ライフサイエンスコーパス: folate

1 uency questionnaire validated against plasma folate.

2 arding cobalamin, folate, and red blood cell folate.

3 iated with modestly higher breast-milk total folate.

4 r most adult patients), and 400-1,000 mug IV folate.

5 ed yeast bioengineering to fortify wine with folate.

6 reduction in growth rate upon withdrawal of folate.

7 ) values for serum concentration biomarkers: folate, 0.49; vitamin B-12, 0.51; alpha-carotene, 0.53;

8 germ cell proliferation is stimulated by the folate 10-formyl-tetrahydrofolate-Glun both in vitro and

9 Folate deficient mice had lower serum folate (-60%).

10 he EARs for iron (97%), vitamin D (96%), and folate (70%).

11 r (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans.

12 HFR and TS activities and, as a consequence, folate abundance.

13 g insights into genes involved in SA-induced folate accumulation, microarray data of responsive genes

14 Pharmacological inhibition of folate action by methotrexate during neurulation induces

15 ellular and molecular mechanisms involved in folate action during neural tube formation.

16 The elucidation of the mechanisms underlying folate action has been challenging.

17 We further demonstrate that folate activates a metabolic regulator AMPKalpha to prom

18 intakes with serum and red blood cell (RBC) folate among 4878 men and nonpregnant, nonlactating wome

19 Folate, an essential micronutrient, is a critical cofact

20 ceive regular chow diet, a diet deficient in folate and B vitamins (Diet), which results in high Hcy,

21 Folate and B vitamins were log transformed and calorie a

22 We examined associations between serum folate and insulin resistance using multiple linear regr

23 el cellular and molecular events mediated by folate and lead to new ways of preventing NTDs.

24 l associations were found for red blood cell folate and other sulfur amino acids.

25 regulator and demonstrated that it controls folate and ubiquinone biosynthesis.

26 ent.We sought to determine breast-milk total folate and unmetabolized folic acid (UMFA) contents and

27 arkers predictive of HFS, including baseline folate and vitamin B12 levels, as well as genetic polymo

28 Most homocysteine-lowering trials with folate and vitamins B6 and/or B12 tested as protective a

29 applied to the efficient production of other folates and a range of other natural compounds with appl

30 fication of micronutrients (provitamin A and folates) and an essential amino acid (lysine) in three m

31 B vitamins [vitamins B-6, B-9 (folate), and B-12] play important roles in nucleotide bi

32 Results Use of supplemental vitamins B6, folate, and B12 was not associated with lung cancer risk

33 a putative interaction between phosvitin and folate, and offer an improved model for the structure of

34 difference was observed regarding cobalamin, folate, and red blood cell folate.

35 Pteridines, such as pterins, folates, and flavins, are heterocyclic metabolites that

36 rthermore, we have demonstrated differential folate- and riboflavin-derivative reactivity by a divers

37 Mean levels of vitamin B-12 and folate are lower in individuals with undiagnosed celiac

38 molecules, as well as in epigenetic control, folates are vital for all living organisms.

39 fatty acids [contained in fish oil (FO)] and folate, are important in achieving normal brain developm

40 a previously unknown molecular link between folate availability and cell function involving PCFT and

41 vel specific molecular link between maternal folate availability and fetal growth, involving regulati

42 cations for our understanding of how altered folate availability causes diseases such as fetal growth

43 cations for our understanding of how altered folate availability causes human diseases such as fetal

44 , including cancer, that have been linked to folate availability.

45 nt transport, and therefore fetal growth, to folate availability.

46 Folate B12-dependent remethylation of homocysteine is im

47 Folates (B9 vitamins) are essential cofactors in one-car

48 enerated from oxidative decomposition of the folate backbone.

49 eural tube defects (NTDs), although just how folates benefit the developing embryo and promote closin

50 The present study reports the presence of folate binding proteins (FBPs) in the plants, coriander

51 ng a unique demethylase fold and a canonical folate-binding domain.

