ライフサイエンスコーパス: fluoro

1 N-[4-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]butyl]benzothi

2 Of these compounds, N-(3-chloro-4-(4-fluoro-1,3-dioxoisoindolin-2-yl)phenyl)-2-picolinamide (

3 ected toward 2-fluoro-1,4-benzoxazines and 2-fluoro-1,4-benzoxazepin-5-ones.

4 S(N)V) reaction, which was directed toward 2-fluoro-1,4-benzoxazines and 2-fluoro-1,4-benzoxazepin-5-

5 ed very rapidly and selectively, affording 5-fluoro-1,4-pyrazoles with bimolecular rate constants up

6 , lower background) than (124)I-1-(2-deoxy-2-fluoro-1-d-arabinofuranosyl)-5-iodouracil for both hdCKD

7 hat characterizes dexamethasone (Dex; 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna

8 l-1,4-diene-3,20-d ione) and RU24858 (9alpha-fluoro-11beta-hydroxy-16alpha-methylpregna-21-cyanide-1,

9 The first published dGCs, RU24782 (9alpha-fluoro-11beta-hydroxy-16alpha-methylpregna-21-thiomethyl

10 vel estrogen receptor (ER) PET radiotracer 4-fluoro-11beta-methoxy-16alpha-(18)F-fluoroestradiol ((18

11 rain by PET with the ER ligand 16alpha-(18)F-fluoro-17beta-estradiol ((18)F-FES) and to evaluate whet

12 16alpha-(18)F-fluoro-17beta-estradiol ((18)F-FES) is a PET tracer for

13 pha expression with the tracer 16alpha-(18)F-fluoro-17beta-estradiol ((18)F-FES) may be valuable to s

14 o-1H-imidazol-2-yl)methyl)pyrrolidin-3-yl)-5-fluoro-1H-benzo [d]imidazole (42) with IC50 values of 44

15 assays, the most potent agonists being di(5-fluoro-1H-indole-3-yl)methane (38, PSB-15160, EC50 80.0

16 tors in Arabidopsis thaliana revealed that 2-fluoro 2-l-fucose (2F-Fuc) reduces root growth at microm

17 y]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluoro -2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophene

18 or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-

19 other 2'-modified analogs, i.e., 2'-deoxy-2'-fluoro-2'-C-methylcytidine (MeFdC) and 2'-fluoro-2'-deox

20 based on the suicide substrate arabinosyl-2'-fluoro-2'-deoxy NAD(+) (F-araNAD(+)), dimeric F-araNAD(+

21 achieved by labelling cells with 2'-[(18)F]-fluoro-2'-deoxy-D-glucose ((18)F-FDG).

22 luorescence microscopy, luciferase assay, 2'-fluoro-2'-deoxyarabinofuranosyl-5-ethyluracil ((3)H-FEAU

23 2'-fluoro-2'-C-methylcytidine (MeFdC) and 2'-fluoro-2'-deoxycytidine (2'-FdC).

24 Here, a stabilized 2'-fluoro-2'-deoxyribose analog of N(2),3-epsilonG was used

25 of 0.4-4.7 muM), which contain one or two 2'-fluoro-2'-deoxyriboses and/or bis-phosphorothioate linka

26 otherapeutic drugs: 5-fluorouracil (5-FU), 5-fluoro-2'-deoxyuridine (FUDR), and camptothecin (CPT).

27 le (BMP = betamethason phosphate, FdUMP = 5'-fluoro-2'-deoxyuridine 5'-monophosphate).

28 se to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobenzene and 2-deoxyurushiol.

