ライフサイエンスコーパス: focal adhesion

1 a strand or an extended structure such as a focal adhesion).

2 -activating protein (RhoGAP) associated with focal adhesions.

3 lasting trailing ends and slower turnover of focal adhesions.

4 ed targeted delivery of integrin vesicles to focal adhesions.

5 y targeting of microtubule plus ends towards focal adhesions.

6 res the cyclical assembly and disassembly of focal adhesions.

7 on of microtubule-stabilizing complexes with focal adhesions.

8 nt and an increase in the area and number of focal adhesions.

9 t heparan sulphate-rich interfaces including focal adhesions.

10 n expression and formation of integrin-based focal adhesions.

11 in deposits via talin1, a major component of focal adhesions.

12 disorganized cell-cell junctions and reduced focal adhesions.

13 podia are disproportionately associated with focal adhesions.

14 regulating the formation and disassembly of focal adhesions.

15 cells expressing paxillin-EGFP to visualize focal adhesions.

16 loss of wide F-actin stress fibers and large focal adhesions.

17 d this in turn blocks maturation of anterior focal adhesions.

18 sociates with alpha-actinin and localizes to focal adhesions.

19 coli protein is required for disassembly of focal adhesions.

20 actin stress fibers anchored in streak-like focal adhesions.

21 and vinculin's molecular clutch mechanism in focal adhesions [11].

22 le of integrins in controlling cytoskeleton, focal adhesion, actomyosin contraction, and actin and mi

23 Paxillin and Hic-5 are homologous focal adhesion adaptor proteins that coordinate cytoskel

24 Turnover of focal adhesions allows cell retraction, which is essenti

25 ults in an overall decrease in the number of focal adhesions along with a concentration of focal adhe

26 glucose-stimulated insulin secretion through focal adhesion and actin remodeling, as well as modulati

27 vern cell motility with a high enrichment in focal adhesion and extracellular matrix-receptor interac

28 e discovery rate (FDR) < 0.05], such as KEGG FOCAL ADHESION and KEGG AXON GUIDANCE, which had been de

29 putative cell communication genes related to focal adhesion and secretion is affected by epistatic ge

30 Mechanistically, LPP increased focal adhesion and stress fiber formation to promote end

31 and metastasis formation via its effects on focal adhesion and survival signaling.

32 r morphology, enhanced cell-matrix adhesion, focal adhesion and, most importantly, increased prolifer

33 with broad lamellipodial protrusions, mature focal adhesions and a gradient of activated Rac1 evident

34 lial cell migration, increases the number of focal adhesions and also compromises cell growth.

35 ligands, and the colocalization of DLC1 with focal adhesions and attenuates tumor suppressor activity

36 -pen showed disruption of filamentous actin, focal adhesions and caveolae-mediated membrane trafficki

37 tein that promotes the maturation of nascent focal adhesions and cell migration.

38 d cultures, expression of syndecan-4 rescues focal adhesions and cell-cell junctions.

39 uced binding probability, leading to smaller focal adhesions and equivalent migration speed relative

40 orylation is required for the development of focal adhesions and invadopodia, key machineries for cel

41 mall protrusions, rapid turnover of immature focal adhesions and lack of a Rac1 activity gradient cha

42 residue Y87 defines its localization to the focal adhesions and leads to activation.

43 sion of pUL7-pUL51 is important to stabilize focal adhesions and maintain cell morphology in infected

44 Here, we show that cadherin-11 localizes to focal adhesions and promotes adhesion to fibronectin in

45 scous response, during which it is lost from focal adhesions and recruited by the cadherin complex to

46 rthermore, Bis-T-23 induced the formation of focal adhesions and stress fibers in cells in which the

47 BKM-120 reduced the numbers of focal adhesions and the velocity of microtubule treadmil

48 We report that, in the absence of focal adhesions and under conditions of confinement, mes

49 bril deposition requires fibronectin-induced focal adhesions, and cell-cell junctions in epithelial c

50 ractile stress fibre accumulation, increased focal adhesions, and higher traction force than controls

51 l adhesion size, formation of zyxin-positive focal adhesions, and reorganization of the actin cytoske

52 thelial cells showed defective lamellipodia, focal adhesions, and repair after wounding, along with i

53 sion of the intracellular signal produced by focal adhesions are determinants of the final cellular a

54 Focal adhesions are dynamic constructs at the leading ed

55 Since focal adhesions are the primary mechanism by which cells

56 keletal stiffness, cell traction stress, and focal adhesion area were significantly lower in the GBM

57 ted by changes in mitochondrial positioning; focal adhesion assembly and stability was decreased in M

58 inner nuclear membrane protein Sun2 promote focal adhesion assembly by activating the small GTPase R

59 orm of SRF/Mkl1 was not sufficient to induce focal adhesion assembly in cells lacking Sun2, however,

60 tination and subsequent degradation regulate focal adhesion assembly, cell migration, and invasion.