52 down-regulated, whereas a gene of a putative folate-binding protein (FPB) was up-regulated, which cor

53 highly sensitive and selective SPR chip for folate biomarker sensing in serum.

54 , while keeping the sensing capabilities for folate biomarkers.

55 accessions, little polymorphism was found in folate biosynthesis genes.

56 key gene encoding the rate-limiting step of folate biosynthesis in wine yeast.

57 Trimethoprim and sulfamethizole are both folate biosynthesis inhibitors.

58 egarding drug synergies in the mycobacterial folate biosynthesis pathway.

59 data showed that exogenous pABA is used for folate biosynthesis, and leads to decreased stress and e

60 mily that implements the penultimate step in folate biosynthesis.

61 The results revealed that folate biosynthetic genes were largely down-regulated, w

62 amino acid, S-adenosyl methionine (SAM) and folate biosynthetic pathways.

63 cations.We examined usual dietary intakes of folate by using the National Cancer Institute method to

64 Mean adequacies of vitamin A, vitamin C, folate, calcium, iron, and zinc and diet diversity score

65 5% CI, 0.67-0.99), as well as high intake of folate, calcium, or fiber.

66 PMX is transported by the reduced folate carrier (RFC) and proton-coupled folate transport

67 s reduced flavin relays a methylene from the folate carrier to the nucleotide acceptor.

68 the inhibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate

69 as enriched in nuclei, accounting for 35% of folate cofactors, explaining previous observations that

70 ption of the methylation pathway mediated by folate compromises normal neural tube closure (NTC) and

71 icator in persons >/=4 y of age (e.g., serum folate concentration <10 nmol/L and RBC folate concentra

72 serum folate concentration <7 nmol/L and RBC folate concentration <305 nmol/L derived with the use of

73 erum folate concentration <10 nmol/L and RBC folate concentration <340 nmol/L derived with the use of

74 icator in persons >/=4 y of age (e.g., serum folate concentration <7 nmol/L and RBC folate concentrat

75 tube defects in women 12-49 y old (e.g., RBC folate concentration <906 nmol/L derived with the use of

76 from supplements was associated with breast folate concentration and species.

77 Women with high plasma folate concentrations (>24.4 ng/mL) were associated with

78 compared with that of women with low plasma folate concentrations (</=24.4 ng/mL).

79 lasma fraction, which correlated with higher folate concentrations.

80 Our study shows that folate content in commercial wine is not related to whit

81 contribution of polyglutamates to the total folate content remained low in the types of product incl

82 Folate content was estimated in tomato (Solanum lycopers

83 Folate contributes to a 1-carbon metabolism, which is es

84 Folate cutoffs for risk of deficiency compared with poss

85 ogether, our study identifies MTHFD1L in the folate cycle as an important metabolic pathway in cancer

86 thesis pathway and mitochondrial one-carbon (folate cycle) metabolism to increase mitochondrial antio

87 We found that an enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1-

88 The folate cycle, through transfer of a carbon unit between

89 The methionine-folate cycle-dependent one-carbon metabolism is implicat

90 Caution is needed in the use of dietary folate data to estimate the prevalence of inadequacy amo

91 s) had lower mean levels of vitamin B-12 and folate (data collected from 2009 through 2012) than pers

92 his work has produced the first standardised folate dataset in Europe, which was used to calculate fo

93 ith anemia, but malaria and vitamin B-12 and folate deficiencies were not.The contribution of iron de

94 nosis and management of iron, cobalamin, and folate deficiencies, the most frequent causes of anemia

95 Cerebral folate deficiency (N=12) was most common, with normal se

96 th CCD had ferritin deficiency (P = .007) or folate deficiency (P = .003) than patients with USCD or

97 Folate deficiency also caused a decrease in phosphorylat

98 KEY POINTS: Folate deficiency during pregnancy is associated with re

99 Folate deficiency has been associated with an increased

100 Folate deficiency in fetal life is strongly associated w

101 Folate deficiency in PHT cells caused inhibition of mTOR

102 Maternal folate deficiency inhibited placental mTORC1 and mTORC2

103 ate sensor in vivo in mice and that maternal folate deficiency inhibits placental mTOR signaling and

