ライフサイエンスコーパス: folate deficiency

1 e beta (beta-pol) is observed in response to folate deficiency.

2 le-strand break repair gene was activated by folate deficiency.

3 h abnormal hepatic methionine metabolism and folate deficiency.

4 rhomocysteinemic mice even in the absence of folate deficiency.

5 fferences in the prevalence of cobalamin and folate deficiency.

6 n due to the mutation was absent in men with folate deficiency.

7 ct of the polymorphism on FOCM is greater in folate deficiency.

8 expense of homocysteine remethylation during folate deficiency.

9 previously described as a model for systemic folate deficiency.

10 loblastic anemia observed in vitamin B12 and folate deficiency.

11 nd p-Tau was exacerbated in cells exposed to folate deficiency.

12 hnRNP-E1 was a plausible candidate sensor of folate deficiency.

13 growth by creating an intracellular state of folate deficiency.

14 ally relevant, sensitive, cellular sensor of folate deficiency.

15 No patients developed iron, vitamin B12 or folate deficiency.

16 ay be the result of vitamin B-12 rather than folate deficiency.

17 ic acid alone or folic acid + iron decreased folate deficiency.

18 omocysteine to form methionine, as occurs in folate deficiency.

19 Ethanol feeding and folate deficiency acted together to decrease the liver S

20 Folate deficiency activated base and nucleotide excision

21 uggest that, in addition to vitamin B-12 and folate deficiencies alone, there may be adverse birth ou

22 Maternal folate deficiency alone is sufficient to induce NTDs in

23 Folate deficiency also caused a decrease in phosphorylat

24 Folate deficiency also increased the CD4(+) to CD8(+) ra

25 Abrupt reversal of folate deficiency also led to a rapid parallel reduction

26 These data indicate that folate deficiency alters the balance and coordination of

27 serum folate levels, and the prevalences of folate deficiency and anemia were not associated with de

28 y anemia was defined as the presence of both folate deficiency and anemia.

29 r intermediates, these data demonstrate that folate deficiency and beta-pol haploinsufficiency intera

30 One-carbon metabolism is compromised by folate deficiency and common genetic polymorphisms.

31 Although FRs are upregulated in folate deficiency and downregulated following folate rep

32 We determined the prevalence of folate deficiency and folate-deficiency anemia within a

33 -and also to its side effects, which include folate deficiency and gastrointestinal upset.

34 ic acid, which has reduced the prevalence of folate deficiency and hyperhomocysteinemia.

35 Folate deficiency and hypomethylation have been implicat

36 ship between hyperhomocysteinemia induced by folate deficiency and premature hearing loss involves im

37 logical and experimental studies have linked folate deficiency and resultant increased homocysteine l

38 hyperhomocysteinemic mice in the absence of folate deficiency and that levels of SAM and SAH are alt

39 e the genetic and epigenetic consequences of folate deficiency and to investigate whether impairment

40 anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin defi

41 levated plasma total homocysteine (tHcy) and folate deficiency, and have shown that folate supplement

42 ine, for detection of either vitamin B-12 or folate deficiency, and methylmalonic acid for detection

43 ome and is the most accurate animal model of folate deficiency anemia described to date that closely

44 dge, no one has determined the prevalence of folate-deficiency anemia after fortification.

45 folic acid fortification, the prevalence of folate-deficiency anemia is nearly nonexistent in a comm

46 Overall, the prevalence of folate-deficiency anemia was <0.1% (1 of 1546 subjects).

47 Folate-deficiency anemia was defined as the presence of

48 ined the prevalence of folate deficiency and folate-deficiency anemia within a sample of the Reasons

49 Notably, the effect of folate deficiency appears more deleterious in female emb

50 In laboratory models, folate deficiency appears to induce p53 mutation.

51 Correction of folate deficiency approximately doubles the efficacy of

52 n American women and elevated serum tHcy and folate deficiency are more prevalent in elderly African

53 h metabolically significant vitamin B(12) or folate deficiency are particularly prone to depression.