29 We have designed a new probe, 3-(18)F-fluoro-2,2-dimethylpropionic acid, also called (18)F-flu

30 Construction of protected 2,3-dideoxy-2-fluoro-2,3-endo-methylene-pentofuranoses from d-glyceral

31 deficient alkenes has been developed using N-fluoro-2,4,6-trimethylpyridinium triflate as the termina

32 ing materials by the F(+) transfer reagent N-fluoro-2,4,6-trimethylpyridinium triflate followed by tr

33 labeled affinity peptide tag, (64)Cu-L19K-(5-fluoro-2,4-dinitrobenzene) ((64)Cu-L19K-FDNB), which bin

34 As a control, L19K was conjugated to 1-fluoro-2,4-dinitrobenzene, resulting in L19K-DNP.

35 derivatization with a new chiral reagent, (5-fluoro-2,4-dinitrophenyl)-N(alpha)-l-tryptophanamide (FD

36 -d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluoro-2,5-anhydro-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[

37 oxol-5-yl)-N-(1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2- (2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl),

38 8-fluoro-2-(5-hydroxy-1-naphthoyl)- and 2-(8-fluoro-2-(4-hydroxy-1-naphthoyl)-1,2,3,4-tetrahydro-5H-p

39 tabolites M3 and M13 were identified as 2-(8-fluoro-2-(5-hydroxy-1-naphthoyl)- and 2-(8-fluoro-2-(4-h

40 Acyclic nucleosides containing a 3-fluoro-2-(phosphonomethoxy)propyl (FPMP) side chain are

41 idin-5-yl)methanone (compound 29) and (S)-(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(1-(5-fluoropyrim

42 of the even more sterically demanding rac-2-fluoro-2-benzyl acetic acid proceeded similarly.

43 The glucose analog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) is commonly use

44 from rats infused with the glucose analog, 2-fluoro-2-deoxy-D-glucose (FDG) in vivo.

45 aphy of the labeled glucose analogue 2[(18)F]fluoro-2-deoxy-D-glucose (FDG).

46 ere studied with dynamic PET imaging of [18F]fluoro-2-deoxy-D-glucose at two occasions with 24-hour i

47 on tomography after an injection of [(18)F]2-fluoro-2-deoxy-d-glucose before the OGTT, and the rate o

48 PET with [18F]fluoro-2-deoxy-D-glucose can be used to image cellular m

49 PET with [(18)F]fluoro-2-deoxy-D-glucose can be used to image cellular m

50 ung inflammation using PET imaging of [(18)F]fluoro-2-deoxy-D-glucose in a porcine experimental model

51 tidal strain had a significant effect on [F]fluoro-2-deoxy-D-glucose net uptake rate Ki in high-stra

52 ell recognized and is exploited with (18)F-2-fluoro-2-deoxy-d-glucose positron emission tomography ((

53 on with obese normal subjects with [(18)F]-2-fluoro-2-deoxy-D-glucose positron emission tomography im

54 positron emission tomography with [(18)F]-2-fluoro-2-deoxy-D-glucose scan in addition to noncontrast

55 hours of mechanical ventilation, dynamic [F]fluoro-2-deoxy-D-glucose scans were acquired to quantify

56 [18F]fluoro-2-deoxy-D-glucose uptake rate was computed for th

57 [(18)F]fluoro-2-deoxy-D-glucose uptake rate was computed for th

58 cruitment or tidal hyperinflation had [(18)F]fluoro-2-deoxy-D-glucose uptakes similar to controls.

59 and intermediate gravitational zones [(18)F]fluoro-2-deoxy-D-glucose uptakes were higher in ventilat

60 y studied with dynamic PET imaging of [(18)F]fluoro-2-deoxy-D-glucose.

61 tissue (ATGU) glucose uptake with [(18) F]2-fluoro-2-deoxy-D-glucose/positron emission tomography, l

62 es, hk1 and pdk1, lung fluorine-18-labeled 2-fluoro-2-deoxyglucose ligand uptake was significantly in

63 sociation between increased normalized (18)F fluoro-2-deoxyglucose PET SUVmax, outcome, and EMT in NS

64 data set that contained fluorine 18 ((18)F) fluoro-2-deoxyglucose positron emission tomography (PET)

65 ic amount of iron(II) triflate (Fe(OTf)2), N-fluoro-2-methylbenzamides undergo chemoselective fluorin

66 up on the alpha-carbon, (S)-2-amino-7-[(18)F]fluoro-2-methylheptanoic acid ((S)-[(18)F]FAMHep, (S)-[(

67 ed amino acid-based tracer, 2-amino-5-[(18)F]fluoro-2-methylpentanoic acid ([(18)F]FAMPe), has been d

68 881 [5-((7-benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol-hydrochloride] (20 mug/mL) was dri

69 s led to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetra hydro-1H-p

70 The lead analogue, [Inp(1),Dpr(3)(6-fluoro-2-naphthoate),1-Nal(4),Thr(8)]ghrelin(1-8), posse

71 ghly efficient method for the synthesis of 2-fluoro-2-nitrostyrenes was described.

