ライフサイエンスコーパス: focally

1 l membrane antigen (EMA) (one diffusely, one focally).

2 2 wave fronts, activation was mapped arising focally.

3 43 carcinomas (49%) were completely (35) or focally (8) negative for p16.

4 ned 30% reduction in intraocular pressure by focally ablating and cauterizing the trabecular meshwork

5 es; positron emission tomographic scans were focally abnormal in 3 of 3 cases.

6 lthough the histopathological appearance was focally abnormal in all cases.

7 ed as the absence of any large (> 1.5 cm) or focally abnormal lymph node.

8 AV-Cre markedly reduced A1 receptor mRNA and focally abolished the postsynaptic response to adenosine

9 deposits in both vaccinated individuals were focally absent in some regions.

10 protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading protease

11 glutamate uncaging was used to randomly and focally activate neurons in the granule cell layer, hilu

12 ted tumor models, expression of p16(LUC) was focally activated by early neoplastic events, enabling v

13 Laser-scanning photo-uncaging of glutamate focally activated neurons in layer II while excitatory s

14 This study evaluated the effects of focally administered acetylcholine on AVN conduction and

15 tion of epithelial and mesenchymal HSPG will focally affect epithelial proliferation rates.

16 delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment

17 rexpressed or endogenous VCP did not seem to focally aggregate inside neurons, TDP-43 and ubiquitin a

18 Initial CAST depletion focally along dendrites coincides topographically with c

19 Focally altered functional connectivity also was observe

20 by more advanced strategies for directly and focally altering neural activity.

21 One such gene, PAX8, is focally amplified in 16% of high-grade serous ovarian ca

22 Myc enhancers coincide with a region that is focally amplified in approximately 3% of acute myeloid l

23 hat were pathogenic in three genomic regions focally amplified in oestrogen receptor-positive breast

24 screening assays, we identified an oncogene, focally amplified lncRNA on chromosome 1 (FAL1), whose c

25 ttern, in which endocardial activation arose focally and either had a propagation sequence similar to

26 n in vitro model of angiogenesis, as well as focally and intensely expressed at sites of pathological

27 inflammatory lung injury may sometimes begin focally and propagate sequentially via the airway networ

28 that inflammatory lung injury may also begin focally and propagate sequentially via the airway networ

29 xamined to determine whether mutations arose focally and spread or whether they emerged independently

30 as designed to explore the dynamics of Tregs focally and systemically in lung transplant recipients.

31 that the beta-catenin mutations were present focally and therefore may occur during tumor progression

32 visual cortical area V5/MT to reduce the SNR focally and thus disrupt visual motion discrimination pe

33 NV, and eotaxin was usually present but more focally and with less intense staining.

34 With a view to creating a focally applicable genetic calcium channel blocker, we o

35 he putative sensory neuron transmitter, were focally applied (0.1 Hz) to solitary motor neurons in cu

36 e preparation, Ca(2+) mobilization evoked by focally applied artificial sweeteners was significantly

37 In this report, we show that focally applied BDNF increases the number of action pote

38 In this study, we show that focally applied forces of this magnitude using a newly d

39 Focally applied GABA and glycine onto outside-out patche

40 how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it ac

41 ctively responded to L-glutamate when it was focally applied to the apical chemosensitive tips of rec

42 Diffuse mesangial sclerosis (focally approaching nodular glomerulosclerosis), focal a

43 fluorescent changes of L(0) were followed by focally arising Ca(2+) waves (L(2)), which propagated at

44 d that the host immune response is modulated focally around areas with biofilm, but inflammation with

45 VPF/VEGF mRNA was also expressed focally at lower levels by infiltrating inflammatory cel

46 1pdm virus-infected ferret lung globally and focally at sites of infection.

47 e at enhancer regions, being anti-correlated focally at transcription factor-binding sites but positi

48 eceptor blockade for 14 days after BA in the focally atherosclerotic rabbit significantly reduced res

49 balloon angioplasty limits restenosis in the focally atherosclerotic rabbit.

50 A measured 24 hours after angioplasty in the focally atherosclerotic rabbit.

51 iles, and standardized uptake value (SUV) in focally avid lesions.

52 at the neural plate is flexible enough to be focally bent and shaped into a neural tube, while retain

53 Cartilage develops focally between areas of epithelial proliferation and su

54 Enhancing activity by focally blocking cortical GABAergic inhibition had a sim

55 lly pigmented, whereas the other 5 were only focally brown-black.

56 ALS begins focally but disseminates to cause paralysis and death.

57 MDLs too may be replaced focally by cytoplasmic pockets, sometimes in the same qu

58 dermal tumors, AKT activity can be activated focally by up-regulation and phosphorylation of the AKT2

59 ganization of pVHL.HIF-1alpha recognition is focally centered on Gln(145) within the L7 loop, and its

60 ixty percent of the tumors revealed at least focally clear-cell cytology.