54 Folate deficiency around the time of Friend virus-infect

55 animal studies to human pregnancy shows that folate deficiency as well as one-time exposure to enviro

56 hat thymidylate biosynthesis is preserved in folate deficiency at the expense of homocysteine remethy

57 Folate deficiency can occur because dietary folate intak

58 e uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT-mediated

59 Though both radiation and folate deficiency caused DNA breaks, they affected the e

60 The nucleotide imbalance due to folate deficiency causes cell cycle arrest in the S phas

61 Folate deficiency causes massive incorporation of uracil

62 Furthermore, because folate deficiency causes neural tube defects, some birth

63 Cerebral folate deficiency (CFD) syndrome is a neurodevelopmental

64 Levels of folate deficiency commonly found resulted in effects sim

65 nutritional status of the subjects, because folate deficiency could confound the effects of low-dose

66 Both radiation and folate deficiency decreased cell proliferation and induc

67 Folate deficiency decreased liver folate levels and incr

68 Folate deficiency decreases thymidylate synthesis from d

69 Red blood cell folate is measured for folate deficiency diagnosis, because it reflects the lon

70 These results indicate that folate deficiency did not exert its enhancement of leuke

71 beta-pol-haploinsufficient mice subjected to folate deficiency displayed additional increases in DNA

72 gether, these findings strongly suggest that folate deficiency disrupts the BBB function by targeting

73 Folate deficiency does not cause NTDs in wild-type mice,

74 KEY POINTS: Folate deficiency during pregnancy is associated with re

75 Folate deficiency, either by diet or drug, increases pla

76 ns may therefore be a means by which dietary folate deficiency enhances carcinogenesis.

77 Folate deficiency enhances colorectal carcinogenesis in

78 In summary, folate deficiency enhances perturbations in hepatic meth

79 women, we also calculated the prevalence of folate deficiency (erythrocyte folate < 317.2 nmol/L) wi

80 ely, knockdown of either protein accelerates folate deficiency-evoked cell toxicity.

81 tudies demonstrated that Aldh1l1, similar to folate deficiency, evokes metabolic stress and causes ap

82 Folate deficiency (FD) has been shown to induce DNA dama

83 However, folate deficiency had no additional effect on the DNA mu

84 Folate deficiency has been associated with an increased

85 Folate deficiency has been associated with many adverse

86 Folate deficiency has been associated with uracil misinc

87 Folate deficiency has been shown to be associated with i

88 ified with folic acid, and the prevalence of folate deficiency has decreased dramatically.

89 Folate deficiency has serious consequences for the fetus

90 Cellular folate deficiency impairs one-carbon metabolism, resulti

91 Dietary or genetic folate deficiency impairs this cycle, leading to develop

92 Thus, folate deficiency impedes tumor growth rate, but supplem

93 In contrast with previous evidence of folate deficiency in adult IBD patients, our data indica

94 cumulation and the apoptosis were induced by folate deficiency in erythroblasts from p53 null mice.

95 Folate deficiency in fetal life is strongly associated w

96 s is one of several factors used to diagnose folate deficiency in humans.

97 cancer and cognitive defects associated with folate deficiency in humans.

98 ors and MTHFD1 protein in the nucleus during folate deficiency in mouse liver and human cell lines ac

99 Folate deficiency in PHT cells caused inhibition of mTOR

100 conjunction with a low-folate diet prevented folate deficiency in pregnant women.

101 We investigated the effect of isolated folate deficiency in rats on DNA methylation and DNA str

102 All patients with cerebral folate deficiency, including one with low CSF levels of

103 In some studies, folate deficiency increased the development and growth o

104 Hence, folate deficiency increases the risk of NTDs in genetica

105 Folate deficiency induced a pronounced global increase i

106 Folate deficiency induces DNA breaks and may alter cellu

107 Our data indicate that folate deficiency induces DNA strand breaks and hypometh

108 e was not associated with changes in iron or folate deficiency, inflammation, or high blood lead.

109 The mechanism by which folate deficiency influences carcinogenesis is not well

110 To elucidate the mechanism by which folate deficiency influences carcinogenicity, we have an

111 Maternal folate deficiency inhibited placental mTORC1 and mTORC2

112 ate sensor in vivo in mice and that maternal folate deficiency inhibits placental mTOR signaling and

113 dicate that the MTHFR C677T polymorphism and folate deficiency interact to increase the stochastic be

114 As a consequence, folate deficiency is a global problem.

115 ers, and seeds are poor in this vitamin, and folate deficiency is a worldwide problem.

