ライフサイエンスコーパス: foamy

1 ma associated with pulmonary infiltration by foamy alveolar macrophages (AMs), increased hydrogen per

2 Increased numbers of large foamy alveolar macrophages and enlarged alveoli were als

3 ipheral inflammation, hyaline membranes, and foamy alveolar macrophages, a phenotype that persists fo

4 Foamy-appearing human leukocyte antigen-DR positive cell

5 Foamy CD11c(+) monocytes arise in the circulation during

6 amming prevents ER dysfunction and inhibits "foamy cell" development, thus establishing a molecular b

7 ipate in the progression of macrophages into foamy cells and that these cytokines are important facto

8 Foamy cells positive for the DEC-205 marker also express

9 maller and had a more lymphocytic core, less foamy cells, less parenchymal inflammation, and slower p

10 he AQUA system was also able to discriminate foamy gland prostate cancers, which are known to have a

11 e on ECD biopsies, we detected expression in foamy histiocytes of the phosphorylated forms of mTOR an

12 Shear-resistant capture of foamy human or mouse monocytes was initiated by high-aff

13 any macrophages were both multinucleated and foamy in appearance.

14 port 36 lineages of basal amphibian and fish foamy-like endogenous retroviruses (FLERVs).

15 , including massive neutrophil infiltration, foamy macrophage accumulation, unwanted cell growth, and

16 inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal

17 ted with emphysema, pulmonary lipidosis, and foamy macrophage infiltrations.

18 n, numerous bacteria were present within the foamy macrophage of the granulomatous lesions along the

19 The foamy macrophage seems to be a key participant in both s

20 We identified foamy macrophage-like cells as the primary source of Wnt

21 large numbers of proliferating and activated foamy macrophage/microglial cells.

22 and potentially involved in the formation of foamy macrophages (FMs) and granulomas.

23 Rod-shaped microglia-like cells and foamy macrophages (myelin-laden) were iNOS negative.

24 ssue destruction/remodeling, accumulation of foamy macrophages and alteration in surfactant compositi

25 in a significant decrease in the presence of foamy macrophages and increased expression of CCR7 and M

26 PTL4) is the most highly upregulated gene in foamy macrophages and it's absence in haematopoietic cel

27 m Abcg1-/- mice revealed elevated numbers of foamy macrophages and leukocytes and the presence of mul

28 at CD47 is expressed in normal myelin and in foamy macrophages and reactive astrocytes within active

29 Highly vacuolated or foamy macrophages are a distinct characteristic of granu

30 uberculosis to proliferate inside lipid-rich foamy macrophages but not under regular culture conditio

31 assical monocytes, but not CD1c(+) DCs, made foamy macrophages easily in vitro with macrophage colony

32 However, we demonstrate in this study that foamy macrophages express high levels of DEC-205, a mark

33 on of TGF localized to epithelioid cells and foamy macrophages in areas of inflammation.

34 Development of foamy macrophages in SP-D-deficient mice is not secondar

35 eostasis and the prevention of emphysema and foamy macrophages in vivo.

36 were predominantly macrophage/microglia and foamy macrophages present within demyelinating lesions a

37 n failed to rescue the emphysema or enlarged foamy macrophages that are characteristic of Sftpd(-/-)

38 ce were decreased compared with WT mice, and foamy macrophages were nearly absent in the TREM2 KO mic

39 We find that foamy macrophages with senescence markers accumulate in

40 is was recognized as clusters of lipid-laden foamy macrophages within the neointima with or without n

41 /- mice; the animals developed emphysema and foamy macrophages without the associated abnormalities i

42 characteristics (multinucleated giant cells, foamy macrophages) consistent with a foreign body reacti

43 4 to 10 weeks, with marked lipid deposition, foamy macrophages, and infiltration of smooth muscle alp

44 at PPAR ligands reduce lipid accumulation in foamy macrophages, and may target other receptors.

45 ar inflammation, with activated lymphocytes, foamy macrophages, and neutrophils.

46 ced lesional area is related to decreases in foamy macrophages, collagen positive areas, and necrotic

47 e thus discriminant, whereas others, such as foamy macrophages, covered both benign and malignant reg

48 wn was associated with local accumulation of foamy macrophages.