72 be the use of a mechanism-based inhibitor, 2-fluoro-2-nitrovinylbenzene, to trap the putative cyclo-a

73 A novel 6-fluoro-2-pentafluorophenyl naphthoate (PFPN) prosthetic

74 PA1163) has been studied by subjecting rac-2-fluoro-2-phenyl acetic acid to the defluorination proces

75 '-pyridinyl)deschloroepibatidine (7a) and 2'-fluoro-3'-(3''-pyridinyl)deschloroepibatidine (8a) were

76 2'-Fluoro-3'-(4''-pyridinyl)deschloroepibatidine (7a) and 2

77 Analysis of 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-2',3'-endo-methylene-uridine b

78 allows the straightforward synthesis of a 3'-fluoro-3'-deoxytetrose adenine phosphonate and can be ex

79 A new synthetic route to a 3'-fluoro-3'-deoxytetrose adenine phosphonate has been deve

80 ion reaction allows access to the desired 3'-fluoro-3'-deoxytetrose moiety.

81 The NRTIs emtricitabine [(-)-2,3'-dideoxy-5-fluoro-3'-thiacytidine, (-)-FTC] and lamivudine, [(-)-2,

82 hydroxy-5,6-dihydronaphthalene-1-carbonyl)-8-fluoro-3,4-dihyd ro-1H-pyrido[4,3-b]indol-5(2H)-yl)aceti

83 ues of CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic

84 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

85 A novel synthetic approach to 6-(18)F-fluoro-3,4-dihydroxy-L-phenylalanine ((18)F-DOPA), invol

86 opa seems to improve the accuracy of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) PET f

87 using PET imaging of the radiotracer 2-(18)F-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-(18)F-FA-85

88 l-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indolin-2-one).

89 affinities were also observed, notably for 6-fluoro-3-(piperidin-4-yl)-1,2-benzoxazole derivatives co

90 Two of these compounds, (S)-(2-fluoro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2

91 ydropyrido[2,3-d]pyrimidin-2-yl)ethyl) -2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)

92 two 18F-labeled PET reporters FHBG [9-(4-18F-fluoro-3-[hydroxymethyl] butyl) guanine] and FLT (18F-3'

93 oses from d-glyceraldehyde and 2,3-dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranos

94 and in vivo data are presented for (E)-3-(4-fluoro-3-hydroxy-phenyl)-N-naphthalen-1-yl-acrylamide 22

95 the production of the fluorinated diketide 2-fluoro-3-hydroxybutyrate at approximately 50 % yield.

96 vivo bioluminescence imaging, and 9-(4-(18)F-fluoro-3-hydroxymethylbutyl) guanine ((18)F-FHBG) small-

97 LHP is synthesized from readily available 4-fluoro-3-methylphenol in six steps featuring a palladium

98 mbrane based off-matrix was achieved using 4-fluoro-3-nitro-azidobenzene (FNAB) cross-linker.

99 x was achieved via azide group activity of 4-fluoro-3-nitro-azidobenzene (FNAB), which act as cross-l

100 c organic crystal, 2,6-dichlorobenzylidine-4-fluoro-3-nitroaniline (DFNA), which also shows thermosal

101 prepared via electrochemical reduction of 4-fluoro-3-nitrobenzene diazonium ion has been developed a

102 A new platform based on 4-Fluoro-3-nitrophenyl (FNP) grafted gold disk electrode p

103 [1-(4,4-difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoind ole-4-carboxamide (NM

104 delta-sultam compound, GNE-3500 (27, 1-{4-[3-fluoro-4-((3S,6R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiaz

105 aniline ring, we generated Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbam

106 were achieved by N(6)-substitution with a 2-fluoro-4-chloro-phenyl- or a methyl- group.