116 A metabolic effect of folate deficiency is an elevation of blood homocysteine.

117 Folic acid is an essential nutrient, and folate deficiency is associated with a variety of disord

118 The data suggest that folate deficiency is associated with gene-specific methy

119 Folate deficiency is linked to many diseases, some of wh

120 Maternal folate deficiency is linked to restricted fetal growth,

121 Folate deficiency is typically indicated when circulatin

122 significant folate for accurately diagnosing folate deficiency, is 5-methyltetrahydrofolic acid (5 MT

123 r folates that can act as vitamins to rescue folate deficiency lack this germ cell stimulatory activi

124 Folate deficiency leads to increased dUMP/dTMP ratios an

125 Folate deficiency leads to neural tube defects and other

126 Because physiological folate deficiency led to the intracellular homocysteinyl

127 Folate deficiency (<11 nmol/L) was associated with 75% a

128 Folate deficiency may accelerate or promote ALD by incre

129 Correction of folate deficiency may decrease the frequency of intragen

130 Our results suggest that folate deficiency may enhance the development of acute l

131 Clinical studies have indicated that folate deficiency may enhance the development of various

132 During folate deficiency mouse liver MTHFD1 levels are enriched

133 Cerebral folate deficiency (N=12) was most common, with normal se

134 rates of folate catabolism and simultaneous folate deficiency occur in several physiological states,

135 cinogenicity, we have analyzed the effect of folate deficiency on base excision repair (BER), the pat

136 e of this study was to address the impact of folate deficiency on hearing loss and to examine the und

137 investigated the functional consequences of folate deficiency on HPV16 in immortalized HPV16-harbori

138 n animal studies that examined the effect of folate deficiency on malignancies, conflicting results h

139 Examples are the effect of folate deficiency on neural tube development during earl

140 thymidine, or deoxyuridine with and without folate deficiency on NTD incidence in the Shmt1 mouse mo

141 We examined the effect of transient folate deficiency on the development of leukemia in mice

142 specific effects of ethanol with or without folate deficiency on the expressions and activities of h

143 ols, and experimental evidence suggests that folate deficiency or focal administration of homocystein

144 ethylation, particularly in populations with folate deficiency or hyperhomocysteinemia or both, may l

145 Acute folate deficiency or incubation of CCRF-CEM with AICAr-r

146 Although < 0.5% of children had folate deficiency or low vitamin B-12 status, the consum

147 th CCD had ferritin deficiency (P = .007) or folate deficiency (P = .003) than patients with USCD or

148 In the absence of clinical folate deficiency, periconceptional supplementation with

149 The prevalence of folate deficiency (plasma folate </= 6.8 nmol/L) in the

150 sensing of varying degrees of physiological folate deficiency, prior to adaptive optimization of cel

151 The prevalence of folate deficiency (RBC folate <or= 160 ng/mL) was <1%.

152 Folate deficiency reduced proliferation of T lymphocytes

153 ciated with fetal abnormalities and cerebral folate deficiency-related developmental disorders.

154 ngitudinal follow-up showed that gestational folate deficiency results in behavioral changes-an anxie

155 Ethanol feeding or folate deficiency, separately or in combination, decreas

156 Folate deficiency (serum folate <11.4 nmol/L, tHcy >13.9

157 ne, which accumulates intracellularly during folate deficiency, stimulated interactions between heter

158 blished "folate trap," creating a functional folate deficiency that may contribute to the metabolic p

159 nosis and management of iron, cobalamin, and folate deficiencies, the most frequent causes of anemia

160 Folate deficiency, therefore, could contribute to abnorm

161 e for beta-pol in the phenotype expressed by folate deficiency, these data are also consistent with t

162 pidemiologic studies have linked nutritional folate deficiency to an increased risk of cancer, but re

163 rradiated or cultured at different levels of folate deficiency to assess cell proliferation, apoptosi

164 umented the resulting decrease in anemia and folate deficiency, to our knowledge, no one has determin

165 trategies are currently implemented to fight folate deficiency, up until now, all of them have their

166 ne synthase reaction, results in a secondary folate deficiency via the accumulation of folate as 5-me

167 Folate deficiency was defined as a serum folate concentr

168 A wide response to folate deficiency was seen in cells from different donor

169 ith anemia, but malaria and vitamin B-12 and folate deficiencies were not.The contribution of iron de

170 Children of mothers with prenatal folate deficiency were at higher risk of emotional probl

171 ons.There was a very low prevalence (<1%) of folate deficiency when serum (<7 nmol/L) and RBC (<305 n

172 finity throughout the range of physiological folate deficiency, which correlated with a proportionate

173 ive patients were subsequently found to have folate deficiency, which left 18 evaluable patients in t

174 Folate deficiency with anemia declined significantly in

175 in a micropig model where combining dietary folate deficiency with chronic ethanol feeding produced

176 Association of folate deficiency with neural tube defects and impact of