61 C complexes and inhibits RhoA activation and focal adhesion assembly.

62 n force to promote actin retrograde flow and focal adhesion assembly.

63 8% CS) involves CS-induced activation of the focal adhesion associated signalosome, which triggers Rh

64 the role of CD103 cytoplasmic domain and the focal adhesion-associated protein paxillin (Pxn) in down

65 otein tyrosine kinase-2, Janus kinase, other focal adhesion-associated proteins, and Rho guanine nucl

66 Myosin X accumulates at nascent focal adhesions at the cell's leading edge, where myosin

67 red that the pUL7-pUL51 complex localizes to focal adhesions at the plasma membrane in both infected

68 forms a vital link between microtubules and focal adhesions at the surface of cells.

69 ocal adhesions along with a concentration of focal adhesions at the wound margin.

70 f ADAMTS10 and ADAMTS6, both of which induce focal adhesions, bind heparin and syndecan-4.

71 Remarkably, Kindlin-2 localizes to not only focal adhesions, but also to the nuclei of chondrocytes.

72 KIF21A, LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1, which dire

73 In focal adhesions, cadherin-11 co-localizes with beta1-int

74 ated with decreased cell spreading, abnormal focal adhesions, changes in the organization of the acti

75 ral stiffness as evidenced by alterations to focal adhesion cluster lengths.

76 the focal adhesion kinase and its associated focal adhesion complex and the consequent acquisition of

77 man skin equivalents, in part by attenuating focal adhesion complex assembly, and prevented and rever

78 g its enzyme activity acts on targets in the focal adhesion complex.

79 6 contributes to the integration of NCAM1 in focal adhesion complexes but, unlike cells lacking PrP,

80 roundings through modulating the activity of focal adhesion complexes.

81 f F-actin stress fibers and reinforcement of focal adhesion contacts.

82 The front focal adhesions contain phospho-Cas which recruits SOCS6

83 1 enhanced CSD-dependent vinculin tension in focal adhesions, dampening force fluctuation and synchro

84 d sensitivity to Mg(2+)- and Ca(2+)-mediated focal adhesion disassembly in metastatic cells, rather t

85 CholA-anchored glycopolymers influenced the focal adhesion distribution.

86 alters actin cytoskeletal rearrangements and focal adhesion dynamics after injury.

87 control integrin activation, thus regulating focal adhesion dynamics and cell migration.

88 ation of ACF7 plays an indispensable role in focal adhesion dynamics and epidermal migration in vitro

89 ACF7 (Actin-Crosslinking Factor 7), promotes focal adhesion dynamics by targeting of microtubule plus

90 during interphase, including cell migration, focal adhesion dynamics, and primary cilia formation.

91 eleton architecture, cell directionality and focal adhesions dynamics.

92 DAMTS6 inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation

93 Importantly, beta-actin mRNA near focal adhesions exhibited sub-diffusive corralled moveme

94 port a novel function of ezrin in regulating focal adhesion (FA) and invadopodia dynamics, two key pr

95 ocesses through mechanochemical signals from focal adhesion (FA) complexes that subsequently modulate

96 , Paxillin, CASL and p130CAS consistent with focal adhesion (FA) formation.

97 FAK and other focal adhesion (FA) proteins associate with the basal bo

98 iates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previou

99 other proteins form protein complexes named focal adhesions (FA) which are considered as the primary

100 in-based structures and functions, including focal adhesions (FAs) and circular dorsal ruffles (CDRs)

101 tein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signalin

102 transmitted by clustered integrins in motile focal adhesions (FAs) and such force is generated by act

103 ation of oncogenic kinases and regulation of focal adhesions (FAs) are crucial molecular events modul

104 Focal adhesions (FAs) are highly dynamic structures that

105 Focal adhesions (FAs) are integrin-based transmembrane a

106 Here we report a population of mitotic focal adhesions (FAs) controls the symmetry of the cleav

107 Focal adhesions (FAs) mechanically couple the extracellu

108 Focal adhesions (FAs) regulate force transfer between th

109 Cells rely on focal adhesions (FAs) to carry out a variety of importan

110 Wild-type APC and APC (m4) localized to focal adhesions (FAs), and APC (m4) was defective in pro

111 amic assembly and disassembly of cell-matrix focal adhesions (FAs), which is essential for efficient

112 ts of Hippo pathway are under the control of focal adhesions (FAs).

