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2 omimetic building blocks containing backbone-fluorinated 1,4-disubstituted 1,2,3-triazole moieties.
3 parallel strand orientation incorporating 2'-fluorinated 2'-deoxyribonucleosides with canonical nucle
4 diated Yamamoto-type diaryl homocoupling of (fluorinated) 2,3-bis(4'-bromophenyl)quinoxaline precurso
5 rmally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantia
9 ta(5) -C5 Me5 )(dppe)] with an electrophilic fluorinating agent (NFSI) results in the formation of th
10 es, with Selectfluor II as the electrophilic fluorinating agent, to afford alkylfluorides in short re
13 oselectivity in glycosylations with a set of fluorinated alcohols as well as carbohydrate acceptors.
14 CC coupling of 1,1-disubstituted allenes and fluorinated alcohols to form homoallylic alcohols bearin
16 s (SiPcs, 1-7) with non-, partially- and per-fluorinated aliphatic (linear or branched at the alpha-c
17 ence of fluorination on the lipophilicity of fluorinated aliphatic alcohols was determined, and the l
18 h this reaction provides efficient access to fluorinated alkanes from a pool of starting materials th
20 and achieves the coupling of a wide range of fluorinated alkyl halides with alkylzinc reagents at roo
23 5.1.0]octanes) based on a domino reaction of fluorinated alpha-bromoenones with beta-amino alcohols w
24 d to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid derivatives, which
25 with sterically unhindered monomers using a fluorinated aluminum salph complex with a substoichiomet
26 nt synthesis methods for the construction of fluorinated amines rely on air and moisture sensitive re
28 With advances in cryoprobe production and fluorinated amino acid incorporation strategies, protein
29 g reaction at the C-terminal position of the fluorinated amino acid was conveniently performed under
33 eatment of [LFe3(PhPz)3OFe][OTf]2 (1) or its fluorinated analog [LFe3(F2ArPz)3OFe][OTf]2 (5) with iod
35 of PIDA is comparable if not superior to its fluorinated analog phenyliodine(III) bis(trifluoroacetat
36 lso report the synthesis and reactivity of a fluorinated analogue and the structure of its covalently
37 od was applied for gram-scale synthesis of a fluorinated analogue of G protein-coupled receptor antag
38 ns (methyl to n-butyl) as well as some omega-fluorinated analogues (3-fluoropropyl and 4-fluorobutyl)
39 lysaccharide, LPS), we designed a library of fluorinated analogues aiming for an [(18)F]-labeled radi
42 application, the synthesis of a new class of fluorinated analogues of the neuroprotective tripeptide
44 er, contains a combination of chiral-racemic fluorinated and achiral hydrogenated dendrons (RHF) in i
45 ms are explored by ab initio calculations of fluorinated and hydrogenated diamond (111) surfaces inte
51 en dictated by the innate electronics of the fluorinated arene, limiting the synthetic utility of the
52 otocatalytic C-F functionalization of highly fluorinated arenes is a powerful method for accessing fu
56 inding protein) using commercially available fluorinated aromatic amino acids and fluorinated precurs
57 n/Prophenol-catalyzed Mannich reaction using fluorinated aromatic ketones as nucleophilic partners fo
58 C-H bond silylation is facile with partially fluorinated aromatic substrates containing two ortho flu
60 ur strategy resulted in materials containing fluorinated azobenzenes that retain their photochemical
64 non-covalent interactions between side-chain fluorinated benzyl esters and main-chain terminal arenes
69 g that the same family of fully or partially fluorinated boron Lewis acids allows for the related H-H
71 alternative strategy, we present the use of fluorinated boronic acid-appended pyridinium salts in co
74 oute to the stereoselective synthesis of key fluorinated building blocks of high value for medicinal
75 ted by gold species meet species with either fluorinated building blocks or fluorinating reagents, ne
78 g 2'-fluoro substituents ((F)iCd, (F)iGd and fluorinated canonical 2'-deoxyribonucleosides) stabilize
81 e the pronounced polarity of C-F bonds, many fluorinated carbon compounds are hydrophobic: a controve
83 e calculated transition states show that the fluorinated catalysts have stronger N-H...O and C-H...F
85 e fluorine effect on the reactivity of alpha-fluorinated CH acids has remained largely unexplored.