104 dicate that the MTHFR C677T polymorphism and folate deficiency interact to increase the stochastic be

105 Maternal folate deficiency is linked to restricted fetal growth,

106 r folates that can act as vitamins to rescue folate deficiency lack this germ cell stimulatory activi

107 ons.There was a very low prevalence (<1%) of folate deficiency when serum (<7 nmol/L) and RBC (<305 n

108 Association of folate deficiency with neural tube defects and impact of

109 All patients with cerebral folate deficiency, including one with low CSF levels of

110 ciated with fetal abnormalities and cerebral folate deficiency-related developmental disorders.

111 ct of the polymorphism on FOCM is greater in folate deficiency.

112 loblastic anemia observed in vitamin B12 and folate deficiency.

113 In late pregnancy, fetal weight in the folate deficient group was decreased (-17%, p < 0.05), w

114 Folate deficient mice had lower serum folate (-60%).

115 ly upregulated in cancer and involve various folate-dependent enzymes.

116 Folate-dependent methylation of septins governs ciliogen

117 at small ubiquitin-like modifier (SUMO)- and folate-dependent nuclear de novo thymidylate (dTMP) bios

118 urements of metabolite concentrations of the folate-dependent one-carbon metabolism and transulfurati

119 epletion, and this effect was exacerbated by folate depletion.

120 Here, we describe MR1 autoreactivity and folate-derivative reactivity in a discrete subset of TRA

121 tor of this cycle, and other oxidation-prone folate derivatives kills human, mouse and chicken cells

122 nzyme to regulate folate metabolism, however folate/DHFR activity in oligodendrocyte development has

123 dentify a previously uncharacterized role of folate/DHFR/AMPKalpha axis in regulating oligodendrocyte

124 Likewise, survivin siRNA-loaded and folate-displaying extracellular vesicles inhibited patie

125 The folate-driven one-carbon (1C) cycle is a fundamental met

126 r goal was to determine whether high dietary folate during pregnancy affects brain development in mur

127 to enhance the content and stability of the folates during post-harvest storage.

128 mited availability of methyl donors, such as folate, during pregnancy may result in abnormal gene met

129 Arabidopsis, and their contributions toward folate enhancement.

130 Here we show that folate enhances oligodendrocyte maturation both in vitro

131 Genetic impairments in folate enzymes increase dependence on dietary choline fo

132 ment is more compatible with UPLC-MS/MS than folate extraction techniques involving the addition of e

133 ddress these limitations, we loaded ATO onto folate (FA)-labeled human serum albumin (HSA) pretreated

134 ed drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that FA-CS-UA-NPs

135 ripe fruit, 5-CH3-THF was the most abundant folate form.

136 The accumulation of folate forms and their distribution varied among accessi

137 estimation of red-ripe fruits detected three folate forms, 5-CH3-THF, 5-CHO-THF, 5,10-CH(+)THF and fo

138 ilation was done in four steps: (1) identify folate-free foods then find folate values for (2) folate

139 not receive the recommended daily intake of folate from diet alone.

140 Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrog

141 equired for intestinal folate absorption and folate homeostasis in humans.

142 Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prosta

143 Although low dietary folate impacts brain development, recent concerns have f

144 Ensuring stability of the increased natural folate in all wines was achieved by the addition of asco

145 significance because of the critical role of folate in normal cell function and the wide range of dis

146 C) analysis indicated high concentrations of folate in the plasma fractions (230microg/g dry matter)

147 The stability of folate in these wines, once opened for consumption, did

148 cylic acid (SA) enhanced the accumulation of folates in coriander, a study was conducted in Arabidops

149 working day for the analysis of vitamin B9 (folate) in infant formula and adult/pediatric nutritiona

150 ate, the fully reduced and bioactive form of folate, in schizophrenia.

151 Folate incorporation increased the frequency of intracel

152 These findings provide new insight into how folate influences human cell physiology and may have imp

153 er in other categories of family history and folate intake (P-interaction = 0.55).