113 ted with sites of integrin attachment termed focal adhesions (FAs).

114 : cytoskeleton tension and integrin-mediated focal adhesions (FAs).

115 induction on formation of stress fibers and focal adhesions, filamentous to soluble actin ratio, mat

116 In turn, focal adhesion formation and FAK/SRC signaling is activa

117 robed in vitro and significant modulation of focal adhesion formation and osteochondral lineage commi

118 by increasing tumor cell tension to promote focal adhesion formation and potentiate growth factor re

119 that plays critical roles in cell migration, focal adhesion formation, and is an important component

120 ical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration,

121 serves as an adaptor molecule to facilitate focal adhesion formation, mediates outside-in signaling

122 affect Rho GTPase activity, trafficking, and focal adhesion formation.

123 The presence and regulation of PKD2 at focal adhesions identifies a novel function for this kin

124 furin processing or catalytic sites restores focal adhesions, implicating its enzyme activity acts on

125 -regulate the glycolysis/gluconeogenesis and focal adhesion in cancers of kidney, liver, lung, and ut

126 ation and synchronously stabilizing cellular focal adhesions in a high-tension mode, paralleling effe

127 ed herpesvirus tegument proteins localize to focal adhesions in addition to cytoplasmic juxtanuclear

128 n) is a major adaptor protein that regulates focal adhesions in conjunction with PIP2 in lipid membra

129 Transfected cadherin-11 also localizes to focal adhesions in different mammalian cell lines, while

130 tivation, as well as to the functionality of focal adhesions in fibroblasts, thereby demonstrating an

131 ion on actin "comet tails" that emanate from focal adhesions in stretch-stimulated cells.

132 ing proteins involved in muscle contraction, focal adhesion, integrin, JAK/STAT, MAPK, growth factor,

133 of FAK or paxillin, KSHV-TK has no effect on focal adhesion integrity or cell morphology.

134 he targeting of active phospho-Src away from focal adhesions into autophagic structures that cancer c

135 The lifecycle of a focal adhesion is a highly coordinated process involving

136 We find that talin in focal adhesions is under tension, which is higher in per

137 quired for cell migration through effects on focal adhesions, its role in NA formation and lamellipod

138 rrent FA assembly and Src activation leading focal adhesion kinase (FAK) activation by 42.6 +/- 12.6

139 In addition, vinculin is necessary for Focal Adhesion Kinase (FAK) activation in 3D as vinculin

140 We identified hyperactivated focal adhesion kinase (FAK) activity in neoplastic PDAC

141 Sorafenib dephosphorylated focal adhesion kinase (FAK) and extracellular signal-reg

142 illin at the centrosome that is dependent on focal adhesion kinase (FAK) and identify an important co

143 Specifically, the disruption of focal adhesion kinase (FAK) and paxillin interactions us

144 by a decrease in the phosphorylation of both focal adhesion kinase (Fak) and protein kinase B (Akt).

145 Pharmacological inhibition of both focal adhesion kinase (FAK) and Raf also induced regress

146 Focal adhesion kinase (FAK) and Src family kinases (SFK)

147 urbation of the key IAC signaling components focal adhesion kinase (FAK) and Src.

148 creases tyrosine phosphorylation of p130Cas, focal adhesion kinase (FAK) and the downstream adaptor p

149 e cell through a pathway including paxillin, focal adhesion kinase (FAK) and vinculin.

