ライフサイエンスコーパス: focus forming

1 PI3K pathway, were undetectable, colony and focus forming abilities of the v-Src-RIE cells were only

2 of Rac1, and to a lesser extent RhoA, block focus forming ability of the GTPase-deficient mutant of

3 tive than ca Rac or ca Cdc42 in rescuing the focus forming ability of the mutants.

4 However, MAPK is not essential for the focus forming ability of the three oncogene-transformed

5 K stimulation by Vav, as well as reduces the focus-forming ability of Vav in NIH3T3 murine fibroblast

6 anced, whereas a dn PAK mutant inhibited the focus-forming ability of Vav3-(6-10).

7 We observed a striking cooperative effect on focus-forming ability when Galpha12 and c-raf-1 cDNAs we

8 Despite having potent focus-forming ability, Vav3-(6-10) has very weak colony-

9 d the transformation phenotype and inhibited focus-forming ability.

10 dimers displayed a five- to sevenfold higher focus-forming ability.

11 resulted in synergistic cooperation of their focus-forming activities, indicating that Ras activates

12 n of Dbs with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP.RhoA i

13 intracellular domain that confers the higher focus forming activity mediated by the beta PDGFR.

14 expression of full-length RalGDS reduced the focus forming activity of activated TC21.

15 ted from human placenta markedly reduced the focus forming activity of cotransfected, malignantly act

16 l residues showed a several 100-fold greater focus forming activity than that seen with deletion of 6

17 In addition to its potent focus forming activity, constitutive overexpression of P

18 ant negative Rho most potently inhibited the focus forming activity, whereas Cdc42 was most effective

19 We have previously purified a protein, focus-forming activity 1 (FFA-1), which is involved in t

20 ve identified and purified a 170-kD protein, focus-forming activity 1 (FFA-1), which is required for

21 ensity, lower cell-doubling times, increased focus-forming activity and higher ability to grow on sem

22 ition, an Ad9 E1 region plasmid demonstrated focus-forming activity in both low-passage-number and es

23 n from a Ras-responsive promoter element and focus-forming activity in NIH 3T3 cells.

24 inhibition of either IKK-1 or IKK-2 reduced focus-forming activity in Ras-transformed RLEs.

25 potent mitogenic effect of thrombin and the focus-forming activity of one of its receptors, protease

26 The observed inhibitory effect of C3G on focus-forming activity of Ras and Sis was always higher

27 Activated PI3K enhanced the focus-forming activity of Vav3-(6-10).

28 of Stat3 resulted in a 60% inhibition of the focus-forming activity of Vav3-(6-10).

29 Compared to wild-type GRF1, the focus-forming activity on NIH 3T3 cells of the GRF1 DH c

30 2 cooperated with Raf and showed synergistic focus-forming activity, both quantitative and qualitativ

31 ial MEK5-ERK5 effectors that might influence focus-forming activity.

32 LV) that is derived from the ampho-mink cell focus-forming (AMP/MCF) retrovirus in the serum of one r

33 The focus-forming and anchorage-independent growth activitie

34 tures were also assayed for infectivity in a focus-forming assay, and a correlation (P = 0.0002) was

35 lymorphic respiratory isolate, using a novel focus-forming assay.

36 transforming activity in a Rat-2 fibroblast focus-forming assay.

37 rphologically transformed NIH 3T3 cells in a focus-forming assay.

38 NIH3T3 cells were used to screen for focus-forming genes using the ERM strategy.

39 photropic (4070A), and amphotropic-mink cell focus-forming hybrid (10A1) envelope constructions have

40 ptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumul

41 Mink cell focus-forming (MCF) murine leukemia viruses (MLVs) are t

42 exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs).

43 To examine the possible role of mink cell focus-forming (MCF) recombinant virus in raising levels

44 classic toxicity of the polytropic mink cell focus-forming (MCF) retrovirus in mink cells.

45 MuLVs comprised ecotropic and mink lung cell focus-forming (MCF) virus classes and are termed Rausche

46 nce to infection by the polytropic mink cell focus-forming (MCF) virus subgroup of murine leukemia vi

47 the sequence similarity of XMRV to mink cell focus-forming (MCF) viruses and the enhanced leukemogeni

48 gence of recombinant polytropic or mink cell focus-forming (MCF) viruses.