87 This strategy provided access to both new fluorinated chemical entities and nonfluorinated derivat
89 for identification of previously unreported fluorinated chemicals in a timely and cost-efficient way
91 xamples of asymmetric reactions that involve fluorinated components either as reactants, catalysts, s
94 mulate TCE dechlorination, while some of the fluorinated compounds in certain AFFF formulations can i
95 trometry detector (LC-ESI-TOFMS) to identify fluorinated compounds in natural waters collected from l
96 e the occurrence and identity of replacement fluorinated compounds in surface water and sediment of t
98 ectfluor in acetone/water provides access to fluorinated compounds under mild and straightforward rea
99 inities, allowing for rapid screening of non-fluorinated compounds when a single fluorinated ligand f
100 ented, enabling the measurement of log P for fluorinated compounds with or without UV activity regard
103 of determining the sorption kinetics of any fluorinated contaminant, this work also highlights the s
104 yields (19)F T2 NMR relaxation values of any fluorinated contaminant, which are among the most danger
105 2,1,3-benzothiadiazole (DTBT) moiety and its fluorinated counterpart are important pi-conjugated buil
106 nus dendrimers contain either chiral-racemic fluorinated dendrons and a green fluorescent dye conjuga
107 tain environmentally friendly chiral-racemic fluorinated dendrons in their hydrophobic part (RF), one
109 a C-F bond driven Diels-Alder reaction of a fluorinated dienophile and a borole that shows remarkabl
110 isocyanate with fluorinated imines 1, while fluorinated dihydropyridin-2(1H)-ones 7 are prepared whe
111 ow that we can achieve the production of the fluorinated diketide 2-fluoro-3-hydroxybutyrate at appro
113 ition of silylated nucleobases onto model C2-fluorinated dithioacetal substrates resulted in 1,2-syn
117 work we explore how an electrolyte additive (fluorinated ethylene carbonate - FEC) mediates the thick
119 e with fluoromalonyl-CoA allows insertion of fluorinated extender units at 43% of the yield of the wi
120 sease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [(19)F]) gas magnetic resonance
121 lic alphagammaalpha-tripeptides derived from fluorinated-furanoid sugar amino acid frameworks act as
122 onic structure calculations, we predict half-fluorinated GaBi honeycomb under tensile strain to harbo
123 e computed the electronic spectrum of a half-fluorinated GaBi nanoribbon with zigzag edges, which sho
125 n MR imaging during inhalation of a normoxic fluorinated gas mixture (perfluoropropane) and by using
127 nes, esters, nitriles, primary amides, alpha-fluorinated halo-acetates and perfluoroalkyl iodides.
130 molecules to this organelle, we synthesized fluorinated hydrophobic analogues of the fluorophore rho
131 al pathway controlled by the ER, we linked a fluorinated hydrophobic rhodol to 5-nitrofuran-2-acrylal
133 ed by the reaction of phenyl isocyanate with fluorinated imines 1, while fluorinated dihydropyridin-2
135 n conjunction with our previous work on PNAs fluorinated in backbone and at N-terminus, it is evident
138 oil at AFFF-impacted sites and suggests that fluorinated intermediates that are not routinely measure
142 phosphorylated, hydroxylated), and labeled (fluorinated, isotopically labeled) side chains to be add
143 ullerene organic solar cells (OSCs) based on fluorinated ITIC-Th1 electron acceptor and a wide-bandga
146 g of non-fluorinated compounds when a single fluorinated ligand for the binding pocket of interest is
147 perfluoropolyether (PFPE), formulated these fluorinated ligands as aqueous nanoemulsions, and then m
148 This work demonstrates the usefulness of fluorinated ligands in designing molecule-selective and
151 copolymers, providing facile access to semi-fluorinated macromolecules using a single methodology wi
