit of adjuvant hepatic arterial infusional floxuridine (HAI-FUDR) in addition to modern systemic ch

21 acil (5-FU) and 5-fluorodeoxyuridine (FdUrd, floxuridine) have activity in multiple tumors, and both

22 delivered concurrently with hepatic arterial floxuridine in 128 patients.

23 ylation facilitates UNG2-dependent repair of floxuridine-induced DNA lesions and promotes tumor cell

24 molecules, we observed that methotrexate and floxuridine inhibited dengue virus infections at low mic

25 control with orally treated Gemcitabine- or Floxuridine-nanogel conjugates.

26 g patients with hepatic arterial infusion of floxuridine plus systemic fluorouracil after liver resec

27 focal liver irradiation with hepatic artery floxuridine prolongs survival in patients with unresecta

28 otrexate and by thymidine in the presence of floxuridine, suggesting an unexpected role for thymidine

29 n cancer cell line that is hypersensitive to floxuridine, we show that GSK-3 phosphorylation facilita

30 re highly sensitive to both methotrexate and floxuridine, whereas other RNA viruses (Sindbis virus an

31 On univariate analysis, receipt of HAI-FUDR (floxuridine) within 1 year of IHP was the only factor as

32 e radiation with concurrent hepatic arterial floxuridine would improve survival in patients with unre

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