61 sed an endothelial monolayer, and reappeared focally compacted on its distal surface, away from the a

62 fection, which was followed by steatosis and focally confluent necrosis.

63 Rapamycin was focally, continuously, and unilaterally infused into the

64 The patients presented with vascularized, focally cystic, nonulcerated eyelid margin lesions.

65 ts the chromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56.

66 rescence (FIAF), geographic atrophy (GA) and focally decreased autofluorescence (FDAF) was analyzed i

67 (18)F-FDG PET images of AD demonstrate focally decreased cerebral metabolism involving especial

68 loss of peritubular capillaries (as noted by focally decreased RECA-1 and OX-2 staining) in areas of

69 Focally decreased thickness was seen in the superior tem

70 n myotubularin-deficient muscle fibers, with focally defective areas recapitulating the global altera

71 nd an adeno-associated viral (AAV) vector to focally delete endogenous adenosine A1 receptors in the

72 Finally, human Sds22 is focally deleted and downregulated in multiple carcinomas

73 e their roles in thalamocortical rhythms, we focally deleted synaptic, gamma2 subunit-containing GABA

74 We have used the method to focally deliver agrin (a molecule implicated as a postsy

75 We used a microfluidic device to focally deliver agrin to protosynaptic AChR clusters in

76 sy-to-fabricate perfusion device designed to focally deliver pharmacological agents to brain slices.

77 ith six serial subconjunctival injections of focally delivered carboplatin chemotherapy (100 microg/d

78 Potential toxicity of focally delivered carboplatin was assessed by histology

79 idence of ocular toxicity was detected after focally delivered Carboplatin.

80 hether constitutively exocytosed membrane is focally delivered to the cleavage furrow.

81 ecules or other molecules of interest can be focally delivered to the myotubes using heterogeneous mi

82 Our previous work introduced a technique for focally denervating the olfactory bulb soon after birth

83 and its metabolite, cholestanol, which were focally deposited at the apical and basal sides of the r

84 acellular matrix protein fibronectin (FN) is focally deposited in regions of atherosclerosis, where i

85 ions, whereas Mel-CAM expression can only be focally detected in 12 of 72 (17%) breast carcinomas.

86 hat the polycomb H3K27me3-repressive mark is focally diminished in TAL1(+) T-ALLs.

87 MTg neurons enriched in GAD67 mRNA, and were focally directed to a distinctive DR subdivision immunoh

88 Although parenchymal amyloid was focally disaggregated, vascular deposits were relatively

89 Although senile plaques focally disrupt neuronal health, the functional response

90 Second, rodents with focally disrupted MFC D1 dopamine receptor (D1DR) signal

91 EGFR amplification was focally distributed in lung cancer specimens, mostly in

92 ficult to detect because they are scarce and focally distributed in multiple sites.

93 orders of brain development and suggest that focally distributed mutations are also prevalent in norm

94 If wave fronts ever arise focally during VF, it should be possible to map them app

95 These regions included focally dysgenetic cortex, the cortex lining schizenceph

96 imaging at the choriocapillaris level showed focally enlarged vessels in 8 of 15 eyes (53%).

97 This focally evoked activity powerfully suppressed distant gr

98 Focally evoked calcium waves in astrocyte cultures have

99 on seizure susceptibility in a rat model of focally evoked complex partial seizures.

100 rographic seizure patterns in a rat model of focally evoked limbic epilepsy.

101 study examined the functional role of MD in focally evoked limbic motor seizures in the rat.

102 D, the enhancement of which protects against focally evoked limbic motor seizures.

103 approach, multiphoton excitation is used to focally excite noncytotoxic photosensitizers that promot

104 as bulky, polypoid intraluminal masses that focally expand the esophagus without causing obstruction

105 led bulky, polypoid intraluminal masses that focally expanded the esophagus without causing obstructi

106 are positioned on a laminin-rich matrix and focally express vimentin and Lewis(x) and show up-regula

107 In addition, the corneal epithelial cells focally expressed Fn mRNA.

108 By IHC, Bmi-1 was focally expressed in the basal layers of almost all esop

109 stochemical staining revealed GSK3beta to be focally expressed in the invasive portions of 12 and 33%

110 wever, unlike most renal carcinomas, it also focally expressed melanocytic proteins.

111 Focally folded myelin has been recognized as a distincti

112 ral neuropathy characterized by distinctive, focally folded myelin sheaths.

113 to be examples of hereditary neuropathy with focally folded myelin sheaths.

114 stains were positive for CD34, vimentin, and focally for CD68, but were negative for S100 and SMA.

115 large- and small-vessel endothelium stained focally for defensin.

116 lly for epithelial markers but instead label focally for melanocytic markers HMB45 and Melan A.