150 We identified focal adhesion kinase (FAK) as a VHR-interacting molecul

151 We previously identified focal adhesion kinase (FAK) as an important regulator of

152 we identify the adhesion proteins talin and focal adhesion kinase (FAK) as proteolytic targets of ca

153 nhibited alpha3beta1 signaling downstream of focal adhesion kinase (FAK) autoactivation at the point

154 n and a ligand resulted in the activation of focal adhesion kinase (FAK) in a protein kinase C depend

155 Focal adhesion kinase (FAK) in platelets regulated their

156 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

157 Focal adhesion kinase (FAK) is a nonreceptor tyrosine ki

158 Nuclear focal adhesion kinase (FAK) is a potentially important r

159 suppresses autophagy and that activation of focal adhesion kinase (FAK) is necessary for PE-stimulat

160 Both Pyk2 and the closely related focal adhesion kinase (FAK) regulate tumor cell invasion

161 Focal adhesion kinase (FAK) regulates different cellular

162 Inhibition of focal adhesion kinase (FAK) rescued SERT function in syn

163 directly bind paxillin, which in turn bound focal adhesion kinase (FAK) resulting in FAK activation

164 ced phosphorylation of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576).

165 we report that Src family kinases (SFK) and focal adhesion kinase (FAK) sustain AKT and MAPK pathway

166 Activated integrins recruit focal adhesion kinase (FAK) that mediates metastatic dow

167 Activation of the tyrosine kinase focal adhesion kinase (FAK) upon cell stimulation by the

168 Focal adhesion kinase (FAK), a key transmitter of growth

169 e is similar to that produced by deletion of focal adhesion kinase (FAK), a signaling partner of paxi

170 hat COUP-TFII also reduces the activation of focal adhesion kinase (FAK), an integrin downstream regu

171 microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP.

172 MUCL1 silencing abrogated phospho-focal adhesion kinase (FAK), Jun NH2-terminal kinase (JN

173 we show that a signaling axis consisting of focal adhesion kinase (FAK), Src, phosphatidylinositol 3

174 how that fibronectin adhesion stimulation of focal adhesion kinase (FAK)-Src signaling is another ups

175 orylation, which is known to be regulated by focal adhesion kinase (FAK).

176 including CRK-like proto-oncogene (CRKL) and focal adhesion kinase (FAK).

177 cessary for promoting autophosphorylation of focal adhesion kinase (FAK).

178 lso led to the incorporation of activity for focal adhesion kinase (FAK).

179 this residue blocks PKD2's interaction with Focal Adhesion Kinase (FAK).

180 ne receptor 4 (CXCR4) and PTK2 (encoding for focal adhesion kinase [FAK]).

181 Focal adhesion kinase activation and satellite cell numb

182 es several oncogenic pathways, such as early focal adhesion kinase activation upstream of PI3K-mTOR,

183 SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension b

184 beta3 and the concomitant phosphorylation of focal adhesion kinase and AKT in podocytes.

185 ion of integrin-beta3 and phosphorylation of focal adhesion kinase and AKT, known mediators of integr

186 f angiogenic factors and mechanotransducers (focal adhesion kinase and beta1-integrin) ex vivo A 3-we

187 omes that could be reversed by knocking down focal adhesion kinase and depleting it from the MVs or b

188 cones and forms a multiprotein complex with focal adhesion kinase and ERK.

189 A induced cytoskeletal changes and activated focal adhesion kinase and ERKs 1/2, and decreased Src ki

190 f transcription 3-mediated activation of the focal adhesion kinase and its associated focal adhesion

191 3a were dependent on TGF-beta1 activation of focal adhesion kinase and PI3K/Akt.

192 ate that integrin-mediated signaling through focal adhesion kinase and the p38 mitogen-activated prot

193 tein phosphatase 2A (PP2A) and inhibition of focal adhesion kinase by MEK/ERK to allow the binding be

194 lecularly supported by the regulation of the focal adhesion kinase by p38delta in the human breast ce

195 to adopt a structure similar to that of the focal adhesion kinase C-terminal focal adhesion-targetin

196 alpain 1, the primary enzyme responsible for focal adhesion kinase degradation, which becomes induced

197 We have found that focal adhesion kinase expression is downregulated under

198 Focal adhesion kinase is an intracellular protein kinase

199 -WASP via activation of small Rho GTPase and focal adhesion kinase mediates TGF-beta1-induced paracel

200 However, modulation of focal adhesion kinase or Src, the major downstream compo

201 initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits integrin an

202 Focal adhesion kinase phosphorylation indicated that CCL

203 T lymphocytes, which induces ATP secretion, focal adhesion kinase phosphorylation, cell polarization

204 mTOR mutations that clustered in focal adhesion kinase targeting domain (FAT) and kinase

205 sin light chain kinase or phosphorylation of focal adhesion kinase was ineffective.