154 ducation and income, smoking, school) and of folate intake (P= 0.009,R(2)= 0.285).

155 a prerequisite to study the relation between folate intake and diseases.

156 at was validated to estimate typical dietary folate intake and the use of FASs at 10-13 and 28-32 wk

157 In summary, high folate intake during pregnancy leads to pseudo-MTHFR def

158 ATIONALE: A potential adverse effect of high folate intake during pregnancy on children's asthma deve

159 opment, recent concerns have focused on high folate intake following food fortification and increased

160 To prospectively investigate folate intake from both food and supplements during preg

161 rrelated with 1-carbon metabolism (1-CM), as folate intake is positively related and total plasma hom

162 found among women with a family history and folate intake less than 400 mug/day (multivariate hazard

163 ed with a diet rich in folate, reach a total folate intake level associated with a slightly increased

164 When folate intake was >2 times the Recommended Dietary Allow

165 Maternal folate intake was assessed with a food frequency questio

166 High folate intake was associated with a reduced risk of prog

167 Alcohol consumption and folate intake were measured by food frequency questionna

168 the highest versus lowest quintile of total folate intake with an adjusted relative risk of 1.23 (95

169 iation of the TCN2 776C-->G polymorphism and folate intake with peripheral neuropathy in elders with

170 ciation was stratified by family history and folate intake, a positive association between alcohol co

171 l and by family history of breast cancer and folate intake, we prospectively followed 93,835 US women

172 differentiation, which could be reversed by folate intake.

173 a family history of breast cancer and lower folate intake.

174 euterated trimethyl amine group) and meeting folate-intake recommendations.

175 population reported inadequate total dietary folate intakes (6%).

176 o examine the relation between self-reported folate intakes and folate status biomarkers and to evalu

177 taset in Europe, which was used to calculate folate intakes in EPIC; a prerequisite to study the rela

178 ndings have implications for women with high folate intakes, particularly if they are polymorphic for

179 on of these products to population's dietary folate intakes.

180 uring neurulation induces NTDs by inhibiting folate interaction with its uptake systems.

181 's tetrahydrofolate-binding site and protein-folate interactions.

182 ed the production of vitamin A, vitamin B12, folate, iron, zinc, calcium, calories, and protein.

183 Folate is a key source of the one-carbon group for DNA m

184 ABSTRACT: Folate is a water-soluble B vitamin that is essential fo

185 addition, we demonstrate that maternal serum folate is positively correlated to placental mTORC1 and

186 Folate is vital for fetal development.

187 Our results indicate that variation in folate level is governed by a more complex regulation at

188 CI, 1.10-1.47; P = .001), and red blood cell folate levels (OR, 1.25; 95% CI, 1.08-1.44; P = .003) we

189 ], 1.99; 95% CI, 1.32-3.00; P = .001), serum folate levels (OR, 1.27; 95% CI, 1.10-1.47; P = .001), a

190 Despite the significant variation in folate levels among tomato accessions, little polymorphi

191 cy (N=12) was most common, with normal serum folate levels and low CSF 5-methyltetrahydrofolate (5-MT

192 Serum and red blood cell folate levels are independent predictors of HFS.

193 ignificantly associated with maternal plasma folate levels during pregnancy (false discovery rate 5%)

194 Low maternal folate levels in pregnancy are associated with fetal gro

195 Analysed folate levels in three brands were greater than label va

196 rms, 5-CH3-THF, 5-CHO-THF, 5,10-CH(+)THF and folate levels ranged from 14 to 46mug/100g fresh weight.

197 The MA revealed that in red-ripe fruits folate levels ranged from 4 to 60mug/100g fresh weight.

198 h MA revealed that MA inaccurately estimates folate levels.

199 olate pathway to understand its linkage with folate levels.

200 uintile had a relatively high intake of food folate (median, 308; interquartile range, 241-366 mug/d)

201 concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemoth

202 Folate-mediated one-carbon metabolism (FOCM) is an inter

203 d fatty acid metabolism, one carbon pool for folate metabolism and flavonoid biosynthesis.