152 ssing, fabrication, and functionalization of fluorinated materials with easy removal of the volatile
153 y for the fabrication of a chemically stable fluorinated metal-organic framework (MOF) material (NbOF
154 rate construction of a hydrolytically stable fluorinated metal-organic framework (MOF), NbOFFIVE-1-Ni
159 ein, we report the synthesis of a library of fluorinated molecules that contain nonafluoro-tert-butyl
160 Various applications could benefit from new fluorinated molecules that offer chemical handles for qu
161 We have been investigating the mechanism of fluorinated monomer insertion by three of the six differ
163 control of the polymerization of main chain fluorinated monomers as exemplified by vinylidene fluori
164 TREN (TREN = tris(2-aminoethyl amine)), semi-fluorinated monomers with side chains containing between
166 ionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-dialkylaminostilbenes (FIDAS agents) off
167 d indole derivatives incorporating partially fluorinated n-propyl and n-butyl groups is described alo
169 s of blend films are improved by using these fluorinated n-type polymers to result in enhanced photoc
171 but our ability to produce site-selectively fluorinated natural products remains limited by challeng
172 Therefore, new approaches for accessing fluorinated nitrogen heterocycles are of great significa
175 Our studies support further evaluation of fluorinated nucleic acid analogues with non-furanose sug
176 organoruthenium(II) chlorido complexes with fluorinated O,O-ligands [(eta(6)-p-cymene)Ru(F3C-acac-Ar
177 minium ions were successfully generated from fluorinated O-acetyl-N,O-acetal l-tartaric acid derivati
179 orption properties often exhibited by highly fluorinated organic compounds, that is molecules rich in
184 The utility of Tf2NH-TiCl4 activation of fluorinated oxazaborolidines is documented by examples i
186 ional functionalities and the formation of 3-fluorinated oxindoles exhibiting an array of four adjace
188 sing Selectfluor to afford the corresponding fluorinated paraconic esters in good yields as a single
193 route into valuable, densely functionalized fluorinated phosphonates that takes advantage of (i) a C
195 d was demonstrated on both unfluorinated and fluorinated plastics, demonstrating high tracer recoveri
196 , we herein report the chemical synthesis of fluorinated PNA monomers and biophysical studies of deri
197 rse phase HPLC show higher hydrophobicity of fluorinated PNA oligomers, dependent on the number and s
198 ne and at N-terminus, it is evident that the fluorinated PNAs have potential to emerge as a new class
201 the authors show a highly efficient route to fluorinated poly(aryl thioethers) via an organocatalyzed
202 erein, we report a highly efficient route to fluorinated poly(aryl thioethers) via an organocatalyzed
203 remarkable reactivity enable rapid access to fluorinated poly(aryl thioethers), but also opens new av
204 of the volatile catalyst and TMSF byproducts.Fluorinated poly(aryl thioethers), unlike their poly(ary
205 can be used as a monomer in vivo to produce fluorinated poly(hydroxyalkanoate) (PHA) bioplastics wit
206 ated by laser-desorption of the near-planar, fluorinated polycyclic aromatic hydrocarbon (PAH), C60H2
207 A modular synthesis of regiospecifically fluorinated polycyclic aromatic hydrocarbons (PAHs) is d
208 assembling giant surfactants consisting of a fluorinated polyhedral oligomeric silsesquioxane (FPOSS)
209 -b-PEO) diblock copolymer tail tethered to a fluorinated polyhedral oligomeric silsesquioxane (FPOSS)
211 hat, among others, degradation of side-chain fluorinated polymers in the environment and landfills ca
212 eir properties to those of the analogous non-fluorinated polymers shows that backbone fluorination le
214 n of these molecules, leading to a series of fluorinated polysubstituted imidazoles in gram scale.
