ライフサイエンスコーパス: fluorine substitution

1 series of copolymers with varying amount of fluorine substitution.

2 ss the generality of the effects produced by fluorine substitution.

3 ucture-activity relationships as a result of fluorine substitution.

4 luoromethanes also decreases with increasing fluorine substitution.

5 identical polymers, except for the number of fluorine substitutions (0, 1, or 2) on the repeat unit (

6 myl-gamma-glutamate to examine the effect of fluorine substitution adjacent to the scissile isopeptid

7 represent a valuable tool for designing new fluorine substitutions and support ligand optimization i

8 In the present investigation, the effect of fluorine substitution at aziridine positions other than

9 anitrocubane, and (8) the effects of geminal fluorine substitution at C-2 of 1,3-diradicals.

10 Differences between fluorine substitution at the 3' and 2' positions may acc

11 In a previous study we reported that fluorine substitution at the carbon positions of aziridi

12 In general, fluorine substitution directly on the left-hand aromatic

13 introduction of a benzyl alcohol group and a fluorine substitution, each of which resulted in over 10

14 itution in SiH2FCH2 is consistent with other fluorine substitution effects.

15 ers, dependent on the number and site of the fluorine substitution: fluorine on carbon adjacent to th

16 Multiple fluorine substitution for hydrogen in the alpha-methylen

17 The assays confirmed that fluorine substitution had marked effects on the affinity

18 ed cyclooctynes (OMe, Cl, F, CN) showed that fluorine substitution has the most dramatic effect on re

19 A study of the effect of fluorine substitution in Baylis-Hillman reactions of var

20 Fluorine substitution in SiH2FCH2 is consistent with oth

21 new N-heterocyclic carbene precursor bearing fluorine substitution in the backbone results in signifi

22 cts, our results suggest that the effects of fluorine substitution in the reactions of fluorinated ty

23 he conformational biases induced by a single fluorine substitution in the template can be enhanced by

24 cant structural perturbation imparted by the fluorine substitution in these complexes is a rotation o

25 3G (or both) mutations were compensated by 2'fluorine substitutions in the mRNA codon.

26 We find that the stabilization imparted by fluorine substitution is additive over that obtained by

27 Increasing fluorine substitution leads to an increase in the entrop

28 Fluorine substitution lowers the inversion barrier impre

29 (X = H, F) as model systems, the effects of fluorine substitution on main-chain conformations, packi

30 synthesized in order to study the effects of fluorine substitution on monoamine oxidase inhibition.

31 our research program to study the effects of fluorine substitution on the biological activities of ne

32 Among nucleoside analogues, a fluorine substitution on the carbohydrate moiety or intr

33 This is reminiscent of the effect of fluorine substitution on the chemistry (inter- and intra

34 The effects of fluorine substitution on the Cope rearrangements of 1,5-

35 The effects of fluorine substitution on the cyclobutylcarbinyl to 4-pen

36 The degree and pattern of fluorine substitution on the inhibitor benzyl ring modul

37 dies of this class of antivirals showed that fluorine substitution on the left-hand phenyl ring in co

38 was used to gain insight into the impact of fluorine substitution on the overall protein structure a

39 The effects of fluorine substitution on the S-isomers were less predict

40 Finally, fluorine substitutions on the phenylazide ring did not c

41 xtension is highly dependent on the specific fluorine substitution pattern.

42 -band gap conjugated molecules with specific fluorine substitution patterns has been synthesized in o

43 oly(hydroxyalkanoate) (PHA) bioplastics with fluorine substitutions ranging from around 5-15 %.

44 Fluorine substitution resulted in a significant decrease

45 7% with PBnDT-DTffBT (2F) but also suggests fluorine substitution should be generally considered in

46 (cat)/K(M) = 30 M(1) s(1)) based on a single fluorine substitution that originates from differences i

47 sulfate with differing mixes of hydrogen and fluorine substitution was also observed.

48 Fluorine substitution was found to confer substantial st

49 Depending on the degree and pattern of fluorine substitution, we observe a face-to-face (aromat

50 Fluorine substitution which increases the contribution o

51 ated a remarkable electronic effect of the 4-fluorine substitution, while the effect of the 4-methyl

52 Although it is commonly thought that fluorine substitution will not result in any significant