117 ected rats from limbic motor seizures evoked focally from area tempestas, an epileptogenic site in th

118 ipant in the generation of seizures elicited focally from piriform cortex; (2) transmission via AMPA

119 ral collector nerve and (2) from single PGNs focally from the caudal ventral artery of the tail.

120 Synaptic responses were recorded focally from the diaphragm synapses during electrical st

121 e DMS suppressed goal-directed behaviors, as focally genetic knockdown of striatopallidal A(2A)Rs in

122 alpha-hydroxylase for de novo synthesis of a focally high 1,25-dihydroxyvitamin D concentration in th

123 ined by cuboidal, ciliated epithelial cells, focally immunopositive for cytokeratin and S-100 protein

124 s expressed diffusely in 12 of 17 tumors and focally in 3 and was undetectable in 2 tumors.

125 3 patients, and nuclear grade 3 was observed focally in 8 patients.

126 usually express heat shock protein 70 except focally in a few tumors.

127 early multiple sclerosis, and present mainly focally in cortical lesions, whereas more diffusely in w

128 MSCTs originated focally in dendritic regions <1 microm in length and dec

129 ger RNA and fibrils appeared transiently and focally in forming cleft regions of submandibular saliva

130 MIG mRNA expression was detected initially focally in infiltrating neutrophils (15 hours after IA e

131 In contrast, when bicuculline was applied focally in the dendritic region, the NMDA-mediated respo

132 an T cells around dermal porcine vessels and focally in the epidermis.

133 goblet, and intermediate cells were present focally in the ileum of SAMP1/YitFc mice by 4 weeks of a

134 na cava, or tricuspid annulus or by ablating focally in the lateral RA.

135 brainstem tumors originating at the tectum, focally in the midbrain, dorsal and exophytic to the bra

136 rns 96% of the time, one potentially arising focally in the Purkinje system that was prevented with a

137 Administration of 4-CIN focally in the retrotrapezoid nucleus (RTN), a medullary

138 When bicuculline was applied focally in the somatic region, the feedback IPSP was blo

139 1), with >25% to 50% of cells being positive focally in the splenic white pulp of six septic but in n

140 tissue enhanced diffusely in two and weakly focally in two.

141 We then focally inactivated kinesin-5 in various regions of the

142 Ten patients demonstrated preoperatively a focally increased (18)F-FDG uptake at the level of the s

143 cose uptake in all ZL control rats, while no focally increased (18)F-FDG uptake was detected in all Z

144 Diffuse or focally increased (18)F-florbetapir uptake was noted in

145 In contrast, CD36 expression focally increased at sites of cartilage injury and coloc

146 The relationship between focally increased autofluorescence (FIAF), geographic at

147 These data indicate that focally increased expression of NGF in one part of a syn

148 cell adhesion molecule (VCAM)-1 staining was focally increased in two of three specimens.

149 Examinations exhibiting focally increased radiotracer uptake were considered pos

150 artilage is different in appearance than the focally increased T2 observed in damaged articular carti

151 On PET, focally increased uptake in the prostate was suggestive

152 (18)F-AFETP demonstrated focally increased uptake in tumors with good visualizati

153 in all patients with cardiac pacemakers and focally increased uptake of mild intensity in 8 of 27 pa

154 CT-corrected PET images revealed focally increased uptake of moderate intensity in all pa

155 us cell carcinoma tissues, both signals were focally increased where high proliferative activity was

156 We show that focally increasing mTORC1 activity during late corticoge

157 ed regions and was able to detect regions of focally induced demyelination.

158 e rejection episodes, DR3 and SODD were more focally induced, generally at sites of mononuclear cell

159 This neuropathy phenotype is associated with focally infolded myelin loops that protrude into the axo

160 Focally infused or systemic rapamycin inhibits the mamma

161 B-334867 (OX(1)R antagonist) into the RTN to focally inhibit OX(1)R and studied the effects of both t

162 To focally inhibit p11 expression in the dorsal striatum, w

163 and NBQX (15 nmol) or vehicle (VEH) solution focally injected into the injury site 15 min later.

164 There was focally intense deposition of eosinophil peroxidase in t

165 s, when administered either systemically, or focally into substantia nigra.

166 atypical cells that fill the lumen and bulge focally into, and frequently compromise, the fibromuscul

167 mative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six (one with focal loss of al

168 s progressed into the subarachnoid space and focally invaded the brain.

169 ologically these tumors consisted largely of focally keratinizing squamous cell carcinoma with high-g

170 medulloepitheliomas were either diffusely or focally LIN28A positive (weak, moderate, or strong).