107 The probes were: alpha-methyl-4-[F-18]-fluoro-4-deoxy-d-glucopyranoside (Me-4FDG), a substrate

108 benzoates [1,3-phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate) (RA-2), 1,2-phenylenebis(methy

109 e) (RA-2), 1,2-phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate), and 1,4-phenylenebis(methylen

110 oate), and 1,4-phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate)] with inhibitory efficacy as d

111 (trifluoromethyl)pyridin-2-yl)oxy)phenyl)(3- fluoro-4-hydroxypyrrolidin-1-yl)methanone 28, a potent i

112 '-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyadenosine (5'-FDA).

113 ered when analyzing the mode of action of 5'-fluoro-5'-deoxyadenosine synthase, the only known enzyme

114 the pharmacokinetics of (18)F-FPEB (3-(18)F-fluoro-5-(2-pyridinylethynyl)benzonitrile), a selective

115 stribution volume of the radioligand (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB

116 , to prepare the radiopharmaceutical (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB

117 (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB

118 oazomycin arabinoside (or (18)F-1-alpha-D-[5-fluoro-5-deoxyarabinofuranosyl]-2-nitroimidazole [(18)F-

119 The hdCKDM/2'-(18)F-fluoro-5-ethyl-1-beta-d-arabinofuranosyluracil ((18)F-FE

120 '-deoxy-3'-(18)F-fluorothymidine or 2'-(18)F-fluoro-5-methyl-1-beta-d-arabinofuranosyluracil may also

121 -axis in CRPC, using (18)F-FDG, (18)F-16beta-fluoro-5alpha-dihydrotestosterone ((18)F-FDHT), and a va

122 2'-Fluoro-6'-methylene carbocyclic adenosine (FMCA) is a po

123 The utility of D-2'-fluoro-6'-methylene cyclopentanol 14 is demonstrated in

124 versatile carbocyclic key intermediate, D-2'-fluoro-6'-methylene cyclopentanol 14, has been developed

125 tential ERbeta-selective PET tracer: 2-(18)F-fluoro-6-(6-hydroxynaphthalen-2-yl)pyridin-3-ol ((18)F-F

126 We recently developed the tracer 2-(18)F-fluoro-6-(6-hydroxynaphthalen-2-yl)pyridin-3-ol ((18)F-F

127 WZB117 (2-fluoro-6-(m-hydroxybenzoyloxy) phenyl m-hydroxybenzoate)

128 We applied this method to 2-[2-(18)F-fluoro-6-(methylamino)-3-pyridinyl]-1-benzofuran-5-ol ((

129 yl]amin o}-3-quinolinecarboxamide (72) and 7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-{[(1S)-1-(1-m

130 ales/8 females) using the oral 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid positron emission tomog

131 Oral 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid was used to determine w

132 lf-assembly of organic TCNQF (-) radicals (2-fluoro-7,7,8,8-tetracyano-p-quinodimethane) and the anis

133 (8S,9R)-47 (talazoparib; BMN 673; (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5

134 8)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-adenine ([(18)F]CFA) an

135 -adenine ([(18)F]CFA) and 2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-guanine ([(18)F]F-AraG)

136 at a novel PET radiotracer, 2'-deoxy-2'-[18F]fluoro-9-beta-D-arabinofuranosylguanine ([18F]F-AraG), t

137 arbanions and, upon protonation, ethyl alpha-fluoro-alpha-nitroarylacetates.

138 yl alkyl fluorides embedded within a vicinal fluoro amine functional group.

139 eparation of a range of enantioenriched beta-fluoro amines (alpha,beta-disubstituted) is described in

140 vivo validation of a lead candidate, (18)F-5-fluoro-aminosuberic acid ((18)F-FASu), as a PET tracer f

141 ilizing properties of both isomers of the 2'-fluoro analogue of Northern methanocarbathymidine (N-MCT

142 The di-2'-alpha-fluoro analogue of thymidylyl(3',5')thymidine, synthesiz

143 vity of JWH-122, JWH-210, and PB-22, their 5-fluoro analogues (MAM-2201, EAM-2201, and 5F-PB-22, resp