215 ailable fluorinated aromatic amino acids and fluorinated precursors as example applications of the me
216 Intramolecular response was measured in fluorinated probes and intermolecular quenching by mixin
218 nces in the isomeric ratio and the yields of fluorinated products obtained from N,N-disubstituted-phe
224 uous flow synthesis of highly functionalized fluorinated pyrazoles and pyrazolines has been developed
227 H, CH2F, and CH2CF3, are used as a source of fluorinated radicals to add fluoroalkyl groups to electr
229 ylacetates, the synthetic equivalence of the fluorinated reagent with alpha-nitro-alpha-diazo carbony
230 atalyst and points to [IPrCuF] as the active fluorinating reagent (IPr=1,3-bis(2,6-diisopropylphenyl)
232 rapid CO2-extrusion and F(*) transfer from a fluorinating reagent yield the desired fluoroalkanes wit
233 f fluoride could lead to a new class of mild fluorinating reagents and a range of functional-group-to
234 s with either fluorinated building blocks or fluorinating reagents, new opportunities arise for the d
236 er a competitive equilibrium with a selected fluorinated reporter ligand, the dissociation constant (
238 e a strong focus on the development of novel fluorinated RNA derivatives that are powerful in NMR spe
240 in, a series of 6-halopurines decorated with fluorinated side chains have been synthesized and evalua
241 his, two cholesterol analogs with truncated, fluorinated side chains have been synthesized and shown
243 ne illustrates the potential ease with which fluorinated small molecules relevant to neuroscience dru
244 g the potential to generate a broad range of fluorinated small-molecule targets in living cells.
245 of the HFC solvent in tandem with the highly fluorinated, solubilizing, weakly coordinating [Al(OR(f)
246 y simply modulating the starting peptide and fluorinated solvent concentrations during synthesis.
248 e to its greater oxidizing abilities in this fluorinated solvent such that in HFIP the reactivity of
249 omniphobic surface that can super-repel even fluorinated solvents, which highly wet all materials.
251 (19)F long-lived states in suitably designed fluorinated spy molecules allows one to perform competit
254 s is observed and calculated for planar ring-fluorinated stilbenes, trans-2,3,5,6,2',3',5',6'-octoflu
256 This work presents the synthesis of various fluorinated structural analogues of FTY720, their in vit
258 yl)pyrrolidin-2-one derivatives, bearing the fluorinated substituent on a tetrasubstituted carbon.
259 presence of the highly electron-withdrawing fluorinated substituent, cyclic alpha-trifluoromethylate
260 d herein, several alternative substrates and fluorinated substrate analogs were prepared to investiga
262 describe the field of reactions of partially fluorinated substrates with transition metal atoms, ions
263 ity of the Povarov reaction to unprecedented fluorinated substrates, generating scaffolds that contai
264 e of substrates to give medicinally relevant fluorinated substructures with complete regiocontrol.
265 al analysis suggested a strong preference of fluorinated sugar rings for either a 2'-endo, 3'-exo (So
266 radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible-light photore
267 nly describes a new synthetic application of fluorinated sulfones, but also provides a new route to f
268 eview, we present the specific properties of fluorinated sulfoximines (including important bioactivit
269 This work demonstrated the utilization of fluorinated sulfur ylides as versatile reagents for Core
271 eal that "polar hydrophobicity" of the fully fluorinated surfaces is caused by a negligible surface/w
272 sites in Ontario, Canada, and two commercial fluorinated surfactant concentrates were characterized i
273 spectrometry assigned molecular formulas to fluorinated surfactant ions, while collision induced dis
276 ge number of novel and infrequently reported fluorinated surfactants in different AFFF formulations.
277 e interfacial tensions using hydrocarbon and fluorinated surfactants including stimuli-responsive and
278 investigated whether commercially available fluorinated surfactants, such as Scotchgard fabric prote
280 we show that lower charge separation in the fluorinated system is associated with the formation of b
283 ane at room temperature, gives rise to novel fluorinated tetrahydrofuran-fused tetrahydroquinolines i
287 erminal end of the alkyl group is completely fluorinated, the balance tips toward fluorophobicity and
289 a wide bandgap polymer donor PM6 containing fluorinated thienyl benzodithiophene (BDT-2F) unit and a
291 The antiparallel self-assembled pore of the fluorinated tripeptides illustrates the selective ion-tr
293 metric properties of urea and thiourea-based fluorinated tripodal receptors are explored here for the
295 rks (MOFs) were synthesized from extensively fluorinated tritopic carboxylate- and tetrazolate-based
296 Supporting this model, substitution with fluorinated Trp analogues, with increased H-bonding prop
299 this protocol, we quantified the amount of a fluorinated xenobiotic (heptafluorobutyric acid, HFBA) i
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