206 Focal adhesion kinase's (FAK) role in regulating cell mi

207 n of ACF7, whose phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin

208 GAP, GRAF1 (GTPase Regulator Associated with Focal Adhesion Kinase).

209 nt change in mass but a 3-fold increase in P-focal adhesion kinase, 1.5-fold increase in P-Akt, and 5

210 ain of IGFBP-1, through integrin engagement, focal adhesion kinase, and integrin-linked kinase, enhan

211 mpaired by inhibitors of NADPH oxidase, Syk, focal adhesion kinase, and proline-rich tyrosine kinase

212 l-regulated kinase 1 and 2, Elk-1, p38, Akt, focal adhesion kinase, mechanistic target of rapamycin,

213 s and myosin phosphatase activity, including focal adhesion kinase, protein tyrosine kinase-2, Janus

214 ein tyrosine kinases (PTKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1, and neural Wisko

215 uding vasodilator-stimulated phosphoprotein, focal adhesion kinase, the membrane phospholipid translo

216 eral application, here we apply the model to focal adhesion kinase, which initiates the chemical sign

217 previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor

218 eptor (CXCR) 1, and the intracellular kinase focal adhesion kinase-1.

219 The intricate interplay of this "MEK/ERK-focal adhesion kinase-DLC1-PP2A" quartet provides a nove

220 cell motility itself, which instead utilizes focal adhesion kinase-fibronectin signalling.

221 hibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of I

222 w that LKB1 kinase activity is essential for focal adhesion kinase-mediated cell adhesion and subsequ

223 oteolysis of the adhesion proteins talin and focal adhesion kinase.

224 otransduction in primary hepatocytes through focal adhesion kinase.

225 ously expressed non-receptor tyrosine kinase focal adhesion kinase.

226 Importantly LAMB1 stimulated ITG-dependent focal adhesion kinase/Src proto-oncogene non-receptor ty

227 dingly, BA caused an increase in the size of focal-adhesion-kinase/paxillin-positive peripheral adhes

228 Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting

229 ase in the number of actin stress fibers and focal adhesions, leading to enhanced cell migration.

230 ata of vinculin during various stages of the focal adhesion lifecycle are consistent with the propose

231 s contraction, but this arrangement required focal adhesion-like structures near the cell-cell juncti

232 ll lines, while endogenous cadherin-11 shows focal adhesion localization in primary human fibroblasts

233 Focal adhesion <1500 mum was present in 87%.

234 ing contact guidance cues induce constrained focal adhesion maturation and associated F-actin alignme

235 role for phosphorylation at NEK3 Thr-165 in focal adhesion maturation and/or turnover to promote bre

236 Our study suggests that dynamin regulates focal adhesion maturation by a mechanism parallel to and

237 Bis-T-23 promoted stress fiber formation and focal adhesion maturation in a dynamin-dependent manner.

238 f the essential and autonomous regulators of focal adhesion maturation suggests a molecular mechanism

239 ng cell spread area, stress fiber formation, focal adhesion maturation, and intracellular stiffening.

240 ls invasiveness of tumor cells by regulating focal adhesion-mediated motility.

241 f LARG which in turn activated Rho A and the focal adhesion molecules FAK, Pyk2 and paxillin.

242 th the ECM, we examined the roles of several focal adhesion molecules in driving unidirectional motio

243 es modulated gene expression, cell area, and focal adhesion number in hASCs.

244 The size and length of focal adhesions of human foreskin fibroblasts gradually

245 the extracellular matrix (ECM) occur through focal adhesions or hemidesmosomes via the engagement of

246 If SOCS6 cannot access focal adhesions, or if cullins or the proteasome are inh

247 ling, including increased phosphorylation of focal adhesion pathway components.

248 cell migration, mobility, proliferation and focal adhesion pathway were hypomethylated and overexpre

249 k between the LRP4-MuSK pathway and integrin-focal adhesion pathway.

250 and alpha5beta1-specific blockade inhibited focal adhesion phosphorylation and IL-13-enhanced contra

251 ather than changes in integrin expression or focal adhesion phosphorylation.

252 ctin, inhibited ASM adhesion, and attenuated focal adhesion phosphorylation.