49 filtration of lymphocytes, plasma cells, and foamy macrophages.

50 with presence of inflammatory infiltrate or foamy macrophages.

51 acterial properties of SBM and its effect on foamy macrophages.

52 utant mice demonstrated thickened septae and foamy macrophages/leukocytes.

53 een observed on several occasions; rubbing a foamy mixture of saliva and leaf onto specific parts of

54 ents in signaling VLA-4 adhesive function on foamy monocytes competent to recruit to VCAM-1 on inflam

55 E-deficient mice, an inflammatory subset of foamy monocytes emerged that made up one fourth of the c

56 It revealed that foamy monocytes from mice on a WD increased their adhesi

57 Recruitment of foamy monocytes to inflamed endothelium expressing VCAM-

58 two lipid-sensing nuclear receptors create a foamy niche within macrophage by modulating oxidized low

59 n mice, including hypomyelinating phenotype, foamy oligodendrocytes, and myelin loss.

60 es of VWMD pathology include myelin loss and foamy oligodendrocytes.

61 Unlike orthoretroviruses, foamy retroviruses (FV) synthesize Pol independently of

62 Foamy storage cells were observed in dorsal root ganglio

63 e kinase deficiency, in vivo selection using foamy vectors with MGMTP140K has broad potential for sev

64 t strong viral enhancers/promoters placed in foamy viral vectors caused extremely low immortalization

65 e of a replication-competent clone of bovine foamy virus (BFV) and have quantitated the amount of spl

66 Here we demonstrate that bovine foamy virus (BFV) expresses high levels of three viral m

67 we describe three miRNAs expressed by bovine foamy virus (BFV), a member of the spumavirus subfamily

68 The foamy virus (FV) genome contains two promoters, the cano

69 The cellular factors that mediate foamy virus (FV) latency are poorly understood.

70 Foamy virus (FV) replication is resistant to most nucleo

71 Foamy virus (FV) replication, while related to that of o

72 METHODOLOGY/PRINCIPAL FINDINGS: We used a foamy virus (FV) vector expressing the P140K mutant of m

73 Foamy virus (FV) vectors are particularly attractive gen

74 domain, whereas similar chimeras with human foamy virus (HFV) (containing no zinc fingers) Gag had a

75 As with the human foamy virus (HFV) and feline foamy virus, we have detect

76 reviously constructed vectors based on human foamy virus (HFV) and found that they were able to trans

77 tional transactivator, termed Bel-1 in human foamy virus (HFV) and Tas or Taf in the related simian f

78 nscriptional transactivator encoded by human foamy virus (HFV) can efficiently activate gene expressi

79 A putative cleavage site of the human foamy virus (HFV) envelope glycoprotein (Env) was altere

80 n investigating the characteristics of human foamy virus (HFV) integration.

81 Human foamy virus (HFV) is a retrovirus of the spumavirus fami

82 Human foamy virus (HFV) is the prototype member of the spumavi

83 Human foamy virus (HFV) is the prototype of the Spumavirus gen

84 Human foamy virus (HFV) is the prototype of the Spumavirus gen

85 genomes of the spumaviruses, of which human foamy virus (HFV) is the prototype, are very similar to

86 The Gag protein of human foamy virus (HFV) lacks Cys-His boxes present in the nuc

87 vectors derived from the nonpathogenic human foamy virus (HFV) to transduce human CD34(+) cells and m

88 The infectivity of human foamy virus (HFV) was examined in primary and cultured h

89 Here we generated nonintegrating foamy virus (NIFV) vectors by introducing point mutation

90 p12-M63-PM15 nonviable mutant with prototype foamy virus (PFV) and Kaposi's sarcoma herpesvirus (KSHV

91 rized the in vitro activity of the prototype foamy virus (PFV) IN from the Spumavirus genus and deter

92 termined crystal structures of the prototype foamy virus (PFV) IN tetramer, in complexes with viral D

93 Here we show that the prototype foamy virus (PFV) intasome is proficient at stable captu

94 l structures revealed a network of prototype foamy virus (PFV) integrase residues that distort tDNA:

95 he recent crystal structure of the prototype foamy virus (PFV) integrase-viral DNA complex revealed n

96 maging tools to determine that the prototype foamy virus (PFV) retroviral intasome searches for an in

97 ate (dNTP) incorporation kinetics of primate foamy virus (PFV) reverse transcriptase (RT) in comparis

98 The prototype foamy virus (PFV) structural protein GAG associates with

99 a retroviral Gag protein from the prototypic foamy virus (PFV) that is almost devoid of ubiquitin acc

100 sarcoma leucosis virus (ASLV) and prototype foamy virus (PFV).

101 the discovery and analysis of an endogenous foamy virus (PSFVaye) within the genome of the aye-aye (

102 -cell lymphotrophic virus (STLV), and simian foamy virus (SFV) and for nucleic acids of these same vi

103 Simian Foamy Virus (SFV) can be transmitted from non-human prim

104 Simian foamy virus (SFV) infection and the subsequent immune re

105 Recently, simian foamy virus (SFV) infection was reported in 4 of 231 ind

106 Zoonotic infections with simian foamy virus (SFV), a retrovirus endemic in most Old Worl

107 , simian type D retrovirus (SRV), and simian foamy virus (SFV).

108 bal redistribution of PFV and macaque simian foamy virus (SFVmac) integration sites toward centromere

109 creased when this insulator was removed from foamy virus and significantly reduced when the insulator

110 fy a novel insulator, and support the use of foamy virus as a vector for gene therapy, especially whe

111 a unique insulator, and supports the use of foamy virus as a vector for gene therapy.

112 Thus, foamy virus assembly is distinct from that of other reve

113 Human foamy virus can establish persistent infections in human

114 aposi sarcoma herpesvirus LANA and prototype foamy virus chromatin-binding sequences that blocked nuc

115 3), human papillomavirus 8 E2, and prototype foamy virus chromatin-binding sequences.

116 In arrested cells no foamy virus DNA band was detected in cells harvested at

117 iter infectious pseudotypes, while the human foamy virus Env protein did not.

118 fied the 18-kDa leader peptide (LP18) of the foamy virus envelope protein (FVenv) as a new substrate

119 Foamy virus evolution closely parallels that of the host

120 e been reported for integrase from prototype foamy virus featuring an additional DNA-binding domain a

121 ation signal sequence in Gag, we observed no foamy virus Gag importation into the nucleus in the abse

122 blished evidence for the first time that the foamy virus genome and Gag translocation into the nucleu

123 The foamy virus genome is detected by confocal microscopy in

124 ken together, these results suggest that the foamy virus genome persists in nondividing cells without

125 This report shows that the foamy virus genome remains unintegrated in G(1)/S phase-

126 little sequence similarity with its primate foamy virus homologs, but the putative nucleocapsid (NC)

127 y to a recent crystal structure of prototype foamy virus IN bound to DNA.

128 , we report a crystal structure of prototype foamy virus IN bound to viral DNA prior to 3'-processing

129 of full-length integrase from the prototype foamy virus in complex with its cognate DNA.

130 al structures of the intasome from prototype foamy virus in complex with target DNA, elucidating the

131 the X-ray crystal structure of the prototype foamy virus IN target capture complex together with our

132 Co-crystal structures of the prototype foamy virus intasome have shown that all three FDA-appro

133 transpososomes with structures of Prototype Foamy Virus intasomes suggests a binding mode for target

134 conserved DD35E catalytic core motif of the foamy virus integrase sequence.

135 nc finger of Spt10p is homologous to that of foamy virus integrase, perhaps suggesting that this inte

136 s compared with those observed for prototype foamy virus integrase.

137 Foamy virus is an attractive vector for gene therapy.

138 Thirteen (56%) were coinfected with a simian foamy virus known to be acquired through severe bites.

139 tly earlier than the LTR promoter during the foamy virus life cycle.

140 mediated by a 36-bp insulator located in the foamy virus long terminal repeat (LTR) that has high-aff

141 We demonstrate that the foamy virus long terminal repeats contain an insulator e

142 discovery of PSFVaye indicates that primate foamy virus might be more broadly distributed than previ

143 microscopy of the transfected cells revealed foamy virus particles.