144 C3 hydroxyl during deamination, 3-deutero-3-fluoro analogues of both substrates were prepared and ch

145 f the yet-unsynthesized bromo-, chloro-, and fluoro- analogues show a progressive lowering of the bar

146 report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphil

147 ault PRs: a standard dose cohort (PR, 15 for Fluoro and CINE), and a reduced dose cohort (PR, 10 for

148 CINE), and a reduced dose cohort (PR, 10 for Fluoro and CINE).

149 the effect of default rates of fluoroscopy (Fluoro) and CINE-acquisition (CINE) on total x-ray dose

150 benzene substituted as 2- or 4-methyl, or 4-fluoro, and defined the significance of thiophene substi

151 essing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.

152 trifluoromethylbenzene derivatives and to 1-fluoro- and 1-trifluoromethyl-2-substituted trans-ethene

153 Comparison of the pKa values of 3-fluoro- and 3,3-difluoro-GABA with that of the fluorine

154 ong reported method to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluorogalactopyranose.

155 6/aug-cc-pVTZ) to meta- and para-substituted fluoro- and trifluoromethylbenzene derivatives and to 1-

156 A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed.

157 Overall, these results establish fluoro as a through-space directing/activating group tha

158 he presence of strongly electron-withdrawing fluoro-bearing sulfonimidoyl moieties, which allowed the

159 g 2'-methoxyphenyl-(N-2'-pyridinyl)-p-[(18)F]fluoro-benzamidoethylpiperazine ([(18)F]MPPF), an antago

160 d 2'-methoxyphenyl-(N-2'-pyridinyl)-p-[(18)F]fluoro-benzamidoethylpiperazine [(18)F]MPPF uptake in th

161 ields the corresponding syn-configured alpha-fluoro beta-hydroxy carboxylic acids which have >98 % ee

162 limination, the resulting transoid alpha-(1'-fluoro)-beta-(phenylsulfonyl)vinyl AA-esters undergo smo

163 ly give the corresponding transoid alpha-(1'-fluoro)-beta-(tributylstannyl)vinyl AA-esters.

164 cacious ProTide prodrug of 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine is provided.

165 Two isomeric aryl 2-deoxy-2-fluoro-beta-glucosides react with a beta-glucosidase at

166 A successful synthesis of alpha-fluoro-beta-ketosulfides using an electrophilic fluorina

167 The resulting products, alpha-fluoro-beta-ketosulfides, are easily oxidized to the cor

168 e easily oxidized to the corresponding alpha-fluoro-beta-ketosulfones, which can be used for further

169 A covalent complex with 3-fluoro-beta-N-acetylneuraminic acid is also presented, s

170 Compound 21 [N-(4'-cyano-3'-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhi

171 eadily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), m

172 coupling reactions of aryl groups with alpha-fluoro carbonyl compounds catalyzed by palladium complex

173 g reactions of aryl electrophiles with alpha-fluoro carbonyl compounds have yet to be disclosed.

174 Fluoro, chloro, bromo, iodo, and gem-dihaloalkenes are v

175 y slightly, suggesting a participation of Sc fluoro-complexes in both processes.

176 Uptake of 1-deoxy-1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluor

177 -d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluor

178 lucose analog, alpha-methyl-4-deoxy-4-[(18)F]fluoro-D-glucopyranoside (Me4FDG), which is not transpor

179 mor xenografts in mice using 2-deoxy-2-[F-18]fluoro-D-glucose ((18)F-FDG) PET imaging.

180 o-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fl

181 te for SGLTs and GLUTs; and 2-deoxy-2-[F-18]-fluoro-d-glucose (2-FDG), a substrate for GLUTs.

182 DG), a substrate for SGLTs; 4-deoxy-4-[F-18]-fluoro-d-glucose (4-FDG), a substrate for SGLTs and GLUT

183 glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]FDG) was studied in EMT6 cell

184 tion and 15% per MBq/ml of 2-deoxy-2-[(18)F]-fluoro-d-glucose ([(18)F]FDG).

185 Finally, 2-deoxy-2-[F-18]fluoro-d-sorbitol ((18)F-FDS) can be easily synthesized

186 g positron emission tomography with 4-[(18)F]fluoro-dapagliflozin (F-Dapa).