49 0002) was measured between the percentage of focus-forming microsporidia and the percentage of expect

50 nexpectedly, at least two types of mink cell focus-forming MuLV elements, arising from endogenous ret

51 Upon inoculation into AKR mice, mink cell focus-forming murine leukemia virus (MCF MLV) accelerate

52 ction of thymic lymphocytes by the mink cell focus-forming murine leukemia virus (MCF MLV) during the

53 fection of thymic lymphocytes by a mink cell focus-forming murine leukemia virus induces apoptosis du

54 of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for vir

55 Using high-throughput focus-forming reduction or luciferase-based neutralizati

56 rmore, the amount of viral nucleoprotein per focus forming unit differed markedly whether viruses wer

57 rved: replication defective (dead; titer < 1 focus-forming unit [FFU]/ml), replication compromised (R

58 assay) and 11.7 h (by replating fluorescent focus-forming unit assay).

59 H77-S particles (5.4 x 10(4) RNA copies per focus-forming unit) was significantly lower than JFH-1 v

60 than JFH-1 virus (1.4 x 10(2) RNA copies per focus-forming unit).

61 on, animals were challenged with 5.0 log(10) focus forming units (FFU) of a wild-type dengue-2 virus.

62 The assay's analytical sensitivity was 10 focus forming units, and respiratory specimens with thre

63 netics and an infectivity titer of 6.7 log10 focus-forming units (FFU)/ml.

64 ce inoculated with greater than 2 x 10(5) R7 focus-forming units (FFUs).

65 ood agreement with the ratio of particles to focus-forming units determined by infectivity assays.

66 ually at immunization titers as low as 10(3) focus-forming units for both RV vaccine vectors.

67 transformation in vitro with an abundance of focus-forming units in monolayer cultures and anchorage-

68 end virus complex was determined to be 10(3) focus-forming units of attenuated virus.

69 trols were infected intranasally with 10 000 focus-forming units of influenza A/WSN/33 (H1N1) per mou

70 days after subcutaneous inoculation of 10(6) focus-forming units of SFTSV.

71 hing HCV infectivity titers of 3.9-4.5 log10 focus-forming units per milliliter.

72 ectious particles of approximately 5 log(10) focus-forming units per mL; passaged TNcc did not requir

73 More R7Delta447 than R7Delta447K focus-forming units were detected in both NIH3T3 and mou

74 elded approximately 4.5 x 10(4) to 1 x 10(5) focus-forming units/ml.

75 of up to 10(6) alkaline phosphatase-positive focus-forming units/ml.

76 nd J8 achieved infectivity titers >4.5 log10 Focus-Forming Units/mL.

77 each group was challenged orally with 10(5) focus-forming-units of virulent HRV at 33 days of age.

78 The spleen focus forming virus (SFFV) gp55-P envelope glycoprotein

79 ority of tumors induced by the murine Spleen Focus Forming virus (SFFV), while fli-1 proved to be the

80 der control of the strong, ubiquitous Spleen Focus Forming Virus promoter within a self-inactivating

81 tor (pSFF) derived from murine Friend spleen focus forming virus was used to transduce murine hematop

82 growth factor beta receptor; gp55 of spleen focus forming virus, which activates the erythropoietin

83 ene of the polycythemic strain of the spleen focus forming virus.

84 Constructs containing the viral spleen-focus-forming virus (SF), ubiquitous promoters, or cell

85 Friend spleen focus-forming virus (SFFV) causes rapid erythroleukemia

86 The Friend spleen focus-forming virus (SFFV) encodes a unique envelope gly

87 The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope gly

88 The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope gly

89 The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope pro

90 The Friend spleen focus-forming virus (SFFV) env gene encodes a 409-amino-

91 The Friend spleen focus-forming virus (SFFV) env gene encodes a glycoprote

92 erythroid progenitor cells by Friend spleen focus-forming virus (SFFV) leads to acute erythroid hype

93 on of erythroid cells with the Friend spleen focus-forming virus (SFFV) leads to the interaction of t

94 throid cells infected with the Friend spleen focus-forming virus (SFFV) proliferate in the absence of

95 dies enhanced the expression of Sfpi1 spleen focus-forming virus (SFFV) proviral integration 1 (PU.1)

96 inkins osteosarcoma oncogene (c-fos), Spleen focus-forming virus (SFFV) proviral integration 1 (PU.1)

97 Infection of mice with Friend spleen focus-forming virus (SFFV) results in a multistage eryth

98 Spi-1) by retroviral insertion of the spleen-focus-forming virus component of Friend virus.

99 The gp55 envelope proteins of the spleen focus-forming virus initiate erythroleukemia in adult mi

100 nd virus-induced erythroleukemia, the spleen focus-forming virus integrates into the PU.1 locus betwe

101 rus envelope glycoprotein (F-gp55) of spleen focus-forming virus or specific mutations in the extrace

102 nt binding sites for CCAAT/CEBPalpha, spleen focus-forming virus, proviral integration oncogene (SPI1

103 oviral insertion in nearly all Friend spleen focus-forming virus-transformed murine erythroleukemia c

104 her MuLV complex but do not include a spleen focus-forming virus.