171 that (i) secondary thalamic alterations are focally located in specific thalamic nuclei depending on

172 To address this issue, we focally lowered the temperature of distinct cortical reg

173 incorporate into nascent thrombi, which are focally lysed from within, an attractive thromboprophyla

174 We focally manipulated activity within the CeA or BLA in ma

175 Here we tested this idea by focally manipulating the brain activity of juvenile zebr

176 antagonists, or a GABA-elevating agent were focally microinfused into MD before evoking seizures by

177 alpha1 noradrenergic agonist (phenylephrine) focally microinjected into DLSC as compared to effects i

178 a, the present study evaluated the effect of focally microinjecting a NMDA antagonist into the amygda

179 us fibroblasts in the perinodal region would focally modify AV nodal conduction and that this modulat

180 We conclude that tFUS can be used to focally modulate human cortical function.

181 ular injury is common in sepsis but presents focally; most renal tubular cells appear normal.

182 ies revealed a severe intensity, diffuse and focally nodular lymphocytic infiltrate composed predomin

183 Eleven gorilla mother-infant dyads were focally observed in weekly 1-hr sessions for 12 months.

184 After treatment, mother-infant pairs were focally observed.

185 se individual mtDNA deletions can accumulate focally, occur with multiple mixed breakpoints, and in t

186 f strength, the first few activations appear focally on the epicardium at almost the same site at the

187 The first global activation cycle appeared focally on the left ventricular apical epicardium 78+/-3

188 persal, BRCA1, BARD1, and Rad51 accumulated, focally, on PCNA+ replication structures, implying an in

189 associated with weight loss, often beginning focally or asymmetrically in the thigh or leg but usuall

190 By focally photolyzing a novel caged IP3 compound in dendri

191 ecurrent inhibitory circuits in layer II, we focally photostimulated interneurons while recording inh

192 r and developed ascites; the tumor cells are focally positive for CA125 and mesothelin.

193 epithelial markers tested, whereas four were focally positive for cytokeratin and two were reactive f

194 Normal valve cusps were only focally positive for smooth muscle actin and LAP.

195 ases; MYB was negative in 5 cases and weakly focally positive in 2 cases.

196 had an LR rate of 27%, whereas patients with focally positive margins had an intermediate rate of LR

197 Among the 45 patients with focally positive margins who received systemic therapy,

198 Immunohisto-chemically, focally positive p53 staining was found in four papillar

199 Focally positive scans often indicate disease requiring

200 es of DVT obtained with 123I-bitistatin were focally positive within 1 hr and improved by 4 hr.

201 n) as one of the following: negative, close, focally positive, or extensively positive.

202 ve, and in 2 of the 79 (3%) the labeling was focally positive.

203 ith intracytoplasmic lipid and glycogen were focally present in tumors of 94% papillary renal cell ca

204 ring spindles; and (3) thalamic spindles are focally projected back to cortex, arriving during the do

205 Miniature end-plate potentials (MEPPs) were focally recorded from the cytoplasmic surface of electro

206 , where theoretical studies suggest they may focally regulate cellular activity.

207 availability is nonuniformly distributed and focally regulated.

208 surface of the endoplasmic reticulum, which focally reorganizes close to the immobilized mitochondri

209 uidic device and surface microengineering to focally stimulate muscle cells with agrin at a small por

210 Ca(2+) entry in L5 pyramidal cell axons when focally stimulated with NMDAR agonists.

211 damental precepts, we developed a method for focally stimulating the living hearing organ with light.

212 s progresses toward deeply invaginated buds, focally synthesized phosphoinositides are dephosphorylat

213 e drug delivery of therapeutic agents in new focally targeted ways.

214 , either sham or active (1Hz, 1,200 pulses), focally targeting the malformations of cortical developm

215 mplanted unilaterally in the NDB to activate focally the projections to PC in unanesthetized rats.

216 reased laminin function are characterized by focally thick and redundant myelin.

217 he tube (52 [19%] cases), and development of focally thickened small-bowel folds (24 [9%] cases).

218 echanism that underlies this effect operates focally to enhance neuronal sensitivity and improve tuni

219 When cobalt or kynurenic acid was applied focally to inhibit electrical activity at the site of pl

220 elevation of PKC appears to contribute only focally to subnormal retinal DeltaPO(2).

221 ependently when arachidonic acid was applied focally to the abluminal surface of the vessels.

222 ewer "core" parvalbumin neurons that project focally to the middle cortical layers and more "matrix"

223 Right atrial streak artifact focally traversed the right coronary artery in only one

224 he graft did not have biomechanical strength focally until 18 months, but the patient has not needed

225 sed in UGS mesenchyme during budding and was focally up-regulated as buds emerged from the anterior,

226 Cholestasis, present focally, was manifested as dilated bile canaliculi, part

227 carcinomas were positive either diffusely or focally, whereas staining was primarily focal or absent

228 evealed that a fraction of GATA1 is retained focally within mitotic chromatin.

229 ndicator of wnt pathway activation, was seen focally within roughly one third of the tumors, though a