187 ated with finite element simulations and 18F-fluoro-deoxy-glucose (18F-FDG) positron emission tomogra

188 mission tomography with (11)C-acetate, (18)F-fluoro-deoxyglucose ((18)FDG), and (18)F-fluoro-thiahept

189 eripheral blood to clinical outcomes and (18)fluoro-deoxyglucose positron emission tomography combine

190 feasibility, validity and reproducibility of fluoro-deoxyglucose-PET/CT for imaging of atheroscleroti

191 Fluoro-deoxyglucose-PET/CT imaging is currently used to

192 Fluoro-deoxyglucose-PET/CT imaging is demonstrated to ha

193 um ions; however, in the cases of chloro and fluoro derivatives, open forms are more preferable.

194 cal withC(C6H4)CH3)DPFN]NTf2 (DPFN = 2,7-bis(fluoro-di(2-pyridyl)methyl)-1,8-naphthyridine; NTf2(-) =

195 H5, 3,5-(CF3)2C6H3, and C6F5; DPFN = 2,7-bis(fluoro-di(2-pyridyl)methyl)-1,8-naphthyridine; X = BAr4(

196 scrimination against the incorporation of 2'-fluoro dNMPs during transcription elongation.

197 ect the yield of RNA and incorporation of 2'-fluoro-dNMPs by Syn5 RNA polymerase have been identified

198 ther decreases the discrimination against 2'-fluoro-dNTPs during RNA synthesis.

199 eads and Fluoro-Ruby or green Retrobeads and Fluoro-Emerald) to map the spatial distribution of cells

200 the appropriate palladium catalyst and alpha-fluoro enolate precursor were used.

201 Bq of (68)Ga-DOTATATE, or 333.8 MBq of (18)F-fluoro-ethyl-choline; 2.5 min/bed position).

202 re included: brain tumor studies using (18)F-fluoro-ethyl-tyrosine ((18)F-FET) (n = 31) and (68)Ga-DO

203 Stereoselective synthesis of 1-fluoro-exo,exo-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octanes

204 ewis acid conditions to afford a series of 1-fluoro-exo,exo-furofurans in moderate yields.

205 The substitution of 2'-fluoro for 2'-hydroxyl moieties in RNA substantially imp

206 two-thirds of the cells were ipsilateral to Fluoro-Gold injection sites in both the RVLM and CVLM, a

207 mouse, this technique was achieved with only Fluoro-Gold, a neurotoxic fluorescent dye with membrane

208 ster) were infused with a retrograde tracer, Fluoro-Gold, and tested for affiliation and aggression t

209 ment and noncovalent interaction between the fluoro group and the aromatic proton on the thiophene si

210 It is known that the fluoro group has only a small effect on the rates of ele

211 er) between gold surface and anti-IL2, where fluoro group of FNP undergoes nucleophilic substitution

212 t of the 5-iodo group with chloro, bromo, or fluoro groups led to losses in potency, as did the intro

213 five fluoro, two fluoro, one fluoro, and no fluoro groups.

214 ation to afford highly enantioenriched alpha-fluoro homoallylic alcohols.

215 inked immunosorbent assay, chemiluminescent, fluoro-immunoassays, electrical detections, surface plas

216 orris Water Maze and a reduction in positive Fluoro-Jade B stained injured neurons and microglial act

217 thology characterized by positive silver and Fluoro-Jade B staining, and microglial proliferation and

218 Furthermore, neuronal injury, expressed as Fluoro-Jade B-positive cells in the hippocampal formatio

219 ssessments, including neurological deficits, Fluoro-Jade C staining, brain edema, Evans blue extravas

220 We obtained baseline 6-[(18)F]fluoro-L-DOPA (FDOPA)-PET scans in 15 nonsmokers and 30

221 ssion tomography with the radiotracer [(18)F]fluoro-l-DOPA to quantify striatal presynaptic dopamine

222 tional groups, and allows access to 6-[(18)F]fluoro-L-DOPA, 6-[(18)F]fluoro-m-tyrosine, and the trans

223 and dopamine synthesis and storage ((18)F-6-fluoro-L-dopa; (18)F-FDOPA).