204 In addition, a novel function of folate metabolism in plants is proposed, i.e., maintenan

205 amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner tha

206 reductase (DHFR) is a key enzyme to regulate folate metabolism, however folate/DHFR activity in oligo

207 ond, our probe captured proteins involved in folate, methionine, and ubiquinone metabolism, suggestin

208 Intakes of choline, folate, methionine, and vitamins B6 and B12 were assesse

209 MAP3K14 expression to tubular cells in acute folate nephropathy and human AKI.

210 nction, inflammation, and apoptosis in acute folate nephropathy and less kidney dysfunction and a low

211 ing of the renal proteome in mice with acute folate nephropathy.

212 ed in Arabidopsis, where twofold increase in folates occurred in foliage upon SA treatment.

213 e arrow results in display of RNA aptamer or folate on the outer surface of the extracellular vesicle

214 Folate one-carbon units support purine and thymidine syn

215 CI, 1.12-1.52; P < .001) and red blood cell folate (OR, 1.28; 95% CI, 1.10-1.49; P = .001) were the

216 In multivariate analyses, serum folate (OR, 1.30; 95% CI, 1.12-1.52; P < .001) and red b

217 atly increased the odds of having high serum folate (OR: 17.6; 95% CI: 5.5, 56.0).When assessing fola

218 ses covaried for six genetic variants in the folate pathway previously associated with symptom severi

219 influenced by common genetic variants in the folate pathway that hinder conversion to its active form

220 orphism was examined in the key genes of the folate pathway to understand its linkage with folate lev

221 The one-carbon folate pathway, specifically methylenetetrahydrofolate d

222 Plasma folate, PLP, and vitamin B-12 concentrations were catego

223 signalling, suggesting that mTOR senses low folate rather than high homocysteine.

224 commended dose, combined with a diet rich in folate, reach a total folate intake level associated wit

225 Finally, binding to the folate receptor (FOLR1) overexpressed in a cancer cell l

226 nclear how Juno - which was previously named folate receptor (FR) 4, based on sequence similarity con

227 Folate receptor (FR) is highly expressed in many types o

228 very and ultrasound-stimulated activation of folate receptor (FR)-targeted phase-change contrast agen

229 erated rat IgE and IgG mAbs specific for the folate receptor (FRalpha), which is expressed widely on

230 We show that knockdown of folate receptor 1 (Folr1; also known as FRalpha) impairs

231 traits-including the expression of CD73 and folate receptor 4, and the epigenetic modification of Tr

232 Folate receptor alpha (FRalpha) autoantibodies have been

233 rug conjugate consisting of a humanized anti-folate receptor alpha (FRalpha) monoclonal antibody link

234 s specific for the cancer-associated antigen folate receptor alpha.

235 The folate receptor homolog FOLR-1 is required for the stimu

236 Our findings support a model in which the folate receptor interacts with cell adhesion molecules,

237 LM are taken up by activated macrophages via folate receptor mediated endocytosis and that their hydr

238 study model, we hypothesized that IMI with a folate receptor targeted near-infrared contrast agent (O

239 FA-HSA-ATO could specifically recognize folate receptor-beta-positive (FRbeta+) chronic myeloid

240 asily internalized by cancer cells through a folate receptor-mediated endocytic pathway.

241 In this research, we have developed a folate receptor-targeting multifunctional dual drug-load

242 ttachment of folic acid ligand recognized by folate receptors of cancer cells is described).

243 JQ-FT is recognized by folate receptors on the plasma membrane and delivered in

244 lic acid as a drug-delivery system targeting folate receptors.

245 viously unknown molecular mechanism by which folate regulates trophoblast cell function.

246 elated molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invaria

247 Folate requirements increase during pregnancy and lactat

248 d cutoffs were 5.6% compared with 16% (serum folate), respectively, and 7.4% compared with 28% (RBC f

249 (1999-2006) to <1% compared with <1% (serum folate), respectively, and to <1% compared with 2.5% (RB

250 ectively, and to <1% compared with 2.5% (RBC folate), respectively.