144 When prototype foamy virus Pol is expressed as an orthoretroviral-like

145 Foamy virus Pol precursor protein processing by the vira

146 However, foamy virus replication also resembles that of hepadnavi

147 Foamy virus replication is cell cycle dependent; however

148 d simian foamy viruses, that is critical for foamy virus replication.

149 or intasomes, from the spumavirus prototype foamy virus revealed a functional integrase tetramer, an

150 elements in spleen necrosis virus and human foamy virus RNA and support the model that divergent ret

151 The full-length sequence of simian foamy virus serotype 2 (SFVmcy-2), isolated from a Taiwa

152 position 50 to alanine (R50A) of the simian foamy virus SFV cpz(hu) inhibits proper capsid assembly

153 The resistance of foamy virus supports the hypothesis that the zinc finger

154 reviously demonstrated the utility of simian foamy virus type 1 (SFV-1) as a vector system by transie

155 We have cloned proviral DNA of simian foamy virus type 1 (SFV-1) from linear unintegrated DNA

156 Tas DNA binding site derived from the simian foamy virus type 1 (SFV-1) internal promoter.

157 structed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-act

158 se a model for transactivation of the simian foamy virus type 1 internal promoter in which Tas intera

159 anscriptional transactivator (Tas) of simian foamy virus type 1 strongly augments gene expression dir

160 hs of the dystrophin open reading frame in a foamy virus vector and quantified packaged vector RNA an

161 These results demonstrate that a foamy virus vector can be administered with therapeutic

162 34+ hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete r

163 In newborn SCID-X1 dogs, injection of a foamy virus vector expressing the human IL2RG gene resul

164 and efficacy of in vivo gene therapy using a foamy virus vector for the correction of canine X-linked

165 2-11 and miR-155 function in vivo, we used a foamy virus vector to express the miRNAs in human hemato

166 ults represent the first successful use of a foamy virus vector to treat a genetic disease, to our kn

167 Foamy virus vectors are well-suited for stable delivery

168 be the first stable packaging cell lines for foamy virus vectors based on SFV-1.

169 This potential was applied by optimising foamy virus vectors carrying the full-length dystrophin

170 ing bone marrow cells marked with integrated foamy virus vectors that express green fluorescent prote

171 We found foamy virus vectors to be remarkably less genotoxic, wel

172 Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion d

173 disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human

174 FV-1 which is distantly related to the human foamy virus will provide a means to understand the biolo

175 We have found an endogenous foamy virus within the genomes of sloths and show that f

176 promoters, an effect not explained solely by foamy virus' modest insertional site preference for nong

177 es of integrase-DNA complexes from prototype foamy virus, a member of the Spumavirus genus of Retrovi

178 Vectors derived from foamy virus, a nonpathogenic retrovirus, show higher pre

179 s have no effect on the infectivity of human foamy virus, a spumaretrovirus lacking zinc fingers in i

180 ly mimic the integrase tetramer of prototype foamy virus, and two flanking integrase dimers that enga

181 as the Tas transactivator encoded by primate foamy virus, fail to inhibit RNA interference in human c

182 howed marked cytopathology characteristic of foamy virus, HFV-infected monocyte-derived macrophages f

183 hanism behind the low genotoxic potential of foamy virus, identifies a unique insulator, and supports

184 mechanism underlying the low genotoxicity of foamy virus, identify a novel insulator, and support the

185 we demonstrate a sequence-specific effect of foamy virus, independent of insertional bias, contributi

186 The observation that BFV, a foamy virus, is able to express viral miRNAs in infected

187 with the human foamy virus (HFV) and feline foamy virus, we have detected a spliced pol mRNA by PCR.

188 HIV, simian immunodeficiency virus, MLV, and foamy virus, we show that global and local integration s

189 man immunodeficiency virus type 2, and human foamy virus, which were produced by cell lines expressin

190 ls followed by viral titration with the FAB (foamy virus-activated beta-galactosidase expression) ass

191 in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)] RT w

192 Alu PCR revealed foamy virus-specific DNA amplification from genomic DNA

193 ys they were allowed to cycle, at which time foamy virus-specific DNA amplification was readily obser

194 mia virus, avian sarcoma leukosis virus, and foamy virus.