224 amine synthesis capacity (Ki) using 6-[(18)F]fluoro-l-m-tyrosine ([(18)F]FMT; a substrate for aromati

225 Using the PET tracer 6-[(18)F]fluoro-l-m-tyrosine, we found strong support for upregul

226 -tyrosine ((18)F-FET), 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-DOPA), and (11)C-methionin

227 ssion tomography and 3,4-dihydroxy-6-[(18)F]-fluoro-l-phenylalanine ([(18)F]-DOPA).

228 ate the pharmacokinetics of 4-borono-2-(18)F-fluoro-L-phenylalanine-fructose ((18)F-FBPA-Fr) in F98 g

229 ssion tomography and 3,4-dihydroxy-6-[(18)F]-fluoro-l-phenylalanine.

230 thymidine levels were imageable with [(18)F]-fluoro-L-thymidine (FLT)-positron emission tomography (P

231 YD in the presence of the substrate analog 3-fluoro-l-tyrosine.

232 esis of each possible stereoisomer of a beta-fluoro lanicemine illustrates the potential ease with wh

233 n with hydroxy, cyano, nitro, acetamido, and fluoro led to high inhibitory activities toward ABCG2.

234 This was achieved using [(18)F]fluoro-levo-dihydroxyphenylalanine dynamic positron emis

235 of novel imaging techniques (6-[fluoride-18]fluoro-levodopa [(18)F-DOPA] PET-CT and glucagon-like pe

236 s access to 6-[(18)F]fluoro-L-DOPA, 6-[(18)F]fluoro-m-tyrosine, and the translocator protein (TSPO) P

237 posite a chemically stable m7dG analogue, 2'-fluoro-m7dG (Fm7dG), by human DNA polymerase beta (polbe

238 atible over a series of polyaryls possessing fluoro, methoxy, and methyl functional groups, subsequen

239 azinyl]ethyl}-N-(2-pyridyl)-N-(trans-4-(18)F-fluoro methylcyclohexane)carboxamide ((18)F-mefway) exhi

240 2'-Fluoro modified RNAs are useful as potential therapeutic

241 2'-Fluoro modified RNAs generally need to be purified after

242 Here we introduce a protocol by which 2'-fluoro modified RNAs with 57 and 58 nucleotides can be r

243 The strategy is compatible with 2'-fluoro-modified (2'F) ribonucleoside triphosphates (rNTP

244 ion, and the presence or absence of an alpha-fluoro moiety.

245 Screening of commercially available fluoro monosaccharides as putative growth inhibitors in

246 e utility of N-(2,5-dimethoxybenzyl)-2-(18)F-fluoro-N-(2-phenoxyphenyl)acetamide ((18)F-PBR06) for de

247 dimethyl-4-oxo-2-thioxoimidazolidin -1-yl)-2-fluoro-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide] and 10

248 The GluN2A-selective antagonist, 3-chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl] benz

249 etylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were prepared u

250 iphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-

251 t of this proposed elementary step, an alpha-fluoro-N-acylpyridinium salt, have been examined.

252 e observations, a small organic molecule, 4'-fluoro-N-phenyl-[1,1'-biphenyl]-3-carboxamide, was desig

253 ch analogue, (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole (57) was chosen f

254 Addition of methyl, fluoro, naphthyl, and benzothiadiazolyl units does not a

255 e catalyst that can deliver beta-amino-alpha-fluoro nitroalkanes with high enantio- and diastereosele

256 uence to highly stereoselectively give alpha-fluoro-nitroalkenes as Z-isomers only.

257 in the formation of the corresponding alpha-fluoro-nitroalkenes in isolated yields up to 92%.

258 ed toward the synthesis of other types of 3'-fluoro nucleoside phosphonates.

259 zations possessing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.