251 espectively, and 7.4% compared with 28% (RBC folate), respectively; risks declined postfortification

252 Mouse models of folate-responsive neural tube defects (NTDs) indicate th

253 h changes in SHMT expression is causative in folate-responsive NTDs.

254 ng regulation of placental mTOR signaling by folate, resulting in changes in placental nutrient trans

255 e-free foods then find folate values for (2) folate-rich foods common across EPIC countries, (3) the

256 Folate sensing by mTOR in PHT cells involves both mTOR C

257 Folate sensing by mTOR in PHT cells involves both mTOR C

258 We propose that mTOR folate sensing in trophoblast cells matches placental nu

259 The involvement of PCFT in mTOR folate sensing is not dependent on its function as a pla

260 t and mitochondrial function, placental mTOR folate sensing may constitute the mechanistic link betwe

261 mTOR folate sensing may have broad biological significance be

262 rlying genetic susceptibility interacts with folate-sensitive metabolic processes at the time of neur

263 ic target of rapamycin (mTOR) functions as a folate sensor in primary human trophoblast (PHT) cells.

264 Here we show that mTOR functions as a folate sensor in primary human trophoblast (PHT) cells.

265 sted the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate d

266 titute the mechanistic link between maternal folate status and fetal growth.

267 association and mechanistic linkage between folate status and insulin resistance remains unclear wit

268 ion between self-reported folate intakes and folate status biomarkers and to evaluate their usefulnes

269 th concerns with regard to both low and high folate status exist in the United States.

270 (OR: 17.6; 95% CI: 5.5, 56.0).When assessing folate status in the United States, where fortification

271 e occurred between intakes and biomarkers of folate status when distributions were examined (i.e., do

272 ched cutoffs leads to a misinterpretation of folate status.

273 tatus indicators reflect the same underlying folate status; however, the higher prevalence estimates

274 ransient expression of p53 or in response to folate stress, which is known to activate p53.

275 Folate supplementation during pregnancy, rather than FO

276 Folate supplementation prevents up to 70% of neural tube

277 ted with symptom severity and/or response to folate supplementation.

278 which allow continued ribosome assembly and folate synthesis, respectively.

279 Other folates that can act as vitamins to rescue folate defici

280 ddiction of ALL to folic acid, we conjugated folate to an alcohol derivative of thapsigargin via a cl

281 Ab can trigger inflammation as well as block folate transport to the fetus and to the developing brai

282 uced folate carrier (RFC) and proton-coupled folate transporter (PCFT).

283 The proton-coupled folate transporter (PCFT, SLC46A1) is required for intes

284 plex 1 and 2 and requires the proton-coupled folate transporter (PCFT, SLC46A1).

285 dentified a tandem array of genes encoding a folate transporter family, TbFT1-3, as major contributor

286 plex 1 and 2 and requires the proton-coupled folate transporter.

287 pendent on its function as a plasma membrane folate transporter.

288 ps: (1) identify folate-free foods then find folate values for (2) folate-rich foods common across EP

289 ty, prepregnancy body mass index, and plasma folate, vitamin B-12, and choline concentrations.

290 markers, including carotenoids, tocopherols, folate, vitamin B-12, and phospholipid fatty acids, were

291 Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation

292 Breast-milk total folate was 18% higher (P < 0.001) in supplement users (n

293 Total folate was associated with 2.56 more digits on the DSST

294 serum folate, where a 25% increase in serum folate was associated with a 3.06% (95% CI, -4.72, -1.37

295 The main contributor to total folate was folic acid, 5-methyl-tetrahydrofolate was the

296 Our findings demonstrate that serum folate was inversely associated with insulin resistance

297 when serum (<7 nmol/L) and RBC (<305 nmol/L) folate were considered, whereas a higher proportion of t

298 ional NHANES, serum and red blood cell (RBC) folate were first measured with the use of a radioprotei

299 The results demonstrate that phosvitin and folate were stable under the HHP conditions applied in t

300 a significant inverse relationship for serum folate, where a 25% increase in serum folate was associa