253 ly, Kras-inhibited cells displayed prominent focal adhesion plaque structures, enhanced adherence pro

254 hich is necessary for the proper function of focal adhesion points.

255 of phospho-Src and phospho-FAK accumulate at focal adhesions, positively regulating adhesion and inva

256 ation of extracellular matrix remodeling and focal adhesion processes in tumors with high TF, support

257 he turnover of adhesion sites, and, in turn, focal adhesions promote the cortical microtubule capture

258 When FAK is present, Ambra1 is recruited to focal adhesions, promoting FAK-regulated cancer cell dir

259 ensus phospho-YxxP, and to the SRC substrate/focal adhesion protein BCAR1 (p130(CAS)) in the presence

260 indlin-2, which is primarily recognized as a focal adhesion protein in EC, was not anticipated to hav

261 class of small molecules aimed at targeting focal adhesion protein interactions that are essential f

262 This gene encodes kindlin-1, a focal adhesion protein involved in activation of the int

263 t that using small molecules to modulate the focal adhesion protein paxillin is an effective strategy

264 Src kinase-dependent pY14Cav1 regulation of focal adhesion protein stabilization, focal adhesion ten

265 Talin is a ubiquitous, large focal adhesion protein that links intracellular networks

266 Here we show that the focal adhesion protein zyxin is crucial in this process.

267 l polarization loss and an impairment of the focal adhesion proteins dynamics.

268 sine kinases and tyrosine phosphorylation of focal adhesion proteins such as paxillin and Hic-5 are i

269 yosin II to the ECM through mechanosensitive focal adhesion proteins that are collectively termed the

270 Adhesion induces phosphorylation of focal adhesion proteins, including Cas (Crk-associated s

271 ides an introduction to the tensin family of focal adhesion proteins.

272 lay a key role in regulating the activity of focal adhesion proteins.

273 in-mediated cell adhesion via the control of focal adhesion remodeling, and discuss how these emergin

274 c-5 are important for actin cytoskeleton and focal adhesion remodelling and contraction.

275 The assembly of focal adhesions requires the recruitment and activation

276 Hic-5, a focal adhesion scaffold protein, has previously been imp

277 pendent of its localization to, and role in, focal adhesion signaling.

278 cytoskeletal rearrangement and activation of focal adhesion signaling.

279 (the Agl-Glt complex) localizes to so-called focal adhesion sites (FASs) that form stationary contact

280 n cytoskeletal architecture and reduction of focal adhesion size and number, all of which were rescue

281 nt mutant (NEK3-T165V) resulted in increased focal adhesion size, formation of zyxin-positive focal a

282 No detectable change in focal adhesion size, measured by immunofluorescence of F

283 phases and left unchanged binding kinetics, focal adhesion sizes, and migration speed.

284 CF7 is regulated spatiotemporally to achieve focal adhesion-specific guidance of microtubule.

285 ration by supporting membrane protrusion and focal adhesion stability.

286 ctive inhibitors to effectively compete with focal adhesion targeting domain of FAK for the binding t

287 that of the focal adhesion kinase C-terminal focal adhesion-targeting domain.

288 ntifies pY14Cav1 as a molecular regulator of focal adhesion tension and suggests that functional inte

289 ion of focal adhesion protein stabilization, focal adhesion tension, and cancer cell migration is CSD

290 llular matrix (ECM)-receptor interaction and focal adhesion that were also seen in transcriptome diff

291 reconstruct small-scale, compactly supported focal adhesions that are often localized and exist only

292 ytoskeleton, allowing forces exerted through focal adhesions to reach the nucleus.

293 av1 Y14 phosphorylation and the CSD promotes focal adhesion traction and, thereby, cancer cell motili

294 -activated protein kinases, tight junctions, focal adhesion, transforming growth factor-beta, vascula

295 CS6) ubiquitin ligase, inhibit Cas-dependent focal adhesion turnover at the front but not rear of mig

296 Microtubules are implicated in focal adhesion turnover, cell polarity establishment, an

297 GAR22beta(-/-) cells showed a more prominent focal adhesion turnover.

298 R22beta(-/-) cells reduced cell motility and focal adhesion turnover.

299 ull-length ADAMTS6 lack heparan sulphate and focal adhesions, whilst depletion of ADAMTS6 induces a p

300 main pathways: Wnt signaling, cell cycle and focal adhesion with the gene Spp1, also known as osteopo