260 Compounds 4g and 4i, bearing a m-fluoro-p-methoxyphenyl or p-ethoxyphenyl moiety at the 5

261 CP) was synthesized using (19)F-labeled 2-(5-fluoro-pentyl)-2-methyl malonic acid ((19)F-FPMA) as the

262 (Z)-Azobenzene (Z-AB) with at least one o-fluoro per ring displays (19)F-(19)F through-space (TS)

263 (2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4 -ylmethyl]-benzamide, a selective T-t

264 ,2-dimethylpropionic acid, also called (18)F-fluoro-pivalic acid ((18)F-FPIA), for the imaging of abe

265 l yields increased, and degradation of the 2-fluoro-propan-1-amine isomer (b) occurred, leading to a

266 (18)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine ((18)F-LMI1195) is a n

267 inephrine transporter (N-[3-bromo-4-(3-(18)F-fluoro-propoxy)-benzyl]-guanidine [LMI1195]) is in clini

268 st (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-p ent

269 le, MIP-1404, PSMA-11, 2-(3-{1-carboxy-5-[(6-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-penta

270 otoreactivity of some aryl propionic acids, (fluoro)quinolones, furocoumarins, metal coordination com

271 "Fluoro" refers to both fluorescent and fluorinated compo

272 trategy was used in rats (red Retrobeads and Fluoro-Ruby or green Retrobeads and Fluoro-Emerald) to m

273 hiation/elimination sequence starting from 2-fluoro-SF5-benzene.

274 bicyclic thymidine analogue carrying a beta-fluoro substituent at C6' (6'F-bcT) has been achieved.

275 Counterintuitively, the axial fluoro substituent in 3 did not change chemical shift up

276 erved by NMR and crystallography with a para-fluoro substituent on the 4-phenylimidazole, but a para-

277 ity to COX-2 (6k = 70 nM, 8e = 60 nM) have a fluoro substituent, making them promising candidates for

278 Oligonucleotides containing 2'-fluoro substituents ((F)iCd, (F)iGd and fluorinated cano

279 ly genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resulting in compounds with high To

280 The stabilization energy values for multiple fluoro-substituted benzene-ethylene complexes are found

281 nd to be very close to those of the multiple fluoro-substituted benzene-methane complexes.

282 studying the regio- and chemoselectivity of fluoro-substituted thienothiophene and benzodithiophene

283 ign and synthesis it was discovered that cis-fluoro substitution on 4-hydroxy- and 4-methoxypiperidin

284 d by introducing bulkier N-substituents, a 2-fluoro substitution, and additional hydroxyl groups at p

285 he lack of efficient turnover of a 2-deoxy-2-fluoro-substrate, and several unsuccessful attempts at c

286 -forming reductive elimination from a Pd(IV) fluoro sulfonamide complex.

287 stems are categorized into 3 major clusters: fluoro-surfactants represent cluster I, identified as st

288 8)F-fluoro-deoxyglucose ((18)FDG), and (18)F-fluoro-thiaheptadecanoic acid ((18)FTHA), a fatty acid t

289 s affords highly regioregular poly(3-alkyl-4-fluoro)thiophenes.

290 In addition, we determined that 5'-(2-fluoro)thiophenyl derivatives all failed to generate a s

291 Total x-ray dose, Fluoro time, and contrast use were compared between grou

292 ethyl-tryptophan, 5-methyl-tryptophan, and 5-fluoro-tryptophan were efficient substrates of VioA.

293 ent derivatizations possessing two NO2, five fluoro, two fluoro, one fluoro, and no fluoro groups.

294 s; namely, a family of quaternary, alpha-(1'-fluoro)vinyl amino acids, bearing the side chains of the

295 beta-difluorovinyl phenyl sulfone, a new (1'-fluoro)vinyl cation equivalent, and an electrophile that

296 The alpha-(1'-fluoro)vinyl trigger, a potential allene-generating func

297 +/- 20 muM; t1/2 = 2.8 min) and D-alpha-(1'-fluoro)vinyllysine (Ki = 470 +/- 30 muM; t1/2 = 3.6 min)

298 arameters for the two antipodes, L-alpha-(1'-fluoro)vinyllysine (Ki = 630 +/- 20 muM; t1/2 = 2.8 min)

299 test of this new inhibitor class, alpha-(1'-fluoro)vinyllysine is seen to act as a time-dependent, i

300 A conformational analysis of o-fluoro Z-azobenzene reveals a slight preference for arom