195 ity, proviral DNA detection and isolation of foamy virus.

196 etroviral vectors based on the nonpathogenic foamy viruses (FV) are an alternative gene-transfer syst

197 Foamy viruses (FV) are complex retroviruses that natural

198 Foamy viruses (FV) are complex retroviruses that possess

199 Retroviral vectors based on foamy viruses (FV) are efficient gene delivery vehicles

200 Foamy viruses (FV) are retroviruses that naturally infec

201 Foamy viruses (FV) are the oldest known genus of retrovi

202 Foamy viruses (FV) comprise a subfamily of retroviruses.

203 Foamy viruses (FV) differ from orthoretroviruses in many

204 iruses but similar to the hepatitis B virus, foamy viruses (FV) require expression of the envelope pr

205 Foamy viruses (FV) synthesize Pol from a spliced pol mRN

206 Spumaviruses, commonly called foamy viruses (FV), are complex retroviruses that establ

207 Foamy viruses (FVs) are ancient retroviruses that are ub

208 Foamy viruses (FVs) are classified in the family Retrovi

209 Although foamy viruses (FVs) are endemic among nonhuman primates,

210 Among all retroviruses, foamy viruses (FVs) are unique in that they regularly ma

211 Foamy viruses (FVs) assemble using pathways distinct fro

212 ysine motif-in the glycoproteins of all five foamy viruses (FVs) for which sequences were available.

213 Foamy viruses (FVs) or spumaviruses are retroviruses tha

214 Foamy viruses (FVs), or spumaviruses, are integrating re

215 Simian and human foamy viruses (SFV and HFV) encode a transcriptional tra

216 lence (4/231, 1.8%) of infection with simian foamy viruses (SFV) among humans occupationally exposed

217 Simian foamy viruses (SFV) are complex retroviruses that are ub

218 oonotic transmission of Old World NHP simian foamy viruses (SFV) has been documented, leading to nonp

219 Simian foamy viruses (SFVs) are highly prevalent in a variety o

220 Simian foamy viruses (SFVs) are ubiquitous, non-pathogenic retr

221 We studied simian foamy viruses (SFVs) from common marmosets, spider monke

222 Simian foamy viruses (SVF) are ubiquitous in nonhuman primates

223 y viruses, suggesting an association between foamy viruses and primates since the haplorrhine-strepsi

224 Foamy viruses are a member of the spumavirus subfamily o

225 Foamy viruses are a ubiquitous family of nonpathogenic r

226 Foamy viruses are complex retroviruses that lead to eith

227 Foamy viruses are complex retroviruses whose replication

228 Foamy viruses are nonpathogenic retroviruses that offer

229 Foamy viruses are retroviruses of the spumavirus family

230 Foamy viruses are retroviruses whose Pol protein is synt

231 icant level of transduction, indicating that foamy viruses could not be pseudotyped with VSV-G to gen

232 Although the tas and ORF-2 regions of foamy viruses have significantly diverged, the results p

233 Foamy viruses have the largest genomes among mammalian r

234 he transcription of genes carried by primate foamy viruses is dependent on two distinct promoter elem

235 These data suggest that foamy viruses possess a replication pathway containing f

236 Thus vectors based on foamy viruses represent a promising approach for HSC gen

237 organization to other complex retroviruses, foamy viruses share several features with their more dis

238 s within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 milli

239 Spumaviruses, commonly called foamy viruses, are complex retroviruses that establish l

240 Foamy viruses, complex retroviruses that infect mammals,

241 coded, respectively, by the human and simian foamy viruses, have been mutationally defined, they show

242 t PSFVaye is divergent from all known simian foamy viruses, suggesting an association between foamy v

243 s (HFV) and Tas or Taf in the related simian foamy viruses, that is critical for foamy virus replicat

244 ed novel vectors, including lentiviruses and foamy viruses.

245 recombination between genetically divergent foamy viruses.